Naspm (BioDeep_00000009503)

 

Secondary id: BioDeep_00001883503

Toxin


代谢物信息卡片


1-Naphthylacetylspermine

化学式: C22H34N4O (370.2732)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 97.44%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN
InChI: InChI=1S/C22H34N4O/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27)

描述信息

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

同义名列表

4 个代谢物同义名

1-Naphthylacetylspermine; Naspm; 1-Naphthylacetyl spermine; 1-Naphthylacetylspermine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CA3, GRIN2B, NASP, PIK3CA
Endoplasmic reticulum membrane 3 DRD1, GRIA1, GRIN2B
Nucleus 4 DRD1, FOS, GRM1, NASP
cytosol 6 CA1, CA3, FOS, GRIA1, PIK3CA, PRKCQ
dendrite 5 DRD2, GRIA1, GRIA2, GRIA4, GRM1
nucleoplasm 2 FOS, NASP
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 13 DRD1, DRD2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B, GRM1, GSG1L, TRPM2, TRPM3
lamellipodium 1 PIK3CA
Early endosome membrane 1 GRIA1
Multi-pass membrane protein 14 DRD1, DRD2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B, GRM1, GSG1L, SYP, TRPM2, TRPM3
Golgi apparatus membrane 1 DRD2
Synapse 3 DRD2, GRIA1, GSG1L
cell surface 2 GRIA1, GRIN2B
dendritic shaft 1 GRIA1
glutamatergic synapse 6 DRD1, DRD2, GRIA1, GRID1, GRM1, GSG1L
Golgi membrane 1 DRD2
lysosomal membrane 1 TRPM2
neuromuscular junction 2 GRIA1, SYP
neuronal cell body 3 GRIA1, GRIA2, GRIA4
postsynapse 1 GRIA2
presynaptic membrane 4 DRD1, DRD2, GRIK1, SYP
synaptic vesicle 1 SYP
Lysosome 2 GRIN2B, TRPM2
Presynapse 1 GRIA1
acrosomal vesicle 1 DRD2
plasma membrane 15 DRD1, DRD2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B, GRM1, GSG1L, PIK3CA, PRKCQ, TRPM2, TRPM3
presynaptic active zone 1 SYP
synaptic vesicle membrane 3 DRD2, GRIA1, SYP
terminal bouton 1 SYP
Membrane 8 GRIA1, GRIA2, GRIA4, GRIN2B, GSG1L, SYP, TRPM2, TRPM3
axon 1 DRD2
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 1 FOS
perinuclear region of cytoplasm 2 PIK3CA, SYP
Schaffer collateral - CA1 synapse 3 GRM1, GSG1L, SYP
intercalated disc 1 PIK3CA
protein-containing complex 1 NASP
intracellular membrane-bounded organelle 1 GRIK1
postsynaptic density 3 GRIA1, GRIA2, GRIN2B
excitatory synapse 3 GRIA1, GRIA2, SYP
neuronal cell body membrane 1 GRIA1
centriolar satellite 1 PRKCQ
ciliary membrane 2 DRD1, DRD2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYP
external side of plasma membrane 2 GRIA1, GRIA2
Extracellular vesicle 1 GRIA4
dendritic spine 6 DRD1, DRD2, GRIA1, GRIA2, GRIA3, GRIA4
perikaryon 2 DRD2, TRPM2
cytoplasmic vesicle 1 TRPM2
neuron spine 1 GRIA1
cell-cell junction 1 GRIA1
recycling endosome 1 GRIA1
postsynaptic membrane 9 DRD1, DRD2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B
presynaptic active zone membrane 1 GRIA1
Cytoplasm, cytoskeleton 1 GRIN2B
GABA-ergic synapse 3 DRD1, DRD2, GRID1
Cell projection, dendritic spine 2 DRD1, GRIA1
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 8 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B, GRM1
kainate selective glutamate receptor complex 1 GRIK1
Late endosome 1 GRIN2B
neuron projection 2 GRIN2B, SYP
cilium 2 DRD1, DRD2
chromatin 2 FOS, NASP
cell projection 1 TRPM2
cytoskeleton 1 GRIN2B
non-motile cilium 2 DRD1, DRD2
postsynaptic density, intracellular component 1 GRIA1
[Isoform 2]: Cell membrane 1 TRPM2
sperm flagellum 1 DRD2
Recycling endosome membrane 1 GRIA1
Endomembrane system 1 SYP
Cytoplasmic vesicle membrane 1 TRPM2
AMPA glutamate receptor complex 4 GRIA1, GRIA2, GRIA3, GRIA4
Cell projection, dendrite 4 DRD1, GRIA1, GRIA4, GRIN2B
specific granule membrane 1 TRPM2
tertiary granule membrane 1 TRPM2
synaptic membrane 2 GRIA1, GRIN2B
nuclear matrix 1 FOS
axon terminus 1 DRD2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 4 GRIA1, GRIA2, GRIA3, GRIA4
endocytic vesicle 1 DRD2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 9 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2B, GRM1, GSG1L
postsynaptic endocytic zone 1 GRIA2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ER to Golgi transport vesicle membrane 1 GRIA1
parallel fiber to Purkinje cell synapse 1 GRIA3
Synapse, synaptosome 1 SYP
protein-DNA complex 1 FOS
ficolin-1-rich granule membrane 1 TRPM2
NMDA selective glutamate receptor complex 1 GRIN2B
[Isoform 1]: Cell membrane 1 TRPM2
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
dendritic spine membrane 1 GRIA1
[Isoform 3]: Cell membrane 1 TRPM2
transcription factor AP-1 complex 1 FOS
asymmetric synapse 1 GRIA2
proximal dendrite 1 GRIA1
G protein-coupled receptor complex 2 DRD1, DRD2
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1


文献列表

  • Dong-Dong Zhang, Yu-Qiu Zhang, Xue-Han Zhang. Prefrontal AMPA receptors are involved in the effect of methylphenidate on response inhibition in rats. Acta pharmacologica Sinica. 2018 Apr; 39(4):607-615. doi: 10.1038/aps.2017.138. [PMID: 29265108]
  • Nadia Jaafari, Jeremy M Henley, Jonathan G Hanley. PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Aug; 32(34):11618-30. doi: 10.1523/jneurosci.5068-11.2012. [PMID: 22915106]
  • Dinesh C Joshi, Mahendra Singh, Karthik Krishnamurthy, Preeti G Joshi, Nanda B Joshi. AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor. Neurochemistry international. 2011 Nov; 59(6):913-21. doi: 10.1016/j.neuint.2011.06.023. [PMID: 21777635]
  • S Kott, C Sager, D Tapken, M Werner, M Hollmann. Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins gamma2, gamma3, gamma4, and gamma8. Neuroscience. 2009 Jan; 158(1):78-88. doi: 10.1016/j.neuroscience.2007.12.047. [PMID: 18304748]
  • Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux, Jacques Fantini, Marc Maresca, Nadira Taïeb, Jean-Marie Pagès, Jean Michel Brunel. Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?. PloS one. 2008 Jul; 3(7):e2765. doi: 10.1371/journal.pone.0002765. [PMID: 18648511]