Thalicarpin (BioDeep_00000007522)

Secondary id: BioDeep_00000866998, BioDeep_00001869492

Chemicals and Drugs

代谢物信息卡片

Thalicarpine

化学式: C41H48N2O8 (696.3410488000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC5=CC(=C(C=C5CC6C7=CC(=C(C=C7CCN6C)OC)OC)OC)OC)OC)OC
InChI: InChI=1S/C41H48N2O8/c1-42-12-10-23-16-32(44-3)34(46-5)20-27(23)29(42)15-26-19-33(45-4)36(48-7)22-31(26)51-37-18-25-14-30-39-24(11-13-43(30)2)17-38(49-8)41(50-9)40(39)28(25)21-35(37)47-6/h16-22,29-30H,10-15H2,1-9H3/t29-,30-/m0/s1

描述信息

C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
C1907 - Drug, Natural Product

同义名列表

2 个代谢物同义名

Thalicarpin; Thalicarpine

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:9509
KEGG: C09655
PubChem: 609931
PubChem: 21470
Metlin: METLIN67863
ChEMBL: CHEMBL507100
CAS: 5373-42-2
PMhub: MS000116586
PMhub: MS000020908
PubChem: 11845
KNApSAcK: C00001920
3DMET: B03168
NIKKAJI: J7.977D

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

88923 - Hernandia guianensis: 10.1248/YAKUSHI1947.86.9_763
121082 - Hernandia nymphaeifolia:
13561 - Hernandia ovigera: 10.1248/YAKUSHI1947.86.9_763
4081 - Solanum lycopersicum: 10.3390/MOLECULES23123330
395328 - Thalictrum alpinum: 10.1021/NP50009A009
46973 - Thalictrum dasycarpum: 10.2307/4117899
46970 - Thalictrum dioicum: 10.1016/S0040-4020(01)82640-5
1277777 - Thalictrum foliolosum: 10.1021/NP50021A003
476039 - Thalictrum minus:
46972 - Thalictrum revolutum: 10.1021/NP50008A005

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yi-Chen Chia, Fang-Rong Chang, Chin-Chung Wu, Che-Ming Teng, Keh-Shaw Chen, Yang-Chang Wu. Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro. Planta medica. 2006 Oct; 72(13):1238-41. doi: 10.1055/s-2006-947196. [PMID: 16981134]
C Stévigny, C Bailly, J Quetin-Leclercq. Cytotoxic and antitumor potentialities of aporphinoid alkaloids. Current medicinal chemistry. Anti-cancer agents. 2005 Mar; 5(2):173-82. doi: 10.2174/1568011053174864. [PMID: 15777224]
G Chen, D J Waxman. Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. The Journal of pharmacology and experimental therapeutics. 1995 Sep; 274(3):1271-7. doi: . [PMID: 7562498]
G Chen, C Ramachandran, A Krishan. Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. Cancer research. 1993 Jun; 53(11):2544-7. doi: . [PMID: 8098661]
G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]
R E Perdue. KB cell culture I. Role in discovery of antitumor agents from higher plants. Journal of natural products. 1982 Jul; 45(4):418-26. doi: 10.1021/np50022a010. [PMID: 7130986]
M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]
O A Abdyldaev. [Certain problems of diagnosis and clinical course of nephroptosis]. Zdravookhranenie Kirgizii. 1975 Jul; ?(4):32-4. doi: NULL. [PMID: 1923]