Thalicarpin (BioDeep_00000007522)

 

Secondary id: BioDeep_00000866998, BioDeep_00001869492

Chemicals and Drugs


代谢物信息卡片


Thalicarpine

化学式: C41H48N2O8 (696.341)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC5=CC(=C(C=C5CC6C7=CC(=C(C=C7CCN6C)OC)OC)OC)OC)OC)OC
InChI: InChI=1S/C41H48N2O8/c1-42-12-10-23-16-32(44-3)34(46-5)20-27(23)29(42)15-26-19-33(45-4)36(48-7)22-31(26)51-37-18-25-14-30-39-24(11-13-43(30)2)17-38(49-8)41(50-9)40(39)28(25)21-35(37)47-6/h16-22,29-30H,10-15H2,1-9H3/t29-,30-/m0/s1

描述信息

C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
C1907 - Drug, Natural Product

同义名列表

3 个代谢物同义名

Thalicarpin; Thalicarpine; Thalicarpine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ABCB1, CTNNB1, HPGDS, PGP
Endoplasmic reticulum membrane 1 RAC2
Nucleus 1 CTNNB1
cytosol 3 CTNNB1, HPGDS, RAC2
centrosome 1 CTNNB1
nucleoplasm 2 CTNNB1, HPGDS
Cell membrane 2 ABCB1, CTNNB1
lamellipodium 2 CTNNB1, RAC2
Multi-pass membrane protein 2 ABCB1, CACNA1I
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 1 ABCB1
glutamatergic synapse 1 CTNNB1
presynaptic membrane 1 CTNNB1
plasma membrane 4 ABCB1, CACNA1I, CTNNB1, RAC2
Membrane 3 ABCB1, CACNA1I, CTNNB1
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 CTNNB1
extracellular exosome 3 ABCB1, CTNNB1, RAC2
perinuclear region of cytoplasm 1 CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
protein-containing complex 1 CTNNB1
intracellular membrane-bounded organelle 1 HPGDS
mitochondrial outer membrane 1 RAC2
transcription regulator complex 1 CTNNB1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, RAC2
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
phagocytic vesicle membrane 1 RAC2
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 RAC2
Endomembrane system 1 CTNNB1
euchromatin 1 CTNNB1
voltage-gated calcium channel complex 1 CACNA1I
beta-catenin-TCF complex 1 CTNNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
catenin complex 1 CTNNB1
NADPH oxidase complex 1 RAC2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Yi-Chen Chia, Fang-Rong Chang, Chin-Chung Wu, Che-Ming Teng, Keh-Shaw Chen, Yang-Chang Wu. Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro. Planta medica. 2006 Oct; 72(13):1238-41. doi: 10.1055/s-2006-947196. [PMID: 16981134]
  • C Stévigny, C Bailly, J Quetin-Leclercq. Cytotoxic and antitumor potentialities of aporphinoid alkaloids. Current medicinal chemistry. Anti-cancer agents. 2005 Mar; 5(2):173-82. doi: 10.2174/1568011053174864. [PMID: 15777224]
  • G Chen, D J Waxman. Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. The Journal of pharmacology and experimental therapeutics. 1995 Sep; 274(3):1271-7. doi: . [PMID: 7562498]
  • G Chen, C Ramachandran, A Krishan. Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. Cancer research. 1993 Jun; 53(11):2544-7. doi: . [PMID: 8098661]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]
  • R E Perdue. KB cell culture I. Role in discovery of antitumor agents from higher plants. Journal of natural products. 1982 Jul; 45(4):418-26. doi: 10.1021/np50022a010. [PMID: 7130986]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]
  • O A Abdyldaev. [Certain problems of diagnosis and clinical course of nephroptosis]. Zdravookhranenie Kirgizii. 1975 Jul; ?(4):32-4. doi: NULL. [PMID: 1923]