Iopanoic acid (BioDeep_00000006685)

 

Secondary id: BioDeep_00001867878

human metabolite blood metabolite


代谢物信息卡片


2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid

化学式: C11H12I3NO2 (570.8002)
中文名称: 碘酸
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CCC(CC1=C(C(=C(C=C1I)I)N)I)C(=O)O
InChI: InChI=1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5478; ORIGINAL_PRECURSOR_SCAN_NO 5476
CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5462; ORIGINAL_PRECURSOR_SCAN_NO 5461
CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5564; ORIGINAL_PRECURSOR_SCAN_NO 5559
CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5494; ORIGINAL_PRECURSOR_SCAN_NO 5489
CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5462; ORIGINAL_PRECURSOR_SCAN_NO 5460
CONFIDENCE standard compound; INTERNAL_ID 349; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5485; ORIGINAL_PRECURSOR_SCAN_NO 5483
V - Various > V08 - Contrast media > V08A - X-ray contrast media, iodinated > V08AC - Watersoluble, hepatotropic x-ray contrast media

同义名列表

11 个代谢物同义名

2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid; Acid, iodopanoic; Iodopanoic acid; Acid, iopanoic; IOPANOIC ACID; Telepaque; Polognost; Iopagnost; Iopanoate; Cholevid; Iopanoic acid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALB, NT5C2, POMC, PRL
Peripheral membrane protein 1 LPL
Nucleus 4 ALB, PRL, THRA, THRB
cytosol 4 ALB, NT5C2, SST, THRA
nuclear body 1 THRB
centrosome 1 ALB
nucleoplasm 3 PRL, THRA, THRB
RNA polymerase II transcription regulator complex 3 PRL, THRA, THRB
Cell membrane 2 LPL, SLC16A2
Multi-pass membrane protein 3 CACNA1I, SLC16A2, UCP1
cell surface 1 LPL
Golgi apparatus 1 ALB
mitochondrial inner membrane 1 UCP1
neuronal cell body 1 SST
Cytoplasm, cytosol 1 NT5C2
plasma membrane 5 CACNA1I, DIO2, LPL, SLC10A2, SLC16A2
Membrane 4 CACNA1I, DIO2, MMP13, SLC16A2
apical plasma membrane 2 SLC10A2, SLC16A2
axon 1 CCK
extracellular exosome 1 ALB
endoplasmic reticulum 1 ALB
extracellular space 10 ALB, CCK, GH1, GNRH1, LPL, MMP13, POMC, PRL, SCT, SST
mitochondrion 1 UCP1
protein-containing complex 1 ALB
Secreted 10 ALB, CCK, GH1, LPL, MMP13, POMC, PRL, SMR3A, SST, TRH
extracellular region 12 ALB, CCK, GH1, GNRH1, LPL, MMP13, POMC, PRL, SCT, SMR3A, SST, TRH
Single-pass membrane protein 1 DIO2
Extracellular side 1 LPL
anchoring junction 1 ALB
Secreted, extracellular space, extracellular matrix 2 LPL, MMP13
chylomicron 1 LPL
very-low-density lipoprotein particle 1 LPL
Apical cell membrane 1 SLC16A2
Mitochondrion inner membrane 1 UCP1
GABA-ergic synapse 1 SST
extracellular matrix 1 MMP13
secretory granule 2 POMC, TRH
ciliary basal body 1 ALB
chromatin 3 PRL, THRA, THRB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 2 GH1, PRL
microvillus 1 SLC10A2
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
neuronal dense core vesicle 1 SST
growth hormone receptor complex 1 GH1
catalytic complex 1 LPL
[Isoform Alpha-2]: Cytoplasm 1 THRA
ciliary transition fiber 1 ALB


文献列表

  • Kyra Jacoblinnert, Christian Imholt, Detlef Schenke, Jens Jacob. Ethyl-iophenoxic acid as a quantitative bait marker for small mammals. Integrative zoology. 2022 Nov; 17(6):981-990. doi: 10.1111/1749-4877.12547. [PMID: 33876888]
  • Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz. Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid. Toxicological sciences : an official journal of the Society of Toxicology. 2022 04; 187(1):139-149. doi: 10.1093/toxsci/kfac014. [PMID: 35179606]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Are R Berentsen, Richard B Chipman, Kathleen M Nelson, Kenneth S Gruver, Frank Boyd, Steven F Volker, Amy J Davis, Ad Vos, Steffen Ortmann, Amy T Gilbert. Placebo Oral Rabies Vaccine Bait Uptake by Small Indian Mongooses (Herpestes auropunctatus) in Southwestern Puerto Rico. Journal of wildlife diseases. 2020 04; 56(2):452-456. doi: 10.7589/2019-03-077. [PMID: 31750771]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Are R Berentsen, Robert T Sugihara, Cynthia G Payne, Israel Leinbach, Steven F Volker, Ad Vos, Steffen Ortmann, Amy T Gilbert. Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker. Journal of visualized experiments : JoVE. 2019 05; ?(147):. doi: 10.3791/59373. [PMID: 31205294]
  • Sonya Gowtage, Gareth A Williams, Ray Henderson, Paul Aylett, Duncan MacMorran, Si Palmer, Andy Robertson, Sandrine Lesellier, Stephen P Carter, Mark A Chambers. Testing of a palatable bait and compatible vaccine carrier for the oral vaccination of European badgers (Meles meles) against tuberculosis. Vaccine. 2017 02; 35(6):987-992. doi: 10.1016/j.vaccine.2016.12.004. [PMID: 28077246]
  • Tam T T N Nguyen, Jesper Østergaard, Bente Gammelgaard. A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection. Analytical and bioanalytical chemistry. 2015 Nov; 407(28):8497-503. doi: 10.1007/s00216-015-8997-3. [PMID: 26329282]
  • Julie Maria Dersch, Tam T T N Nguyen, Jesper Østergaard, Stefan Stürup, Bente Gammelgaard. Selective analysis of human serum albumin based on SEC-ICP-MS after labelling with iophenoxic acid. Analytical and bioanalytical chemistry. 2015 Apr; 407(10):2829-36. doi: 10.1007/s00216-015-8507-7. [PMID: 25650002]
  • Mickael Sage, Isabelle Fourel, Jennifer Lahoreau, Vivien Siat, Philippe Berny, Sophie Rossi. Iophenoxic acid derivatives as markers of oral baits to wildlife. New tools for their detection in tissues of a game species and safety considerations for human exposure. Environmental science and pollution research international. 2013 May; 20(5):2893-904. doi: 10.1007/s11356-012-1172-x. [PMID: 23001758]
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