Benzthiazide (BioDeep_00000006593)

 

Secondary id: BioDeep_00001867793

human metabolite blood metabolite


代谢物信息卡片


6-Chloro-1,1-dioxo-3-(phenylmethylsulphanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulphonamide

化学式: C15H14ClN3O4S3 (430.98349540000004)
中文名称: 苯并噻嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 95.24%

分子结构信息

SMILES: C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
InChI: InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)

描述信息

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic

同义名列表

17 个代谢物同义名

6-Chloro-1,1-dioxo-3-(phenylmethylsulphanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulphonamide; 6-Chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide; 3-[(benzylsulfanyl)methyl]-6-chloro-1,1-dioxo-4H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide; 3-((Benzylthio)methyl)-6-chloro-7-sulphamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulphamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulphamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; Benzothiazide; Benzthiazidum; benzthiazide; Benzotiazida; regulon; Exna



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

1 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Domenico Tricarico, Diana Conte Camerino. Recent advances in the pathogenesis and drug action in periodic paralyses and related channelopathies. Frontiers in pharmacology. 2011; 2(?):8. doi: 10.3389/fphar.2011.00008. [PMID: 21687503]
  • R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
  • V Sanz-Nebot, I Toro, R Bergés, R Ventura, J Segura, J Barbosa. Determination and characterization of diuretics in human urine by liquid chromatography coupled to pneumatically assisted electrospray ionization mass spectrometry. Journal of mass spectrometry : JMS. 2001 Jun; 36(6):652-7. doi: 10.1002/jms.166. [PMID: 11433538]
  • J P Huang, C H Yuan, J Shiea, Y C Chen. Rapid screening for diuretic doping agents in urine by C60-assisted laser-desorption-ionization-time-of-flight mass spectrometry. Journal of analytical toxicology. 1999 Sep; 23(5):337-42. doi: 10.1093/jat/23.5.337. [PMID: 10488920]
  • R A Adler, L S Costanzo, M E Stauffer. Hypercalciuria in hyperprolactinemic rats: effects of benzthiazide. Metabolism: clinical and experimental. 1986 Jul; 35(7):668-72. doi: 10.1016/0026-0495(86)90176-9. [PMID: 3724459]
  • M C Meyer, P Hwang, A B Straughn, K Rotenberg. HPLC determination of benzthiazide in biologic material. Biopharmaceutics & drug disposition. 1982 Jan; 3(1):1-9. doi: 10.1002/bdd.2510030102. [PMID: 7082774]
  • J P DELAHAYE, C VALLON, M PELLET, A GONIN. [THERAPEUTIC TRIAL OF TRIAMTERENE AND TRIAMTERENE-BENZTHIAZIDE IN CARDIOLOGY]. Journal de medecine de Lyon. 1964 Jan; 45(?):185-92. doi: NULL. [PMID: 14113141]
  • F POTTON, J L DESSIMOND. [HYPOCALCIURIC EFFECT OF BENZTHIAZIDE]. Lyon medical. 1963 Nov; 210(?):1043-72. doi: NULL. [PMID: 14099113]
  • J MIROUZE, C JAFFIOL. [IMPORTANCE OF BENZTHIAZIDE, AN ORIGINAL SULFONAMIDE DIURETIC]. Gazette medicale de France. 1963 Sep; 70(?):2765-9. doi: NULL. [PMID: 14121074]