Echothiophate (BioDeep_00000006389)

 

Secondary id: BioDeep_00001868460

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate

化学式: C9H23NO3PS+ (256.1136)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 33.23%

分子结构信息

SMILES: CCOP(=O)(OCC)SCC[N+](C)(C)C
InChI: InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1

描述信息

Echothiophate is only found in individuals that have used or taken this drug. It is a potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.Echothiophate Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D004791 - Enzyme Inhibitors

同义名列表

10 个代谢物同义名

diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate; (2-Diethoxyphosphinylthioethyl)trimethylammonium; Echothiophate Iodide; Phospholine iodide; Echothiophic acid; Ecothiopic acid; Echothiophate; Ecothiopatum; Phospholine; Echothiophate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AFMID, ALB, AXIN2, BDNF, CHAT, CNR1, POMC
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 2 PNPLA6, PON1
Nucleus 5 ACHE, AFMID, ALB, AXIN2, CHAT
cytosol 5 AFMID, ALB, AXIN2, CHAT, PNPLA6
dendrite 1 BDNF
centrosome 2 ALB, AXIN2
Cell membrane 2 ACHE, CNR1
Cell projection, axon 1 CNR1
Multi-pass membrane protein 2 CACNA1I, CNR1
Synapse 3 ACHE, CHAT, TAC1
cell surface 2 ACHE, MSLN
glutamatergic synapse 1 CNR1
Golgi apparatus 3 ACHE, ALB, MSLN
growth cone 1 CNR1
neuromuscular junction 1 ACHE
neuronal cell body 1 TAC1
presynaptic membrane 1 CNR1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 AFMID
Presynapse 1 CNR1
plasma membrane 8 ACHE, AXIN2, BCHE, BTC, CACNA1I, CNR1, F2, MSLN
Membrane 6 ACHE, BDNF, BTC, CACNA1I, MSLN, PNPLA6
axon 4 BDNF, CCK, CNR1, TAC1
extracellular exosome 3 ALB, F2, PON1
endoplasmic reticulum 2 ALB, PNPLA6
extracellular space 10 ACHE, ALB, BCHE, BDNF, BTC, CCK, F2, POMC, PON1, TAC1
perinuclear region of cytoplasm 2 ACHE, BDNF
mitochondrion 1 GATD3
protein-containing complex 1 ALB
Secreted 8 ACHE, ALB, BCHE, BDNF, CCK, F2, POMC, TRH
extracellular region 13 ACHE, ALB, BCHE, BDNF, BTC, CCK, F2, MSLN, PLA2G7, POMC, PON1, TAC1, TRH
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
Extracellular side 1 ACHE
anchoring junction 1 ALB
high-density lipoprotein particle 2 PLA2G7, PON1
low-density lipoprotein particle 1 PLA2G7
actin cytoskeleton 1 CNR1
beta-catenin destruction complex 1 AXIN2
Membrane raft 1 CNR1
GABA-ergic synapse 1 CNR1
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 F2
secretory granule 2 POMC, TRH
neuron projection 1 CHAT
ciliary basal body 1 ALB
centriole 1 ALB
Secreted, extracellular space 1 PLA2G7
spindle pole 1 ALB
blood microparticle 4 ALB, BCHE, F2, PON1
Lipid-anchor, GPI-anchor 1 ACHE
side of membrane 2 ACHE, MSLN
secretory granule lumen 1 POMC
Golgi lumen 1 F2
endoplasmic reticulum lumen 5 ALB, BCHE, BDNF, F2, MSLN
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
Single-pass type III membrane protein 1 PNPLA6
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 BTC
synaptic cleft 1 ACHE
spherical high-density lipoprotein particle 1 PON1
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB


文献列表

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