Bethanechol (BioDeep_00000006356)

 

Secondary id: BioDeep_00001868402

human metabolite blood metabolite


代谢物信息卡片


(2-Hydroxypropyl)trimethylammonium carbamic acid

化学式: C7H17N2O2+ (161.129)
中文名称: 氨甲酰甲胆碱, 氯贝胆碱
谱图信息: 最多检出来源 Homo sapiens(blood) 8.54%

分子结构信息

SMILES: CC(C[N+](C)(C)C)OC(=O)N
InChI: InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1

描述信息

Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem]
N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics > N07AB - Choline esters
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists

同义名列表

39 个代谢物同义名

(2-Hydroxypropyl)trimethylammonium carbamic acid; 2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium; (2-Hydroxypropyl)trimethylammonium carbamate; 1-(trimethylazaniumyl)propan-2-yl carbamate; Pharmascience brand OF bethanechol chloride; Hamilton brand OF bethanechol chloride; Glenwood brand OF bethanechol chloride; 2-Carbamoyloxypropyl-trimethylazanium; Organon brand OF bethanechol chloride; Roberts brand OF bethanechol chloride; Carbamylmethylcholine chloride; beta-Methyl carbachol chloride; Carbamoyl-beta-methylcholine; Carbamyl-beta-methylcholine; Amidopropyldimethylbetaine; Carbamoyl-b-methylcholine; Bethaine choline chloride; Carbamoyl-β-methylcholine; PMS Bethanechol chloride; Carbamyl-b-methylcholine; PMS-Bethanechol chloride; Carbamyl-β-methylcholine; PMSBethanechol chloride; Chloride, bethanechol; Bethanechol chloride; Hermes, myo; Besacholine; Myotonachol; Bethanechol; Myo hermes; Myocholine; Bethanecol; Urecholine; Myotonine; Urocarb; Duvoid; BTC; Bethanechol; Bethanechol cation



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CHAT, GAL, MYLK, PPY
Peripheral membrane protein 1 ACHE
Nucleus 2 ACHE, CHAT
cytosol 5 ATP12A, CHAT, MYLK, PRKCQ, SST
Cell membrane 3 ACHE, CCKBR, GAL
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 3 ATP12A, CACNA1I, CCKBR
Synapse 4 ACHE, CHAT, MYLK, TAC1
cell surface 1 ACHE
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 3 GAL, SST, TAC1
Cytoplasmic vesicle, secretory vesicle 1 NTS
plasma membrane 9 ACHE, ATP12A, BCHE, CACNA1I, CCKBR, GAL, GCG, MYLK, PRKCQ
Membrane 3 ACHE, CACNA1I, CCKBR
apical plasma membrane 1 ATP12A
axon 2 CCK, TAC1
basolateral plasma membrane 1 ATP12A
extracellular space 11 ACHE, BCHE, CCK, GAL, GAST, GCG, INS, PPY, SCT, SST, TAC1
perinuclear region of cytoplasm 1 ACHE
intracellular membrane-bounded organelle 2 CCKBR, NTS
Secreted 11 ACHE, BCHE, CCK, GAL, GAST, GCG, INS, NTS, PPY, SST, VIP
extracellular region 14 ACHE, BCHE, CCK, GAL, GAST, GCG, INS, MLN, NTS, PPY, SCT, SST, TAC1, VIP
Single-pass membrane protein 1 MLN
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
actin cytoskeleton 2 ATP12A, MYLK
Apical cell membrane 1 ATP12A
Cell projection, lamellipodium 1 MYLK
GABA-ergic synapse 1 SST
basement membrane 1 ACHE
secretory granule 1 GAL
neuron projection 2 CHAT, VIP
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
side of membrane 1 ACHE
stress fiber 1 MYLK
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BCHE, GCG, INS
axon terminus 1 NTS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 INS, NTS
Sarcoplasmic reticulum membrane 1 MLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
nuclear envelope lumen 1 BCHE
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
synaptic cleft 1 ACHE
[Glucagon-like peptide 1]: Secreted 1 GCG
potassium:proton exchanging ATPase complex 1 ATP12A
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Matthew P Keasey, Chiharu Lovins, Cuihong Jia, Theo Hagg. Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice. Physiological reports. 2022 05; 10(9):e15301. doi: 10.14814/phy2.15301. [PMID: 35531929]
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  • Sara Chowdhury, Songyan Wang, Judit Dunai, Rachel Kilpatrick, Lauren Z Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wice. Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus. PloS one. 2016; 11(6):e0156852. doi: 10.1371/journal.pone.0156852. [PMID: 27304975]
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