FMNH2 (BioDeep_00000004771)
Secondary id: BioDeep_00001869111
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C17H23N4O9P (458.1203)
中文名称:
谱图信息:
最多检出来源 Macaca mulatta(otcml) 16.56%
分子结构信息
SMILES: CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)CC(C(C(COP(=O)(O)O)O)O)O
InChI: InChI=1S/C17H23N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,18,22-24H,5-6H2,1-2H3,(H2,27,28,29)(H2,19,20,25,26)/t11-,12+,14-/m0/s1
描述信息
FMNH2 is the reduced form of flavin mononucleotide. It is a substrate of the enzyme FMN reductase (EC 1.5.1.29), an enzyme that catalyzes the chemical reaction FMNH2 + NAD(P)+ <=> FMN + NAD(P)H + H+. Flavin mononucleotide (FMN), or riboflavin-5′-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase. During a catalytic cycle, the reversible interconversion of oxidized (FMN), semiquinone (FMNH•) and reduced (FMNH2) forms occurs in the various oxidoreductases. FMN is a stronger oxidizing agent than NAD and is particularly useful because it can take part in both one- and two-electron transfers.
FMNH is a substrate for 2,4-dienoyl-CoA reductase (mitochondrial). [HMDB]
同义名列表
11 个代谢物同义名
{[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-1H,2H,3H,4H,5H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid; 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[G]pteridin-1-ID-10(5H)-YL)-5-O-phosphonato-D-ribitol; 1,5-Dihydroriboflavin 5-(dihydrogen phosphoric acid); 1,5-Dihydroriboflavin 5-(dihydrogen phosphate); Flavin mononucleotide hydroquinone; Flavin mononucleotide (reduced); Reduced flavin mononucleotide; Reduced FMN; fmnh(.); FMNH2; FMNH
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:16048
- KEGG: C01847
- PubChem: 445395
- PubChem: 711
- HMDB: HMDB0001142
- Metlin: METLIN6034
- MetaCyc: |Reduced-flavodoxins|
- MetaCyc: FMNH2
- foodb: FDB022449
- chemspider: 393046
- CAS: 5666-16-0
- PMhub: MS000017364
- PubChem: 4964
- PDB-CCD: FNR
- NIKKAJI: J1.888.371F
- RefMet: FMNH
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
18 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(18)
- Kandutsch-Russell Pathway (Cholesterol Biosynthesis):
Fe2+ + Hydrogen Ion + Lathosterol + Oxygen ⟶ 7-Dehydrocholesterol + Fe3+ + Water - Sulfur Metabolism:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Butanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Propanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Ethanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Isethionate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Methanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Butanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Propanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Ethanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Isethionate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Sulfur Metabolism (Methanesulfonate):
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Uracil Degradation III:
Hydrogen Ion + Malonic semialdehyde + NADPH ⟶ Hydroxypropionic acid + NADP - Uracil Degradation III:
FMNH2 + Oxygen + Uracil ⟶ Flavin Mononucleotide + Hydrogen Ion + Peroxyaminoacrylate - Bloch Pathway (Cholesterol Biosynthesis):
Desmosterol + NADP ⟶ Cholesterol + Hydrogen Ion + NADPH - Mevalonate Pathway:
(S)-2,3-Epoxysqualene ⟶ Lanosterol - Juvenile Hormone Synthesis:
Juvenile Hormone III + Water ⟶ Juvenile Hormone III Acid + Methanol
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Benjamin Ricken, Boris A Kolvenbach, Christian Bergesch, Dirk Benndorf, Kevin Kroll, Hynek Strnad, Čestmír Vlček, Ricardo Adaixo, Frederik Hammes, Patrick Shahgaldian, Andreas Schäffer, Hans-Peter E Kohler, Philippe F-X Corvini. FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics.
Scientific reports.
2017 Nov; 7(1):15783. doi:
10.1038/s41598-017-16132-8. [PMID: 29150672] - L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate.
The Journal of urology.
1979 May; 121(5):630-4. doi:
10.1016/s0022-5347(17)56913-x. [PMID: 439260]
