Calcium (BioDeep_00000004376)
Main id: BioDeep_00000759914
Secondary id: BioDeep_00001868468
human metabolite blood metabolite
代谢物信息卡片
Calcium Cation
化学式: Ca+2 (39.9626)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [Ca+2]
InChI: InChI=1S/Ca/q+2
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:39124
- ChEBI: CHEBI:39123
- ChEBI: CHEBI:29108
- KEGG: C00076
- PubChem: 271
- DrugBank: DB14577
- CAS: 125302-08-1
- CAS: 14127-61-8
- PMhub: MS000016790
- ChEBI: CHEBI:22984
- PubChem: 3376
- PDB-CCD: CA
- NIKKAJI: J3.736B
- KNApSAcK: 22984
分类词条
相关代谢途径
Reactome(102)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of vitamins and cofactors
- Visual phototransduction
- Sensory Perception
- Metabolism of proteins
- Disease
- Diseases of hemostasis
- Defects of Formation of Fibrin Clot (Clotting Cascade)
- Defective factor IX causes hemophilia B
- Diseases of programmed cell death
- Drug ADME
- Metabolism of lipids
- Metabolism of steroids
- Metabolism of cofactors
- Diseases of metabolism
- Transport of small molecules
- SLC-mediated transmembrane transport
- Developmental Biology
- Signaling Pathways
- Signaling by Rho GTPases
- RHO GTPase Effectors
- Cell Cycle
- Cell Cycle, Mitotic
- M Phase
- Mitotic Prophase
- Chromatin organization
- Chromatin modifying enzymes
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3
- Immune System
- Innate Immune System
- Antimicrobial peptides
- Ion channel transport
- Stimuli-sensing channels
- Nucleotide metabolism
- Nucleotide catabolism
- Disorders of transmembrane transporters
- SLC transporter disorders
- Transport of inorganic cations/anions and amino acids/oligopeptides
- Biosynthesis of specialized proresolving mediators (SPMs)
- Fatty acid metabolism
- Metabolism of nitric oxide: NOS3 activation and regulation
- eNOS activation and regulation
- eNOS activation
- Signaling by Receptor Tyrosine Kinases
- Signaling by VEGF
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate NADPH Oxidases
- Infectious disease
- Gene expression (Transcription)
- RNA Polymerase II Transcription
- Generic Transcription Pathway
- Adaptive Immune System
- Leishmania infection
- Bacterial Infection Pathways
- Parasitic Infection Pathways
- Arachidonic acid metabolism
- Sodium/Calcium exchangers
- Carbohydrate metabolism
- Integration of energy metabolism
- Diseases of carbohydrate metabolism
- Extracellular matrix organization
- Degradation of the extracellular matrix
- Phospholipid metabolism
- Glycerophospholipid biosynthesis
- Neuronal System
- Transmission across Chemical Synapses
- Neurotransmitter release cycle
- Viral Infection Pathways
- Signaling by GPCR
- GPCR ligand binding
- Class A/1 (Rhodopsin-like receptors)
- Peptide ligand-binding receptors
- GPCR downstream signalling
- G alpha (i) signalling events
- Olfactory Signaling Pathway
- Ion transport by P-type ATPases
- Hemostasis
- Cell surface interactions at the vascular wall
- Glycogen metabolism
- Glycogen breakdown (glycogenolysis)
- Glycosaminoglycan metabolism
- Heparan sulfate/heparin (HS-GAG) metabolism
- Chondroitin sulfate/dermatan sulfate metabolism
- Sphingolipid metabolism
- Glycosphingolipid metabolism
- Opioid Signalling
- DARPP-32 events
- Intracellular signaling by second messengers
- Metal sequestration by antimicrobial proteins
- Inositol phosphate metabolism
- Sphingolipid catabolism
- Digestion and absorption
- Digestion
- Platelet homeostasis
- VEGFR2 mediated vascular permeability
- Muscle contraction
- Smooth Muscle Contraction
- Glycosphingolipid catabolism
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Metabolism of steroid hormones
BioCyc(132)
- superpathway of pyrimidine ribonucleosides salvage
- pyrimidine ribonucleosides salvage II
- UTP and CTP dephosphorylation I
- superpathway of anaerobic energy metabolism (invertebrates)
- superpathway of N-acetylneuraminate degradation
- superpathway of hexitol degradation (bacteria)
- superpathway of chorismate metabolism
- superpathway of anaerobic sucrose degradation
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
- glycolysis IV (plant cytosol)
- trans-4-hydroxy-L-proline degradation II
- pyrimidine deoxyribonucleotides de novo biosynthesis III
- superpathway of polyamine biosynthesis I
- superpathway of arginine and polyamine biosynthesis
- superpathway of L-citrulline metabolism
- formaldehyde oxidation
- methanol oxidation to formaldehyde I
- methanol and methylamine oxidation to formaldehyde
- superpathway of C1 compounds oxidation to CO2
- 12-epi-hapalindole biosynthesis
- formaldehyde assimilation I (serine pathway)
- caffeine degradation III (bacteria, via demethylation)
- formaldehyde oxidation II (glutathione-dependent)
- rutin degradation
- protein N-glycosylation processing phase (mammalian)
- protein N-glycosylation processing phase (plants and animals)
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- ginsenosides biosynthesis
- volatile esters biosynthesis (during fruit ripening)
- peptidoglycan maturation (meso-diaminopimelate containing)
- hydroxycinnamic acid tyramine amides biosynthesis
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
- berberine biosynthesis
- stachyose biosynthesis
- γ-butyrobetaine degradation
- aromatic biogenic amine degradation (bacteria)
- 4-deoxy-L-threo-hex-4-enopyranuronate degradation
- superpathway of microbial D-galacturonate and D-glucuronate degradation
- L-carnitine degradation II
- mixed acid fermentation
- nicotine degradation II (pyrrolidine pathway)
- superpathway of CMP-sialic acids biosynthesis
- glycocholate metabolism (bacteria)
- superpathway of glycerol degradation to 1,3-propanediol
- superpathway of glyoxylate bypass and TCA
- isovitexin glycosides biosynthesis
- superpathway of L-lysine degradation
- L-lysine fermentation to acetate and butanoate
- tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis and salvage
- N10-formyl-tetrahydrofolate biosynthesis
- NADH to cytochrome bo oxidase electron transfer I
- NADH to cytochrome bd oxidase electron transfer I
- bile acids degradation
- tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)
- superpathway of tetrahydroxyxanthone biosynthesis
- superpathway of glycolysis and the Entner-Doudoroff pathway
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
- Entner-Doudoroff pathway I
- NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
- superpathway NAD/NADP - NADH/NADPH interconversion (yeast)
- spermidine biosynthesis I
- phosphatidate metabolism, as a signaling molecule
- gluconeogenesis I
- glycolysis II (from fructose 6-phosphate)
- glycolysis I (from glucose 6-phosphate)
- superpathway NAD/NADP - NADH/NADPH interconversion
- NAD/NADP-NADH/NADPH cytosolic interconversion
- eupatolitin 3-O-glucoside biosynthesis
- ammonia oxidation III
- volatile benzenoid biosynthesis I (ester formation)
- L-lysine degradation IV
- stephacidin A biosynthesis
- lysine degradation I (saccharopine pathway)
- (S,S)-butanediol degradation
- homogalacturonan biosynthesis
- colanic acid building blocks biosynthesis
- sanguinarine and macarpine biosynthesis
- (aminomethyl)phosphonate degradation
- CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
- 3-phosphoinositide biosynthesis
- suberin monomers biosynthesis
- pyrimidine deoxyribonucleotides de novo biosynthesis I
- L-glutamine degradation II
- protein N-glycosylation initial phase (eukaryotic)
- superpathway of pyrimidine deoxyribonucleosides degradation
- diacylglycerol and triacylglycerol biosynthesis
- L-lysine degradation XI (mammalian)
- phosphatidylinositol biosynthesis II (eukaryotes)
- superpathway of purine deoxyribonucleosides degradation
- trehalose degradation IV
- superpathway of purine nucleotides de novo biosynthesis I
- 4-amino-3-hydroxybenzoate degradation
- orcinol degradation
- anaerobic energy metabolism (invertebrates, cytosol)
- UDP-sugars interconversion
- nitrilotriacetate degradation
- peptidoglycan biosynthesis II (staphylococci)
- drosopterin and aurodrosopterin biosynthesis
- superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)
- (S,S)-butanediol biosynthesis
- superpathway of 2,3-butanediol biosynthesis
- vitexin and derivatives biosynthesis
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis
- superpathway of rifamycin B biosynthesis
- starch degradation III
- L-histidine biosynthesis
- superpathway of β-D-glucuronosides degradation
- glycolysis V (Pyrococcus)
- UDP-α-D-xylose biosynthesis
- cardiolipin biosynthesis II
- phosphatidylglycerol biosynthesis II (non-plastidic)
- methylerythritol phosphate pathway II
- rhamnogalacturonan type I degradation II (bacteria)
- glycerol degradation II
- D-fructuronate degradation
- superpathway of hexuronide and hexuronate degradation
- UTP and CTP dephosphorylation II
- D-myo-inositol (1,4,5)-trisphosphate biosynthesis
- sphingolipid biosynthesis (plants)
- L-carnitine biosynthesis
- 2'-deoxy-α-D-ribose 1-phosphate degradation
- erythro-tetrahydrobiopterin biosynthesis I
- UDP-D-xylose biosynthesis
- protein N-glycosylation (eukaryotic) initial steps
- citrulline-nitric oxide cycle
- nitric oxide biosynthesis II (mammals)
- coenzyme M biosynthesis I
- superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PlantCyc(21)
- superpathway of anaerobic sucrose degradation
- glycolysis IV (plant cytosol)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
- hydroxycinnamic acid tyramine amides biosynthesis
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- volatile esters biosynthesis (during fruit ripening)
- stachyose biosynthesis
- berberine biosynthesis
- tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)
- superpathway of tetrahydroxyxanthone biosynthesis
- eupatolitin 3-O-glucoside biosynthesis
- volatile benzenoid biosynthesis I (ester formation)
- phosphatidate metabolism, as a signaling molecule
- L-histidine biosynthesis
- vitexin and derivatives biosynthesis
- suberin monomers biosynthesis
- palmatine biosynthesis
- sanguinarine and macarpine biosynthesis
- homogalacturonan biosynthesis
代谢反应
555 个相关的代谢反应过程信息。
Reactome(503)
- Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - G alpha (i) signalling events:
ATP ⟶ PPi + cAMP - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
H2O + cAMP ⟶ AMP - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - G alpha (i) signalling events:
H2O + cAMP ⟶ AMP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
GHRL + octanoic acid ⟶ GHRL - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Peptide hormone metabolism:
H2O + agt ⟶ agt - Insulin processing:
Ca2+ + Zn2+ + ins ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Peptide hormone metabolism:
ghr + octanoic acid ⟶ ghr - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Integration of energy metabolism:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Regulation of insulin secretion:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
Agt + H2O ⟶ Agt - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
Agt + H2O ⟶ Agt - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Metabolism of proteins:
EIF5A2 + NAD + SPM ⟶ 1,3-diaminopropane + H+ + H0ZKZ7 + NADH - Peptide hormone metabolism:
H0ZI58 + H2O ⟶ H0ZI58 - Insulin processing:
Ca2+ + H0ZG98 + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
H2O + LYZ:PGN ⟶ MurNAc:Peptide + betaGlcNAc - Metal sequestration by antimicrobial proteins:
CO3(2-) + Fe3+ + tf ⟶ LTF:2xFe3+:2xCO3(2-) - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Downstream signaling events of B Cell Receptor (BCR):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
Ca2+ + Calcineurin (CaN) + Calcium:calmodulin ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of nitric oxide: NOS3 activation and regulation:
ADMA + H2O ⟶ DMA + L-Cit - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
ADMA + H2O ⟶ DMA + L-Cit - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
ISCIT + TPN ⟶ 2OG + H+ + TPNH + carbon dioxide - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
GTP + H2O ⟶ DHNTP + HCOOH - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
RHOA:GTP:Mg2+ + ppDVL:DAAM1 ⟶ ppDVL:DAAM1:RHOA:GTP - Ca2+ pathway:
CALM1:4xCa2+ + CAMK2A ⟶ CAMK2:CaM - Immune System:
cAMP + epac-1 ⟶ RAPGEF3:cAMP complex - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
MYC gene: H2B K121ub nucleosome + SAM ⟶ MYC gene:H2B K121ub H3K4me3 nucleosome + SAH - Beta-catenin independent WNT signaling:
RHOA:GTP:Mg2+ + ppDVL:DAAM1 ⟶ ppDVL:DAAM1:RHOA:GTP - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Ca2+ pathway:
H2O + cGMP ⟶ GMP - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
H2O + cGMP ⟶ GMP - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Immune System:
cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Adaptive Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - B Cell Activation:
STIM1:Calcium ⟶ Ca2+ + STIM1 Dimer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
A8JUV3 + CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:p-NFATC1,2,3 - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
Ac-CoA + NFKB1:p-S276-RELA:p300/CBP ⟶ CoA + NFKB1:p-S276,5AcK-RELA:p300/CBP - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
STIM1:Calcium ⟶ Ca2+ + STIM1 Dimer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - DARPP-32 events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
PRKG dimer + cGMP ⟶ PRKG homodimer:cGMP - Ca2+ pathway:
PRKG dimer + cGMP ⟶ PRKG homodimer:cGMP - Disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Infectious disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Uptake and actions of bacterial toxins:
ATP ⟶ PPi + cAMP - Uptake and function of anthrax toxins:
ATP ⟶ PPi + cAMP - Listeria monocytogenes entry into host cells:
CDH1:CTNNB1:CTNND1 + InlA ⟶ InlA:CDH1:CTNNB1:CTNND1 - InlA-mediated entry of Listeria monocytogenes into host cells:
CDH1:CTNNB1:CTNND1 + InlA ⟶ InlA:CDH1:CTNNB1:CTNND1 - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + PPP3R1:PPP3CA,B + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - FCERI mediated Ca+2 mobilization:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - C-type lectin receptors (CLRs):
CLEC7A + zymosan ⟶ CLEC7A:1,3-beta-D-glucan - CLEC7A (Dectin-1) signaling:
CLEC7A + zymosan ⟶ CLEC7A:1,3-beta-D-glucan - CLEC7A (Dectin-1) induces NFAT activation:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PS + Prkcb ⟶ Activated PKC beta - Calcineurin activates NFAT:
Ca2+ + Calcineurin (CaN) + Calmodulin:Calcium + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
Ca2+ + Calcineurin (CaN) + Calmodulin:Calcium ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling Pathways:
H2O + cAMP ⟶ AMP - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Beta-catenin independent WNT signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Innate Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PS + Prkcb ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Immune System:
H2O + PC ⟶ Cho + PA - Innate Immune System:
H2O + PC ⟶ Cho + PA - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of nitric oxide: NOS3 activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of cofactors:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
PAK1,2,3 dimer + p-VAV family:PIP3:RAC1:GTP ⟶ 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling by WNT:
ATP + AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex ⟶ ADP + p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex - Beta-catenin independent WNT signaling:
ATP + CAMK2:CaM ⟶ ADP + p-T286 CAMK2:CaM - Ca2+ pathway:
ATP + CAMK2:CaM ⟶ ADP + p-T286 CAMK2:CaM - Immune System:
ATP + Ag-substrate:E3:E2:Ub ⟶ AMP + E3:Ub:substrate + PPi - Adaptive Immune System:
ATP + Ag-substrate:E3:E2:Ub ⟶ AMP + E3:Ub:substrate + PPi - B Cell Activation:
ATP + H0YZ45 + PI(3,4,5)P3 ⟶ ADP + p-Y139-DAPP1:PIP3 - Downstream signaling events of B Cell Receptor (BCR):
ATP + CARMA1 oligomer ⟶ ADP + p-CARMA1 Oligomer - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + Phosphorylated NFATC1,2,3 ⟶ Calcineurin:Phosphorylated NFATC1,2,3 - Innate Immune System:
ATP + DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer + UBE2N:UBE2V1 ⟶ AMP + DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 + PPi + UBE2N:UBE2V1 - Fc epsilon receptor (FCERI) signaling:
ATP + DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer + UBE2N:UBE2V1 ⟶ AMP + DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 + PPi + UBE2N:UBE2V1 - FCERI mediated Ca+2 mobilization:
ATP + p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 ⟶ ADP + p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases - C-type lectin receptors (CLRs):
ATP + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers ⟶ AMP + PPi + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers - CLEC7A (Dectin-1) signaling:
ATP + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers ⟶ AMP + PPi + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - eNOS activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Beta-catenin independent WNT signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Bacterial Infection Pathways:
H+ + NADH + dlaT(ox.) ⟶ NAD + dlaT - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
ATP + Ca2+ ⟶ Ca2+ + PPi + cAMP - Activation of NMDA receptors and postsynaptic events:
ATP + Ca2+ ⟶ Ca2+ + PPi + cAMP - Post NMDA receptor activation events:
ATP + Ca2+ ⟶ Ca2+ + PPi + cAMP - CREB phosphorylation through the activation of Adenylate Cyclase:
ATP + Ca2+ ⟶ Ca2+ + PPi + cAMP - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Fatty acid metabolism:
Ac-CoA + H2O ⟶ CH3COO- + CoA-SH - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Homologues of KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Homologues of KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases activate IQGAPs:
Active RAC1/CDC42 + IQGAP ⟶ RAC1,CDC42:GTP:IQGAPs - Effects of PIP2 hydrolysis:
2AG + H2O ⟶ AA + Glycerol + H+ - Hemostasis:
AMP + GTP ⟶ ADP + GDP - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers:
ATP + H0YZ45 + PI(3,4,5)P3 ⟶ ADP + p-Y139-DAPP1:PIP3 - Muscle contraction:
ATP + Calcium Bound Sarcomere Protein Complex ⟶ ATP:Calcium Bound Sarcomere Protein Complex - Smooth Muscle Contraction:
ATP + Calcium Bound Myosin Actin Complex ⟶ ATP:Calcium Bound Myosin Actin Complex - Neuronal System:
ATP + L-Glu + NH4+ ⟶ ADP + L-Gln + Pi - Transmission across Chemical Synapses:
ATP + L-Glu + NH4+ ⟶ ADP + L-Gln + Pi - Neurotransmitter receptors and postsynaptic signal transmission:
ATP ⟶ ADP - Activation of NMDA receptors and postsynaptic events:
ATP ⟶ ADP - Post NMDA receptor activation events:
ATP ⟶ ADP - CREB phosphorylation through the activation of CaMKK:
ATP + Homologues of CAMKK1 ⟶ ADP + Homologues of p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
2AG + H2O ⟶ AA + Glycerol + H+ - GPCR downstream signalling:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (i) signalling events:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Opioid Signalling:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - G-protein mediated events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - PLC beta mediated events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Ca-dependent events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CaM pathway:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Calmodulin induced events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CaMK IV-mediated phosphorylation of CREB:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Intracellular signaling by second messengers:
ATP + PI4P ⟶ ADP + PI(4,5)P2 - DAG and IP3 signaling:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + E1BIP3 ⟶ ADP + phospho-p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Homologues of CAMKK1 ⟶ ADP + Homologues of p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + F1NKZ8 ⟶ ADP + phospho-p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Neuronal System:
HCN channels + cAMP ⟶ HCN channel bound to cAMP - Transmission across Chemical Synapses:
ATP ⟶ ADP - Neurotransmitter receptors and postsynaptic signal transmission:
ATP ⟶ ADP - Activation of NMDA receptors and postsynaptic events:
ATP ⟶ ADP - Post NMDA receptor activation events:
ATP ⟶ ADP - CREB phosphorylation through the activation of CaMKK:
ATP + Homologues of CAMKK1 ⟶ ADP + Homologues of p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
2AG + H2O ⟶ AA + Glycerol + H+ - GPCR downstream signalling:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (i) signalling events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Opioid Signalling:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - G-protein mediated events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - PLC beta mediated events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Ca-dependent events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CaM pathway:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Calmodulin induced events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CaMK IV-mediated phosphorylation of CREB:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Intracellular signaling by second messengers:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - DAG and IP3 signaling:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + F1LQD2 ⟶ ADP + phospho-p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Homologues of CAMKK1 ⟶ ADP + Homologues of p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Ion channel transport:
ATP + Cu2+ + H2O ⟶ ADP + Cu2+ + Pi - Ion transport by P-type ATPases:
ATP + Cu2+ + H2O ⟶ ADP + Cu2+ + Pi - Opioid Signalling:
H2O + cAMP ⟶ AMP - G-protein mediated events:
H2O + cAMP ⟶ AMP - PLC beta mediated events:
H2O + cAMP ⟶ AMP - Ca-dependent events:
H2O + cAMP ⟶ AMP - CaM pathway:
H2O + cAMP ⟶ AMP - Calmodulin induced events:
H2O + cAMP ⟶ AMP - CaMK IV-mediated phosphorylation of CREB:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Intracellular signaling by second messengers:
H2O + cAMP ⟶ AMP - DAG and IP3 signaling:
H2O + cAMP ⟶ AMP - CREB phosphorylation through the activation of CaMKK:
ATP + H0Z197 ⟶ ADP + phospho-p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - CREB phosphorylation through the activation of CaMKK:
ATP + F6TJ34 ⟶ ADP + phospho-p-CAMKK1 - Activation of CaMK IV:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin
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PathBank(52)
- Acebutolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Alprenolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Atenolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Betaxolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Bisoprolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Esmolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Metoprolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nadolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Oxprenolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Penbutolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Pindolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Propranolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Quinidine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Procainamide (Antiarrhythmic) Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Disopyramide Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Fosphenytoin (Antiarrhythmic) Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Phenytoin (Antiarrhythmic) Action Pathway:
Hydrogen Ion + NADPH + Oxygen + Phenytoin ⟶ NADP + Phenytoin arene-oxide + Water - Lidocaine (Antiarrhythmic) Action Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline - Mexiletine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Tocainide Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Flecainide Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Ibutilide Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Diltiazem Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nebivolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Carvedilol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Labetalol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Verapamil Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Amlodipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Felodipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Isradipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nifedipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nimodipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nisoldipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Nitrendipine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Striated Muscle Contraction:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Bopindolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Carteolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Timolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Sotalol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Epinephrine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Dobutamine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Isoprenaline Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Arbutamine Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Amiodarone Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Levobunolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Metipranolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Bevantolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Practolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Bupranolol Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Muscle/Heart Contraction:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Muscle/Heart Contraction:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Muscle/Heart Contraction:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate
PharmGKB(0)
11 个相关的物种来源信息
- 85549 - Artemia salina:
- 3078 - Auxenochlorella pyrenoidosa: 10.1016/J.LFS.2004.10.055
- 3077 - Chlorella vulgaris: 10.1016/J.LFS.2004.10.055
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 98504 - Matricaria chamomilla: 10.1556/AALIM.29.2000.1.5
- 166987 - Montanoa frutescens: 10.1016/0010-7824(83)90003-3
- 166988 - Montanoa grandiflora: 10.1016/0010-7824(83)90003-3
- 166995 - Montanoa leucantha: 10.1016/0010-7824(83)90003-3
- 167007 - Montanoa tomentosa: 10.1016/0010-7824(83)90003-3
- 115506 - Phytelephas aequatorialis: 10.1007/BF02907355
- 3641 - Theobroma cacao: 10.1515/ZNC-1998-9-1002
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M L Sistrunk, D M Antosiewicz, M M Purugganan, J Braam. Arabidopsis TCH3 encodes a novel Ca2+ binding protein and shows environmentally induced and tissue-specific regulation.
The Plant cell.
1994 Nov; 6(11):1553-65. doi:
10.1105/tpc.6.11.1553. [PMID: 7827491] - R Sumimoto, T Shinomiya, N Kamada, A Yamaguchi, T Urushihara, Y Fukuda, K Dohi. Lack of evidence that a transplanted liver causes acute graft-versus-host disease in rats. A comparison of liver and spleen grafts.
Transplantation.
1992 Mar; 53(3):646-9. doi:
10.1097/00007890-199203000-00029. [PMID: 1549859]
