Fructose 1-phosphate (BioDeep_00000003380)
Secondary id: BioDeep_00001869441
human metabolite PANOMIX_OTCML-2023 Endogenous natural product
代谢物信息卡片
化学式: C6H13O9P (260.0297)
中文名称: 果糖-1-磷酸
谱图信息:
最多检出来源 Homo sapiens(otcml) 6.99%
分子结构信息
SMILES: C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)O
InChI: InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5-,6-/m1/s1
描述信息
Fructose 1-phosphate, also known as D-fructose-1-p, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Metabolism of fructose thus essentially results in intermediates of glycolysis. The final product of glycolysis (pyruvate) may then undergo gluconeogenesis, enter the TCA cycle or be stored as fatty acids. Fructose 1-phosphate exists in all living organisms, ranging from bacteria to humans. Within humans, fructose 1-phosphate participates in a number of enzymatic reactions. In particular, fructose 1-phosphate can be biosynthesized from D-fructose through the action of the enzyme ketohexokinase. In addition, fructose 1-phosphate can be converted into dihydroxyacetone phosphate and glyceraldehyde; which is catalyzed by the enzyme fructose-bisphosphate aldolase a. Because fructokinase has a high Vmax fructose entering cells is quickly phosphorylated to fructose 1-phosphate. In humans, fructose 1-phosphate is involved in fructose intolerance, hereditary. Hypoglycemia results from inhibition of glycogenolysis and gluconeogenesis. It is generated mainly by hepatic fructokinase but is also generated in smaller amounts in the small intestinal mucosa and proximal epithelium of the renal tubule. Aldolase B converts it into glyceraldehyde and dihydroxyacetone phosphate (DHAP). Symptoms of hereditary fructose intolerance are apathy, drowsiness, sweatiness and tremulousness.
Fructose 1-phosphate is an intermediate metabolite in the Fructose and mannose metabolism pathway. [HMDB]
KEIO_ID F009
同义名列表
24 个代谢物同义名
{[(2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methoxy}phosphonic acid; [(2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methoxyphosphonic acid; beta-D-Fructofuranose 1-phosphoric acid; b-D-Fructofuranose 1-phosphoric acid; Β-D-fructofuranose 1-phosphoric acid; 1-O-Phosphono-Beta-D-Fructofuranose; beta-D-Fructose 1-phosphoric acid; b-D-Fructofuranose 1-phosphate; Β-D-fructose 1-phosphoric acid; b-D-Fructose 1-phosphoric acid; Β-D-fructofuranose 1-phosphate; D-fructofuranose 1-phosphate; beta-D-Fructose 1-phosphate; Fructose 1-phosphoric acid; Β-D-fructose 1-phosphate; b-D-Fructose 1-phosphate; D-Fructose 1-phosphate; D-Fructose-1-phosphate; Fructose 1-phosphate; Fructose-1-phosphate; D-Fructose-1-p; Fructose-1-p; SCHEMBL1532479; D-Fructose 1-phosphate
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:139419
- ChEBI: CHEBI:37515
- KEGG: C01094
- PubChem: 10400369
- PubChem: 439394
- PubChem: 717
- HMDB: HMDB0001076
- Metlin: METLIN378
- ChEMBL: CHEMBL605021
- Wikipedia: Fructose 1-phosphate
- MetaCyc: FRU1P
- foodb: FDB022410
- chemspider: 8575807
- CAS: 15978-08-2
- MoNA: KO000754
- MoNA: KO000756
- MoNA: KO000758
- MoNA: KO000755
- MoNA: KO000757
- PMhub: MS000009572
- ChEBI: CHEBI:18105
- PubChem: 4329
- KNApSAcK: C00019676
- PDB-CCD: F1X
- 3DMET: B04765
- NIKKAJI: J219.923H
- RefMet: Fructose 1-phosphate
- KNApSAcK: 18105
- LOTUS: LTS0044491
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
15 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(2)
- Hexoses metabolism in proximal tubules:
Glucose ⟶ Sorbitol
- Polyol pathway:
D-Glucose ⟶ D-Sorbitol
Plant Reactome(0)
INOH(2)
- Fructose and Mannose metabolism ( Fructose and Mannose metabolism ):
D-Sorbitol + NADP+ ⟶ D-Glucose + NADPH
- D-Fructose 1-phosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde ( Fructose and Mannose metabolism ):
D-Fructose 1-phosphate ⟶ D-Glyceraldehyde + Dihydroxy-acetone phosphate
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(11)
- Fructose and Mannose Degradation:
D-Fructose 2,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
- Fructosuria:
D-Fructose 2,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
- Fructose Intolerance, Hereditary:
D-Fructose 2,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
- Fructose Metabolism:
Adenosine triphosphate + D-Fructose ⟶ -D-Fructose 6-phosphate + Adenosine diphosphate
- Fructose and Mannose Degradation:
Fructose 1,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
- Fructose Intolerance, Hereditary:
Fructose 1,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
- Fructosuria:
Adenosine triphosphate + D-Fructose ⟶ Adenosine diphosphate + Fructose 6-phosphate
- Fructose Intolerance, Hereditary:
Adenosine triphosphate + D-Fructose ⟶ Adenosine diphosphate + Fructose 6-phosphate
- Fructose and Mannose Degradation:
Adenosine triphosphate + D-Fructose ⟶ Adenosine diphosphate + Fructose 6-phosphate
- Fructose and Mannose Degradation:
Adenosine triphosphate + D-Fructose ⟶ Adenosine diphosphate + Fructose 6-phosphate
- Fructosuria:
Fructose 1,6-bisphosphate + Water ⟶ Fructose 6-phosphate + Phosphate
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0044491
- 543 - Enterobacteriaceae: LTS0044491
- 561 - Escherichia: LTS0044491
- 562 - Escherichia coli: LTS0044491
- 1236 - Gammaproteobacteria: LTS0044491
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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