Sulfluramid (BioDeep_00000002949)

 

Secondary id: BioDeep_00000397758

human metabolite blood metabolite


代谢物信息卡片


N-Ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulphonamide

化学式: C10H6F17NO2S (526.984778)
中文名称: 氟虫胺
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CCNS(=O)(=O)C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
InChI: InChI=1S/C10H6F17NO2S/c1-2-28-31(29,30)10(26,27)8(21,22)6(17,18)4(13,14)3(11,12)5(15,16)7(19,20)9(23,24)25/h28H,2H2,1H3

描述信息

同义名列表

10 个代谢物同义名

N-Ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulphonamide; N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide; N-Ethylperfluorooctane-1-sulphonamide; N-Ethylperfluorooctane-1-sulfonamide; N-Ethyl(perfluorooctane)sulfonamide; N-Ethylperfluorooctanesulfonamide; N-Ethylperfluorooctylsulphonamide; N-Ethylperfluorooctylsulfonamide; Sulphluramid; Sulfluramid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Emily Marques, Marisa Pfohl, Wei Wei, Giuseppe Tarantola, Lucie Ford, Ogochukwu Amaeze, Jessica Alesio, Sangwoo Ryu, Xuelian Jia, Hao Zhu, Geoffrey D Bothun, Angela Slitt. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicology and applied pharmacology. 2022 05; 442(?):115991. doi: 10.1016/j.taap.2022.115991. [PMID: 35337807]
  • Tarcísio M M Mota Filho, Roberto S Camargo, José C Zanuncio, Luis E P Stefanelli, Carlos A O de Matos, Luiz C Forti. Contamination routes and mortality of the leaf-cutting ant Atta sexdens (Hymenoptera: Formicidae) by the insecticides fipronil and sulfluramid through social interactions. Pest management science. 2021 Oct; 77(10):4411-4417. doi: 10.1002/ps.6475. [PMID: 33982404]
  • Susanna D Mitro, Sharon K Sagiv, Abby F Fleisch, Lindsay M Jaacks, Paige L Williams, Sheryl L Rifas-Shiman, Antonia M Calafat, Marie-France Hivert, Emily Oken, Tamarra M James-Todd. Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Postpartum Health in Project Viva: A Prospective Cohort. The Journal of clinical endocrinology and metabolism. 2020 09; 105(9):. doi: 10.1210/clinem/dgaa431. [PMID: 32620010]
  • Rodrigo A Nascimento, Deborah B O Nunoo, Ekhine Bizkarguenaga, Lara Schultes, Itsaso Zabaleta, Jonathan P Benskin, Saulo Spanó, Juliana Leonel. Sulfluramid use in Brazilian agriculture: A source of per- and polyfluoroalkyl substances (PFASs) to the environment. Environmental pollution (Barking, Essex : 1987). 2018 Nov; 242(Pt B):1436-1443. doi: 10.1016/j.envpol.2018.07.122. [PMID: 30142559]
  • Shuyan Zhao, Tao Zhou, Lingyan Zhu, Bohui Wang, Ze Li, Liping Yang, Lifen Liu. Uptake, translocation and biotransformation of N-ethyl perfluorooctanesulfonamide (N-EtFOSA) by hydroponically grown plants. Environmental pollution (Barking, Essex : 1987). 2018 Apr; 235(?):404-410. doi: 10.1016/j.envpol.2017.12.053. [PMID: 29306808]
  • Jonathan P Benskin, Michael G Ikonomou, Frank A P C Gobas, Timothy H Begley, Million B Woudneh, John R Cosgrove. Biodegradation of N-ethyl perfluorooctane sulfonamido ethanol (EtFOSE) and EtFOSE-based phosphate diester (SAmPAP diester) in marine sediments. Environmental science & technology. 2013 Feb; 47(3):1381-9. doi: 10.1021/es304336r. [PMID: 23305554]
  • Kurt R Rhoads, Elisabeth M L Janssen, Richard G Luthy, Craig S Criddle. Aerobic biotransformation and fate of N-ethyl perfluorooctane sulfonamidoethanol (N-EtFOSE) in activated sludge. Environmental science & technology. 2008 Apr; 42(8):2873-8. doi: 10.1021/es702866c. [PMID: 18497137]
  • David E Lefebvre, Ivan Curran, Cheryl Armstrong, Laurie Coady, Monique Parenteau, Virginia Liston, Michael Barker, Syed Aziz, Kathryn Rutherford, Pascale Bellon-Gagnon, Jacintha Shenton, Rekha Mehta, Genevieve Bondy. Immunomodulatory effects of dietary potassium perfluorooctane sulfonate (PFOS) exposure in adult Sprague-Dawley rats. Journal of toxicology and environmental health. Part A. 2008; 71(23):1516-25. doi: 10.1080/15287390802391943. [PMID: 18923994]
  • Geary W Olsen, Han-Yao Huang, Kathy J Helzlsouer, Kristen J Hansen, John L Butenhoff, Jeffrey H Mandel. Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood. Environmental health perspectives. 2005 May; 113(5):539-45. doi: 10.1289/ehp.7544. [PMID: 15866760]
  • Deanna J Luebker, Kris J Hansen, Nathan M Bass, John L Butenhoff, Andrew M Seacat. Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology. 2002 Jul; 176(3):175-85. doi: 10.1016/s0300-483x(02)00081-1. [PMID: 12093614]
  • J G Machado-Neto, M E Queiroz, D Carvalho, A J Bassini. Risk of intoxication with sulfluramid in a packing plant of Mirex-S. Bulletin of environmental contamination and toxicology. 1999 May; 62(5):515-9. doi: 10.1007/s001289900906. [PMID: 10227829]
  • K L Kees, T M Smith, M L McCaleb, D H Prozialeck, R S Cheeseman, T E Christos, W C Patt, K E Steiner. Perfluorocarbon-based antidiabetic agents. Journal of medicinal chemistry. 1992 Mar; 35(5):944-53. doi: 10.1021/jm00083a021. [PMID: 1548684]
  • R O Manning, J V Bruckner, M E Mispagel, J M Bowen. Metabolism and disposition of sulfluramid, a unique polyfluorinated insecticide, in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1991 Jan; 19(1):205-11. doi: NULL. [PMID: 1673400]
  • R G Schnellmann, R O Manning. Perfluorooctane sulfonamide: a structurally novel uncoupler of oxidative phosphorylation. Biochimica et biophysica acta. 1990 Apr; 1016(3):344-8. doi: 10.1016/0005-2728(90)90167-3. [PMID: 2331477]