Estazolam (BioDeep_00000002305)

 

Secondary id: BioDeep_00000408822

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene

化学式: C16H11ClN4 (294.0672)
中文名称: 艾司唑仑
谱图信息: 最多检出来源 Homo sapiens(blood) 40.35%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Estazolam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/estazolam (retrieved 2024-12-31) (BioDeep RN: BioDeep_00000002305). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4
InChI: InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

描述信息

Estazolam is only found in individuals that have used or taken this drug. It is a benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. [PubChem]Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

14 个代谢物同义名

12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene; 8-Chloro-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine; Hormona brand OF estazolam; Abbott brand OF estazolam; Takeda brand OF estazolam; Estazolamum; estazolam; Nuctalon; Tasedan; ProSom; D-40TA; D40TA; Estazolam; Estazolam



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HPGDS, POMC
Peripheral membrane protein 1 CYP2E1
Endosome membrane 1 LY96
Endoplasmic reticulum membrane 7 CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Nucleus 1 ALB
cytosol 3 ALB, CLC, HPGDS
dendrite 1 HTR1A
trans-Golgi network 1 PCSK5
centrosome 1 ALB
nucleoplasm 1 HPGDS
Cell membrane 2 HTR1A, TNF
Cytoplasmic granule 1 CLC
Multi-pass membrane protein 1 HTR1A
Synapse 1 HTR1A
cell surface 1 TNF
Golgi apparatus 2 ALB, PCSK5
Golgi membrane 2 INS, PCSK5
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 CLC
plasma membrane 6 CYP2C19, CYP2C9, HTR1A, LRP5, LY96, TNF
Membrane 5 CYP2A6, CYP2D6, CYP3A4, LRP5, PCSK5
extracellular exosome 1 ALB
endoplasmic reticulum 3 ALB, CYP2D6, LRP5
extracellular space 8 ALB, CLC, CXCL8, IL6, INS, PCSK5, POMC, TNF
mitochondrion 1 CYP2D6
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 8 CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HPGDS
Microsome membrane 5 CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Single-pass type I membrane protein 1 LRP5
Secreted 7 ALB, CLC, CXCL8, IL6, INS, LY96, POMC
extracellular region 10 ALB, CLC, CXCL8, IL6, INS, LY86, LY96, PCSK5, POMC, TNF
Single-pass membrane protein 1 CYP2D6
anchoring junction 1 ALB
external side of plasma membrane 1 TNF
Wnt signalosome 1 LRP5
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNF
collagen-containing extracellular matrix 1 CLC
secretory granule 1 POMC
receptor complex 2 LRP5, LY96
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 LY96
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Cell projection, dendrite 1 HTR1A
lipopolysaccharide receptor complex 1 LY96
secretory granule lumen 2 INS, POMC
Golgi lumen 2 INS, PCSK5
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
cytoplasmic microtubule 1 CYP2A6
Wnt-Frizzled-LRP5/6 complex 1 LRP5
CRLF-CLCF1 complex 1 CLC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
CNTFR-CLCF1 complex 1 CLC
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Zhuo-Wei Gao, Dong Shen. The anxiolytic-like effects of estazolam on a PTSD animal model. Psychiatry research. 2018 11; 269(?):529-535. doi: 10.1016/j.psychres.2018.08.118. [PMID: 30195748]
  • Yin-Fei Zhang, Kai-Li Zhou, Yan-Yue Lou, Dong-Qi Pan, Jie-Hua Shi. Investigation of the binding interaction between estazolam and bovine serum albumin: multi-spectroscopic methods and molecular docking technique. Journal of biomolecular structure & dynamics. 2017 12; 35(16):3605-3614. doi: 10.1080/07391102.2016.1264889. [PMID: 27882826]
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