Estazolam (BioDeep_00000002305)

 

Secondary id: BioDeep_00000408822

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene

化学式: C16H11ClN4 (294.0672196)
中文名称: 艾司唑仑
谱图信息: 最多检出来源 Homo sapiens(blood) 7.69%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Estazolam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/estazolam (retrieved 2024-11-05) (BioDeep RN: BioDeep_00000002305). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4
InChI: InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

描述信息

Estazolam is only found in individuals that have used or taken this drug. It is a benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. [PubChem]Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

12 个代谢物同义名

12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene; 8-Chloro-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine; Hormona brand OF estazolam; Abbott brand OF estazolam; Takeda brand OF estazolam; Estazolamum; estazolam; Nuctalon; Tasedan; ProSom; D-40TA; D40TA



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui-Zhong Fu, Yue-Long Fang, Shu-He Cai, Xiu-Ming Chen, Jian Lin, Li-Fang Su. [Clinical efficacy of shallow-needle therapy combined with estazolam on insomnia of liver stagnation transforming into fire pattern: a randomized controlled trial]. Zhen ci yan jiu = Acupuncture research. 2022 Dec; 47(12):1107-12. doi: 10.13702/j.1000-0607.20220287. [PMID: 36571227]
  • Jialing Zhang, Zhinan Zhang, Shengtao Huang, Xiaoke Qiu, Lixing Lao, Yong Huang, Zhang-Jin Zhang. Acupuncture for cancer-related insomnia: A systematic review and meta-analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154160. doi: 10.1016/j.phymed.2022.154160. [PMID: 35636168]
  • Wen-Zhong Wu, Shi-Yu Zheng, Cheng-Yong Liu, Shan Qin, Xiao-Qiu Wang, Jin-Li Hu, Qing-Yun Wan, Ya-Nan Zhao, Han-Qing Xi. [Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2021 Jul; 41(7):721-4. doi: 10.13703/j.0255-2930.20200704-k0001. [PMID: 34259401]
  • Yujiao Chen, Yuqian Wu, Shouliang Li, Simiao Du, Xuemin Hao, Jian Zhang, Pengai Gu, Jiachen Sun, Lei Jiang, Qijin Gai, Xiaomin Liu, Kaimei Nie, Li Zhong, Guixue Wang, Jun Cao. Large-scale isolation and antitumor mechanism evaluation of compounds from the traditional Chinese medicine Cordyceps Militaris. European journal of medicinal chemistry. 2021 Feb; 212(?):113142. doi: 10.1016/j.ejmech.2020.113142. [PMID: 33450619]
  • Guiyu Feng, Mei Han, Xun Li, Le Geng, Yingchun Miao. Clinical effectiveness of Tui Na for insomnia compared with estazolam: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine. 2019 Dec; 47(?):102186. doi: 10.1016/j.ctim.2019.08.020. [PMID: 31779989]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Zhuo-Wei Gao, Dong Shen. The anxiolytic-like effects of estazolam on a PTSD animal model. Psychiatry research. 2018 11; 269(?):529-535. doi: 10.1016/j.psychres.2018.08.118. [PMID: 30195748]
  • Yin-Fei Zhang, Kai-Li Zhou, Yan-Yue Lou, Dong-Qi Pan, Jie-Hua Shi. Investigation of the binding interaction between estazolam and bovine serum albumin: multi-spectroscopic methods and molecular docking technique. Journal of biomolecular structure & dynamics. 2017 12; 35(16):3605-3614. doi: 10.1080/07391102.2016.1264889. [PMID: 27882826]
  • Xiaoshu Zhu, Yuklan Liew, Zhao Lan Liu. Chinese herbal medicine for menopausal symptoms. The Cochrane database of systematic reviews. 2016 Mar; 3(?):CD009023. doi: 10.1002/14651858.cd009023.pub2. [PMID: 26976671]
  • Wei-dong Wang, Gui-xia Li, Lan Hong, Yan-jiao Liu, Yang Zhao, Ying-na Lin, Fang Wang, Tao Li, Xue Yan, Yan-ying Huang. Low Resistance Thought Induction Sleep-regulating Technique (TIP3-2) combined with medication for primary insomnia: a randomized controlled trial. International journal of behavioral medicine. 2014 Aug; 21(4):618-28. doi: 10.1007/s12529-014-9415-5. [PMID: 24875654]
  • Qing Chang, Hongying Ma, Fangjie Wang, Honglian Ou, Ming Zou. [Determination of 10 sedative-hypnotics in human plasma using pulse splitless injection technique and gas chromatography-mass spectrometry]. Se pu = Chinese journal of chromatography. 2011 Nov; 29(11):1082-6. doi: . [PMID: 22393695]
  • Jiu-xi Yuan, Yu-jin Wang, Ke-ming Yun. [Stability of estazolam in dog tissues preserved in formaldehyde solution]. Fa yi xue za zhi. 2011 Apr; 27(2):117-9, 124. doi: NULL. [PMID: 21604450]
  • Chao-Yun Xia, Cheng-Yi Xia, Shi-Ping Deng, Pei-Jun Zhu. The XIA's No. 1 sleeping Prescription for the treatment of insomnia of the deficiency type: a clinical observation of 60 cases. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2009 Sep; 29(3):211-5. doi: 10.1016/s0254-6272(09)60068-6. [PMID: 19894388]
  • Xianghui Liang, Zhiyong Dai, Wen'en Liu. [Simultaneous determination of 5 sedative hypnotics in human plasma by reversed phase high-performance liquid chromatography]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2009 Jul; 34(7):689-92. doi: . [PMID: 19648689]
  • Yan-li Ju, Xu Chi, Jian-xin Liu. Forty cases of insomnia treated by suspended moxibustion at Baihui (GV 20). Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2009 Jun; 29(2):95-6. doi: 10.1016/s0254-6272(09)60040-6. [PMID: 19663092]
  • Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds. Biomedical chromatography : BMC. 2009 Apr; 23(4):357-64. doi: 10.1002/bmc.1122. [PMID: 18937304]
  • Hai-cong Li, Xiao-guang Chen, Xin Tian. [Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2009 Mar; 29(3):204-7. doi: . [PMID: 19548433]
  • Yan Li, Bi-yun Xu, Fang Xiao. [Effect of modified xiaoyao powder for improving sleep in patients with psychological stress insomnia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2009 Mar; 29(3):208-11. doi: ". [PMID: 19548434]
  • Yuan Tian, Jingjing Zhang, Hui Lin, Jiabi Liang, Zunjian Zhang, Yun Chen. High performance liquid chromatography-tandem mass spectrometric determination of rupatadine in human plasma and its pharmacokinetics. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):899-906. doi: 10.1016/j.jpba.2008.03.015. [PMID: 18472381]
  • Ying Liu, Fengguo Xu, Zunjian Zhang, Rui Song, Yuan Tian. Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2008 Jul; 22(7):736-45. doi: 10.1002/bmc.991. [PMID: 18384064]
  • Kei Zaitsu, Akihiro Miki, Munehiro Katagi, Hitoshi Tsuchihashi. Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization. Forensic science international. 2008 Jan; 174(2-3):189-96. doi: 10.1016/j.forsciint.2007.04.224. [PMID: 17555899]
  • Yahdiana Harahap, Lucy Sasongko, Budi Prasaja, Ega Indriati, Windy Lusthom, Lipin. Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. Arzneimittel-Forschung. 2008; 58(10):501-4. doi: 10.1055/s-0031-1296548. [PMID: 19025059]
  • Ya-Bo Xuan, Jing Guo, Lin-Peng Wang, Xi Wu. [Randomized and controlled study on effect of acupuncture on sleep quality in the patient of primary insomnia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2007 Dec; 27(12):886-8. doi: ". [PMID: 18271228]
  • Jingjing Zhang, Jiabi Liang, Yuan Tian, Zunjian Zhang, Yun Chen. Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of aniracetam in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Oct; 858(1-2):129-34. doi: 10.1016/j.jchromb.2007.08.010. [PMID: 17826366]
  • Wen Liu, Hua-Lin Cai, Huan-de Li. High performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI) method for simultaneous determination of venlafaxine and its three metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):405-11. doi: 10.1016/j.jchromb.2006.12.019. [PMID: 17222591]
  • Hai-Cong Li, Yi-Ling Yang, Ming Ma. [Comparative study on treatment of somnipathy in patients with hypertension by traditional Chinese medicine and by estazolam]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2007 Feb; 27(2):123-6. doi: . [PMID: 17342998]
  • Haijuan Dong, Fengguo Xu, Zunjian Zhang, Yuan Tian, Yun Chen. Simultaneous determination of spironolactone and its active metabolite canrenone in human plasma by HPLC-APCI-MS. Journal of mass spectrometry : JMS. 2006 Apr; 41(4):477-86. doi: 10.1002/jms.1006. [PMID: 16541392]
  • Beibei Zhang, Zunjian Zhang, Yuan Tian, Fengguo Xu, Yun Chen. High-performance liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry determination of zaleplon in human plasma. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(3):707-14. doi: 10.1016/j.jpba.2005.06.031. [PMID: 16087308]
  • Boni Elewski, Amir Tavakkol. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Therapeutics and clinical risk management. 2005 Dec; 1(4):299-306. doi: . [PMID: 18360572]
  • Yiling Yang, Haicong Li, Shuyi Zhang, Qiubing Li, Xueqing Yang, Xiaoguang Chen, Dong Zhao, Yan Wang. TCM treatment for 63 cases of senile dyssomnia. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2005 Mar; 25(1):45-9. doi: . [PMID: 15889523]
  • Piotr Adamowicz, Maria Kała. Date-rape drugs scene in Poland. Przeglad lekarski. 2005; 62(6):572-5. doi: . [PMID: 16225127]
  • Xiaoyan Chen, Liyan Zhao, Haiyan Xu, Dafang Zhong. Simultaneous determination of albendazole and its major active metabolite in human plasma using a sensitive and specific liquid chromatographic-tandem mass spectrometric method. Journal of pharmaceutical and biomedical analysis. 2004 Jun; 35(4):829-36. doi: 10.1016/j.jpba.2004.02.022. [PMID: 15193727]
  • Toshiaki Aoshima, Takashi Fukasawa, Yohei Otsuji, Naoyuki Okuyama, Gisa Gerstenberg, Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara, Koichi Otani. Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam. Progress in neuro-psychopharmacology & biological psychiatry. 2003 May; 27(3):535-8. doi: 10.1016/s0278-5846(02)00357-3. [PMID: 12691790]
  • Karen S Scott, Yuji Nakahara. A study into the rate of incorporation of eight benzodiazepines into rat hair. Forensic science international. 2003 Apr; 133(1-2):47-56. doi: 10.1016/s0379-0738(03)00049-5. [PMID: 12742689]
  • Rui Cui, Dean Zhou. Treatment of phlegm- and heat-induced insomnia by acupuncture in 120 cases. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2003 Mar; 23(1):57-8. doi: ". [PMID: 12747205]
  • Toshimasa Toyo'oka, Yusuke Kumaki, Masayoshi Kanbori, Masaru Kato, Yuji Nakahara. Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid-chromatography with electrospray ionization mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2003 Jan; 30(6):1773-87. doi: 10.1016/s0731-7085(02)00520-4. [PMID: 12485719]
  • Yohei Otsuji, Naoyuki Okuyama, Toshiaki Aoshima, Takashi Fukasawa, Kimiyasu Kato, Gisa Gerstenberg, Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara, Koichi Otani. No effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of estazolam. Therapeutic drug monitoring. 2002 Jun; 24(3):375-8. doi: 10.1097/00007691-200206000-00008. [PMID: 12021628]
  • Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara, Naoyuki Okuyama, Koichi Otani. Determination of estazolam in plasma by high-performance liquid chromatography with solid-phase extraction. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2002 May; 18(5):525-8. doi: 10.2116/analsci.18.525. [PMID: 12036118]
  • Stephane Pirnay, Ivan Ricordel, Danielle Libong, Stéphane Bouchonnet. Sensitive method for the detection of 22 benzodiazepines by gas chromatography-ion trap tandem mass spectrometry. Journal of chromatography. A. 2002 Apr; 954(1-2):235-45. doi: 10.1016/s0021-9673(02)00190-5. [PMID: 12058908]
  • Takashi Uezono, Hiroshi Shiono, Keiko Shimizu, Kento Ogawa, Osamu Saito, Masatsugu Yoshida, Hajime Mizukami, Kazuo Matsubara. Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug. Legal medicine (Tokyo, Japan). 2002 Mar; 4(1):34-6. doi: 10.1016/s1344-6223(01)00042-6. [PMID: 12935689]
  • Jing-kai Gu, Rong Xia, Da-fang Zhong, Lu Sun. [Identification of estazolam, alprazolam and triazolam in human urine by LC/MSn]. Yao xue xue bao = Acta pharmaceutica Sinica. 2002 Feb; 37(2):138-40. doi: . [PMID: 12579961]
  • B Marc, F Baudry, P Vaquero, L Zerrouki, S Hassnaoui, H Douceron. Sexual assault under benzodiazepine submission in a Paris suburb. Archives of gynecology and obstetrics. 2000 Apr; 263(4):193-7. doi: 10.1007/s004040050282. [PMID: 10834331]
  • L Dal Bo, F Verga, A Marzo, P La Commare, M L De Vito. Gas chromatographic assay for estazolam in human plasma and results of a bioequivalence study. Pharmacological research. 1997 Apr; 35(4):329-33. doi: 10.1006/phrs.1997.0144. [PMID: 9264050]
  • E Tanaka, M Terada, S Misawa, C Wakasugi. Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel. Journal of chromatography. B, Biomedical applications. 1996 Jun; 682(1):173-8. doi: 10.1016/0378-4347(96)00121-1. [PMID: 8832439]
  • M Tomita, T Okuyama. Application of capillary electrophoresis to the simultaneous screening and quantitation of benzodiazepines. Journal of chromatography. B, Biomedical applications. 1996 Apr; 678(2):331-7. doi: 10.1016/0378-4347(95)00512-9. [PMID: 8738039]
  • A Goldnik, M Gajewska, M Gajewska. Determination of estazolam and alprazolam in serum by HPLC. Acta poloniae pharmaceutica. 1994; 51(4-5):311-2. doi: NULL. [PMID: 7701946]
  • J F Kelly, D J Greenblatt. Rapid and sensitive gas chromatographic determination of estazolam. Journal of chromatography. 1993 Nov; 621(1):102-4. doi: 10.1016/0378-4347(93)80082-f. [PMID: 8308079]
  • A D Fraser, A F Isner, W Bryan. Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC. Journal of analytical toxicology. 1993 Nov; 17(7):427-31. doi: 10.1093/jat/17.7.427. [PMID: 8309217]
  • A Boukhabza, A A Lugnier, P Kintz, P Mangin. Simultaneous HPLC analysis of the hypnotic benzodiazepines nitrazepam, estazolam, flunitrazepam, and triazolam in plasma. Journal of analytical toxicology. 1991 Nov; 15(6):319-22. doi: 10.1093/jat/15.6.319. [PMID: 1779659]
  • L E Gustavson, P J Carrigan. The clinical pharmacokinetics of single doses of estazolam. The American journal of medicine. 1990 Mar; 88(3A):2S-5S. doi: 10.1016/0002-9343(90)90278-l. [PMID: 1968715]
  • A Scotto di Tella, P Ricci, C Di Nunzio, P Cassandro. A new method for the determination in blood and urine of a novel triazolobenzodiazepine (estazolam) by HPLC. Journal of analytical toxicology. 1986 Mar; 10(2):65-7. doi: 10.1093/jat/10.2.65. [PMID: 2871229]
  • J M Machinist, B A Bopp, D J Anderson, G R Granneman, R C Sonders, K Tolman, K Buchi, D Rollins. Metabolism of 14C-estazolam in dogs and humans. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Jan; 16(1):11-20. doi: 10.3109/00498258609043501. [PMID: 2868576]
  • A Mancinelli, G Guiso, S Garattini, R Urso, S Caccia. Kinetic and pharmacological studies on estazolam in mice and man. Xenobiotica; the fate of foreign compounds in biological systems. 1985 Mar; 15(3):257-65. doi: 10.3109/00498258509045357. [PMID: 2862746]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • M D Allen, D J Greenblatt, J D Arnold. Single- and multiple-dose kinetics of estazolam, a triazolo benzodiazepine. Psychopharmacology. 1979; 66(3):267-74. doi: 10.1007/bf00428318. [PMID: 43552]
  • E M Sellers, R Thakur. Partial agonist properties and toxicity of oral oxilorphan. Journal of clinical pharmacology. 1976 Apr; 16(4):183-7. doi: 10.1002/j.1552-4604.1976.tb01515.x. [PMID: 4472]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]