Dyphylline (BioDeep_00000001847)

 

Secondary id: BioDeep_00001867700

human metabolite blood metabolite PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


7-(2,3-dihydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C10H14N4O4 (254.1015)
中文名称: 二羟丙茶碱
谱图信息: 最多检出来源 Homo sapiens(blood) 32.44%

分子结构信息

SMILES: Cn1c(=O)c2c(ncn2CC(O)CO)n(C)c1=O
InChI: InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

描述信息

Dyphylline is only found in individuals that have used or taken this drug. It is a theophylline derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. [PubChem]The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
KEIO_ID D183; [MS2] KO008931
KEIO_ID D183
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema[1][2].
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema[1][2].

同义名列表

36 个代谢物同义名

7-(2,3-dihydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine; 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine; 7-(beta,gamma-Dihydroxypropyl)theophylline; (+-)-7-(2,3-Dihydroxypropyl)theophylline; 7-(Β,γ-dihydroxypropyl)theophylline; (1,2-Dihydroxy-3-propyl)thiophyllin; 7-(2,3-Dihydroxypropyl)theophylline; 7-(b,g-Dihydroxypropyl)theophylline; Dihydroxypropyl theophylline; Dihydroxypropyltheophylline; Wallace brand OF dyphylline; Savage brand OF dyphylline; Lunsco brand OF dyphylline; Hauck brand OF dyphylline; Major brand OF dyphylline; Dihydroxypropyl theopylin; Dilor brand OF dyphylline; (+-)-Diprophylline; (+-)-Dyphylline; Diprophyllinum; Diprophylline; Diprophyllin; Diprofilline; Dipropylline; Neothylline; Diprofillin; Diprofilina; dyphylline; Diphylline; Lufyllin; Dilin; Dylix; dT; Dyphylline



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACOT12, CASP3, CYP2C9, MYLK3, PDE4D, PFDN5, PIK3CA, PTGS2, TNK1
Peripheral membrane protein 3 PDE4A, PTGS2, TNK1
Endoplasmic reticulum membrane 2 CYP2C9, PTGS2
Nucleus 5 CASP3, MPO, PDE4A, PDE4D, PFDN5
cytosol 9 ACOT12, CASP3, LIPE, MYLK3, PDE10A, PDE4A, PDE4D, PFDN5, PIK3CA
centrosome 1 PDE4D
nucleoplasm 4 ACOT12, CASP3, MPO, PDE4A
Cell membrane 1 LIPE
lamellipodium 1 PIK3CA
ruffle membrane 1 PDE4A
glutamatergic synapse 1 CASP3
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuronal cell body 1 CASP3
Cytoplasm, cytosol 3 ACOT12, LIPE, PDE10A
Lysosome 2 GAA, MPO
plasma membrane 8 CYP2C9, GAA, KNG1, PDE4A, PDE4D, PIK3CA, PRSS27, TNK1
Membrane 5 GAA, LIPE, PDE4A, PDE4D, TNK1
apical plasma membrane 1 PDE4D
caveola 2 LIPE, PTGS2
extracellular exosome 3 GAA, KNG1, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 1 PTGS2
extracellular space 5 CCL8, CTRL, INS, KNG1, MPO
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 PDE4A, PDE4D, PIK3CA
intercalated disc 1 PIK3CA
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 3 CYP2C9, GAA, MPO
Microsome membrane 2 CYP2C9, PTGS2
postsynaptic density 1 CASP3
Secreted 2 GAA, INS
extracellular region 5 GAA, INS, KNG1, MPO, PRSS27
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PDE4D
actin cytoskeleton 1 MYLK3
Apical cell membrane 1 PDE4D
Cell projection, ruffle membrane 1 PDE4A
Cytoplasm, cytoskeleton 1 PDE4D
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
intercellular bridge 1 ACOT12
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
intermediate filament cytoskeleton 1 PFDN5
azurophil granule 1 MPO
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 INS, KNG1, PTGS2
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 PDE4D
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
extrinsic component of membrane 1 PDE4A
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calcium channel complex 1 PDE4D
phagocytic vesicle lumen 1 MPO
prefoldin complex 1 PFDN5
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cytoplasm, perinuclear region 1 PDE4A
[Isoform 3]: Cytoplasm, cytosol 1 PDE4A
autolysosome lumen 1 GAA
[Isoform 2]: Cytoplasm, perinuclear region 1 PDE4A
[Isoform 6]: Cytoplasm, perinuclear region 1 PDE4A
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

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