19-Norprogesterone (BioDeep_00000009930)
代谢物信息卡片
19-Norpregn-4-ene-3,20-dione
化学式: C20H28O2 (300.2089)
中文名称: 19-去甲肾上腺素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C
InChI: InChI=1S/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:34188
- KEGG: C14489
- PubChem: 228864
- Metlin: METLIN70099
- ChEMBL: CHEMBL284109
- CAS: 472-54-8
- PMhub: MS000023752
- PubChem: 17395489
- NIKKAJI: J11.976H
- KNApSAcK: 34188
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenxian Tan, Joseph Aizen, Peter Thomas. Membrane progestin receptor alpha mediates progestin-induced sperm hypermotility and increased fertilization success in southern flounder (Paralichthys lethostigma).
General and comparative endocrinology.
2014 May; 200(?):18-26. doi:
10.1016/j.ygcen.2014.02.003. [PMID: 24530629] - Sonja Janmaat, Yvette Akwa, Mohamed Doulazmi, Joëlle Bakouche, Vanessa Gautheron, Philippe Liere, Bernard Eychenne, Antoine Pianos, Paul Luiten, Ton Groothuis, Etienne-Emile Baulieu, Jean Mariani, Rachel M Sherrard, Florence Frédéric. Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.
Age (Dordrecht, Netherlands).
2011 Dec; 33(4):565-78. doi:
10.1007/s11357-010-9203-3. [PMID: 21222044] - Alfred O Mueck, Regine Sitruk-Ware. Nomegestrol acetate, a novel progestogen for oral contraception.
Steroids.
2011 May; 76(6):531-9. doi:
10.1016/j.steroids.2011.02.002. [PMID: 21335021] - Stefano Lello. Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy.
Drugs.
2010 Mar; 70(5):541-59. doi:
10.2165/11532130-000000000-00000. [PMID: 20329803] - S Lello. [Nomegestrol acetate: clinical pharmacology].
Minerva ginecologica.
2009 Oct; 61(5):459-63. doi:
. [PMID: 19749678] - Julia Lepenies, Paul M Stewart, Marcus Quinkler. The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2009 Jun; 31(4):376-9. doi:
10.1080/10641960902977932. [PMID: 19811365] - L McRobb, D J Handelsman, R Kazlauskas, S Wilkinson, M D McLeod, A K Heather. Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay.
The Journal of steroid biochemistry and molecular biology.
2008 May; 110(1-2):39-47. doi:
10.1016/j.jsbmb.2007.10.008. [PMID: 18395441] - Liqin Zhao, Roberta Diaz Brinton. Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease.
BMC neuroscience.
2006 Mar; 7(?):24. doi:
10.1186/1471-2202-7-24. [PMID: 16533397] - Regine Sitruk-Ware. New progestagens for contraceptive use.
Human reproduction update.
2006 Mar; 12(2):169-78. doi:
10.1093/humupd/dmi046. [PMID: 16291771] - G Benagiano, F M Primiero, M Farris. Clinical profile of contraceptive progestins.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2004 Sep; 9(3):182-93. doi:
10.1080/13625180400007736. [PMID: 15697108] - Régine Sitruk-Ware. New progestogens: a review of their effects in perimenopausal and postmenopausal women.
Drugs & aging.
2004; 21(13):865-83. doi:
10.2165/00002512-200421130-00004. [PMID: 15493951] - Diana L Blithe, Lynnette K Nieman, Richard P Blye, Pamela Stratton, Maureen Passaro. Development of the selective progesterone receptor modulator CDB-2914 for clinical indications.
Steroids.
2003 Nov; 68(10-13):1013-7. doi:
10.1016/s0039-128x(03)00118-1. [PMID: 14667994] - C Pélissier, C Jamin, J-C Colau. [Effects of a 19-norprogesterone derivative, the fourth decade nomegestrol acetate, on lipids].
Annales d'endocrinologie.
2003 Jun; 64(3):216-26. doi:
. [PMID: 12910065] - C Jamin, A Batallan, P Madelenat. [Antigonadotropic effects of a 19-nor-progesterone derivative: the example of nomegestrol acetate].
Gynecologie, obstetrique & fertilite.
2003 Jan; 31(1):70-81. doi:
10.1016/s1297-9589(02)00009-7. [PMID: 12659788] - V Brache, D R Mishell, P Lahteenmaki, F Alvarez, K Elomaa, T Jackanicz, A Faundes. Ovarian function during use of vaginal rings delivering three different doses of Nestorone.
Contraception.
2001 May; 63(5):257-61. doi:
10.1016/s0010-7824(01)00199-8. [PMID: 11448466] - S Kamata, T Matsui, N Haga, M Nakamura, K Odaguchi, T Itoh, T Shimizu, T Suzuki, M Ishibashi, F Yamada. Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives.
Journal of medicinal chemistry.
1987 Sep; 30(9):1647-58. doi:
10.1021/jm00392a022. [PMID: 3040999] - J Botella, J Porthe-Nibelle, J Paris, B Lahlou. Interaction of new 19 nor progesterone derivatives with progestagen, mineralocorticoid and glucocorticoid cytosolic receptors.
Journal de pharmacologie.
1986 Oct; 17(4):699-706. doi:
NULL. [PMID: 3560978] - P Komanicky, J C Melby. Experimental hypertension induced by 19-nor-progesterone treatment in the rat.
Endocrinology.
1981 Oct; 109(4):1164-7. doi:
10.1210/endo-109-4-1164. [PMID: 7285864] - C E Hall, C E Gomez-Sanchez, S Hungerford, E P Gomez-Sanchez. Mineralocorticoid and hypertensive effects of 19-nor-progesterone.
Endocrinology.
1981 Oct; 109(4):1168-75. doi:
10.1210/endo-109-4-1168. [PMID: 7285865] - J W Funder, W R Adam. 19-Nor progesterone is a mineralocorticoid agonist.
Endocrinology.
1981 Jul; 109(1):313-5. doi:
10.1210/endo-109-1-313. [PMID: 6263590] - G H THOMAS. Ketonic metabolites of progesterone and 19-norprogesterone in rabbit urine.
The Biochemical journal.
1962 Jun; 83(?):450-5. doi:
10.1042/bj0830450. [PMID: 13920778]
