OM-174 (BioDeep_00000009656)
代谢物信息卡片
化学式: C52H100N2O20P2 (1134.6344)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(OCC2OC(OP(=O)(O)O)C(NC(=O)CC(O)CCCCCCCCCCC)C(O)C2O)OC(CO)C(OP(=O)(O)O)C1O
InChI: InChI=1S/C52H100N2O20P2/c1-4-7-10-13-16-19-22-25-28-31-38(56)34-42(57)53-45-48(61)47(60)41(72-52(45)74-76(66,67)68)37-69-51-46(49(62)50(40(36-55)71-51)73-75(63,64)65)54-43(58)35-39(32-29-26-23-20-17-14-11-8-5-2)70-44(59)33-30-27-24-21-18-15-12-9-6-3/h38-41,45-52,55-56,60-62H,4-37H2,1-3H3,(H,53,57)(H,54,58)(H2,63,64,65)(H2,66,67,68)/t38-,39-,40-,41-,45-,46-,47-,48-,49-,50-,51-,52-/m1/s1
描述信息
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- KEGG: C13907
- PubChem: 9833422
- Metlin: METLIN69741
- ChEMBL: CHEMBL374223
- PMhub: MS000023462
- ChEBI: CHEBI:34898
- PubChem: 854152
- 3DMET: B04608
- NIKKAJI: J1.419.420G
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cédric Seignez, Amandine Martin, Claire-Emmanuelle Rollet, Cindy Racoeur, Alessandra Scagliarini, Jean-François Jeannin, Ali Bettaieb, Catherine Paul. Senescence of tumor cells induced by oxaliplatin increases the efficiency of a lipid A immunotherapy via the recruitment of neutrophils.
Oncotarget.
2014 Nov; 5(22):11442-51. doi:
10.18632/oncotarget.2556. [PMID: 25347345] - Nicolas Isambert, Pierre Fumoleau, Catherine Paul, Christophe Ferrand, Sylvie Zanetta, Jacques Bauer, Kevin Ragot, Gérard Lizard, Jean-François Jeannin, Marc Bardou. Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors.
BMC cancer.
2013 Apr; 13(?):172. doi:
10.1186/1471-2407-13-172. [PMID: 23547558] - Ricardo P Garay, Patrice Viens, Jacques Bauer, Gérard Normier, Marc Bardou, Jean-François Jeannin, Carlo Chiavaroli. Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help.
European journal of pharmacology.
2007 Jun; 563(1-3):1-17. doi:
10.1016/j.ejphar.2007.02.018. [PMID: 17383632] - Mark De Ridder, Valeri N Verovski, Carlo Chiavaroli, Dirk L Van den Berge, Christinne Monsaert, Kalun Law, Guy A Storme. The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase.
International journal of radiation oncology, biology, physics.
2006 Dec; 66(5):1473-80. doi:
10.1016/j.ijrobp.2006.07.1381. [PMID: 17056198] - Olivier R Martin, Wei Zhou, Xinfu Wu, Sophie Front-Deschamps, Stéphane Moutel, Katharina Schindl, Patricia Jeandet, Claude Zbaeren, Jacques A Bauer. Synthesis and immunobiological activity of an original series of acyclic lipid a mimics based on a pseudodipeptide backbone.
Journal of medicinal chemistry.
2006 Oct; 49(20):6000-14. doi:
10.1021/jm060482a. [PMID: 17004714] - Cartesio D'Agostini, Francesca Pica, Giuseppe Febbraro, Sandro Grelli, Carlo Chiavaroli, Enrico Garaci. Antitumour effect of OM-174 and cyclophosphamide on murine B16 melanoma in different experimental conditions.
International immunopharmacology.
2005 Jul; 5(7-8):1205-12. doi:
10.1016/j.intimp.2005.02.013. [PMID: 15914325] - Claire B Larmonier, Laurent Arnould, Nicolas Larmonier, Sylvie Baumann, Monique Moutet, Valérie Saint-Giorgio, Alena Pance, Jean-François Jeannin. Kinetics of tumor cell apoptosis and immune cell activation during the regression of tumors induced by lipid A in a rat model of colon cancer.
International journal of molecular medicine.
2004 Mar; 13(3):355-61. doi:
. [PMID: 14767564] - Valentin Meraldi, Régine Audran, Jackeline F Romero, Vincent Brossard, Jacques Bauer, José Alejandro López, Giampietro Corradin. OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei.
Vaccine.
2003 Jun; 21(19-20):2485-91. doi:
10.1016/s0264-410x(03)00093-8. [PMID: 12744882] - Bernard Pajak, Virginie Garze, Gwyn Davies, Jacques Bauer, Muriel Moser, Carlo Chiavaroli. The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo.
Vaccine.
2003 Feb; 21(9-10):836-42. doi:
10.1016/s0264-410x(02)00529-7. [PMID: 12547591] - N Onier, S Hilpert, L Arnould, V Saint-Giorgio, J G Davies, J F Jeannin, J F Jeannin. Cure of colon cancer metastasis in rats with the new lipid A OM 174. Apoptosis of tumor cells and immunization of rats.
Clinical & experimental metastasis.
1999 Jun; 17(4):299-306. doi:
10.1023/a:1006663017149. [PMID: 10545016]
