10,10-Bis(pyridin-4-ylmethyl)anthracen-9-one (BioDeep_00000009573)

 

Secondary id: BioDeep_00001876043

human metabolite blood metabolite


代谢物信息卡片


10,10-bis[(pyridin-4-yl)methyl]-9,10-dihydroanthracen-9-one

化学式: C26H20N2O (376.1576)
中文名称: 10,10二(4-吡啶甲基)-9(10H)-蒽酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5
InChI: InChI=1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2



数据库引用编号

11 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CA3, KCNE3, KCNQ1, PRKAA2
Nucleus 3 FOS, PLCZ1, PRKAA2
cytosol 7 CA1, CA3, FOS, KCNA6, PLCZ1, PRKAA2, PRKCQ
dendrite 2 KCNE3, PRKAA2
nucleoplasm 3 FOS, PLCZ1, PRKAA2
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 9 KCNA6, KCNE1, KCNE3, KCNMA1, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5
Multi-pass membrane protein 8 KCNA3, KCNA6, KCNMA1, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5
Synapse 2 KCNQ2, KCNQ3
cell surface 2 KCNE1, KCNQ3
glutamatergic synapse 2 GHRL, KCNA3
Golgi apparatus 2 NPY, PRKAA2
neuronal cell body 2 KCNQ1, PRKAA2
postsynapse 1 GHRL
presynaptic membrane 1 KCNA3
Lysosome 2 KCNE1, KCNQ1
plasma membrane 12 KCNA3, KCNA6, KCNE1, KCNE3, KCNMA1, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5, KNG1, PRKCQ
Membrane 10 KCNA3, KCNA6, KCNE3, KCNE4, KCNMA1, KCNQ1, KCNQ2, KCNQ3, KCNQ5, PRKAA2
apical plasma membrane 4 KCNE1, KCNE4, KCNMA1, KCNQ1
axon 3 GHRL, KCNA3, PRKAA2
basolateral plasma membrane 1 KCNQ1
caveola 1 KCNMA1
extracellular exosome 2 CA1, KNG1
endoplasmic reticulum 2 FOS, KCNQ1
extracellular space 3 GHRL, KNG1, NPY
perinuclear region of cytoplasm 2 KCNA3, PLCZ1
Schaffer collateral - CA1 synapse 1 GHRL
mitochondrion 1 KCNQ3
intracellular membrane-bounded organelle 1 KCNA6
pronucleus 1 PLCZ1
Single-pass type I membrane protein 2 KCNE1, KCNE3
Secreted 2 GHRL, NPY
extracellular region 3 GHRL, KNG1, NPY
Single-pass membrane protein 2 KCNE3, KCNE4
neuronal cell body membrane 1 KCNE3
centriolar satellite 1 PRKCQ
neuronal dense core vesicle lumen 1 GHRL
perikaryon 1 KCNE3
Z disc 1 KCNE1
nucleolus 1 PLCZ1
Early endosome 1 KCNQ1
vesicle 1 KCNE3
postsynaptic membrane 2 KCNA3, KCNMA1
Apical cell membrane 2 KCNE1, KCNQ1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 4 KCNA3, KCNE1, KCNE3, KCNQ1
GABA-ergic synapse 1 NPY
collagen-containing extracellular matrix 1 KNG1
lateral plasma membrane 1 KCNQ1
nuclear speck 1 PRKAA2
Late endosome 1 KCNQ1
neuron projection 1 KCNQ1
ciliary base 1 KCNQ1
chromatin 1 FOS
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
Basolateral cell membrane 1 KCNQ1
[Isoform 2]: Cell membrane 1 KCNA3
monoatomic ion channel complex 1 KCNQ1
Cytoplasmic vesicle membrane 1 KCNQ1
axon initial segment 2 KCNQ2, KCNQ3
Cell projection, dendrite 1 KCNE3
cytoplasmic stress granule 1 PRKAA2
basal plasma membrane 1 KCNQ4
potassium channel complex 1 KCNA6
voltage-gated potassium channel complex 11 KCNA3, KCNA6, KCNE1, KCNE3, KCNE4, KCNMA1, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5
secretory granule lumen 1 GHRL
endoplasmic reticulum lumen 2 GHRL, KNG1
nuclear matrix 1 FOS
platelet alpha granule lumen 1 KNG1
axon terminus 1 KCNA6
transport vesicle 1 KCNQ1
node of Ranvier 2 KCNQ2, KCNQ3
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 NPY
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
Basal cell membrane 1 KCNQ4
protein-DNA complex 1 FOS
[Isoform 1]: Cell membrane 1 KCNA3
nucleotide-activated protein kinase complex 1 PRKAA2
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
sperm head 1 PLCZ1
clathrin coat 1 KCNQ5
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
lumenal side of membrane 1 KCNQ1
basolateral part of cell 2 KCNE3, KCNQ1


文献列表

  • Min Xu, Peng Sun, Ying Zhang, Ci-Hang Yang, Xin Wei, Xiao-Xia Ma, Chong-Ren Yang, Kun-Ming Ni, Ying-Jun Zhang, Xiao-Ming Li. DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy. Scientific reports. 2017 05; 7(1):1701. doi: 10.1038/s41598-017-01734-z. [PMID: 28490750]
  • Bo-Chuan Teng, Yan Song, Fan Zhang, Tian-Yang Ma, Jin-Long Qi, Hai-Lin Zhang, Gang Li, KeWei Wang. Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents. Acta pharmacologica Sinica. 2016 Aug; 37(8):1054-62. doi: 10.1038/aps.2016.33. [PMID: 27264315]
  • A D Wickenden, J L Krajewski, B London, P K Wagoner, W A Wilson, S Clark, R Roeloffs, G McNaughton-Smith, G C Rigdon. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Molecular pharmacology. 2008 Mar; 73(3):977-86. doi: 10.1124/mol.107.043216. [PMID: 18089837]
  • Thomas Jespersen, Morten Grunnet, Hanne B Rasmussen, Nils B Jørgensen, Henrik S Jensen, Kamilla Angelo, Søren-Peter Olesen, Dan A Klaerke. The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?. Biochemical and biophysical research communications. 2006 Mar; 341(4):979-88. doi: 10.1016/j.bbrc.2006.01.046. [PMID: 16476578]
  • R Søgaard, T Ljungstrøm, K A Pedersen, S P Olesen, B S Jensen. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. American journal of physiology. Cell physiology. 2001 Apr; 280(4):C859-66. doi: 10.1152/ajpcell.2001.280.4.c859. [PMID: 11245603]
  • R A Earl, R Zaczek, C A Teleha, B N Fisher, C M Maciag, M E Marynowski, A R Logue, S W Tam, W J Tinker, S M Huang, R J Chorvat. 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. Journal of medicinal chemistry. 1998 Nov; 41(23):4615-22. doi: 10.1021/jm9803424. [PMID: 9804701]