Naspm (BioDeep_00000009503)
Secondary id: BioDeep_00001883503
Toxin
代谢物信息卡片
化学式: C22H34N4O (370.2732)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 97.44%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN
InChI: InChI=1S/C22H34N4O/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27)
描述信息
Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34097
- KEGG: C13674
- PubChem: 129695
- Metlin: METLIN69627
- ChEMBL: CHEMBL25101
- CAS: 122306-11-0
- PMhub: MS000023295
- PubChem: 586266
- PDB-CCD: GYY
- NIKKAJI: J446.343I
- medchemexpress: HY-12506
- KNApSAcK: 34097
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Dong-Dong Zhang, Yu-Qiu Zhang, Xue-Han Zhang. Prefrontal AMPA receptors are involved in the effect of methylphenidate on response inhibition in rats.
Acta pharmacologica Sinica.
2018 Apr; 39(4):607-615. doi:
10.1038/aps.2017.138
. [PMID: 29265108] - Nadia Jaafari, Jeremy M Henley, Jonathan G Hanley. PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Aug; 32(34):11618-30. doi:
10.1523/jneurosci.5068-11.2012
. [PMID: 22915106] - Dinesh C Joshi, Mahendra Singh, Karthik Krishnamurthy, Preeti G Joshi, Nanda B Joshi. AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor.
Neurochemistry international.
2011 Nov; 59(6):913-21. doi:
10.1016/j.neuint.2011.06.023
. [PMID: 21777635] - S Kott, C Sager, D Tapken, M Werner, M Hollmann. Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins gamma2, gamma3, gamma4, and gamma8.
Neuroscience.
2009 Jan; 158(1):78-88. doi:
10.1016/j.neuroscience.2007.12.047
. [PMID: 18304748] - Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux, Jacques Fantini, Marc Maresca, Nadira Taïeb, Jean-Marie Pagès, Jean Michel Brunel. Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?.
PloS one.
2008 Jul; 3(7):e2765. doi:
10.1371/journal.pone.0002765
. [PMID: 18648511]