Lynestrenol (BioDeep_00000009416)

   

Volatile Flavor Compounds


代谢物信息卡片


19-norpregn-4-en-20-yn-17alpha-ol

化学式: C20H28O (284.2140038)
中文名称: 利奈孕醇
谱图信息: 最多检出来源 Viridiplantae(plant) 92.31%

分子结构信息

SMILES: C#CC1(O)CCC2C3CCC4=CCCCC4C3CCC21C
InChI: InChI=1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,6,15-18,21H,4-5,7-13H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1

描述信息

G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DC - Estren derivatives
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
Same as: D01580

同义名列表

4 个代谢物同义名

19-norpregn-4-en-20-yn-17alpha-ol; Lynestrenol; ST 20:3;O; Lynestrenol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Kimberly K Scarsi, Yoninah S Cramer, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert W Coombs, Kristine Coughlin, Laura E Moran, Carmen D Zorrilla, Victor Akelo, Mariam Aziz, Ruth K Friedman, David Gingrich, Shobha Swaminathan, Catherine Godfrey, Susan E Cohn. Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study. The lancet. HIV. 2019 09; 6(9):e601-e612. doi: 10.1016/s2352-3018(19)30155-9. [PMID: 31498109]
  • Jianjia Fan, Yoko Shimizu, Jeniffer Chan, Anna Wilkinson, Ayaka Ito, Peter Tontonoz, Edie Dullaghan, Liisa A M Galea, Tom Pfeifer, Cheryl L Wellington. Hormonal modulators of glial ABCA1 and apoE levels. Journal of lipid research. 2013 Nov; 54(11):3139-50. doi: 10.1194/jlr.m042473. [PMID: 23999864]
  • A Massart, H Portier, F Rosado, H Toumi, E Filaire. Lipid peroxidation in judoists using oral contraceptives. International journal of sports medicine. 2012 Oct; 33(10):781-8. doi: 10.1055/s-0032-1306282. [PMID: 22562736]
  • Giovanni Fazio, Filippo Ferrara, Giuseppe Barbaro, Gullotti Alessandro, Giovanni Ferrro, Giuseppina Novo, Salvatore Novo. Protrhombotic effects of contraceptives. Current pharmaceutical design. 2010; 16(31):3490-6. doi: 10.2174/138161210793563374. [PMID: 20858187]
  • M Djangidze, M Djugeli, N Museridze, L Zakaraia. [State of the hypothalamo-hypophyseal-ovarian system in young nullipara women with ectopia of the cervix of uterus during taking the hormonal contraceptives]. Georgian medical news. 2007 Oct; ?(151):26-31. doi: NULL. [PMID: 18071207]
  • Dominik Rachoń, Krystyna Suchecka-Rachoń, Łukasz Hak, Jolanta Myśliwska. Effects of intranasal 17beta-estradiol administration on serum bioactive interleukin-6 and C-reactive protein levels in healthy postmenopausal women. Menopause (New York, N.Y.). 2006 Sep; 13(5):840-5. doi: 10.1097/01.gme.0000227400.60816.52. [PMID: 16894332]
  • Bronisława Pietrzak, Miroslaw Wielgos, Pawel Kaminski, Katarzyna Bobrowska. Two routes of hormonal replacement therapy in symptomatic menopausal women after kidney transplantation. Neuro endocrinology letters. 2006 Jun; 27(3):387-91. doi: NULL. [PMID: 16816826]
  • Irving Sivin, Daniel R Mishell, Francisco Alvarez, Vivian Brache, Kaisa Elomaa, Pekka Lähteenmäki, Rebeca Massai, Patricia Miranda, Horacio Croxatto, Catherine Dean, Margaret Small, Harold Nash, Theodore M Jackanicz. Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial. Contraception. 2005 Feb; 71(2):122-9. doi: 10.1016/j.contraception.2004.08.010. [PMID: 15707562]
  • J Endrikat, E Mih, B Düsterberg, K Land, C Gerlinger, W Schmidt, D Felsenberg. A 3-year double-blind, randomized, controlled study on the influence of two oral contraceptives containing either 20 microg or 30 microg ethinylestradiol in combination with levonorgestrel on bone mineral density. Contraception. 2004 Mar; 69(3):179-87. doi: 10.1016/j.contraception.2003.10.002. [PMID: 14969664]
  • Sanna Palovaara, Gunnel Tybring, Kari Laine. The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects. British journal of clinical pharmacology. 2003 Aug; 56(2):232-7. doi: 10.1046/j.1365-2125.2003.01868.x. [PMID: 12895199]
  • Sidsel Graff-Iversen, Serena Tonstad. Use of progestogen-only contraceptives/medications and lipid parameters in women age 40 to 42 years: results of a population-based cross-sectional Norwegian Survey. Contraception. 2002 Jul; 66(1):7-13. doi: 10.1016/s0010-7824(02)00311-6. [PMID: 12169374]
  • A M van Heusden, H J T Coelingh Bennink, B C J M Fauser. FSH and ovarian response: spontaneous recovery of pituitary-ovarian activity during the pill-free period vs. exogenous recombinant FSH during high-dose combined oral contraceptives. Clinical endocrinology. 2002 Apr; 56(4):509-17. doi: 10.1046/j.1365-2265.2002.01518.x. [PMID: 11966744]
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  • K Huovinen, M J Tikkanen, S Autio, T Härkönen, L Lommi, S Varonen, M L Wilska. Serum lipids and lipoproteins during therapeutic amenorrhea induced by lynestrenol and depot-medroxyprogesterone acetate. Acta obstetricia et gynecologica Scandinavica. 1991; 70(4-5):349-54. doi: 10.3109/00016349109007886. [PMID: 1836088]
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  • M Bandyopadhyay, A K Ghosh. Monoamineoxidase activity in certain brain regions associated with xanthurenic acid excretion in rats on oral contraceptive steroids. The Indian journal of medical research. 1989 Jun; 90(?):191-6. doi: . [PMID: 2767743]
  • J Holst, T Bäckström, S Hammarbäck, B von Schoultz. Progestogen addition during oestrogen replacement therapy--effects on vasomotor symptoms and mood. Maturitas. 1989 Mar; 11(1):13-20. doi: 10.1016/0378-5122(89)90116-3. [PMID: 2725334]
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  • M Ciavatti, D Blache, S Renaud. Hormonal contraceptive increases plasma lipid peroxides in female rats. Relationship to platelet aggregation and lipid biosynthesis. Arteriosclerosis (Dallas, Tex.). 1989 Jan; 9(1):84-9. doi: 10.1161/01.atv.9.1.84. [PMID: 2536271]
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  • A T Teichmann, P Cremer, H Wieland, W Kuhn, D Seidel. Lipid metabolic changes during hormonal treatment of endometriosis. Maturitas. 1988 May; 10(1):27-33. doi: 10.1016/0378-5122(88)90128-4. [PMID: 2969446]
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  • J A Gevers Leuven, C Kluft, R M Bertina, L W Hessel. Effects of two low-dose oral contraceptives on circulating components of the coagulation and fibrinolytic systems. The Journal of laboratory and clinical medicine. 1987 Jun; 109(6):631-6. doi: . [PMID: 3108429]
  • E Kubista, G Müller, J Spona. [Treatment of mastopathies with cyclic mastodynia. Clinical results and hormonal profiles]. Revue francaise de gynecologie et d'obstetrique. 1987 Apr; 82(4):221-7. doi: NULL. [PMID: 3589362]
  • R Siegberg, C G Nilsson, U H Stenman, O Widholm. The effect of oral contraceptives on hormone profiles of oligomenorrheic adolescent cycles. Contraception. 1987 Jan; 35(1):29-40. doi: 10.1016/0010-7824(87)90048-5. [PMID: 3568657]
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  • A Ruokonen, K Käär. Effects of desogestrel, levonorgestrel and lynestrenol on serum sex hormone binding globulin, cortisol binding globulin, ceruloplasmin and HDL-cholesterol. European journal of obstetrics, gynecology, and reproductive biology. 1985 Jul; 20(1):13-8. doi: 10.1016/0028-2243(85)90078-4. [PMID: 3161762]
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  • V Wynn. [Influence of progestins on adverse effects of oral contraceptives]. Contraception, fertilite, sexualite. 1985 Jan; 13(1 Suppl):425-30. doi: . [PMID: 12280210]
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  • J A Leuven, L Havekes, H A van der Kooij-Pontier, R J Starmans, H Jansen, M L Bouwhuis-Hoogerwerf, H A de Pagter, L W Hessel. Effect of low-dose oral contraceptives on lipoproteins and lipolytic enzymes: differences between two commonly used preparations. Metabolism: clinical and experimental. 1984 Nov; 33(11):1039-42. doi: 10.1016/0026-0495(84)90234-8. [PMID: 6493047]
  • C Pelissier-langbort. [Contraception using normal dose progestins]. Contraception, fertilite, sexualite. 1984 Oct; 12(10):1099-109. doi: . [PMID: 12266559]
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  • G Cullberg, J Adelgaard, J N Andersen, E S Andersen, H Berg, E W Bergink, G Buhl, J H Pedersen, L Poulsen. Restovar--new low-dose, combined, oral contraceptive. Effects on serum proteins, free testosterone and clinical efficacy. Contraceptive delivery systems. 1984 Apr; 5(2):97-104. doi: . [PMID: 12266201]
  • A Saure, J E Heikkinen, P Ylostalo. The effect of two low-dose oral contraceptives and non-hormonal contraception on serum lipids and high-density lipoprotein cholesterol. Contraceptive delivery systems. 1984 Apr; 5(2):83-90. doi: NULL. [PMID: 12266199]
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  • A T Teichmann, H Wieland, P Cremer, W Kuhn, D Seidel. [Lipoprotein changes during hormonal treatment of endometriosis with lynestrenol and danazol]. Geburtshilfe und Frauenheilkunde. 1984 Mar; 44(3):171-6. doi: 10.1055/s-2008-1036873. [PMID: 6562983]
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  • J Holst, S Cajander, K Carlström, M G Damber, B von Schoultz. Percutaneous oestrogen therapy opposed by lynestrenol or natural progesterone--effects on circulating oestrogens, FSH, sex hormone binding globulin and pregnancy zone protein. Maturitas. 1983 Jun; 5(1):1-8. doi: 10.1016/0378-5122(83)90015-4. [PMID: 6410156]
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