Crinine (BioDeep_00000009138)

代谢物信息卡片

1,2-Didehydrocrinan-3-ol

化学式: C16H17NO3 (271.1208372)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 0.54%

分子结构信息

SMILES: C1CN2CC3=CC4=C(C=C3C15C2CC(C=C5)O)OCO4
InChI: InChI=1S/C16H17NO3/c18-11-1-2-16-3-4-17(15(16)6-11)8-10-5-13-14(7-12(10)16)20-9-19-13/h1-2,5,7,11,15,18H,3-4,6,8-9H2/t11-,15+,16+/m0/s1

描述信息

同义名列表

2 个代谢物同义名

Crinine; 1,2-Didehydrocrinan-3-ol

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:31437
KEGG: C12162
PubChem: 398937
PubChem: 101727
Metlin: METLIN64410
ChEMBL: CHEMBL1221864
MetaCyc: CPD-19428
KNApSAcK: C00024384
KNApSAcK: C00028251
PMhub: MS000022885
MetaboLights: MTBLC31437
PubChem: 14309
NIKKAJI: J964.437G

分类词条

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

Amaryllidacea alkaloids biosynthesis: 4'-O-methylnorbelladine + O₂ + a reduced [NADPH-hemoprotein reductase] ⟶ (4aS,10bR)-noroxomaritidine + H₂O + an oxidized [NADPH-hemoprotein reductase]

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

Amaryllidacea alkaloids biosynthesis: SAM + norbelladine ⟶ 4'-O-methylnorbelladine + H⁺ + SAH

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

414783 - Ammocharis tinneana: 10.1016/S0031-9422(99)00118-1
527043 - Brunsvigia gregaria:
527043 - Brunsvigia gregaria: 10.1055/S-2006-959383
379211 - Brunsvigia orientalis: 10.1016/S0031-9422(96)00506-7
527044 - Brunsvigia radulosa: 10.1016/S0031-9422(99)00575-0
1234383 - Calostemma purpureum: 10.1002/CBER.19570900920
164437 - Crinum americanum: 10.1016/S0031-9422(00)81704-5
205937 - Crinum asiaticum:
223245 - Crinum asiaticum var. sinicum:
209086 - Crinum bulbispermum:
28480 - Crinum jagus: 10.1007/BF00579844
209098 - Crinum kirkii:
209099 - Crinum latifolium: 10.1248/CPB.32.3015
414784 - Crinum lugardiae:
180140 - Crinum macowanii:
180140 - Crinum macowanii: 10.1016/S0305-1978(00)00096-X
82223 - Crinum moorei:
414790 - Crinum stuhlmannii: 10.1055/S-2006-957554
527290 - Crossyne flava: 10.1016/0031-9422(95)00191-9
82232 - Galanthus elwesii: 10.1016/J.PHYTOCHEM.2003.12.013
59040 - Hymenocallis littoralis: 10.1016/0031-9422(95)00372-E
59042 - Nerine bowdenii: 10.1002/CBER.19560890910
693595 - Pancratium foetidum: 10.1055/S-2002-26754
644807 - Pancratium maritimum:
644807 - Pancratium maritimum: 10.1055/S-2006-957549

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Guanqun Zhan, Biao Gao, Junfei Zhou, Tingting Liu, Guijuan Zheng, Zhong Jin, Guangmin Yao. Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities. Phytochemistry. 2023 Mar; 207(?):113564. doi: 10.1016/j.phytochem.2022.113564. [PMID: 36535411]
Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2019 10; 29(20):126642. doi: 10.1016/j.bmcl.2019.126642. [PMID: 31515186]
Sarah S Takla, Eman Shawky, Hala M Hammoda, Fikria A Darwish. Green techniques in comparison to conventional ones in the extraction of Amaryllidaceae alkaloids: Best solvents selection and parameters optimization. Journal of chromatography. A. 2018 Sep; 1567(?):99-110. doi: 10.1016/j.chroma.2018.07.009. [PMID: 30033169]
Sean Henry, Ria Kidner, Mary R Reisenauer, Igor V Magedov, Robert Kiss, Véronique Mathieu, Florence Lefranc, Ramesh Dasari, Antonio Evidente, Xiaojie Yu, Xiuye Ma, Alexander Pertsemlidis, Regina Cencic, Jerry Pelletier, David A Cavazos, Andrew J Brenner, Alexander V Aksenov, Snezna Rogelj, Alexander Kornienko, Liliya V Frolova. 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells. European journal of medicinal chemistry. 2016 Sep; 120(?):313-28. doi: 10.1016/j.ejmech.2016.05.004. [PMID: 27218860]
Jean Paulo de Andrade, Ying Guo, Mercè Font-Bardia, Teresa Calvet, Jullie Dutilh, Francesc Viladomat, Carles Codina, Jerald J Nair, Jose A Silveira Zuanazzi, Jaume Bastida. Crinine-type alkaloids from Hippeastrum aulicum and H. calyptratum. Phytochemistry. 2014 Jul; 103(?):188-195. doi: 10.1016/j.phytochem.2014.03.007. [PMID: 24768284]
Giovanni Luchetti, Robert Johnston, Véronique Mathieu, Florence Lefranc, Kathryn Hayden, Anna Andolfi, Delphine Lamoral-Theys, Mary R Reisenauer, Cody Champion, Stephen C Pelly, Willem A L van Otterlo, Igor V Magedov, Robert Kiss, Antonio Evidente, Snezna Rogelj, Alexander Kornienko. Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells. ChemMedChem. 2012 May; 7(5):815-22. doi: 10.1002/cmdc.201100608. [PMID: 22389235]
You-Yi Zhao, Yong-Qi Liang, Yu Chen, Hao Sun, Ming Wang, Xu Feng. [Study on chemical constituents of the bulbs of Lycoris longituba]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Sep; 34(9):1366-8. doi: ". [PMID: 22260001]