CMC_13393 (BioDeep_00000861171)

Main id: BioDeep_00000001411

 

PANOMIX_OTCML-2023


代谢物信息卡片


1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

化学式: C21H32O2 (316.24021719999996)
中文名称: 孕烯醇酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

同义名列表

51 个代谢物同义名

1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone; 17beta-[1-Ketoethyl]-Delta5-androsten-3beta-ol; Pregn-5-en-20-one, 3-hydroxy-, (3-beta)-; Pregn-5-en-20-one, 3-hydroxy-, (3beta)-; Pregn-5-en-20-one, 3beta-hydroxy- (8CI); Pregnenolone (progesterone precursor); 3beta-Hydroxy-Delta5-pregnen-20-one; (3BETA)-3-HYDROXYPREGN-5-en-20-one; Pregn-5-en-20-one, 3-beta-hydroxy-; Pregn-5-en-20-one, 3beta-hydroxy-; 3-beta-Hydroxypregn-5-en-20-one; Delta5-Pregnene-3beta-ol-20-one; 3beta-hydroxypregn-5-ene-20-one; 3beta-Hydroxy-5-pregnene-20-one; Delta5-Pregnen-3beta-ol-20-one; 3beta-Hydroxy-5-pregnen-20-one; 3beta-hydroxypregn-5-en-20-one; Pregn-5-ene-3beta-ol-20-one; Pregn-5-en-3beta-ol-20-one; 5-Pregnen-3-beta-ol-20-one; Pregnenolona [INN-Spanish]; Pregnenolonum [INN-Latin]; 5-Pregnen-3beta-ol-20-one; Pregnenolone (JAN\INN); delta5-Pregnenolone; Prestwick0_000546; Prestwick3_000546; Prestwick2_000546; Prestwick1_000546; EINECS 205-647-4; Spectrum5_002057; 5-Pregnenolone; BSPBio_000591; Prestwick_859; BPBio1_000651; ZINC03861150; Pregnenolone; SPBio_002512; LMST02030088; 81630_FLUKA; P9129_SIGMA; 116907-59-6; CHEBI:16581; ST5308463; CMC_13393; NSC 1616; 145-13-1; D00143; C01953; PLO; 3β-Hydroxy-5-pregnen-20-one



数据库引用编号

14 个数据库交叉引用编号

分类词条

45 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ádám Horváth, Anita Steib, Andrea Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti-Pintér, Eva Kudová, Rita Skoda-Földes, Zsuzsanna Helyes, Éva Szőke. Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094637. [PMID: 38731855]
  • Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao, Yu Wu. The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice. Journal of neuroinflammation. 2023 Dec; 20(1):293. doi: 10.1186/s12974-023-02976-7. [PMID: 38062440]
  • Maritta Kunert, Chloe Langley, Rosalind Lucier, Kerstin Ploss, Carlos E Rodríguez López, Delia A Serna Guerrero, Eva Rothe, Sarah E O'Connor, Prashant D Sonawane. Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants. Nature plants. 2023 Sep; ?(?):. doi: 10.1038/s41477-023-01515-9. [PMID: 37723202]
  • Yiqin Lin, Yingle Chen, Jingyang Zeng, Shunyuan Li. Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway. Neuroimmunomodulation. 2022; 29(4):486-492. doi: 10.1159/000525690. [PMID: 35995035]
  • Alexander Becker, Claudia Götz, Mathias Montenarh, Stephan E Philipp. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313133. [PMID: 34884938]
  • Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari. Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency. Journal of pharmaceutical and biomedical analysis. 2021 Nov; 206(?):114388. doi: 10.1016/j.jpba.2021.114388. [PMID: 34597839]
  • Britton Trabert, Ashley M Geczik, Doug C Bauer, Diana S M Buist, Jane A Cauley, Roni T Falk, Gretchen L Gierach, Trisha F Hue, James V Lacey, Andrea Z LaCroix, Kara A Michels, Jeffrey A Tice, Xia Xu, Louise A Brinton, Cher M Dallal. Association of Endogenous Pregnenolone, Progesterone, and Related Metabolites with Risk of Endometrial and Ovarian Cancers in Postmenopausal Women: The B∼FIT Cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 11; 30(11):2030-2037. doi: 10.1158/1055-9965.epi-21-0669. [PMID: 34465588]
  • K Rehm, A K Hankele, S E Ulbrich, L Bigler. Simultaneous quantification of progestogens in plasma and serum by UHPLC-HRMS employing multiplexed targeted single ion monitoring. Talanta. 2021 Sep; 232(?):122358. doi: 10.1016/j.talanta.2021.122358. [PMID: 34074386]
  • Johanna Ruhnau, Stephanie Hübner, Donna Sunny, Till Ittermann, Michaela F Hartmann, Jan De Lafollie, Stefan A Wudy, Matthias Heckmann. Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry. The Journal of clinical endocrinology and metabolism. 2021 08; 106(9):e3725-e3738. doi: 10.1210/clinem/dgab194. [PMID: 33822093]
  • Melanie H Jacobson, Cheryl R Stein, Mengling Liu, Marra G Ackerman, Jennifer K Blakemore, Sara E Long, Graziano Pinna, Raquel Romay-Tallon, Kurunthachalam Kannan, Hongkai Zhu, Leonardo Trasande. Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption. The Journal of clinical endocrinology and metabolism. 2021 06; 106(7):1887-1899. doi: 10.1210/clinem/dgab199. [PMID: 33792735]
  • Li Yu, Miao Liu, Zhenxin Wang, Te Liu, Suying Liu, Beili Wang, Baishen Pan, Xi Dong, Wei Guo. Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome. Reproductive biology and endocrinology : RB&E. 2021 May; 19(1):74. doi: 10.1186/s12958-021-00749-6. [PMID: 34001150]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari. Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study. The journal of headache and pain. 2021 Mar; 22(1):13. doi: 10.1186/s10194-021-01231-9. [PMID: 33757421]
  • Yilin Liu, Ilia G Denisov, Stephen G Sligar, James R Kincaid. Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. Journal of the American Chemical Society. 2021 03; 143(10):3729-3733. doi: 10.1021/jacs.1c00581. [PMID: 33656879]
  • Melina A Pagotto, María L Roldán, Sara M Molinas, Trinidad Raices, Gerardo B Pisani, Omar P Pignataro, Liliana A Monasterolo. Impairment of renal steroidogenesis at the onset of diabetes. Molecular and cellular endocrinology. 2021 03; 524(?):111170. doi: 10.1016/j.mce.2021.111170. [PMID: 33482284]
  • Graziano Pinna. Sex and COVID-19: A Protective Role for Reproductive Steroids. Trends in endocrinology and metabolism: TEM. 2021 01; 32(1):3-6. doi: 10.1016/j.tem.2020.11.004. [PMID: 33229187]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121(?):104827. doi: 10.1016/j.psyneuen.2020.104827. [PMID: 32828068]
  • Y V Faletrov, K A Gilep, A S Falchevskaya, M S Horetski, J V Panada, E V Andrievskaya, E V Rudaya, N S Frolova, A Brzostek, R Plocinska, V M Shkumatov. [In silico modeling of izoniazid-steroid conjugates interactions with cytochromes P450 of mycobacteria and their bioconversion in vitro by the cells]. Biomeditsinskaia khimiia. 2020 Sep; 66(5):378-385. doi: 10.18097/pbmc20206605378. [PMID: 33140731]
  • Mathijs Drummen, Lea Tischmann, Blandine Gatta-Cherifi, Daniela Cota, Isabelle Matias, Anne Raben, Tanja Adam, Margriet Westerterp-Plantenga. Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study. The Journal of clinical endocrinology and metabolism. 2020 07; 105(7):. doi: 10.1210/clinem/dgaa193. [PMID: 32333763]
  • Jeffrey M McManus, Nima Sharifi. Structure-dependent retention of steroid hormones by common laboratory materials. The Journal of steroid biochemistry and molecular biology. 2020 04; 198(?):105572. doi: 10.1016/j.jsbmb.2019.105572. [PMID: 31883923]
  • Wenqi Jin, Rui Ma, Lu Zhai, Xiaohao Xu, Tingting Lou, Qingxia Huang, Jing Wang, Daqing Zhao, Xiangyan Li, Liwei Sun. Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells. Life sciences. 2020 Mar; 245(?):117337. doi: 10.1016/j.lfs.2020.117337. [PMID: 31972205]
  • Natasja G J Costermans, Nicoline M Soede, Marco Blokland, Frederike van Tricht, Jaap Keijer, Bas Kemp, Katja J Teerds. Steroid profile of porcine follicular fluid and blood serum: Relation with follicular development. Physiological reports. 2019 12; 7(24):e14320. doi: 10.14814/phy2.14320. [PMID: 31883224]
  • Jingjing Jiang, Xue Liu, Xiaotian Liu, Zhongyan Tian, Haiqing Zhang, Xinling Qian, Zhicheng Luo, Dandan Wei, Shuna Jin, Chongjian Wang, Zhenxing Mao. The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort. European journal of endocrinology. 2019 Dec; 181(6):603-614. doi: 10.1530/eje-19-0352. [PMID: 31581126]
  • Jude Prah, Ali Winters, Kiran Chaudhari, Jessica Hersh, Ran Liu, Shao-Hua Yang. Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress. Brain research. 2019 11; 1723(?):146378. doi: 10.1016/j.brainres.2019.146378. [PMID: 31425677]
  • Bingyan Cao, Chunxiu Gong, Di Wu, Xuejun Liang, Wenjing Li, Min Liu, Chang Su, Miao Qin, Xi Meng, Liya Wei. A cross-sectional survey of adrenal steroid hormones among overweight/obese boys according to puberty stage. BMC pediatrics. 2019 11; 19(1):414. doi: 10.1186/s12887-019-1755-5. [PMID: 31690265]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Hiroshi Miura, Tatsuya Yamazaki, Motohiro Kikuchi, Minoru Sakaguchi. Plasma steroid hormone concentrations and their relationships in Suffolk ewes during gestation and parturition. Animal science journal = Nihon chikusan Gakkaiho. 2019 Nov; 90(11):1426-1431. doi: 10.1111/asj.13286. [PMID: 31486265]
  • Ruben Vanholme, Lisa Sundin, Keletso Carol Seetso, Hoon Kim, Xinyu Liu, Jin Li, Barbara De Meester, Lennart Hoengenaert, Geert Goeminne, Kris Morreel, Jurgen Haustraete, Huei-Hsuan Tsai, Wolfgang Schmidt, Bartel Vanholme, John Ralph, Wout Boerjan. COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. Nature plants. 2019 10; 5(10):1066-1075. doi: 10.1038/s41477-019-0510-0. [PMID: 31501530]
  • Monica Aleman, Patrick M McCue, Munashe Chigerwe, John E Madigan. Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age. Journal of veterinary internal medicine. 2019 Sep; 33(5):2286-2293. doi: 10.1111/jvim.15618. [PMID: 31489708]
  • L I Velikanova, Z R Shafigullina, N V Vorokhobina, E V Malevanaya. Gas Chromatography-Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing's Syndrome. Bulletin of experimental biology and medicine. 2019 Sep; 167(5):676-680. doi: 10.1007/s10517-019-04597-8. [PMID: 31630306]
  • Marika Matousova, Radko Soucek, Eva Tloustova, Barbora Slavikova, Hana Chodounska, Helena Mertlikova-Kaiserova, Eva Kudova. Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability. Steroids. 2019 07; 147(?):4-9. doi: 10.1016/j.steroids.2018.09.012. [PMID: 30296546]
  • Philippe Liere, Charlotte A Cornil, Marie Pierre de Bournonville, Antoine Pianos, Matthieu Keller, Michael Schumacher, Jacques Balthazart. Steroid profiles in quail brain and serum: Sex and regional differences and effects of castration with steroid replacement. Journal of neuroendocrinology. 2019 02; 31(2):e12681. doi: 10.1111/jne.12681. [PMID: 30585662]
  • K V Tugaeva, N N Sluchanko. Steroidogenic Acute Regulatory Protein: Structure, Functioning, and Regulation. Biochemistry. Biokhimiia. 2019 Jan; 84(Suppl 1):S233-S253. doi: 10.1134/s0006297919140141. [PMID: 31213205]
  • Steven J Kleene, Brian J Siroky, Julio A Landero-Figueroa, Bradley P Dixon, Nolan W Pachciarz, Lu Lu, Nancy K Kleene. The TRPP2-dependent channel of renal primary cilia also requires TRPM3. PloS one. 2019; 14(3):e0214053. doi: 10.1371/journal.pone.0214053. [PMID: 30883612]
  • Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis. Theriogenology. 2019 Jan; 123(?):139-144. doi: 10.1016/j.theriogenology.2018.06.024. [PMID: 30308389]
  • Jeffrey M McManus, Kelsey Bohn, Mohammad Alyamani, Yoon-Mi Chung, Eric A Klein, Nima Sharifi. Rapid and structure-specific cellular uptake of selected steroids. PloS one. 2019; 14(10):e0224081. doi: 10.1371/journal.pone.0224081. [PMID: 31622417]
  • Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan, Yanmin Huang. Synthesis and antiproliferative activity of 17-[1',2',3']-selenadiazolylpregnenolone compounds. Steroids. 2018 12; 140(?):151-158. doi: 10.1016/j.steroids.2018.10.004. [PMID: 30296550]
  • Ying Sze, Andrew C Gill, Paula J Brunton. Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress. Journal of neuroendocrinology. 2018 11; 30(11):e12644. doi: 10.1111/jne.12644. [PMID: 30194779]
  • Dongdong Liang, Zhaofei Fan, Yuxia Zou, Xungang Tan, Zhihao Wu, Shuang Jiao, Jun Li, Peijun Zhang, Feng You. Characteristics of Cyp11a during Gonad Differentiation of the Olive Flounder Paralichthys olivaceus. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092641. [PMID: 30200601]
  • Nadia Berkane, Philippe Liere, Guillaume Lefevre, Nadia Alfaidy, Roland Abi Nahed, Jessica Vincent, Jean-Paul Oudinet, Antoine Pianos, Annie Cambourg, Patrick Rozenberg, Pierre Galichon, Alexandra Rousseau, Tabassome Simon, Michael Schumacher, Nathalie Chabbert-Buffet, Alexandre Hertig. Abnormal steroidogenesis and aromatase activity in preeclampsia. Placenta. 2018 09; 69(?):40-49. doi: 10.1016/j.placenta.2018.07.004. [PMID: 30213483]
  • Abdelmoneim Khashana, Hoda Ahmed, Amal Ahmed, Amina Abdelwahab, Timo Saarela, Mika Rämet, Mikko Hallman. Cortisol precursors in neonates with vasopressor-resistant hypotension in relationship to demographic characteristics. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2018 Sep; 31(18):2473-2477. doi: 10.1080/14767058.2017.1344966. [PMID: 28629239]
  • Martina I Boxler, Gabriel L Streun, Matthias E Liechti, Yasmin Schmid, Thomas Kraemer, Andrea E Steuer. Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes. Journal of proteome research. 2018 08; 17(8):2900-2907. doi: 10.1021/acs.jproteome.8b00438. [PMID: 29947220]
  • Shamaila Fraz, Abigail H Lee, Joanna Y Wilson. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 2018 May; 198(?):1-9. doi: 10.1016/j.aquatox.2018.02.006. [PMID: 29494825]
  • HuaLin Cai, Xiang Zhou, George G Dougherty, Ravinder D Reddy, Gretchen L Haas, Debra M Montrose, Matcheri Keshavan, Jeffrey K Yao. Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology. 2018 04; 90(?):43-51. doi: 10.1016/j.psyneuen.2018.02.004. [PMID: 29433072]
  • S Caceres, B Monsalve, L Peña, P J de Andres, A Alonso-Diez, M J Illera, W A Woodward, J M Reuben, G Silvan, J C Illera. In vitro and in vivo effect of flutamide on steroid hormone secretion in canine and human inflammatory breast cancer cell lines. Veterinary and comparative oncology. 2018 Mar; 16(1):148-158. doi: 10.1111/vco.12324. [PMID: 28589573]
  • K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. Andrologia. 2018 Feb; 50(1):. doi: 10.1111/and.12803. [PMID: 28295471]
  • Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey, Adina F Turcu. Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro. The Journal of clinical endocrinology and metabolism. 2018 01; 103(1):320-327. doi: 10.1210/jc.2017-01525. [PMID: 29126147]
  • Brittany L Mason, Erin Van Enkevort, Francesca Filbey, Christine E Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E Sherwood Brown. Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. Journal of clinical psychopharmacology. 2017 Dec; 37(6):684-688. doi: 10.1097/jcp.0000000000000793. [PMID: 29045302]
  • Erin L Legacki, Barry A Ball, C Jo Corbin, Shavahn C Loux, Kirsten E Scoggin, Scott D Stanley, Alan J Conley. Equine fetal adrenal, gonadal and placental steroidogenesis. Reproduction (Cambridge, England). 2017 10; 154(4):445-454. doi: 10.1530/rep-17-0239. [PMID: 28878092]
  • Yu-Chi Huang, Chi-Fa Hung, Pao-Yen Lin, Yu Lee, Chih-Ching Wu, Su-Ting Hsu, Chien-Chih Chen, Mian-Yoon Chong, Chieh-Hsin Lin, Liang-Jen Wang. Gender differences in susceptibility to schizophrenia: Potential implication of neurosteroids. Psychoneuroendocrinology. 2017 Oct; 84(?):87-93. doi: 10.1016/j.psyneuen.2017.06.017. [PMID: 28686904]
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