Pentetrazol (BioDeep_00000858476)
Main id: BioDeep_00000002870
代谢物信息卡片
Pentylenetetrazole
化学式: C6H10N4 (138.090542)
中文名称: 戊四唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC2=NN=NN2CC1
InChI: InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
描述信息
R - Respiratory system > R07 - Other respiratory system products > R07A - Other respiratory system products > R07AB - Respiratory stimulants
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
Same as: D07409
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34910
- KEGG: C13692
- KEGGdrug: D07409
- PubChem: 5917
- DrugBank: DB13415
- ChEMBL: CHEMBL116943
- MeSH: Pentylenetetrazole
- CAS: 20192-24-9
- CAS: 54-95-5
- PubChem: 586281
- NIKKAJI: J22.644K
- RefMet: Pentylenetetrazole
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Baudry N Nsuala, Gill Enslin, Weiyang Chen, Clinton Veale, Alvaro Viljoen. Chemical profiling, anticonvulsant and anxiolytic effects of the smoke constituents isolated from Leonotis leonurus (L.) R.Br.
Journal of ethnopharmacology.
2024 Sep; 331(?):118271. doi:
10.1016/j.jep.2024.118271. [PMID: 38688356] - E Tahmasebi, H Monsef-Esfahani, M Vazirian, P Sharafi-Badr, M Sharifzadeh, S N Sadati Lamardi. Anticonvulsant effects of Paeonia daurica subsp. macrophylla root extracts in pentylenetetrazol-induced seizure models in mice.
Neurologia.
2024 May; 39(4):329-339. doi:
10.1016/j.nrleng.2021.08.004. [PMID: 38616060] - Rodrigo Mendoza-Madrigal, María Eva González-Trujano, Daniela Onofre-Campos, Gabriel Fernando Moreno-Pérez, Jazmin Guadalupe Castellanos-Mijangos, David Martínez-Vargas. Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Apr; 173(?):116352. doi:
10.1016/j.biopha.2024.116352. [PMID: 38417289] - Zhaoxia Li, Zhiliang Gao, Cong Chang, Zhuanglei Gao. Anticonvulsive Effect of Glucosyl Xanthone Mangiferin on Pentylenetetrazol (PTZ)-Induced Seizure-Provoked Mice.
Applied biochemistry and biotechnology.
2024 Apr; 196(4):2161-2175. doi:
10.1007/s12010-023-04651-2. [PMID: 37486538] - Y Xiong, X Liang, X Liang, W Li, Y Qian, W Xie. [Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2024 Mar; 44(3):515-522. doi:
10.12122/j.issn.1673-4254.2024.03.13. [PMID: 38597443] - Rui Ren, Ming-Yan Zhang, Tengyun Shu, Ya-Ting Kong, Li-Hua Su, Hai-Zhou Li. Steroidal Saponins from Water Eggplant (Fruits of Solanum torvum) Exhibit Anti-Epileptic Activity against Pentylenetetrazole-Induced Seizure Model in Zebrafish.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061316. [PMID: 38542951] - Mervt M Almostafa, Maged E Mohamed, Nancy S Younis. Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways.
International immunopharmacology.
2024 Mar; 129(?):111657. doi:
10.1016/j.intimp.2024.111657. [PMID: 38335655] - Dayanne Terra Tenório Nonato, Gislei Frota Aragão, Raquel Magalhães Castelo Branco Craveiro, Maria Gonçalves Pereira, Silvânia Maria Mendes Vasconcelos, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Pedro Marcos Gomes Soares, Marcos Aurélio de Sousa Lima, Ana Maria Sampaio Assreuy, Edna Maria Camelo Chaves. Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116212. doi:
10.1016/j.biopha.2024.116212. [PMID: 38364734] - Nastaran Moussavi, Wietske van der Ent, Drissa Diallo, Rokia Sanogo, Karl E Malterud, Camila V Esguerra, Helle Wangensteen. Inhibition of Seizure-Like Paroxysms and Toxicity Effects of Securidaca longepedunculata Extracts and Constituents in Zebrafish Danio rerio.
ACS chemical neuroscience.
2024 Jan; ?(?):. doi:
10.1021/acschemneuro.3c00642. [PMID: 38270158] - Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar. Effects of the uremic toxin indoxyl sulfate on seizure activity, learning and brain oxidative stress parameters in mice.
Neuroscience letters.
2024 Jan; 820(?):137594. doi:
10.1016/j.neulet.2023.137594. [PMID: 38096971] - Aurelien Fossueh Foutsop, Gilbert Ateufack, Blesdel Maxwell Adassi, Francis Bray Yassi, Tatiana Diebo Kom, Chretien Mbeugangkeng Noungoua, Adolph Petsou, Gwladys Temkou Ngoupaye. The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties.
Neurochemical research.
2023 Oct; 48(10):3228-3248. doi:
10.1007/s11064-023-03982-0. [PMID: 37436614] - Yueqi Yang, Xueyan Wang, Lu Chen, Shiben Wang, Jun Han, Zhengping Wang, Min Wen. A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Marine drugs.
2023 Aug; 21(9):. doi:
10.3390/md21090464. [PMID: 37755077] - Ankita Rajput, Palvi Sharma, Nitish Kumar, Hasandeep Singh, Tanveer Singh, Sharabjit Singh, Preet Mohinder Singh Bedi, Balbir Singh, Saroj Arora, Sarabjit Kaur. Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies.
Metabolic brain disease.
2023 Jul; ?(?):. doi:
10.1007/s11011-023-01252-0. [PMID: 37436587] - Balbine Kamleu Nkwingwa, Eglantine Keugong Wado, Harquin Simplice Foyet, Parfait Bouvourne, Vanessa Tita Jugha, Alain Hart Mann Youbi Mambou, Raymond Bess Bila, Germain Sotoing Taiwe. Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 165(?):115093. doi:
10.1016/j.biopha.2023.115093. [PMID: 37392651] - Mahin Bashiri-Nahnjeh, Abdolrahman Sarihi, Ahmad Ebadi, Dara Dastan, Mojdeh Mohammadi. In silico molecular modeling, neuro-behavioral profile, and toxicity assessment of the essential oil of Ferula gummosa Boiss. as an anti-seizure agent.
Journal of ethnopharmacology.
2023 Jun; 309(?):116347. doi:
10.1016/j.jep.2023.116347. [PMID: 36894108] - Xiaohan Zhang, Xiaofeng Yu, Miao Tuo, Zhenran Zhao, Junhong Wang, Tong Jiang, Mengwen Zhang, Ying Wang, Yanping Sun. Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures.
Epilepsia open.
2023 Jun; ?(?):. doi:
10.1002/epi4.12771. [PMID: 37277986] - Cletus Anes Ukwubile, Emmanuel Oise Ikpefan, Musa Yusuf Dibal, Vivian Amarachukwu Umeano, David Nnamdi Menkiti, Clement Chidi Kaosi, Simon Paul, Ademola Clement Famurewa, Henry Nettey, Timothy Samuel Yerima. Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats.
Journal of ethnopharmacology.
2023 May; 314(?):116632. doi:
10.1016/j.jep.2023.116632. [PMID: 37211190] - Q U Dongxiao, G E Yiqin, Zhuo Limin, Chen Liji, Xue Yonghua, Cheng Jiwei, Tao Jie, L I Guoyi, Zhu Yudan, Xiao Qian. Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Apr; 43(2):286-294. doi:
10.19852/j.cnki.jtcm.20220928.002. [PMID: 36994516] - Samson Sahile Salile, Hamin John Lee, Paul Sewes Frederick Alberts, Teferra Abula, Joseph Valentino Raimondo, Gary Ivan Stafford. In vitro and in vivo anti-seizure activity of hydromethanolic extract and fractions of Pterolobium stellatum.
Journal of ethnopharmacology.
2023 Mar; 304(?):116073. doi:
10.1016/j.jep.2022.116073. [PMID: 36543277] - Hongyuan Lu, Qinbiao Wang, Xiaowen Jiang, Yanyun Zhao, Miao He, Minjie Wei. The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis.
Molecules (Basel, Switzerland).
2023 Mar; 28(6):. doi:
10.3390/molecules28062805. [PMID: 36985783] - Maxwell Blesdel Adassi, Gwladys Temkou Ngoupaye, Francis Bray Yassi, Aurelien Fossueh Foutsop, Tatiana Diebo Kom, Elisabeth Ngo Bum. Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Journal of ethnopharmacology.
2023 Mar; 303(?):115995. doi:
10.1016/j.jep.2022.115995. [PMID: 36509255] - Burcu Azak Pazarlar, Cansu Bilister Egilmez, Mumin Alper Erdogan, Oytun Erbas. Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats.
Neurochemical research.
2023 Feb; ?(?):. doi:
10.1007/s11064-023-03885-0. [PMID: 36780043] - Sana Javaid, Faleh Alqahtani, Waseem Ashraf, Syed Muhammad Muneeb Anjum, Muhammad Fawad Rasool, Tanveer Ahmad, Fawaz Alasmari, Abdullah F Alasmari, Saleh Abdullah Alqarni, Imran Imran. Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 160(?):114406. doi:
10.1016/j.biopha.2023.114406. [PMID: 36791567] - Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi. Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF.
European journal of pharmacology.
2023 Feb; 944(?):175583. doi:
10.1016/j.ejphar.2023.175583. [PMID: 36764352] - Adrianna Skiba, Ewelina Kozioł, Simon Vlad Luca, Barbara Budzyńska, Piotr Podlasz, Wietske Van Der Ent, Elham Shojaeinia, Camila V Esguerra, Mohammed Nour, Laurence Marcourt, Jean-Luc Wolfender, Krystyna Skalicka-Woźniak. Evaluation of the Antiseizure Activity of Endemic Plant Halfordia kendack Guillaumin and Its Main Constituent, Halfordin, on a Zebrafish Pentylenetetrazole (PTZ)-Induced Seizure Model.
International journal of molecular sciences.
2023 Jan; 24(3):. doi:
10.3390/ijms24032598. [PMID: 36768918] - Lijun Zhou, Yaping Gao, Hongyuan Lu, Wenwu Liu, Xiangbo Xu, Bo Xing, Xu Liang, Nan Wang, Xiaowen Jiang, Qingchun Zhao. Notopterygium incisum Root Extract (NRE) Alleviates Epileptiform Symptoms in PTZ-Induced Acute Seizure Mice.
CNS & neurological disorders drug targets.
2023; 22(5):774-783. doi:
10.2174/1871527321666220406111745. [PMID: 35388767] - Ngoc Buu Tran, Sook-Jeong Lee. Effects of Gryllus bimaculatus and Oxya chinensis sinuosa extracts on brain damage via blood-brain barrier control and apoptosis in mice with pentylenetetrazol-induced epilepsy.
PloS one.
2023; 18(9):e0291191. doi:
10.1371/journal.pone.0291191. [PMID: 37695764] - Abdulsalam Alkhudhayri, Ahmed E Abdel Moneim, Sara Rizk, Amira A Bauomy, Mohamed A Dkhil. The Neuroprotective Effect Associated with Echinops spinosus in an Acute Seizure Model Induced by Pentylenetetrazole.
Neurochemical research.
2023 Jan; 48(1):273-283. doi:
10.1007/s11064-022-03738-2. [PMID: 36074199] - Neda Fatahinezhad, Zahra Lorigooini, Mehran Arabi, Zahra Rabiei, Sedighe Kazemi Sheykhshabani, Mahmoud Rafieian-Kopaei. Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat.
Neurochemical research.
2022 Dec; 47(12):3792-3804. doi:
10.1007/s11064-022-03759-x. [PMID: 36287300] - Qinglei Wang, Rong Wang, Cheng Zheng, Linlin Zhang, Hong Meng, Yi Zhang, Linke Ma, Bilian Chen, Juanjuan Wang. Anticonvulsant Activity of Bombyx batryticatus and Analysis of Bioactive Extracts Based on UHPLC-Q-TOF MS/MS and Molecular Networking.
Molecules (Basel, Switzerland).
2022 Nov; 27(23):. doi:
10.3390/molecules27238315. [PMID: 36500408] - Ying Hao, Yitao Ou, Cheng Zhang, Hao Chen, Hu Yue, Zhongjin Yang, Xiaofen Zhong, Wenhui Hu, Ping Sun. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
Brain research.
2022 11; 1795(?):148073. doi:
10.1016/j.brainres.2022.148073. [PMID: 36075466] - Mozhdeh Radpour, Samira Choopani, Hamid Gholami Pourbadie, Mohammad Sayyah. Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats.
Experimental neurology.
2022 11; 357(?):114202. doi:
10.1016/j.expneurol.2022.114202. [PMID: 35970203] - Abubakar Muhammad Bello, Hamza Adegoke Salami, Ibrahim Samaila Malgwi, Samaila Musa Chiroma. Stem bark chloroform extract of Bombax costatum Pellegr. & Vuillet exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in rats.
Annales pharmaceutiques francaises.
2022 Oct; ?(?):. doi:
10.1016/j.pharma.2022.09.007. [PMID: 36220462] - Gamze Bayrak, Ismet Burcu Turkyilmaz, Refiye Yanardag. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
Journal of biochemical and molecular toxicology.
2022 Oct; 36(10):e23169. doi:
10.1002/jbt.23169. [PMID: 35833322] - Taiwo G Olubodun-Obadun, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo Afolayan, Ekene Nwose, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Journal of food biochemistry.
2022 10; 46(10):e14342. doi:
10.1111/jfbc.14342. [PMID: 35851712] - Nouf M Alyami, Saba Abdi, Hanadi M Alyami, Rafa Almeer. Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity.
Neurochemical research.
2022 Oct; 47(10):3012-3023. doi:
10.1007/s11064-022-03647-4. [PMID: 35838827] - Hanbin Chen, Shirley Weng In Siu, Clarence Tsun Ting Wong, Jianwen Qiu, Alex Kwok-Kuen Cheung, Simon Ming Yuen Lee. Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis.
Archives of toxicology.
2022 09; 96(9):2589-2608. doi:
10.1007/s00204-022-03311-4. [PMID: 35604417] - Hakan Sahin, Oguz Yucel, Serkan Emik, Gozde Erkanli Senturk. Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage.
ACS chemical neuroscience.
2022 07; 13(13):1923-1937. doi:
10.1021/acschemneuro.2c00124. [PMID: 35713692] - Amina E Essawy, Soad Ahmed El-Sayed, Ehab Tousson, Horeya S Abd El-Gawad, Reem Hasaballah Alhasani, Heba-Tallah Abd Elrahim Abd Elkader. Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy.
Environmental science and pollution research international.
2022 Jul; 29(32):48573-48587. doi:
10.1007/s11356-022-19251-6. [PMID: 35194715] - Urszula Doboszewska, Jan Sawicki, Adam Sajnóg, Aleksandra Szopa, Anna Serefko, Katarzyna Socała, Mateusz Pieróg, Dorota Nieoczym, Katarzyna Mlyniec, Gabriel Nowak, Danuta Barałkiewicz, Ireneusz Sowa, Piotr Wlaź. Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy-The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene.
Cells.
2022 Jun; 11(13):. doi:
10.3390/cells11131987. [PMID: 35805072] - Yuetao Wen, Guangliang Zhang, Lin Liu, Peng Zhang, Lan Lin, Rong Mei, Fengli Zhang, Yangmei Chen, Rong Li. HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABAAR-mediated inhibitory synaptic transmission in pentylenetetrazole rat model.
Neuroscience research.
2022 May; ?(?):. doi:
10.1016/j.neures.2022.05.006. [PMID: 35609730] - Yunyuan Huang, Haiyan Xu, Pei Wang, Rurong Gu, Xiaokang Li, Yixiang Xu, Jiqun Wang, Sicong Qiao, Donglei Shi, Zhaobing Gao, Jian Li. Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation.
ACS chemical neuroscience.
2022 04; 13(7):978-986. doi:
10.1021/acschemneuro.1c00774. [PMID: 35333519] - Parisa Khatami, Naser Mirazi, Maryam Khosravi, Maryam Bananej. Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway.
Journal of molecular neuroscience : MN.
2022 Apr; 72(4):880-887. doi:
10.1007/s12031-022-01967-2. [PMID: 35084669] - Marwa M Nagib, Sicheng Zhang, Nelufar Yasmen, Lexiao Li, Ruida Hou, Ying Yu, Vijay K Boda, Zhongzhi Wu, Wei Li, Jianxiong Jiang. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Epilepsia.
2022 04; 63(4):1003-1015. doi:
10.1111/epi.17190. [PMID: 35179226] - Mayeso Naomi Victoria Gwedela, Haruhi Terai, Fanuel Lampiao, Katsuyoshi Matsunami, Hidenori Aizawa. Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae.
Journal of ethnopharmacology.
2022 Feb; 284(?):114763. doi:
10.1016/j.jep.2021.114763. [PMID: 34688800] - Eman M El Nashar, Walaa Obydah, Mansour A Alghamdi, Somaya Saad, Asmaa Yehia, Ayda Maryoud, Nedaa A Kiwan, Wardah A Alasmari, Abdelaziz M Hussein. Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis.
Journal of integrative neuroscience.
2022 Jan; 21(1):21. doi:
10.31083/j.jin2101021. [PMID: 35164457] - Xiaomei Jiang, Yan Wang, Jia Liu. Simultaneous determination of four cobalamins in rat plasma using online solid phase extraction coupled to high performance liquid chromatography-tandem mass spectrometry: Application to pentylenetetrazole-induced seizures in Sprague-Dawley rats.
PloS one.
2022; 17(6):e0269645. doi:
10.1371/journal.pone.0269645. [PMID: 35671315] - Rifat Jahan, Mohammad Yousaf, Hamayun Khan, Nousheen Bibi, Musarrat Ijaz, Touseef Rehan, Shahid Ali Shah. ZOMEC via the p-Akt/Nrf2 Pathway Restored PTZ-Induced Oxidative Stress-Mediated Memory Dysfunction in Mouse Model.
BioMed research international.
2022; 2022(?):8902262. doi:
10.1155/2022/8902262. [PMID: 36193329] - Ganggang Li, Shiyue Zhang, Yating Cheng, Ye Lu, Zhixia Jia, Xiaohui Yang, Shaodan Zhang, Wenxiang Guo, Lin Pei. Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells.
Brain research.
2022 01; 1774(?):147723. doi:
10.1016/j.brainres.2021.147723. [PMID: 34780748] - Ibrahim Ethem Torun, Yasemin Baranoglu Kılınc, Erkan Kilinc. Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.
Arquivos de neuro-psiquiatria.
2022 01; 80(1):48-55. doi:
10.1590/0004-282x-anp-2021-0101. [PMID: 35239805] - Libor Uttl, Tomáš Hložek, Pavel Mareš, Tomáš Páleníček, Hana Kubová. Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010094. [PMID: 35008517] - Danielle Fernanda Fernandes Vieira, Antonio Luiz Gomes Junior, Keylla da Conceição Machado, Wcleubianne Matias Nascimento Maia, Tassio Lessa do Nascimento, Maria Alexsandra de Sousa Rios, Luciano da Silva Lopes. Evaluation of the anticonvulsant and antioxidant activity of alkylated cardanol in rodents.
Natural product research.
2021 Dec; 35(24):6168-6174. doi:
10.1080/14786419.2020.1831496. [PMID: 33143464] - Erkan Kilinc, Seyit Ankarali, Didem Ayhan, Handan Ankarali, Ibrahim Ethem Torun, Ayhan Cetinkaya. Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.
The Journal of nutritional biochemistry.
2021 12; 98(?):108830. doi:
10.1016/j.jnutbio.2021.108830. [PMID: 34333116] - Thamyres V N da Silva, Marcelo F Torres, Luís A Sampaio, Moisés Hamoy, José M Monserrat, Luis André L Barbas. Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.
Fish physiology and biochemistry.
2021 Dec; 47(6):1851-1864. doi:
10.1007/s10695-021-01010-y. [PMID: 34562200] - Fatemeh Aghaie, Fatemeh Moradifar, Abdolkarim Hosseini. Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats.
Fundamental & clinical pharmacology.
2021 Dec; 35(6):1045-1054. doi:
10.1111/fcp.12689. [PMID: 33930202] - Amal Yousfan, Noelia Rubio, Mohammad Al-Ali, Abdul Hakim Nattouf, Houmam Kafa. Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model.
Biomaterials science.
2021 Nov; 9(22):7547-7564. doi:
10.1039/d1bm01251g. [PMID: 34652351] - Illa S Johari, Norsyifa Harun, Zarif M Sofian, Mohammed Shoaib. Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats.
Psychopharmacology.
2021 Nov; 238(11):3183-3191. doi:
10.1007/s00213-021-05934-4. [PMID: 34333672] - Eman A Fayed, Ahmed Ragab, Rogy R Ezz Eldin, Ashraf H Bayoumi, Yousry A Ammar. In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Bioorganic chemistry.
2021 11; 116(?):105300. doi:
10.1016/j.bioorg.2021.105300. [PMID: 34525393] - Mehdi Valipour, Nima Naderi, Elmira Heidarli, Fatemeh Shaki, Farzaneh Motafeghi, Fereshteh Talebpour Amiri, Saeed Emami, Hamid Irannejad. Design, synthesis and biological evaluation of naphthalene-derived (arylalkyl)azoles containing heterocyclic linkers as new anticonvulsants: A comprehensive in silico, in vitro, and in vivo study.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Nov; 166(?):105974. doi:
10.1016/j.ejps.2021.105974. [PMID: 34390829] - Antoine Kavaye Kandeda, Fleur Clarisse Okomolo Moto, Rigobert Espoir Mbomo Ayissi, Jean Pierre Omam Omam, Lucie Ojong, Elisabeth Ngo Bum. Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.
Journal of ethnopharmacology.
2021 Oct; 279(?):114338. doi:
10.1016/j.jep.2021.114338. [PMID: 34144196] - Ewelina Kozioł, Krzysztof Jóźwiak, Barbara Budzyńska, Peter A M de Witte, Daniëlle Copmans, Krystyna Skalicka-Woźniak. Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111420. [PMID: 34768849] - Aliance Romain Fokoua, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Rodolphe Chouna, Oluwabusayo Folarin, James Olopade, Pepin Alango Nkeng-Efouet, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Télesphore Benoît Nguelefack. The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic activity against pentylenetetrazol kindling in male Wistar rats.
Metabolic brain disease.
2021 10; 36(7):2015-2027. doi:
10.1007/s11011-021-00825-1. [PMID: 34460047] - Mateusz Pieróg, Katarzyna Socała, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź. Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164841. [PMID: 34443428] - Kinga Gawel, Wirginia Kukula-Koch, Nancy Saana Banono, Dorota Nieoczym, Katarzyna M Targowska-Duda, Lidia Czernicka, Jolanta Parada-Turska, Camila V Esguerra. 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147745. [PMID: 34299361] - Ana Carolina Mendes Hacke, Edmar Miyoshi, Jacqueline Aparecida Marques, Romaiana Picada Pereira. Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Journal of ethnopharmacology.
2021 Jul; 275(?):114142. doi:
10.1016/j.jep.2021.114142. [PMID: 33910044] - Jiao Dang, Yam Nath Paudel, Xueliang Yang, Qingyu Ren, Shanshan Zhang, Xiuna Ji, Kechun Liu, Meng Jin. Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress.
ACS chemical neuroscience.
2021 07; 12(13):2542-2552. doi:
10.1021/acschemneuro.1c00314. [PMID: 34128378] - Arlindo César Matias Pereira, Brenda Lorena Sánchez-Ortíz, Ester Lopes de Melo, Lorane Izabel da Silva Hage-Melim, Raphaelle Sousa Borges, Xuebo Hu, José Carlos Tavares Carvalho. Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 06; 394(6):1177-1190. doi:
10.1007/s00210-021-02050-0. [PMID: 33515278] - Aliance Romain Fokoua, Magloire K Ndjenda, Adeline Kaptué Wuyt, Francis Desire Tatsinkou Bomba, Appolinaire Kene Dongmo, Rodolphe Chouna, Pepin Alango Nkeng-Efouet, Télesphore Benoît Nguelefack. Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Journal of ethnopharmacology.
2021 May; 272(?):113955. doi:
10.1016/j.jep.2021.113955. [PMID: 33610704] - M E González-Trujano, E Urbina-Trejo, F Santos-Valencia, B Villasana-Salazar, L Carmona-Aparicio, D Martínez-Vargas. Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Journal of ethnopharmacology.
2021 May; 271(?):113866. doi:
10.1016/j.jep.2021.113866. [PMID: 33485978] - Ahmet Sevki Taskiran, Mustafa Ergul. The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line.
Chemico-biological interactions.
2021 May; 340(?):109447. doi:
10.1016/j.cbi.2021.109447. [PMID: 33771525] - Mohammad-Mahdi Ghanbari, Ali Gharibi Loron, Mohammad Sayyah. The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
Brain research bulletin.
2021 05; 170(?):74-80. doi:
10.1016/j.brainresbull.2021.02.011. [PMID: 33581310] - Nahid Sarahian, Mohammad Taghi Mohammadi, Shamsi Darabi, Nastaran Faghihi. Fenofibrate protects the neurovascular unit and ameliorates plasma corticosterone levels in pentylenetetrazole-induced kindling seizure in mice.
Brain research.
2021 05; 1758(?):147343. doi:
10.1016/j.brainres.2021.147343. [PMID: 33556377] - Priscilla Kolibea Mante, Nana Ofori Adomako, Paulina Antwi, Nana Kofi Kusi-Boadum, Newman Osafo. Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111354. doi:
10.1016/j.biopha.2021.111354. [PMID: 33561642] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ritesh Kumar, Renu Arora, Sudhir Chandra Sarangi, Shankar Ganeshan N, Amit Agarwal, Thomas Kaleekal, Yogendra Kumar Gupta. Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Journal of ethnopharmacology.
2021 Apr; 270(?):113784. doi:
10.1016/j.jep.2021.113784. [PMID: 33429032] - Emmanuel O Okwuofu, Gbenga E Ogundepo, Abigail M Akhigbemen, Akinpelu L Abiola, Raymond I Ozolua, Ighodaro Igbe, Ononiwu Chinazamoku. Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice.
Metabolic brain disease.
2021 04; 36(4):571-579. doi:
10.1007/s11011-021-00684-w. [PMID: 33559804] - Priya Mishra, Amit Kumar Mittal, Satyendra Kumar Rajput, Jitendra Kumar Sinha. Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Journal of ethnopharmacology.
2021 Mar; 267(?):113509. doi:
10.1016/j.jep.2020.113509. [PMID: 33141053] - Ying Zhang, Jing Zhao, Obaid Afzal, Imran Kazmi, Fahad A Al-Abbasi, Abdulmalik S A Altamimi, Zhen Yang. Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy through Nrf2/ARE/HO-1 pathway.
Journal of biochemical and molecular toxicology.
2021 Feb; 35(2):e22634. doi:
10.1002/jbt.22634. [PMID: 32991785] - Ahmet Sevki Taskiran, Yasar Tastemur. The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats.
Experimental brain research.
2021 Feb; 239(2):591-599. doi:
10.1007/s00221-020-06012-5. [PMID: 33385251] - Priya Mishra, Jitendra Kumar Sinha, Satyendra Kumar Rajput. Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures.
Epilepsy & behavior : E&B.
2021 02; 115(?):107653. doi:
10.1016/j.yebeh.2020.107653. [PMID: 33358679] - María Eva González-Trujano, Gerardo Contreras-Murillo, Claudia Andrea López-Najera, Fernando Josué Hidalgo-Flores, Andrés Navarrete-Castro, Concepción Gamboa Sánchez, Víctor Manuel Magdaleno-Madrigal. Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats.
Journal of ethnopharmacology.
2021 Jan; 265(?):113299. doi:
10.1016/j.jep.2020.113299. [PMID: 32841694] - Sandhyarani Guggilla, Middela Karthik, Boini Shylendra. Regulation of Antioxidant Enzyme Levels in Rat Brain.
Advances in experimental medicine and biology.
2021; 1339(?):21-26. doi:
10.1007/978-3-030-78787-5_3. [PMID: 35023085] - Arooj Mohsin Alvi, Lina Tariq Al Kury, Abdullah Alattar, Ikram Ullah, Asmaa Jan Muhammad, Reem Alshaman, Fawad Ali Shah, Arif Ullah Khan, Jinxing Feng, Shupeng Li. Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway.
Oxidative medicine and cellular longevity.
2021; 2021(?):9966663. doi:
10.1155/2021/9966663. [PMID: 34422216] - Ju Young Eor, Pei Lei Tan, Yoon Ji Son, Min Jin Kwak, Sae Hun Kim. Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure.
Epilepsy research.
2021 01; 169(?):106506. doi:
10.1016/j.eplepsyres.2020.106506. [PMID: 33276243] - Ahmet Sevki Taskiran, Mustafa Ergul, Handan Gunes, Aysegul Ozturk, Bilal Sahin, Ercan Ozdemir. The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line.
Cellular and molecular neurobiology.
2021 Jan; 41(1):173-183. doi:
10.1007/s10571-020-00956-6. [PMID: 32862257] - Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Darisi Venkata Kishore, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad. Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways.
Neurotoxicity research.
2020 Dec; 38(4):1010-1023. doi:
10.1007/s12640-020-00267-0. [PMID: 32803629] - Dong Liang, Fei Fan, Wei Ding, Yuan Fang, Lan Hu, Bibo Lei, Mingqiang Zhang. Increased Seizure Susceptibility for Rats Subject to Early Life Hypoxia Might Be Associated with Brain Dysfunction of NRG1-ErbB4 Signaling in Parvalbumin Interneurons.
Molecular neurobiology.
2020 Dec; 57(12):5276-5285. doi:
10.1007/s12035-020-02100-3. [PMID: 32870492] - Antonia Amanda Cardoso de Almeida, José Roberto de Oliveira Ferreira, Rusbene Bruno Fonseca de Carvalho, Marcia Dos Santos Rizzo, Luciano da Silva Lopes, Dalton Dittz, João Marcelo de Castro E Souza, Paulo Michel Pinheiro Ferreira. Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 12; 393(12):2301-2314. doi:
10.1007/s00210-020-01943-w. [PMID: 32653979] - Xiaobo Fang, Yanling Liang, Dunjin Chen, Yanmei Liu, Mengshu Xie, Weixi Zhang. Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
Cytokine.
2020 11; 135(?):155212. doi:
10.1016/j.cyto.2020.155212. [PMID: 32702431] - Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar. Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Epilepsy research.
2020 11; 167(?):106435. doi:
10.1016/j.eplepsyres.2020.106435. [PMID: 32784064] - Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura, Yusuke Masuo, Tomoe Komori, Takahiro Ishimoto, Jun-Ichi Matsuo, Yukio Kato. Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice.
Neurochemical research.
2020 Nov; 45(11):2664-2678. doi:
10.1007/s11064-020-03118-8. [PMID: 32844295] - Christianah A Elusiyan, Ana Luiza Gonçalves Faria, Ane Emanuelle Queiroga Mendes, Iransé Oliveira Silva, José Luis Rodrigues Martins, Daniel Alves Rosa, Gustavo Rodrigues Pedrino, Elson Alves Costa, Mohamed Ali Ibrahim, Jordan K Zjawiony, James Oluwagbamigbe Fajemiroye. Involvement of the Benzodiazepine Site in the Anticonvulsant Activity of Tapinanthus globiferus against Pentylenetetrazole-induced Seizures in Mice.
Planta medica.
2020 Nov; 86(16):1204-1215. doi:
10.1055/a-1209-1254. [PMID: 32668477] - Yan Wang, Guangfei Wang, Jie Tao, Xiaoxia Li, Lan Hu, Qin Li, Jinmiao Lu, Youbin Li, Zhiping Li. Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.
Brain research.
2020 10; 1745(?):146923. doi:
10.1016/j.brainres.2020.146923. [PMID: 32504548] - Xiangmiao Qiu, Lu Zhang, Masako Kinoshita, Wanlin Lai, Wen Zheng, Anjiao Peng, Wanling Li, Linghui Yang, Lin Zhang, Meng Gong, Lei Chen. Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis.
Metabolomics : Official journal of the Metabolomic Society.
2020 10; 16(10):110. doi:
10.1007/s11306-020-01731-w. [PMID: 33037443] - Touran Mahmoudi, Zahra Lorigooini, Mahmoud Rafieian-Kopaei, Mehran Arabi, Zahra Rabiei, Elham Bijad, Sedigheh Kazemi. Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Behavioral and brain functions : BBF.
2020 Oct; 16(1):7. doi:
10.1186/s12993-020-00169-3. [PMID: 33023622] - María Yolanda Rios, Alfredo Ortega, Blanca Domínguez, Myrna Déciga, Vianey de la Rosa. Glaucacetalin E and galphimidin B from Galphimia glauca and their anxiolytic activity.
Journal of ethnopharmacology.
2020 Sep; 259(?):112939. doi:
10.1016/j.jep.2020.112939. [PMID: 32417425] - Théo Brillatz, Maxime Jacmin, Konstantina Vougogiannopoulou, Eleftherios A Petrakis, Eleftherios Kalpoutzakis, Joëlle Houriet, Léonie Pellissier, Adriano Rutz, Laurence Marcourt, Emerson Ferreira Queiroz, Alexander D Crawford, Alexios-Leandros Skaltsounis, Jean-Luc Wolfender. Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.
Journal of ethnopharmacology.
2020 Sep; 259(?):112954. doi:
10.1016/j.jep.2020.112954. [PMID: 32445663] - A Kapucu, S Ustunova, K Akgun-Dar. Valeriana officinalis extract and 7-Nitroindozole ameliorated seizure behaviours, and 7-Nitroindozole reduced blood pressure and ECG parameters in pentylenetetrazole-kindled rats.
Polish journal of veterinary sciences.
2020 Sep; 23(3):349-357. doi:
10.24425/pjvs.2020.133652. [PMID: 33006866] - Zartashia Kazmi, Sara Zeeshan, Adnan Khan, Sumra Malik, Adeeb Shehzad, Eun Kyoung Seo, Salman Khan. Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.
Neurotoxicology.
2020 07; 79(?):150-163. doi:
10.1016/j.neuro.2020.05.005. [PMID: 32450180]