Indeloxazine (BioDeep_00000008399)

 

Secondary id: BioDeep_00000859081

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-(((1H-INDEN-7-YL)OXY)METHYL)MORPHOLINE

化学式: C14H17NO2 (231.12592220000002)
中文名称: 茚洛秦
谱图信息: 最多检出来源 Homo sapiens(blood) 92.31%

分子结构信息

SMILES: C(OC1=CC=CC2=C1CC=C2)C1CNCCO1
InChI: InChI=1S/C14H17NO2/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12/h1-4,6,12,15H,5,7-10H2

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Same as: D08077

同义名列表

9 个代谢物同义名

2-(((1H-INDEN-7-YL)OXY)METHYL)MORPHOLINE; Indeloxazine hydrochloride, (+)-isomer; 2-[(1H-inden-7-yloxy)methyl]morpholine; 2-(7-Indenyloxymethyl)morpholine; Indeloxazine hydrochloride; Indeloxazine, (+)-isomer; (+)-indeloxazine; Indeloxazine; Indeloxazine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nobuhito Murai, Nobuaki Takeshita, Fusako Nishigaki, Megumi Irie, Seiji Tamura, Toshiaki Aoki, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain. Neurological research. 2015 Jun; 37(6):525-30. doi: 10.1179/1743132815y.0000000007. [PMID: 25591424]
  • N Murai, H Fushiki, S Honda, Y Murakami, A Iwashita, M Irie, S Tamura, Y Nagakura, T Aoki. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. 2015 Mar; 289(?):262-9. doi: 10.1016/j.neuroscience.2014.12.065. [PMID: 25595980]
  • Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Hiroko Yamamoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy. Neuropharmacology. 2014 Apr; 79(?):10-6. doi: 10.1016/j.neuropharm.2013.10.030. [PMID: 24211301]
  • Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. The Journal of pharmacology and experimental therapeutics. 2014 Mar; 348(3):372-82. doi: 10.1124/jpet.113.208686. [PMID: 24338505]
  • M Minami, H Arai, T Takahashi, M Kimura, I Noguchi, T Suzuki, R Inoue. A preliminary study on plasma concentrations of bifemelane, indeloxazine and propentofylline in aged patients with organic brain disorders. Progress in neuro-psychopharmacology & biological psychiatry. 1995 Jan; 19(1):59-64. doi: 10.1016/0278-5846(94)00104-p. [PMID: 7708932]
  • M Suno, A Nagaoka. [Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1988 May; 91(5):295-9. doi: 10.1254/fpj.91.295. [PMID: 3410376]
  • H Kamimura, R Kawai, H Kudo. Metabolic fate of indeloxazine hydrochloride: alpha-glucoside formation in rats. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Feb; 18(2):141-9. doi: 10.3109/00498258809041650. [PMID: 3287777]
  • H Kamimura, Y Enjoji, H Sasaki, R Kawai, H Kaniwa, K Niigata, S Kageyama. Disposition and metabolism of indeloxazine hydrochloride, a cerebral activator, in rats. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Jun; 17(6):645-58. doi: 10.3109/00498258709043972. [PMID: 3630201]
  • H Kamimura, H Sasaki, K Yokoi, S Kawamura. Determination of indeloxazine in plasma by liquid chromatography and gas chromatography-mass spectrometry. Journal of pharmaceutical sciences. 1985 May; 74(5):559-61. doi: 10.1002/jps.2600740514. [PMID: 4020634]
  • A G Hayes, T Chang. Determination of indeloxazine, a new antidepressant agent, in human plasma by gas-liquid chromatography with electron-capture detection. Journal of chromatography. 1983 Jan; 272(1):176-80. doi: 10.1016/s0378-4347(00)86115-0. [PMID: 6841538]