Indeloxazine (BioDeep_00000008399)

 

Secondary id: BioDeep_00000859081

human metabolite blood metabolite


代谢物信息卡片


2-(((1H-INDEN-7-YL)OXY)METHYL)MORPHOLINE

化学式: C14H17NO2 (231.1259)
中文名称: 茚洛秦
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: C(OC1=CC=CC2=C1CC=C2)C1CNCCO1
InChI: InChI=1S/C14H17NO2/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12/h1-4,6,12,15H,5,7-10H2

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Same as: D08077

同义名列表

9 个代谢物同义名

2-(((1H-INDEN-7-YL)OXY)METHYL)MORPHOLINE; Indeloxazine hydrochloride, (+)-isomer; 2-[(1H-inden-7-yloxy)methyl]morpholine; 2-(7-Indenyloxymethyl)morpholine; Indeloxazine hydrochloride; Indeloxazine, (+)-isomer; (+)-indeloxazine; Indeloxazine; Indeloxazine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, CA1, CA3, CHAT, FGF2, GAP43, HTR4
Peripheral membrane protein 1 GAP43
Endosome membrane 2 HTR4, SLC6A4
Endoplasmic reticulum membrane 1 DRD1
Mitochondrion membrane 1 MAOA
Nucleus 4 AXIN2, CHAT, DRD1, FGF2
cytosol 7 AXIN2, CA1, CA3, CHAT, MAOA, PRKCQ, SST
dendrite 3 DRD2, GAP43, HTR4
centrosome 1 AXIN2
Cell membrane 6 DRD1, DRD2, GAP43, HTR3A, HTR4, SLC6A4
Cytoplasmic side 2 GAP43, MAOA
Cleavage furrow 1 HTR3A
Cell projection, axon 1 GAP43
Multi-pass membrane protein 6 CACNA1I, DRD1, DRD2, HTR3A, HTR4, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 6 CHAT, DRD2, GAP43, HTR3A, HTR4, SLC6A4
glutamatergic synapse 3 DRD1, DRD2, HTR4
Golgi apparatus 1 NPY
Golgi membrane 1 DRD2
lysosomal membrane 1 EGF
neuronal cell body 1 SST
postsynapse 2 HTR3A, HTR4
presynaptic membrane 3 DRD1, DRD2, SLC6A4
Presynapse 2 GAP43, SLC6A4
acrosomal vesicle 1 DRD2
endosome 1 HTR4
plasma membrane 11 AXIN2, CACNA1I, DRD1, DRD2, EGF, GAP43, HTR3A, HTR4, KNG1, PRKCQ, SLC6A4
synaptic vesicle membrane 1 DRD2
Membrane 6 CACNA1I, EGF, HTR3A, HTR4, MAOA, SLC6A4
axon 1 DRD2
extracellular exosome 3 CA1, EGF, KNG1
extracellular space 6 EGF, FGF2, IGF1, KNG1, NPY, SST
mitochondrion 1 MAOA
postsynaptic density 1 GAP43
Secreted 4 FGF2, IGF1, NPY, SST
extracellular region 6 EGF, FGF2, IGF1, KNG1, NPY, SST
Mitochondrion outer membrane 1 MAOA
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 1 MAOA
centriolar satellite 1 PRKCQ
ciliary membrane 2 DRD1, DRD2
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, GAP43
beta-catenin destruction complex 1 AXIN2
postsynaptic membrane 4 DRD1, DRD2, HTR3A, SLC6A4
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 5 DRD1, DRD2, GAP43, NPY, SST
Cell projection, dendritic spine 1 DRD1
collagen-containing extracellular matrix 1 KNG1
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 1 HTR3A
Cell projection, neuron projection 1 SLC6A4
neuron projection 3 CHAT, HTR3A, SLC6A4
cilium 2 DRD1, DRD2
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
non-motile cilium 2 DRD1, DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
Cell projection, dendrite 2 DRD1, GAP43
filopodium membrane 1 GAP43
exocytic vesicle 1 IGF1
endoplasmic reticulum lumen 1 KNG1
platelet alpha granule lumen 3 EGF, IGF1, KNG1
axon terminus 1 DRD2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DRD2
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 NPY, SST
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 MAOA
clathrin-coated endocytic vesicle membrane 1 EGF
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
Cell projection, filopodium membrane 1 GAP43
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
G protein-coupled receptor complex 2 DRD1, DRD2
Cell projection, growth cone membrane 1 GAP43
growth cone membrane 1 GAP43
serotonergic synapse 1 SLC6A4


文献列表

  • Nobuhito Murai, Nobuaki Takeshita, Fusako Nishigaki, Megumi Irie, Seiji Tamura, Toshiaki Aoki, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain. Neurological research. 2015 Jun; 37(6):525-30. doi: 10.1179/1743132815y.0000000007. [PMID: 25591424]
  • N Murai, H Fushiki, S Honda, Y Murakami, A Iwashita, M Irie, S Tamura, Y Nagakura, T Aoki. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. 2015 Mar; 289(?):262-9. doi: 10.1016/j.neuroscience.2014.12.065. [PMID: 25595980]
  • Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Hiroko Yamamoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy. Neuropharmacology. 2014 Apr; 79(?):10-6. doi: 10.1016/j.neuropharm.2013.10.030. [PMID: 24211301]
  • Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. The Journal of pharmacology and experimental therapeutics. 2014 Mar; 348(3):372-82. doi: 10.1124/jpet.113.208686. [PMID: 24338505]
  • M Minami, H Arai, T Takahashi, M Kimura, I Noguchi, T Suzuki, R Inoue. A preliminary study on plasma concentrations of bifemelane, indeloxazine and propentofylline in aged patients with organic brain disorders. Progress in neuro-psychopharmacology & biological psychiatry. 1995 Jan; 19(1):59-64. doi: 10.1016/0278-5846(94)00104-p. [PMID: 7708932]
  • M Suno, A Nagaoka. [Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1988 May; 91(5):295-9. doi: 10.1254/fpj.91.295. [PMID: 3410376]
  • H Kamimura, R Kawai, H Kudo. Metabolic fate of indeloxazine hydrochloride: alpha-glucoside formation in rats. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Feb; 18(2):141-9. doi: 10.3109/00498258809041650. [PMID: 3287777]
  • H Kamimura, Y Enjoji, H Sasaki, R Kawai, H Kaniwa, K Niigata, S Kageyama. Disposition and metabolism of indeloxazine hydrochloride, a cerebral activator, in rats. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Jun; 17(6):645-58. doi: 10.3109/00498258709043972. [PMID: 3630201]
  • H Kamimura, H Sasaki, K Yokoi, S Kawamura. Determination of indeloxazine in plasma by liquid chromatography and gas chromatography-mass spectrometry. Journal of pharmaceutical sciences. 1985 May; 74(5):559-61. doi: 10.1002/jps.2600740514. [PMID: 4020634]
  • A G Hayes, T Chang. Determination of indeloxazine, a new antidepressant agent, in human plasma by gas-liquid chromatography with electron-capture detection. Journal of chromatography. 1983 Jan; 272(1):176-80. doi: 10.1016/s0378-4347(00)86115-0. [PMID: 6841538]