O,O,S-trimethyl phosphorothiate (BioDeep_00000810648)

   


代谢物信息卡片


O,O,S-Trimethyl phosphorothioate

化学式: C3H9O3PS (156.001)
中文名称: O,O,S-三甲基酯硫代磷酸, O、 O,S-三甲基硫代磷酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COP(=O)(OC)SC
InChI: InChI=1S/C3H9O3PS/c1-5-7(4,6-2)8-3/h1-3H3



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, CAT, CYP1A1, CYP2E1, ELANE, SERPINB2, XDH
Peripheral membrane protein 2 CYP1A1, CYP2E1
Endosome membrane 1 LEPR
Endoplasmic reticulum membrane 4 CYP1A1, CYP2E1, CYP4B1, HSP90B1
Nucleus 2 ALB, HSP90B1
cytosol 5 ALB, CAT, ELANE, HSP90B1, XDH
phagocytic vesicle 1 ELANE
centrosome 1 ALB
Cell membrane 1 LEPR
Multi-pass membrane protein 1 LEPR
Golgi apparatus membrane 1 LEPR
Synapse 1 CRH
cell surface 2 ELANE, PLAU
Golgi apparatus 2 ALB, LEPR
Golgi membrane 1 LEPR
mitochondrial inner membrane 2 CYP1A1, CYP2E1
smooth endoplasmic reticulum 1 HSP90B1
endosome 1 LEPR
plasma membrane 4 BCHE, F2, PLAU, SERPINB2
Membrane 4 CAT, CYP4B1, HSP90B1, LEPR
basolateral plasma membrane 1 LEPR
extracellular exosome 6 ALB, CAT, ELANE, F2, HSP90B1, PLAU
endoplasmic reticulum 2 ALB, HSP90B1
extracellular space 9 ALB, BCHE, CRH, ELANE, F2, IL2, PLAU, SERPINB2, XDH
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 2 CAT, CYP1A1
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 3 CAT, CYP1A1, CYP2E1
Microsome membrane 2 CYP1A1, CYP2E1
Single-pass type I membrane protein 1 LEPR
Secreted 6 ALB, BCHE, CRH, F2, IL2, PLAU
extracellular region 11 ALB, BCHE, CAT, CRH, ELANE, F2, HSP90B1, IL2, LEPR, PLAU, SERPINB2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 2 LEPR, PLAU
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
midbody 1 HSP90B1
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
focal adhesion 3 CAT, HSP90B1, PLAU
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 ELANE, F2, HSP90B1
secretory granule 1 ELANE
receptor complex 1 LEPR
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, F2
Basolateral cell membrane 1 LEPR
Cornified envelope 1 SERPINB2
specific granule membrane 1 PLAU
tertiary granule membrane 1 PLAU
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 4 ALB, BCHE, F2, HSP90B1
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 ALB
specific granule lumen 1 ELANE
azurophil granule lumen 1 ELANE
serine-type endopeptidase complex 1 PLAU
nuclear envelope lumen 1 BCHE
Sarcoplasmic reticulum lumen 1 HSP90B1
serine protease inhibitor complex 1 PLAU
Cytoplasmic vesicle, phagosome 1 ELANE
endocytic vesicle lumen 1 HSP90B1
protein complex involved in cell-matrix adhesion 1 PLAU
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
[Isoform E]: Secreted 1 LEPR
ciliary transition fiber 1 ALB


文献列表

  • Linfang Huang, Megumi Toyoshima, Akihiro Asakawa, Kayoko Inoue, Kouji Harada, Tomomi Kinoshita, Shilin Chen, Akio Koizumi. Levels of N-acylethanolamines in O,O,S-trimethylphosphorothioate (OOS-TMP)-treated C57BL/6J mice and potential anti-obesity, anti-diabetic effects of OOS-TMP in hyperphagia and hyperglycemia mouse models. Pharmacology, biochemistry, and behavior. 2009 Mar; 92(1):1-5. doi: 10.1016/j.pbb.2008.10.003. [PMID: 18992273]
  • Linfang Huang, Megumi Toyoshima, Akihiro Asakawa, Kayoko Inoue, Kouji Harada, Tomomi Kinoshita, Akio Koizumi. Roles of neuropeptides in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice. Biochemical and biophysical research communications. 2007 Oct; 362(1):177-182. doi: 10.1016/j.bbrc.2007.07.174. [PMID: 17698039]
  • K Ohtaka, A Koizumi. Enhanced levels of lipid peroxidation and xanthine oxidase activity in the lung of male Sprague-Dawley rats following treatment with O,O,S-trimethyl phosphorothioate. Pharmacology & toxicology. 1994 Sep; 75(3-4):206-11. doi: 10.1111/j.1600-0773.1994.tb00348.x. [PMID: 7800664]
  • S Keadtisuke, W Dheranetra, T Nakatsugawa, T R Fukuto. Liver damage induced in rats by malathion impurities. Toxicology letters. 1990 Jun; 52(1):35-46. doi: 10.1016/0378-4274(90)90163-g. [PMID: 2356569]
  • D Dinsdale, R D Verschoyle. Ultrastructural effects of phosphorothionates and other inhibitors of lung monooxygenases: protection against trialkylphosphorothiolate-induced lung injury. Experimental lung research. 1989 May; 15(3):459-71. doi: 10.3109/01902148909087871. [PMID: 2787242]
  • S Keadtisuke, W Dheranetra, T R Fukuto. Detection of kidney damage by malathion impurities using a microdissection technique. Toxicology letters. 1989 Apr; 47(1):53-9. doi: 10.1016/0378-4274(89)90085-4. [PMID: 2652380]
  • M L Bezençon, S K Durham, J Roux, E M Grandjean, T Imamura. A pneumotoxin, O,O,S-trimethyl phosphorothioate, induces hemorheological alteration in rats. Archives of toxicology. 1989; 63(4):325-30. doi: 10.1007/bf00278647. [PMID: 2764721]
  • J Hasegawa, M Suzuki, Y Wada, S Kamiyama, A Koizumi. Hyperethanolaminuria in O, O, S-trimethyl phosphorothioate toxicity in rats. Industrial health. 1988; 26(4):215-23. doi: 10.2486/indhealth.26.215. [PMID: 3230054]
  • S Keadtisuke, T R Fukuto. Dysproteinuria induced in rats by O,O,S-trimethyl phosphorothioate. Toxicology letters. 1987 Jun; 37(1):33-9. doi: 10.1016/0378-4274(87)90164-0. [PMID: 3590228]
  • K E Rodgers, T Imamura, B H Devens. Organophosphorus pesticide immunotoxicity: effects of O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems. Immunopharmacology. 1986 Dec; 12(3):193-202. doi: 10.1016/0162-3109(86)90003-2. [PMID: 3493228]
  • A Koizumi, V Tada, T Imamura. Similarity of isozyme pattern of serum lactate dehydrogenase following treatments with O,O,S-trimethyl phosphorothioate and paraquat. Toxicology letters. 1986 Apr; 31(1):85-90. doi: 10.1016/0378-4274(86)90197-9. [PMID: 3715918]
  • T Imamura, I K Thomas. Alterations of alveolar macrophage function and level of bronchopulmonary protease inhibitors in O,O,S-trimethyl phosphorothioate-induced lung injury. Toxicology. 1985 Oct; 37(1-2):79-89. doi: 10.1016/0300-483x(85)90114-3. [PMID: 4060171]
  • T R Fukuto. Toxicological properties of trialkyl phosphorothioate and dialkyl alkyl- and arylphosphonothioate esters. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1983; 18(1):89-117. doi: 10.1080/03601238309372359. [PMID: 6833715]
  • S G Lee, T R Fukuto. Inhibition of rat liver and plasma carboxylesterases by impurities present in technical phenthoate. Journal of toxicology and environmental health. 1982 Oct; 10(4-5):717-28. doi: 10.1080/15287398209530290. [PMID: 7161823]
  • N Umetsu, N M Mallipudi, R F Toia, R B March, T R Fukuto. Toxicological properties of phosphorothioate and related esters present as impurities in technical organophosphorus insecticides. Journal of toxicology and environmental health. 1981 Mar; 7(3-4):481-97. doi: 10.1080/15287398109529996. [PMID: 7288900]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]