Phensuximide (BioDeep_00000007794)

 

Secondary id: BioDeep_00001868208

human metabolite blood metabolite


代谢物信息卡片


1-methyl-3-phenylpyrrolidine-2,5-dione

化学式: C11H11NO2 (189.079)
中文名称: 苯琥胺
谱图信息: 最多检出来源 Homo sapiens(blood) 35.07%

分子结构信息

SMILES: CN1C(=O)CC(C1=O)C1=CC=CC=C1
InChI: InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3

描述信息

Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent

同义名列表

6 个代谢物同义名

1-methyl-3-phenylpyrrolidine-2,5-dione; Phensuximide, (+-)-isomer; Phensuccimide; Phensuximide; Milontin; Phensuximide



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 CYP2C19, GNAT3, IL16
Endoplasmic reticulum membrane 1 CYP2C19
Nucleus 1 IL16
cytosol 2 DPYS, IL16
dendrite 2 HTR1B, HTR1D
Cell membrane 8 CX3CR1, GNGT1, GRM8, HCAR2, HTR1B, HTR1D, PTGER3, SUCNR1
Lipid-anchor 1 GNGT1
Cytoplasmic side 1 GNGT1
Multi-pass membrane protein 7 CX3CR1, GRM8, HCAR2, HTR1B, HTR1D, PTGER3, SUCNR1
Synapse 1 HTR1D
cell junction 1 HCAR2
cell surface 1 CX3CR1
presynaptic membrane 1 HTR1B
acrosomal vesicle 1 GNAT3
plasma membrane 11 CX3CR1, CYP2C19, GNAT3, GRM8, HCAR2, HTR1B, HTR1D, IL16, PTGER3, SSTR1, SUCNR1
Membrane 3 GRM8, HCAR2, PTGER3
apical plasma membrane 1 GNAT3
extracellular exosome 2 DPYS, SUCNR1
endoplasmic reticulum 1 HTR1B
extracellular space 4 CXCL5, CXCL8, IL16, IL7
perinuclear region of cytoplasm 1 CX3CR1
protein-containing complex 1 GNAT3
intracellular membrane-bounded organelle 1 CYP2C19
Secreted 4 CXCL5, CXCL8, IL16, IL7
extracellular region 4 CXCL5, CXCL8, IL16, IL7
neuronal cell body membrane 1 CX3CR1
photoreceptor inner segment 2 GNAT3, GNGT1
photoreceptor outer segment 1 GNAT3
external side of plasma membrane 1 CX3CR1
focal adhesion 1 IL16
collagen-containing extracellular matrix 1 IL7
axoneme 1 GNAT3
nuclear speck 1 IL16
neuron projection 2 CX3CR1, SSTR1
Flemming body 1 IL16
nuclear envelope 1 PTGER3
heterotrimeric G-protein complex 2 GNAT3, GNGT1
[Isoform 1]: Cytoplasm 1 IL16
calyx of Held 1 HTR1B
photoreceptor disc membrane 1 GNGT1
macropinosome membrane 1 CX3CR1
G protein-coupled serotonin receptor complex 1 HTR1B
serotonergic synapse 1 HTR1B
dendritic tree 1 CX3CR1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • G O Rankin, K W Beers, D W Nicoll, D K Anestis, H C Shih, P I Brown, J L Hubbard. Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat. Toxicology. 1992 Aug; 74(1):77-88. doi: 10.1016/0300-483x(92)90045-g. [PMID: 1514190]
  • G O Rankin, K Cressey-Veneziano, R T Wang, P I Brown. Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. Journal of applied toxicology : JAT. 1986 Oct; 6(5):349-56. doi: 10.1002/jat.2550060509. [PMID: 3772011]