Ajugarin I (BioDeep_00000007142)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Ajugarin I

化学式: C24H34O7 (434.2304)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CC(=O)OCC12C(OC(C)=O)CC(C)C(C)(CCC3=CC(=O)OC3)C1CCCC21CO1
InChI: InChI=1S/C24H34O7/c1-15-10-20(31-17(3)26)24(14-29-16(2)25)19(6-5-8-23(24)13-30-23)22(15,4)9-7-18-11-21(27)28-12-18/h11,15,19-20H,5-10,12-14H2,1-4H3/t15-,19-,20+,22+,23+,24+/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Ajugarin I; Ajugarin I



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BCL2, CASP3, KEAP1, MAPK8, TXN
Endoplasmic reticulum membrane 3 BCL2, HMOX1, TRPM8
Nucleus 7 BCL2, CASP3, GABPA, HMOX1, KEAP1, MAPK8, TXN
cytosol 6 BCL2, CASP3, HMOX1, KEAP1, MAPK8, TXN
nucleoplasm 6 CASP3, GABPA, HMOX1, KEAP1, MAPK8, TXN
Cell membrane 2 TRPM8, TRPV1
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 2 TRPM8, TRPV1
Synapse 1 MAPK8
glutamatergic synapse 1 CASP3
neuronal cell body 2 CASP3, TRPV1
plasma membrane 2 TRPM8, TRPV1
Membrane 4 BCL2, HMOX1, TRPM8, TRPV1
axon 1 MAPK8
extracellular exosome 1 TXN
endoplasmic reticulum 3 BCL2, HMOX1, KEAP1
extracellular space 1 HMOX1
perinuclear region of cytoplasm 1 HMOX1
mitochondrion 1 BCL2
protein-containing complex 1 BCL2
postsynaptic density 1 CASP3
Secreted 1 TXN
extracellular region 2 DNAH9, TXN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
centriolar satellite 1 KEAP1
motile cilium 1 DNAH9
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TRPM8, TRPV1
midbody 1 KEAP1
postsynaptic membrane 1 TRPV1
Membrane raft 1 TRPM8
pore complex 1 BCL2
microtubule 1 DNAH9
GABA-ergic synapse 1 TRPV1
axoneme 1 DNAH9
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
chromatin 1 GABPA
actin filament 1 KEAP1
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Cul3-RING ubiquitin ligase complex 1 KEAP1
myelin sheath 1 BCL2
plasma membrane raft 1 TRPM8
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Single-pass type IV membrane protein 1 HMOX1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
inclusion body 1 KEAP1
BAD-BCL-2 complex 1 BCL2
outer dynein arm 1 DNAH9
distal portion of axoneme 1 DNAH9


文献列表

  • K Cocquyt, P Cos, P Herdewijn, L Maes, P E Van den Steen, G Laekeman. Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Nov; 18(14):1229-37. doi: 10.1016/j.phymed.2011.08.063. [PMID: 22015320]
  • Raju Gautam, Sanjay M Jachak, Arvind Saklani. Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition. Journal of ethnopharmacology. 2011 Jan; 133(2):928-30. doi: 10.1016/j.jep.2010.11.003. [PMID: 21073945]
  • Josep Coll. NMR shift data of neo-clerodane diterpenes from the genus Ajuga. Phytochemical analysis : PCA. 2002 Nov; 13(6):372-80. doi: 10.1002/pca.671. [PMID: 12494759]
  • M Odek-Ogunde, M S Rajab. Antihypertensive effect of the clerodane diterpene ajugarin I on experimentally hypertensive rats. East African medical journal. 1994 Sep; 71(9):587-90. doi: . [PMID: 7875092]