Etonitazene (BioDeep_00000668590)

   


代谢物信息卡片


2-[2-[(4-ethoxyphenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine

化学式: C22H28N4O3 (396.2161)
中文名称: 依托尼秦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OCC
InChI: InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent

同义名列表

3 个代谢物同义名

2-[2-[(4-ethoxyphenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine; Etonitazene; Etonitazene



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, GRK5, HMGB1, POMC, RBM19
Peripheral membrane protein 1 HMGB1
Endoplasmic reticulum membrane 2 DRD1, PLD2
Nucleus 2 DRD1, HMGB1
cytosol 5 CA1, GRK3, GRK5, GYPA, PRKCQ
dendrite 2 OPRM1, PDYN
nucleoplasm 3 GYPA, HMGB1, RBM19
Cell membrane 8 DRD1, GPRC5A, GYPA, HMGB1, OPRD1, OPRM1, PLD2, SCN4A
Lipid-anchor 1 PLD2
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 5 DRD1, GPRC5A, OPRD1, OPRM1, SCN4A
Synapse 3 NPS, OPRM1, PDYN
cell surface 1 HMGB1
glutamatergic synapse 1 DRD1
Golgi apparatus 1 OPRM1
neuronal cell body 1 PDYN
postsynapse 1 GRK3
presynaptic membrane 2 DRD1, OPRD1
Presynapse 2 GRK3, PLD2
endosome 2 HMGB1, OPRM1
plasma membrane 12 DRD1, GPRC5A, GRK3, GRK5, GYPA, HMGB1, OPRD1, OPRM1, PDYN, PLD2, PRKCQ, SCN4A
synaptic vesicle membrane 1 OPRD1
Membrane 5 GYPA, OPRD1, OPRM1, RBM19, SCN4A
axon 1 OPRM1
extracellular exosome 2 CA1, GPRC5A
endoplasmic reticulum 2 HMGB1, OPRM1
extracellular space 2 HMGB1, POMC
intracellular membrane-bounded organelle 2 GPRC5A, PLD2
Single-pass type I membrane protein 1 GYPA
Secreted 3 HMGB1, PDYN, POMC
extracellular region 4 HMGB1, NPS, PDYN, POMC
Single-pass membrane protein 1 GYPA
hippocampal mossy fiber to CA3 synapse 1 PDYN
Extracellular side 1 HMGB1
centriolar satellite 1 PRKCQ
ciliary membrane 1 DRD1
nuclear membrane 1 GRK5
dendritic spine 1 DRD1
perikaryon 1 OPRM1
nucleolus 2 GPRC5A, RBM19
vesicle 1 GPRC5A
postsynaptic membrane 1 DRD1
GABA-ergic synapse 1 DRD1
Cell projection, dendritic spine 1 DRD1
secretory granule 1 POMC
nuclear speck 2 GRK5, RBM19
receptor complex 1 GPRC5A
neuron projection 2 OPRD1, OPRM1
cilium 1 DRD1
cell projection 1 GRK3
Chromosome 2 HMGB1, RBM19
Nucleus, nucleolus 1 RBM19
non-motile cilium 1 DRD1
Cytoplasmic vesicle membrane 1 GPRC5A
Nucleus, nucleoplasm 1 RBM19
Cell projection, dendrite 2 DRD1, OPRM1
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 2 HMGB1, POMC
transcription repressor complex 1 HMGB1
axon terminus 2 OPRD1, PDYN
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 OPRD1, PDYN
aggresome 1 PRKCQ
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
dendrite membrane 1 OPRD1
condensed chromosome 1 HMGB1
Cell projection, cilium membrane 1 DRD1
voltage-gated sodium channel complex 1 SCN4A
ankyrin-1 complex 1 GYPA
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
G protein-coupled receptor complex 1 DRD1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1


文献列表

  • Marthe M Vandeputte, Nick Verougstraete, Donna Walther, Grant C Glatfelter, Jeroen Malfliet, Michael H Baumann, Alain G Verstraete, Christophe P Stove. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass. Archives of toxicology. 2022 06; 96(6):1865-1880. doi: 10.1007/s00204-022-03294-2. [PMID: 35449307]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Christian Doll, Jens Konietzko, Florian Pöll, Thomas Koch, Volker Höllt, Stefan Schulz. Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. British journal of pharmacology. 2011 Sep; 164(2):298-307. doi: 10.1111/j.1476-5381.2011.01382.x. [PMID: 21449911]