Norethindrone acetate (BioDeep_00000006674)
代谢物信息卡片
Norethindrone acetate; Norethisterone acetate
化学式: C22H28O3 (340.2038)
中文名称: 醋酸炔诺酮
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: C#CC1(OC(C)=O)CCC2C3CCC4=CC(=O)CCC4C3CCC21C
InChI: InChI=1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:7628
- KEGG: C08152
- KEGGdrug: D00953
- PubChem: 5832
- Metlin: METLIN44171
- ChEMBL: CHEMBL1201146
- MeSH: Norethindrone Acetate
- CAS: 51-98-9
- PMhub: MS000019752
- PubChem: 10352
- NIKKAJI: J1.910K
- KNApSAcK: 7628
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- XiaoHong Lan, Shan Cai, Guoxing Li, Kousalya Prabahar, Benjamin Hernández-Wolters, Yanru Yin. Effects of Transdermal 17β-Estradiol + Norethisterone Acetate on Cardiovascular Disease Risk Factors in Postmenopausal Women: A Meta-Analysis of Data From Randomized, Controlled Trials.
Clinical therapeutics.
2023 Oct; ?(?):. doi:
10.1016/j.clinthera.2023.09.002. [PMID: 37852812] - Hong Liu, Jiang Zhan, Jiao He, Lili Zhong, Jing Yang, Qiaomei Dai, Xianlin Zhang. The effect of 17β-estradiol plus norethisterone acetate on blood pressure and inflammation markers: A meta-analysis of randomized controlled trials.
European journal of obstetrics, gynecology, and reproductive biology.
2023 Apr; 285(?):59-68. doi:
10.1016/j.ejogrb.2023.04.004. [PMID: 37060841] - Wenjuan Tao, Xiangying Cai, Mohammad Khaldoun Al Masri, Mihnea-Alexandru Găman, Kousalya Prabahar, Saeed Baradwan, Peijun Mao. The effect of transdermal 17β-estradiol combined with norethisterone acetate treatment on the lipid profile in postmenopausal women: A meta-analysis and systematic review of randomized controlled trials.
Steroids.
2022 09; 185(?):109061. doi:
10.1016/j.steroids.2022.109061. [PMID: 35688182] - Ahmed Abu-Zaid, Mihnea-Alexandru Gaman, Parsa Jamilian, Bolaji Lilian Ilesanmi-Oyelere, Parmida Jamilian, Saeed Baradwan, Juhaina S Bajaman, Kamar Allayl Alras, Emad Kutbi, Ahmed Khalid Maher Al-Ghrairi, Dalya Dhia Sadulah Sadulah, Ebraheem Albazee, Osama Alomar, Ismail A Al-Badawi, Hany Salem. The effect of 17β-estradiol plus norethisterone acetate treatment on the lipid profile in women: a dose-response meta-analysis of randomized controlled trials.
Experimental gerontology.
2022 08; 165(?):111855. doi:
10.1016/j.exger.2022.111855. [PMID: 35640782] - Ahmed Nader, Nael M Mostafa, Farah Ali, Mohamad Shebley. Drug-Drug Interaction Studies of Elagolix with Oral and Transdermal Low-Dose Hormonal Add-Back Therapy.
Clinical pharmacokinetics.
2021 01; 60(1):133-143. doi:
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Hormone molecular biology and clinical investigation.
2020 Jul; 41(3):. doi:
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Clinical endocrinology.
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Contraception.
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Fertility and sterility.
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Climacteric : the journal of the International Menopause Society.
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Maturitas.
2008 Mar; 59(3):249-58. doi:
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Maturitas.
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Climacteric : the journal of the International Menopause Society.
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Akusherstvo i ginekologiia.
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Menopause (New York, N.Y.).
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Atherosclerosis.
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Climacteric : the journal of the International Menopause Society.
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The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
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Fertility and sterility.
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Menopause (New York, N.Y.).
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Maturitas.
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Maturitas.
2006 Jan; 53(2):158-65. doi:
10.1016/j.maturitas.2005.03.011. [PMID: 16368469] - Gulay Kurtay, Batuhan Ozmen, Imge Erguder. A comparison of effects of sequential transdermal administration versus oral administration of estradiol plus norethisterone acetate on serum NO levels in postmenopausal women.
Maturitas.
2006 Jan; 53(1):32-8. doi:
10.1016/j.maturitas.2005.02.004. [PMID: 16325022] - Paolo Vercellini, Giuliana Pietropaolo, Olga De Giorgi, Roberta Pasin, Annalisa Chiodini, Pier Giorgio Crosignani. Treatment of symptomatic rectovaginal endometriosis with an estrogen-progestogen combination versus low-dose norethindrone acetate.
Fertility and sterility.
2005 Nov; 84(5):1375-87. doi:
10.1016/j.fertnstert.2005.03.083. [PMID: 16275232] - Cristiana Vitale, Alessandra Cornoldi, Otavio Gebara, Antonello Silvestri, Mauricio Wajngarten, Elena Cerquetani, Massimo Fini, José Antonio F Ramires, Giuseppe M C Rosano. Interleukin-6 and flow-mediated dilatation as markers of increased vascular inflammation in women receiving hormone therapy.
Menopause (New York, N.Y.).
2005 Sep; 12(5):552-8. doi:
10.1097/01.gme.0000172267.24949.70. [PMID: 16145309] - Mehmet A Osmanağaoğlu, Selen Osmanağaoğlu, Tayfun Osmanağaoğlu, Bakiye Okumuş, Hasan Bozkaya. Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women.
Fertility and sterility.
2005 Aug; 84(2):384-93. doi:
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Acta obstetricia et gynecologica Scandinavica.
2005 May; 84(5):474-7. doi:
10.1111/j.0001-6349.2005.00661.x. [PMID: 15842212] - Jan Brynhildsen, Mats Hammar. Lipids and clotting factors during low dose transdermal estradiol/norethisterone use.
Maturitas.
2005 Apr; 50(4):344-52. doi:
10.1016/j.maturitas.2004.10.001. [PMID: 15780536] - G Christodoulakos, I Lambrinoudaki, C Panoulis, V Sioulas, D Rizos, G Caramalis, D Botsis, G Creatsas. Serum androgen levels and insulin resistance in postmenopausal women: association with hormone therapy, tibolone and raloxifene.
Maturitas.
2005 Apr; 50(4):321-30. doi:
10.1016/j.maturitas.2004.08.002. [PMID: 15780533] - Susana Bassol, Sebastian Carranza-Lira, Cuauhtemoc Celis-Gonzalez, Samuel Santoyo, Alfonso Murillo, Norma Martinez, Javier Santos, Victoriano Llaca, Fernanda Rio de la Loza, Jesus Zarain, Angela Maggio da Fonseca, Aroldo F Camargos, Edmund C Baracat, Marcos F da Sá, Juana Bayo, Liliana Adaro, Carlos Gurucharri, Martha Murga, Nestor Siseles, Fabiana Sayegh, Antonio Tempone, Luis M Tempone, Roberto I Tozzini, Roberto Boccanera, Carlos Naranjo, Fabio Sanchez, Gustavo Gomez, Stella Blanco, Roberto Reyes-Marquez, Gerhard Albrecht, Pedro Cano Rios. The impact of a monophasic continuous estro-progestogenic treatment on Latin American menopausal women.
Maturitas.
2005 Mar; 50(3):189-95. doi:
10.1016/j.maturitas.2004.05.014. [PMID: 15734600] - Rebecca A Shirk, Zhiming Zhang, Richard C Winneker. Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat.
The Journal of steroid biochemistry and molecular biology.
2005 Mar; 94(4):361-8. doi:
10.1016/j.jsbmb.2004.12.026. [PMID: 15857755] - Marie Hofling, Kjell Carlström, Gunilla Svane, Edward Azavedo, Helenius Kloosterboer, Bo Von Schoultz. Different effects of tibolone and continuous combined estrogen plus progestogen hormone therapy on sex hormone binding globulin and free testosterone levels--an association with mammographic density.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2005 Feb; 20(2):110-5. doi:
10.1080/09513590400021151. [PMID: 15823831] - Ata Topçuoglu, Hafize Uzun, Seval Aydin, Nurhan Kahraman, Suphi Vehid, Gorkem Zeybek, Deniz Topçuoglu. The effect of hormone replacement therapy on oxidized low density lipoprotein levels and paraoxonase activity in postmenopausal women.
The Tohoku journal of experimental medicine.
2005 Jan; 205(1):79-86. doi:
10.1620/tjem.205.79. [PMID: 15635276] - Tak-Hong Cheung, Keith Wing-kit Lo, So-Fan Yim, Christopher Lam, Edith Lau, Christopher Haines. Dose effects of progesterone in add-back therapy during GnRHa treatment.
The Journal of reproductive medicine.
2005 Jan; 50(1):35-40. doi:
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Atherosclerosis.
2004 Nov; 177(1):89-96. doi:
10.1016/j.atherosclerosis.2004.05.030. [PMID: 15488870] - F Al-Azzawi, M Wahab, S Sami, A J Proudler, J Thompson, J Stevenson. Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2004 Sep; 7(3):292-300. doi:
10.1080/13697130400001364. [PMID: 15669554] - Yasameen A Shakir, Göran Samsioe, Christina Nerbrand, Jonas Lidfeldt. Combined hormone therapy in postmenopausal women with features of metabolic syndrome. Results from a population-based study of Swedish women: Women's Health in the Lund Area study.
Menopause (New York, N.Y.).
2004 Sep; 11(5):549-55. doi:
10.1097/01.gme.0000133076.09175.6d. [PMID: 15356408] - George Christodoulakos, Irene Lambrinoudaki, Constantinos Panoulis, Constantinos Papadias, Emmanuel Economou, George Creatsas. Effect of hormone therapy and raloxifene on serum VE-cadherin in postmenopausal women.
Fertility and sterility.
2004 Sep; 82(3):634-8. doi:
10.1016/j.fertnstert.2004.03.030. [PMID: 15374707] - Inga-Stina Odmark, Torbjörn Bäckström, Magnus Haeger, Björn Jonsson, Marie Bixo. Effects of continuous combined conjugated estrogen/medroxyprogesterone acetate and 17beta-estadiol/norethisterone acetate on lipids and lipoproteins.
Maturitas.
2004 Jun; 48(2):137-46. doi:
10.1016/j.maturitas.2003.08.004. [PMID: 15172088] - George E Christodoulakos, Constantinos P C Panoulis, Irene V Lambrinoudaki, Dimitrios S Botsis, Spyros G Dendrinos, Emanuel Economou, George C Creatsas. The effect of hormone therapy and raloxifene on serum matrix metalloproteinase-2 and -9 in postmenopausal women.
Menopause (New York, N.Y.).
2004 May; 11(3):299-305. doi:
10.1097/01.gme.0000097848.95550.07. [PMID: 15167309] - G E Christodoulakos, I V Lambrinoudaki, C P Panoulis, C A Papadias, E E Kouskouni, G C Creatsas. Effect of hormone replacement therapy, tibolone and raloxifene on serum lipids, apolipoprotein A1, apolipoprotein B and lipoprotein(a) in Greek postmenopausal women.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2004 May; 18(5):244-57. doi:
10.1080/09513590410001715207. [PMID: 15346660] - A O Mueck, H Seeger, D Wallwiener. Endogenous estradiol metabolism during treatment with oral contraceptives.
International journal of clinical pharmacology and therapeutics.
2004 Mar; 42(3):160-4. doi:
10.5414/cpp42160. [PMID: 15049436] - C Borgfeldt, C Li, G Samsioe. Low-dose oral combination of 17beta-estradiol and norethisterone acetate in postmenopausal women decreases factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1.
Climacteric : the journal of the International Menopause Society.
2004 Mar; 7(1):78-85. doi:
10.1080/13697130310001651508. [PMID: 15259286] - P Conner, A Christow, W Kersemaekers, G Söderqvist, L Skoog, K Carlström, E Tani, M Mol-Arts, B von Schoultz. A comparative study of breast cell proliferation during hormone replacement therapy: effects of tibolon and continuous combined estrogen-progestogen treatment.
Climacteric : the journal of the International Menopause Society.
2004 Mar; 7(1):50-8. doi:
10.1080/13697130310001651472. [PMID: 15259283] - Radhika K Ailawadi, Smeeta Jobanputra, Meera Kataria, Bilgin Gurates, Serdar E Bulun. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study.
Fertility and sterility.
2004 Feb; 81(2):290-6. doi:
10.1016/j.fertnstert.2003.09.029. [PMID: 14967362] - Sirpa Eviö, Aila Tiitinen, Kalevi Laitinen, Olavi Ylikorkala, Matti J Välimäki. Effects of alendronate and hormone replacement therapy, alone and in combination, on bone mass and markers of bone turnover in elderly women with osteoporosis.
The Journal of clinical endocrinology and metabolism.
2004 Feb; 89(2):626-31. doi:
10.1210/jc.2003-030198. [PMID: 14764773] - Helena Forsblad d'Elia, Stephan Christgau, Lars-Ake Mattsson, Tore Saxne, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten. Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456].
Arthritis research & therapy.
2004; 6(5):R457-68. doi:
10.1186/ar1215. [PMID: 15380045] - A R Scott, P Dhindsa, J Forsyth, P Mansell. Effect of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with diabetes.
Diabetes, obesity & metabolism.
2004 Jan; 6(1):16-22. doi:
10.1111/j.1463-1326.2004.00294.x. [PMID: 14686958] - Alessandra Crisafulli, Domenica Altavilla, Giovanni Squadrito, Adolfo Romeo, Elena B Adamo, Rolando Marini, Maria A Inferrera, Herbert Marini, Alessandra Bitto, Rosario D'Anna, Francesco Corrado, Sebastiano Bartolone, Nicola Frisina, Francesco Squadrito. Effects of the phytoestrogen genistein on the circulating soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin system in early postmenopausal women.
The Journal of clinical endocrinology and metabolism.
2004 Jan; 89(1):188-92. doi:
10.1210/jc.2003-030891. [PMID: 14715848] - Bora Cengiz, Cem Atabekoglu, Esra Cetinkaya, Sevim Dincer Cengiz. Effect of hormone replacement therapy on serum levels of tumor markers in healthy postmenopausal women.
Maturitas.
2003 Dec; 46(4):301-6. doi:
10.1016/s0378-5122(03)00220-2. [PMID: 14625127] - Mehmet Yilmazer, Veysel Fenkci, Semin Fenkci, Murat Sonmezer, Orhan Aktepe, Mustafa Altindis, Gulay Kurtay. Hormone replacement therapy, C-reactive protein, and fibrinogen in healthy postmenopausal women.
Maturitas.
2003 Dec; 46(4):245-53. doi:
10.1016/s0378-5122(03)00217-2. [PMID: 14625121] - Babur Kaleli, Basak Yildirim, Suleyman Demir, Erkan Alatas. Effects of low-dose 17-beta-estradiol plus norethisterone acetate and tibolone on fasting plasma homocysteine levels in postmenopausal women.
Acta obstetricia et gynecologica Scandinavica.
2003 Dec; 82(12):1107-11. doi:
10.1046/j.1600-0412.2003.00232.x. [PMID: 14616255] - Antonio Cano, Joaquin Calaf, Javier Molina. The lipid and clinical effects of sequential transdermal estradiol and estradiol/norethisterone acetate in 674 women.
Archives of gynecology and obstetrics.
2003 Oct; 268(4):317-22. doi:
10.1007/s00404-002-0441-1. [PMID: 14504877] - Stanisław Radowicki, Katarzyna Skórzewska, Joanna Matuszkiewicz-Rowińska. [Changes in bone density in hemodialysed women treated with transdermal hormone replacement therapy].
Ginekologia polska.
2003 Sep; 74(9):997-1001. doi:
NULL. [PMID: 14674158] - Olavi Ylikorkala, Sirpa Eviö, Matti Välimäki, Aila Tiitinen. Effects of hormone therapy and alendronate on C-reactive protein, E-selectin, and sex hormone-binding globulin in osteoporotic women.
Fertility and sterility.
2003 Sep; 80(3):541-5. doi:
10.1016/s0015-0282(03)00753-2. [PMID: 12969695] - Nicoletta Biglia, Simona Ambroggio, Riccardo Ponzone, Luca Sgro, Ester Ujcic, Fabrizia Actis Dato, Piero Sismondi. Modification of serum IGF-I, IGFBPs and SHBG levels by different HRT regimens.
Maturitas.
2003 Aug; 45(4):283-91. doi:
10.1016/s0378-5122(03)00156-7. [PMID: 12927315] - B von Schoultz. Clinical efficacy and safety of combined estradiol valerate and dienogest: a new no-bleed treatment.
Climacteric : the journal of the International Menopause Society.
2003 Aug; 6 Suppl 2(?):24-32. doi:
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Human reproduction (Oxford, England).
2003 Aug; 18(8):1747-52. doi:
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Journal of endocrinological investigation.
2003 Jun; 26(6):545-51. doi:
10.1007/bf03345218. [PMID: 12952369] - Francesco Squadrito, Domenica Altavilla, Alessandra Crisafulli, Antonino Saitta, Domenico Cucinotta, Nunziata Morabito, Rosario D'Anna, Francesco Corrado, Pietro Ruggeri, Nicola Frisina, Giovanni Squadrito. Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study.
The American journal of medicine.
2003 Apr; 114(6):470-6. doi:
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