Sulbactam (BioDeep_00000006598)

   


代谢物信息卡片


Sulbactam (sodium salt)

化学式: C8H11NO5S (233.0357916)
中文名称: 舒巴坦酸
谱图信息: 最多检出来源 Anoectochilus roxburghii(viridiplantae) 50%

分子结构信息

SMILES: CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)C
InChI: InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CG - Beta-lactamase inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D065093 - beta-Lactamase Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C2140 - Adjuvant > C183118 - Beta-lactamase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

Sulbactam; Sulbactam (sodium salt)



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ashok K Rout, Saurabh Gautam, Vipin Kumar Mishra, Mandar Bopardikar, Budheswar Dehury, Himanshu Singh. NMR insights into β-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii. Journal of magnetic resonance (San Diego, Calif. : 1997). 2024 May; 362(?):107689. doi: 10.1016/j.jmr.2024.107689. [PMID: 38677224]
  • Xupeng Shao, Yuanyuan Ren, Na Xie, Kailiang Fan, Haiyan Sun, Jiamin Lu, Jiuxiang Wei, Xincheng Tian. Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis. Medical science monitor : international medical journal of experimental and clinical research. 2023 Jun; 29(?):e939203. doi: 10.12659/msm.939203. [PMID: 37271979]
  • Yaqian Li, Guangcai Yu, Longke Shi, Liwen Zhao, Zixin Wen, Baotian Kan, Wenjun Wang, Xiangdong Jian. Severe methyl bromide poisoning causing early acute renal failure and anuria: a case report. The Journal of international medical research. 2022 Oct; 50(10):3000605221122619. doi: 10.1177/03000605221122619. [PMID: 36250482]
  • Irina Staib-Lasarzik, Sophie Lehr, Ann Kristin Rosner, Ralph Timaru-Kast, Katharina Hoeter, Kai Bruns, Daniel Wollschläger, Stefan Heinrich, Serge C Thal, Kristin Engelhard. Influence of intraoperative fluid replacement on ampicillin serum levels and surgical site infections. Surgery. 2022 Aug; 172(2):648-654. doi: 10.1016/j.surg.2022.03.041. [PMID: 35570162]
  • Sukrit Srisakul, Dhammika Leshan Wannigama, Paul G Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Thammakorn Saethang, Sirirat Luk-In, Tingting Liao, Naris Kueakulpattana, Aye Mya Sithu Shein, Lin Gan, Rosalyn Kupwiwat, Chanikan Tanasatitchai, Pattama Wapeesittipan, Phatthranit Phattharapornjaroen, Vishnu Nayak Badavath, Asada Leelahavanichkul, Tanittha Chatsuwan. Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin-sulbactam combination therapy. Scientific reports. 2022 07; 12(1):11390. doi: 10.1038/s41598-022-15386-1. [PMID: 35794134]
  • Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler. Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility. Microbiology spectrum. 2022 06; 10(3):e0054222. doi: 10.1128/spectrum.00542-22. [PMID: 35647655]
  • Viviane Chaiben, Carolina Hikari Yamada, João Paulo Telles, Ana Paula de Andrade, Lavinia Nery Villa Stangler Arend, Victoria Stadler Tasca Ribeiro, Leticia Ramos Dantas, Paula Hansen Suss, Felipe Francisco Tuon. A carbapenem-resistant Acinetobacter baumannii outbreak associated with a polymyxin shortage during the COVID pandemic: an in vitro and biofilm analysis of synergy between meropenem, gentamicin and sulbactam. The Journal of antimicrobial chemotherapy. 2022 05; 77(6):1676-1684. doi: 10.1093/jac/dkac102. [PMID: 35368079]
  • Tetsushu Onita, Kazuro Ikawa, Noriyuki Ishihara, Hiroki Tamaki, Takahisa Yano, Kohji Naora, Norifumi Morikawa. Pharmacodynamic Evaluation of Ampicillin-sulbactam in Pediatric Patients Using Plasma and Urine Data. The Pediatric infectious disease journal. 2022 05; 41(5):411-416. doi: 10.1097/inf.0000000000003496. [PMID: 35195566]
  • Shunsuke Takahara, Takeo Tokura, Ryota Nishida, Atsuo Uefuji, Katsuhito Ichimura, Hirotaka Nishihara, Kenji Aoki, Hiroyuki Takayama, Natsuko Nakagawa, Toshihiko Harada. Ampicillin/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study. Injury. 2022 Apr; 53(4):1517-1522. doi: 10.1016/j.injury.2022.01.033. [PMID: 35090733]
  • Licai Mo, Jiajia Wang, Jiao Qian, Minfei Peng. Antibiotic Sensitivity of Proteus mirabilis Urinary Tract Infection in Patients with Urinary Calculi. International journal of clinical practice. 2022; 2022(?):7273627. doi: 10.1155/2022/7273627. [PMID: 36628152]
  • Li-Ping Han, Han-Yan Xiao, Li-Li Fang. A retrospective study of azithromycin and ceftizoxime for the management of children with Mycoplasma pneumoniae pneumonia. Medicine. 2021 Nov; 100(44):e27564. doi: 10.1097/md.0000000000027564. [PMID: 34871221]
  • Tetsushu Onita, Kazuro Ikawa, Kogenta Nakamura, Genya Nishikawa, Ikuo Kobayashi, Noriyuki Ishihara, Hiroki Tamaki, Takahisa Yano, Kohji Naora, Norifumi Morikawa. Prostatic Pharmacokinetic/Pharmacodynamic Evaluation of Ampicillin-Sulbactam for Bacterial Prostatitis and Preoperative Prophylaxis. Journal of clinical pharmacology. 2021 06; 61(6):820-831. doi: 10.1002/jcph.1800. [PMID: 33314138]
  • Tomokazu Suzuki, Erika Sugiyama, Kenji Nozawa, Masataka Tajima, Kyoka Takahashi, Masayoshi Yoshii, Hidenori Suzuki, Vilasinee H Sato, Hitoshi Sato. Effects of dosing frequency on the clinical efficacy of ampicillin/sulbactam in Japanese elderly patients with pneumonia: A single-center retrospective observational study. Pharmacology research & perspectives. 2021 04; 9(2):e00746. doi: 10.1002/prp2.746. [PMID: 33764686]
  • Kathrin Rothe, Susanne Feihl, Jochen Schneider, Fabian Wallnöfer, Milena Wurst, Marina Lukas, Matthias Treiber, Tobias Lahmer, Markus Heim, Michael Dommasch, Birgit Waschulzik, Alexander Zink, Christiane Querbach, Dirk H Busch, Roland M Schmid, Gerhard Schneider, Christoph D Spinner. Rates of bacterial co-infections and antimicrobial use in COVID-19 patients: a retrospective cohort study in light of antibiotic stewardship. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Apr; 40(4):859-869. doi: 10.1007/s10096-020-04063-8. [PMID: 33140176]
  • Demet Nalbant, Joshua A Reeder, Peizhi Li, Cormac T O'Sullivan, William K Rogers, Guohua An. Development and validation of a simple and sensitive LC-MS/MS method for quantification of ampicillin and sulbactam in human plasma and its application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2021 Mar; 196(?):113899. doi: 10.1016/j.jpba.2021.113899. [PMID: 33508765]
  • Yee-Huang Ku, Wen-Liang Yu. Cefoperazone/sulbactam: New composites against multiresistant gram negative bacteria?. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2021 03; 88(?):104707. doi: 10.1016/j.meegid.2021.104707. [PMID: 33418147]
  • Zerrin Orbak, Fuat Laloglu, Hulya Akat. Effectiveness of lopinavir/ritonavir on COVID-19-related pneumonia in a child with COVID-19-associated Kawasaki disease. Cardiology in the young. 2021 Mar; 31(3):507-510. doi: 10.1017/s1047951120004291. [PMID: 33183365]
  • Kaihang Yu, Weiliang Zeng, Ye Xu, Wenli Liao, Wenya Xu, Tieli Zhou, Jianming Cao, Lijiang Chen. Bloodstream infections caused by ST2 Acinetobacter baumannii: risk factors, antibiotic regimens, and virulence over 6 years period in China. Antimicrobial resistance and infection control. 2021 01; 10(1):16. doi: 10.1186/s13756-020-00876-6. [PMID: 33461617]
  • Yuanjun Wu, Yong Wu, Yong Yang, Baochan Chen, Jianqun Li, Ganping Guo, Fu Xiong. Case Report: First Case of Cefotaxime-Sulbactam-Induced Acute Intravascular Hemolysis in a Newborn With ABO Blood Type Incompatibility by the Mechanism of Non-Immunologic Protein Adsorption. Frontiers in immunology. 2021; 12(?):698541. doi: 10.3389/fimmu.2021.698541. [PMID: 35003054]
  • Kayoko Matsubara, Kazuaki Matsumoto, Yuta Yokoyama, Erika Watanabe, Yuki Enoki, Akari Shigemi, Kazuro Ikawa, Hideyuki Terazono, Norifumi Morikawa, Tamao Ohshige, Yasuo Takeda. Dosing Optimization of Ampicillin-Sulbactam Based on Cystatin C in Elderly Patients with Pneumonia. Biological & pharmaceutical bulletin. 2021; 44(5):732-736. doi: 10.1248/bpb.b20-00781. [PMID: 33952829]
  • Zhi Rao, Zi-Long Dang, Bin Li, Lei Zhu, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei. Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients. Therapeutic drug monitoring. 2020 08; 42(4):578-587. doi: 10.1097/ftd.0000000000000736. [PMID: 32049891]
  • Haoran Mu, Man Yang, Yueyue Zhang, Yajing Zhang, Juan Wang, Weijie Yuan, Shu Rong. Pet-related Pasteurella multocida induced peritonitis in peritoneal dialysis: a case report and review of the literatures. BMC nephrology. 2020 03; 21(1):102. doi: 10.1186/s12882-020-01765-1. [PMID: 32192435]
  • Liang Meng, Lingti Kong, Chenchen Wu, Benquan Qi, Xiaofei Wu. Pharmacokinetics of cefoperazone/sulbactam in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after external ventricular drains. European journal of clinical pharmacology. 2020 Jan; 76(1):127-129. doi: 10.1007/s00228-019-02773-3. [PMID: 31642959]
  • Yan Tan, Qianhui Song, Wenfang Liu, Ming Li, Jian Xiao, Chuanpin Chen. Dual-channel Microchip Electrophoresis with Amperometric Detection System for Rapid Analysis of Cefoperazone and Sulbactam. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2019 Oct; 35(10):1103-1109. doi: 10.2116/analsci.19p088. [PMID: 31231088]
  • Yuzhu Dong, Ying Li, Ying Zhang, Tao Zhang, Li Zhu, Yaling Dong, Taotao Wang. Cefoperazone/sulbactam therapeutic drug monitoring in patients with liver cirrhosis: Potential factors affecting the pharmacokinetic/pharmacodynamic target attainment. Basic & clinical pharmacology & toxicology. 2019 Oct; 125(4):353-359. doi: 10.1111/bcpt.13245. [PMID: 31056857]
  • John O'Donnell, Richard A Preston, Grigor Mamikonyan, Emily Stone, Robin Isaacs. Pharmacokinetics, Safety, and Tolerability of Intravenous Durlobactam and Sulbactam in Subjects with Renal Impairment and Healthy Matched Control Subjects. Antimicrobial agents and chemotherapy. 2019 09; 63(9):. doi: 10.1128/aac.00794-19. [PMID: 31307978]
  • Sutep Jaruratanasirikul, Wajanarat Nitchot, Wibul Wongpoowarak, Maseetoh Samaeng, Monchana Nawakitrangsan. Population pharmacokinetics and Monte Carlo simulations of sulbactam to optimize dosage regimens in patients with ventilator-associated pneumonia caused by Acinetobacter baumannii. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Aug; 136(?):104940. doi: 10.1016/j.ejps.2019.05.018. [PMID: 31132402]
  • Friederike Bachmann, Thomas Adam, Frank Friedersdorff, Lutz Liefeldt, Torsten Slowinski, Klemens Budde, Johannes Waiser. Perioperative antibiotic prophylaxis in renal transplantation: a single-center comparison between two regimens and a brief survey among the Eurotransplant renal transplantation centers. World journal of urology. 2019 May; 37(5):957-967. doi: 10.1007/s00345-018-2440-2. [PMID: 30109484]
  • Stelios F Assimakopoulos, Vassilis Karamouzos, Aikaterini Lefkaditi, Christina Sklavou, Fevronia Kolonitsiou, Mirto Christofidou, Fotini Fligou, Charalambos Gogos, Markos Marangos. Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study. Le infezioni in medicina. 2019 Mar; 27(1):11-16. doi: NULL. [PMID: 30882373]
  • Keith A Rodvold, Mark H Gotfried, Robin D Isaacs, John P O'Donnell, Emily Stone. Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects. Antimicrobial agents and chemotherapy. 2018 11; 62(11):. doi: 10.1128/aac.01089-18. [PMID: 30126953]
  • Yun Cai, Deqing Yang, Jin Wang, Rui Wang. Amikacin and cefoperazone/sulbactam alone or in combination against carbapenem-resistant Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease. 2018 Jun; 91(2):186-190. doi: 10.1016/j.diagmicrobio.2018.01.023. [PMID: 29486972]
  • Xiu-Jun Wu, Xin Huang, Hai-Yan Shi, Xing-Kai Chen, Qian Dong, Guo-Xiang Hao, Yan Li, Yi Zheng, Wei Zhao. Determination of cefoperazone and sulbactam in serum by HPLC-MS/MS: An adapted method for therapeutic drug monitoring in children. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4143. [PMID: 29148595]
  • Hongbin Chen, Qi Wang, Yuyao Yin, Shuguang Li, Deng-Ke Niu, Hui Wang. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. International journal of antimicrobial agents. 2018 Apr; 51(4):655-658. doi: 10.1016/j.ijantimicag.2017.12.006. [PMID: 29247687]
  • L Cheng, Y L Gong, X Q Luo, C Zhang, M X Liu, Y Z Peng. [Clinical characteristics of burn patients infected with Stenotrophomonas maltophilia and antibiotic resistance of the strains]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2018 Feb; 34(2):78-82. doi: 10.3760/cma.j.issn.1009-2587.2018.02.004. [PMID: 29973024]
  • Shijie Wen, Changyuan Wang, Yingjie Duan, Xiaokui Huo, Qiang Meng, Zhihao Liu, Shilei Yang, Yanna Zhu, Huijun Sun, Xiaodong Ma, Siyun Yang, Kexin Liu. OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam. International journal of pharmaceutics. 2018 Feb; 537(1-2):172-182. doi: 10.1016/j.ijpharm.2017.12.037. [PMID: 29277663]
  • Yoshitsugu Higashi, Shigeki Nakamura, Yasuhiro Tsuji, Chika Ogami, Kaoru Matsumoto, Koyomi Kawago, Kotaro Tokui, Ryuji Hayashi, Ippei Sakamaki, Yoshihiro Yamamoto. Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature. Internal medicine (Tokyo, Japan). 2018 Jan; 57(2):253-258. doi: 10.2169/internalmedicine.9010-17. [PMID: 29093391]
  • Sarah M Depenbrock, Katharine M Simpson, Andrew J Niehaus, Jeffrey Lakritz, Mark G Papich. Pharmacokinetics of ampicillin-sulbactam in serum and synovial fluid samples following regional intravenous perfusion in the distal portion of a hind limb of adult cattle. American journal of veterinary research. 2017 Dec; 78(12):1372-1379. doi: 10.2460/ajvr.78.12.1372. [PMID: 29182388]
  • Yusuke Yamanaka, Akira Shimabukuro. Septic abortion presenting as a right lower trapezius abscess secondary to Bacteroides fragilis bacteraemia. BMJ case reports. 2017 Aug; 2017(?):. doi: 10.1136/bcr-2016-219135. [PMID: 28827296]
  • Imran Ali, Muhammad Shabbir. Antibiotics susceptibility patterns of uropathogenic E. coli with special reference to fluoroquinolones in different age and gender groups. JPMA. The Journal of the Pakistan Medical Association. 2017 Aug; 67(8):1161-1165. doi: NULL. [PMID: 28839298]
  • Toyomitsu Sawai, Takumi Nakao, Shota Yamaguchi, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Katsunori Yanagihara, Hiroshi Mukae. Detection of high serum levels of β-D-Glucan in disseminated nocardial infection: a case report. BMC infectious diseases. 2017 Apr; 17(1):272. doi: 10.1186/s12879-017-2370-4. [PMID: 28407752]
  • Sutep Jaruratanasirikul, Wibul Wongpoowarak, Thitima Wattanavijitkul, Waroonrat Sukarnjanaset, Maseetoh Samaeng, Monchana Nawakitrangsan, Natnicha Ingviya. Population Pharmacokinetics and Pharmacodynamics Modeling To Optimize Dosage Regimens of Sulbactam in Critically Ill Patients with Severe Sepsis Caused by Acinetobacter baumannii. Antimicrobial agents and chemotherapy. 2016 12; 60(12):7236-7244. doi: 10.1128/aac.01669-16. [PMID: 27671056]
  • Pan Hongguang, Li Lan, Wu Zebin, Chen Guowei. Pediatric nasal orbital cellulitis in Shenzhen (South China): Etiology, management, and outcomes. International journal of pediatric otorhinolaryngology. 2016 Aug; 87(?):98-104. doi: 10.1016/j.ijporl.2016.06.007. [PMID: 27368452]
  • Yuta Yokoyama, Kazuaki Matsumoto, Kazuro Ikawa, Erika Watanabe, Hiroyuki Yamamoto, Yutaka Imoto, Norifumi Morikawa, Yasuo Takeda. The pharmacokinetics of ampicillin-sulbactam in anuric patients: dosing optimization for prophylaxis during cardiovascular surgery. International journal of clinical pharmacy. 2016 Aug; 38(4):771-5. doi: 10.1007/s11096-016-0286-5. [PMID: 27001408]
  • Yeliz Çetinkol, Murat Telli, Arzu Altunçekiç Yıldırım, Mustafa Kerem Çalgın. [Evaluation of the efficacy of colistin/sulbactam combination on carbapenem-resistant Acinetobacter baumannii strains]. Mikrobiyoloji bulteni. 2016 Jul; 50(3):460-5. doi: 10.5578/mb.26289. [PMID: 27525401]
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  • Yang Xili, Li Yue, Zhan Jianhua, Guo Fei, Min Dinghong, Wang Nianyun, Li Guohui, Guo Guanghua. [Analysis of the mechanism of drug resistance of VIM-2-type metallo-β-lactamase-producing Acineto- bacter baumannii isolated from burn patients and its homology]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2015 Jun; 31(3):205-10. doi: . [PMID: 26564568]
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  • Sema Aşkin Keçeli, Ayse Willke, Gulden Sonmez Tamer, Ozden Buyukbaba Boral, Nese Sonmez, Penbe Cağatay. Interaction between caspofungin or voriconazole and cefoperazone-sulbactam or piperacillin-tazobactam by in vitro and in vivo methods. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2014 May; 122(5):412-7. doi: 10.1111/apm.12159. [PMID: 24033828]
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  • Elena Soto, Satoshi Shoji, Chieko Muto, Yoshiro Tomono, Scott Marshall. Population pharmacokinetics of ampicillin and sulbactam in patients with community-acquired pneumonia: evaluation of the impact of renal impairment. British journal of clinical pharmacology. 2014 Mar; 77(3):509-21. doi: 10.1111/bcp.12232. [PMID: 24102758]
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