Trimethaphan (BioDeep_00000006435)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

3,5-dibenzyl-4-oxo-8λ⁴-thia-3,5-diazatricyclo[6.3.0.0²,⁶]undecan-8-ylium

化学式: C22H25N2OS+ (365.16875)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 55.36%

分子结构信息

SMILES: C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
InChI: InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

描述信息

Trimethaphan is only found in individuals that have used or taken this drug. It is a nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. [PubChem]Trimethaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimethaphans hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural.
C - Cardiovascular system > C02 - Antihypertensives > C02B - Antiadrenergic agents, ganglion-blocking > C02BA - Sulfonium derivatives
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D005730 - Ganglionic Blockers
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents

同义名列表

6 个代谢物同义名

3,5-dibenzyl-4-oxo-8λ⁴-thia-3,5-diazatricyclo[6.3.0.0²,⁶]undecan-8-ylium; Trimetaphanum; TRIMETHAPHAN; Thimethaphan; Trimetaphan; Trimethaphan

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:9728
KEGG: C07174
PubChem: 23576
HMDB: HMDB0015248
DrugBank: DB01116
ChEMBL: CHEMBL1201329
Wikipedia: Trimetaphan camsilate
MeSH: Trimethaphan
chemspider: 22044
CAS: 7187-66-8
CAS: 7728-39-4
PMhub: MS000019472
PubChem: 9383
NIKKAJI: J209.355C
RefMet: Trimethaphan
KNApSAcK: 9728

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jens Jordan, Cyndya Shibao, Italo Biaggioni. Multiple system atrophy: using clinical pharmacology to reveal pathophysiology. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 Feb; 25(1):53-9. doi: 10.1007/s10286-015-0271-4. [PMID: 25757803]
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Melissa Li, Xiaoling Dai, Stephanie Watts, David Kreulen, Gregory Fink. Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Nov; 295(5):R1546-54. doi: 10.1152/ajpregu.00783.2007. [PMID: 18768769]
Yehonatan Sharabi, David S Goldstein, Oladi Bentho, Ahmed Saleem, Sandra Pechnik, Marilla F Geraci, Courtney Holmes, Karel Pacak, Graeme Eisenhofer. Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma. Journal of hypertension. 2007 Nov; 25(11):2286-95. doi: 10.1097/hjh.0b013e3282ef5fac. [PMID: 17921824]
Frans H H Leenen, Anne Fourney, Elizabeth Coletta, Roselyn White. Effects of hypertension on cardiovascular responses to epinephrine in humans. American journal of physiology. Heart and circulatory physiology. 2007 Jun; 292(6):H3025-31. doi: 10.1152/ajpheart.01200.2006. [PMID: 17307999]
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Yehonatan Sharabi, Basil Eldadah, Sheng-Ting Li, Rhaguveer Dendi, Sandra Pechnik, Courtney Holmes, David S Goldstein. Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes. Clinical neuropharmacology. 2006 May; 29(3):97-105. doi: 10.1097/01.wnf.0000220822.80640.0d. [PMID: 16772807]
Demetra D Christou, Pamela Parker Jones, Jens Jordan, André Diedrich, David Robertson, Douglas R Seals. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation. 2005 Feb; 111(4):494-8. doi: 10.1161/01.cir.0000153864.24034.a6. [PMID: 15687139]
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Jens Jordan, John R Shannon, Andre Diedrich, Bonnie K Black, David Robertson. Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension (Dallas, Tex. : 1979). 2002 Jan; 39(1):173-8. doi: 10.1161/hy1201.097202. [PMID: 11799098]
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B Nellgård, G B Mackensen, G Massey, R D Pearlstein, D S Warner. The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. Anesthesia and analgesia. 2000 Jul; 91(1):145-51. doi: 10.1097/00000539-200007000-00027. [PMID: 10866902]
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J Jordan, J R Shannon, G Jacob, B Pohar, D Robertson. Interaction of genetic predisposition and environmental factors in the pathogenesis of idiopathic orthostatic intolerance. The American journal of the medical sciences. 1999 Nov; 318(5):298-303. doi: 10.1097/00000441-199911000-00003. [PMID: 10555091]
D S Goldstein, K J Swoboda, J M Miles, S W Coppack, A Aneman, C Holmes, I Lamensdorf, G Eisenhofer. Sources and physiological significance of plasma dopamine sulfate. The Journal of clinical endocrinology and metabolism. 1999 Jul; 84(7):2523-31. doi: 10.1210/jcem.84.7.5864. [PMID: 10404831]
G B Mackensen, B Nellgård, Y Miura, C T Chu, F Dexter, R D Pearlstein, D S Warner. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 1999 Mar; 90(3):873-81. doi: 10.1097/00000542-199903000-00031. [PMID: 10078690]
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J S Petersen, W Liu, D R Kapusta, K J Varner. Metformin inhibits ganglionic neurotransmission in renal nerves. Hypertension (Dallas, Tex. : 1979). 1997 May; 29(5):1173-7. doi: 10.1161/01.hyp.29.5.1173. [PMID: 9149683]
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M Endoh, T Takamura, T Shiga, R Ogawa. [Effect of intra-operative fluid on renal function during hypotensive anesthesia with trimethaphan]. Masui. The Japanese journal of anesthesiology. 1996 Jan; 45(1):15-20. doi: NULL. [PMID: 8865719]
P C Chang, E Grossman, I J Kopin, D S Goldstein, C J Folio, C Holmes. On the existence of functional angiotensin II receptors on vascular sympathetic nerve terminals in the human forearm. Journal of hypertension. 1995 Nov; 13(11):1275-84. doi: 10.1097/00004872-199511000-00009. [PMID: 8984125]
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N Nagata, T Matsukado, M Takeshita, G Yoshikawa, M Takasaki. [Effect of deliberate hypotension on renal functions during epidural block plus inhalation anesthesia: a comparison of prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1994 Oct; 43(10):1472-7. doi: . [PMID: 7815696]
P C Chang, E Grossman, I J Kopin, D S Goldstein. On the existence of functional beta-adrenoceptors on vascular sympathetic nerve endings in the human forearm. Journal of hypertension. 1994 Jun; 12(6):681-90. doi: NULL. [PMID: 7963493]
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M Takasaki, S Sakimura, M Takeshita, T Hamakawa. [Pharmacokinetics of epidurally administered bupivacaine during prostaglandin E1- or trimetaphan-induced hypotension]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):779-84. doi: NULL. [PMID: 1608154]
M Horiuchi. [Effects of hypotensive anesthesia with prostaglandin E1 or trimethaphan on renal microstructure]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):785-90. doi: NULL. [PMID: 1608155]
T G Monk, M Mueller, P F White. Treatment of stress response during balanced anesthesia. Comparative effects of isoflurane, alfentanil, and trimethaphan. Anesthesiology. 1992 Jan; 76(1):39-45. doi: 10.1097/00000542-199201000-00006. [PMID: 1346082]
Y Nomura, M Nomura, H Koizumi, K Ozaki, M Kawamata, M Fujita. [Effects of induced hypotensive anesthesia on the blood coagulation-fibrinolysis system measured by thrombelastography--comparison between prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1992 Jan; 41(1):86-91. doi: . [PMID: 1545507]
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K Nakazawa, C Taneyama, K T Benson, G K Unruh, H Goto. Mixtures of sodium nitroprusside and trimethaphan for induction of hypotension. Anesthesia and analgesia. 1991 Jul; 73(1):59-63. doi: 10.1213/00000539-199107000-00012. [PMID: 1858992]
K Hirota, M Muraoka, S Takahashi, E Ogasawara, H Ishihara, A Matsuki. [Effect of induced hypotension with prostaglandin E1 or trimetaphan on endocrine functions in surgical patients]. Masui. The Japanese journal of anesthesiology. 1991 May; 40(5):763-8. doi: NULL. [PMID: 2072520]
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