Tautomycin (BioDeep_00000005803)

 

Secondary id: BioDeep_00001868995

natural product


代谢物信息卡片


Tautomycin from Streptomyces spiroverticillatus

化学式: C41H66O13 (766.4503)
中文名称: 互变霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)[C@H]([C@@H]([C@@H](CC(=O)[C@@H](C)[C@H](CC[C@@H](C)[C@H]1[C@@H](C)CC[C@@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(=O)C)O2)O1)O)O)OC)OC(=O)C[C@H](C1=C(C)C(=O)OC1=O)O
InChI: InChI=1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1

描述信息

D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D004791 - Enzyme Inhibitors

同义名列表

3 个代谢物同义名

Tautomycin from Streptomyces spiroverticillatus; Tautomycin; Tautomycin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, AR, CASP3, MYLK, NR3C2, PPP1CA, PPP1CB, PPP1R12A, PPP2CA, PRKX, RAF1, RHOA
Endoplasmic reticulum membrane 3 CD4, NR3C2, RHOA
Nucleus 10 AKT1, AR, CASP3, NR3C2, PPP1CA, PPP1CB, PPP2CA, PRKX, RAF1, RHOA
cytosol 13 AKT1, AR, CASP3, MYLK, NR3C2, PDE3B, PPP1CA, PPP1CB, PPP1R12A, PPP2CA, PRKCQ, RAF1, RHOA
centrosome 1 PPP1R12A
nucleoplasm 8 AKT1, AR, CASP3, NR3C2, PPP1CA, PPP1CB, PPP1R12A, PRKX
Cell membrane 4 AKT1, CD4, RAF1, RHOA
Lipid-anchor 1 RHOA
Cytoplasmic side 1 RHOA
Cleavage furrow 2 MYLK, RHOA
lamellipodium 3 AKT1, MYLK, RHOA
ruffle membrane 1 RHOA
Multi-pass membrane protein 1 PDE3B
Synapse 2 MYLK, PPP2CA
cell cortex 2 AKT1, RHOA
cell junction 1 RHOA
glutamatergic synapse 4 AKT1, CASP3, PPP1CA, RHOA
Golgi apparatus 2 PDE3B, RAF1
Golgi membrane 1 INS
neuronal cell body 1 CASP3
postsynapse 2 AKT1, RHOA
Presynapse 1 PPP1CA
endosome 1 RHOA
plasma membrane 11 AKT1, AR, CD4, F2, MYLK, PPP1CA, PPP1R12A, PPP2CA, PRKCQ, RAF1, RHOA
Membrane 4 AKT1, AR, PDE3B, PPP2CA
extracellular exosome 5 F2, PPP1CA, PPP1CB, PPP2CA, RHOA
endoplasmic reticulum 1 PDE3B
extracellular space 2 F2, INS
guanyl-nucleotide exchange factor complex 1 PDE3B
adherens junction 1 PPP1CA
mitochondrion 2 PPP2CA, RAF1
protein-containing complex 2 AKT1, AR
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 CD4
Secreted 3 F2, INS, PRB1
extracellular region 3 F2, INS, PRB1
cytoplasmic side of plasma membrane 1 RHOA
mitochondrial outer membrane 1 RAF1
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 CD4
actin cytoskeleton 2 MYLK, PPP1R12A
dendritic spine 2 PPP1CA, RHOA
perikaryon 1 PPP1CA
Z disc 1 PPP1R12A
microtubule cytoskeleton 2 AKT1, PPP2CA
nucleolus 3 PPP1CA, PPP1CB, PPP1R12A
midbody 1 RHOA
Early endosome 1 CD4
cell-cell junction 1 AKT1
vesicle 2 AKT1, RHOA
Cell projection, lamellipodium 2 MYLK, RHOA
Membrane raft 2 CD4, PPP2CA
focal adhesion 3 PPP1CB, PPP1R12A, RHOA
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 F2
contractile muscle fiber 1 PPP1R12A
nuclear speck 1 AR
receptor complex 1 NR3C2
ciliary basal body 1 AKT1
chromatin 2 AR, NR3C2
cell periphery 1 RHOA
cytoskeleton 1 RHOA
Nucleus, nucleolus 2 PPP1CA, PPP1CB
spindle pole 1 PPP2CA
Cytoplasm, cell cortex 1 RHOA
blood microparticle 1 F2
Cytoplasm, cytoskeleton, spindle pole 1 PPP2CA
endosome lumen 1 INS
Chromosome, centromere 1 PPP2CA
Nucleus, nucleoplasm 2 PPP1CA, PPP1CB
Cell projection, dendrite 1 RHOA
pseudopodium 1 RAF1
stress fiber 2 MYLK, PPP1R12A
secretory granule lumen 1 INS
secretory granule membrane 1 RHOA
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 CD4, F2, INS
kinetochore 1 PPP1R12A
transport vesicle 1 INS
FAR/SIN/STRIPAK complex 1 PPP2CA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
chromosome, centromeric region 1 PPP2CA
clathrin-coated endocytic vesicle membrane 1 CD4
Cytoplasm, cytoskeleton, stress fiber 2 MYLK, PPP1R12A
A band 1 PPP1R12A
PTW/PP1 phosphatase complex 3 PPP1CA, PPP1CB, PPP1R12A
ficolin-1-rich granule membrane 1 RHOA
death-inducing signaling complex 1 CASP3
apical junction complex 1 RHOA
T cell receptor complex 1 CD4
protein serine/threonine phosphatase complex 1 PPP2CA
protein phosphatase type 2A complex 1 PPP2CA
glycogen granule 1 PPP1CA


文献列表

  • Atsushi Takemiya, Shota Yamauchi, Takayuki Yano, Chie Ariyoshi, Ken-ichiro Shimazaki. Identification of a regulatory subunit of protein phosphatase 1 which mediates blue light signaling for stomatal opening. Plant & cell physiology. 2013 Jan; 54(1):24-35. doi: 10.1093/pcp/pcs073. [PMID: 22585556]
  • Xiaolong Chen, Xiaohui Zhu, Yicheng Ding, Yinchu Shen. Antifungal activity of tautomycin and related compounds against Sclerotinia sclerotiorum. The Journal of antibiotics. 2011 Aug; 64(8):563-9. doi: 10.1038/ja.2011.55. [PMID: 21772304]
  • Faisal Thayyullathil, Shahanas Chathoth, Allen Shahin, Jaleel Kizhakkayil, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadari. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. Journal of cellular biochemistry. 2011 Apr; 112(4):1138-53. doi: 10.1002/jcb.23033. [PMID: 21308747]
  • Chung-Liang Chien, Yung-Chia Chen, Ming-Fong Chang, Andrew S Greenberg, Seu-Mei Wang. Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochemistry and cell biology. 2005 Jun; 123(4-5):429-39. doi: 10.1007/s00418-005-0771-8. [PMID: 15844002]
  • Svante Resjö, Olga Göransson, Linda Härndahl, Stanislaw Zolnierowicz, Vincent Manganiello, Eva Degerman. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cellular signalling. 2002 Mar; 14(3):231-8. doi: 10.1016/s0898-6568(01)00238-8. [PMID: 11812651]
  • J P Lauritsen, C Menné, J Kastrup, J Dietrich, N Odum, C Geisler. beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase. Biochimica et biophysica acta. 2000 Sep; 1497(3):297-307. doi: 10.1016/s0167-4889(00)00065-3. [PMID: 10996654]
  • M D Galigniana, G P Vicent, G Piwien-Pilipuk, G Burton, C P Lantos. Mechanism of action of the potent sodium-retaining steroid 11, 19-oxidoprogesterone. Molecular pharmacology. 2000 Jul; 58(1):58-70. doi: 10.1124/mol.58.1.58. [PMID: 10860927]
  • A V Vener, A Rokka, H Fulgosi, B Andersson, R G Herrmann. A cyclophilin-regulated PP2A-like protein phosphatase in thylakoid membranes of plant chloroplasts. Biochemistry. 1999 Nov; 38(45):14955-65. doi: 10.1021/bi990971v. [PMID: 10555977]
  • S Mukhopadhyay, C R Webster, M S Anwer. Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/taurocholate cotransport. The Journal of biological chemistry. 1998 Nov; 273(45):30039-45. doi: 10.1074/jbc.273.45.30039. [PMID: 9792726]
  • G Piwien-Pilipuk, M D Galigniana. Tautomycin inhibits phosphatase-dependent transformation of the rat kidney mineralocorticoid receptor. Molecular and cellular endocrinology. 1998 Sep; 144(1-2):119-30. doi: 10.1016/s0303-7207(98)00142-7. [PMID: 9863632]
  • K N Fish, C Soderberg-Naucler, J A Nelson. Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900. Journal of virology. 1998 Aug; 72(8):6657-64. doi: 10.1128/jvi.72.8.6657-6664.1998. [PMID: 9658112]
  • Y Tojyo, A Tanimura, Y Matsumoto. Suppression of capacitative Ca2+ entry by serine/threonine phosphatase inhibitors in rat parotid acinar cells. Japanese journal of pharmacology. 1995 Dec; 69(4):381-9. doi: 10.1254/jjp.69.381. [PMID: 8786642]
  • Y Koike, Y Ozaki, R Qi, K Satoh, K Kurota, Y Yatomi, S Kume. Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets. Cell calcium. 1994 May; 15(5):381-90. doi: 10.1016/0143-4160(94)90013-2. [PMID: 8033196]
  • H Yuasa, K Yoshida, H Iwata, H Nakanishi, M Suganuma, M Tatematsu. Increase of labeling indices in gastrointestinal mucosae of mice and rats by compounds of the okadaic acid type. Journal of cancer research and clinical oncology. 1994; 120(4):208-12. doi: 10.1007/bf01372558. [PMID: 8288675]
  • T Kurisaki, J Magae, K Nagai, A Hirata, I Kusaka, H Shinji, M Morikawa, T Yoshida, K Isono, M Yamasaki. Morphological changes and reorganization of actinfilaments in human myeloid leukemia cells induced by a novel protein phosphatase inhibitor, tautomycin. Cell structure and function. 1993 Feb; 18(1):33-9. doi: 10.1247/csf.18.33. [PMID: 8389250]
  • C MacKintosh, S Klumpp. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS letters. 1990 Dec; 277(1-2):137-40. doi: 10.1016/0014-5793(90)80828-7. [PMID: 2176611]