Pentaporphyrin I (BioDeep_00000005719)

 

Secondary id: BioDeep_00001868729

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1,3,5,7,9,11,13(22),14,16,18(21),19-undecaene

化学式: C20H14N4 (310.1218)
中文名称: 卟啉
谱图信息: 最多检出来源 Homo sapiens(otcml) 44.28%

分子结构信息

SMILES: C1=CC2=CC3=CC=C(N3)C=C4C=CC(=N4)C=C5C=CC(=N5)C=C1N2
InChI: InChI=1S/C20H14N4/c1-2-14-10-16-5-6-18(23-16)12-20-8-7-19(24-20)11-17-4-3-15(22-17)9-13(1)21-14/h1-12,21-22H



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

39 个相关的代谢反应过程信息。

Reactome(39)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ABCB1, BCL2, CAT, CPOX, HMBS
Peripheral membrane protein 2 CYP1B1, PPOX
Endosome membrane 1 ABCB6
Endoplasmic reticulum membrane 4 ABCB6, BCL2, CYP1B1, HMOX1
Mitochondrion membrane 1 ABCG2
Nucleus 3 BCL2, HMOX1, MPO
cytosol 9 ABCB6, BCL2, CAT, CPOX, HMBS, HMOX1, MB, UROD, UROS
mitochondrial membrane 2 ABCG2, PPOX
nucleoplasm 5 ABCB6, ABCG2, HMOX1, MPO, UROD
Cell membrane 3 ABCB1, ABCB6, ABCG2
Cytoplasmic side 1 HMOX1
Early endosome membrane 1 ABCB6
Multi-pass membrane protein 3 ABCB1, ABCB6, ABCG2
Golgi apparatus membrane 1 ABCB6
Synapse 1 PPOX
cell surface 3 ABCB1, EPO, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 2 ABCB6, ATRN
Golgi membrane 2 ABCB6, INS
lysosomal membrane 1 ABCB6
mitochondrial inner membrane 2 FECH, PPOX
postsynapse 1 PPOX
synaptic vesicle 1 PPOX
Lysosome 1 MPO
endosome 1 ABCB6
plasma membrane 5 ABCB1, ABCB6, ABCG2, ATRN, F2
Membrane 8 ABCB1, ABCB6, ABCG2, BCL2, CAT, CPOX, CYP1B1, HMOX1
apical plasma membrane 2 ABCB1, ABCG2
extracellular exosome 8 ABCB1, ABCB6, ATRN, CAT, EPO, F2, MB, MPO
Lysosome membrane 1 ABCB6
endoplasmic reticulum 3 ABCB6, BCL2, HMOX1
extracellular space 7 ATRN, EPO, F2, HMOX1, INS, MPO, TNR
perinuclear region of cytoplasm 2 HMOX1, PPOX
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 8 ABCB6, BCL2, CAT, CPOX, CYP1B1, FECH, PPOX, UROS
protein-containing complex 2 BCL2, CAT
intracellular membrane-bounded organelle 3 CAT, CYP1B1, MPO
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 ATRN
Secreted 3 EPO, F2, INS
extracellular region 7 CAT, EPO, F2, INS, MPO, PPOX, TNR
Mitochondrion outer membrane 2 ABCB6, BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 ABCB6, BCL2, HMOX1
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 2 CAT, FECH
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Secreted, extracellular space, extracellular matrix 1 TNR
neuronal dense core vesicle lumen 1 PPOX
cytoplasmic vesicle 1 PPOX
Melanosome membrane 1 ABCB6
sarcoplasm 1 MB
Apical cell membrane 2 ABCB1, ABCG2
Mitochondrion inner membrane 2 FECH, PPOX
Membrane raft 2 ABCG2, TNR
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 2 CPOX, PPOX
collagen-containing extracellular matrix 2 F2, TNR
secretory granule 1 MPO
Late endosome membrane 1 ABCB6
brush border membrane 1 ABCG2
blood microparticle 1 F2
[Isoform 3]: Secreted 1 ATRN
endosome lumen 1 INS
cell body 1 EPO
myelin sheath 1 BCL2
azurophil granule 1 MPO
multivesicular body membrane 1 ABCB6
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, EPO, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 2 F2, INS
transport vesicle 1 INS
Secreted, extracellular exosome 1 ABCB6
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 ABCB6
perineuronal net 1 TNR
Single-pass type IV membrane protein 1 HMOX1
ATP-binding cassette (ABC) transporter complex 1 ABCB6
Endosome, multivesicular body membrane 1 ABCB6
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 2 ABCB1, ABCG2
endolysosome membrane 1 ABCB6
[Isoform 1]: Cell membrane 1 ATRN
Rough endoplasmic reticulum 1 PPOX
Intermembrane side 1 PPOX
Cytoplasm, sarcoplasm 1 MB
catalase complex 1 CAT
vacuolar membrane 1 ABCB6
BAD-BCL-2 complex 1 BCL2
tenascin complex 1 TNR


文献列表

  • Vanda Andrade, M Luísa Mateus, M Camila Batoréu, Michael Aschner, A P Marreilha dos Santos. Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese. Neurotoxicology. 2014 Dec; 45(?):168-77. doi: 10.1016/j.neuro.2014.10.009. [PMID: 25451970]
  • Marcus C Durrant. A computational study of ligand binding affinities in iron(III) porphine and protoporphyrin IX complexes. Dalton transactions (Cambridge, England : 2003). 2014 Jul; 43(25):9754-65. doi: 10.1039/c4dt01103a. [PMID: 24846575]
  • James S Woods, Sarah E Armel, Denise I Fulton, Jason Allen, Kristine Wessels, P Lynne Simmonds, Doreen Granpeesheh, Elizabeth Mumper, J Jeffrey Bradstreet, Diana Echeverria, Nicholas J Heyer, James P K Rooney. Urinary porphyrin excretion in neurotypical and autistic children. Environmental health perspectives. 2010 Oct; 118(10):1450-7. doi: 10.1289/ehp.0901713. [PMID: 20576582]