5-Amino-6-ribitylamino uracil (BioDeep_00000005637)

 

Secondary id: BioDeep_00001869340

human metabolite Endogenous


代谢物信息卡片


5-amino-6-{[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino}-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C9H16N4O6 (276.107)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 7.51%

分子结构信息

SMILES: C(C(C(C(CO)O)O)O)NC1=C(C(=O)NC(=O)N1)N
InChI: InChI=1S/C9H16N4O6/c10-5-7(12-9(19)13-8(5)18)11-1-3(15)6(17)4(16)2-14/h3-4,6,14-17H,1-2,10H2,(H3,11,12,13,18,19)/t3-,4+,6-/m0/s1

描述信息

5-Amino-6-ribitylamino uracil is an intermediate in riboflavin metabolism. It is converted from 5-amino-6-(5-phosphoribitylamino)uracil via dephosphorylation by the enzyme phosphohistidine phosphatase 1 (EC 3.1.3.-). It is considered to be the second product of the riboflavin synthase reaction (PMID: 14245407). Humans do not have all the enzymes needed to synthesize or metabolize riboflavin. However, gut microflora do have the necessary enzymatic machinery to produce and metabolize this vitamin. Riboflavin (or vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. Riboflavin is yellow or yellow-orange in colour and in addition to being used as a food colouring it is also used to fortify some foods including baby foods, breakfast cereals, pastas, sauces, processed cheese, fruit drinks, vitamin-enriched milk products, some energy drinks, and vitamin supplements.
5-amino-6-(d-ribitylamino)uracil, also known as 5-amino-6-ribitylamino-2,4-(1h,3h)pyrimidinedione or 5-arpd, is a member of the class of compounds known as pentoses. Pentoses are monosaccharides in which the carbohydrate moiety contains five carbon atoms. 5-amino-6-(d-ribitylamino)uracil is soluble (in water) and a very weakly acidic compound (based on its pKa). 5-amino-6-(d-ribitylamino)uracil can be found in a number of food items such as radish (variety), chinese cabbage, common beet, and spinach, which makes 5-amino-6-(d-ribitylamino)uracil a potential biomarker for the consumption of these food products. 5-amino-6-(d-ribitylamino)uracil exists in E.coli (prokaryote) and yeast (eukaryote).

同义名列表

26 个代谢物同义名

5-amino-6-{[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino}-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-[(5-Amino-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)amino]-1-deoxy-D-ribitol; 1-[(5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]-1-deoxy-D-ribitol; 5-amino-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidine-2,4-dione; 1-[(5-amino-2,6-dihydroxypyrimidin-4-yl)amino]-1-deoxy-D-ribitol; 4-(1’-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine; 6-(1-D-Ribitylamino)-5-amino-2,4-dihydroxypyrimidine; 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine; 4-(1-D-Ribitylamino)-5-amino-2,6 dihydroxypyrimidine; 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione; 5-Amino-6-ribitylamino-2,4-(1H,3H)pyrimidinedione; 4-Ribitylamino-5-amino-2,6-dihydroxypyrimidine; 5-Amino-2,6-dioxo-4-ribitylaminopyrimidine; 6-(1-D-Ribitylamino)-5-aminouracil; 5-Amino-6-(1-D-ribitylamino)uracil; 4-(1-D-Ribitylamino)-5-aminouracil; 5-Amino-6-(D-ribitylamino)uracil; 4-(Ribitylamino)-5-aminouracil; 5-Amino-4-D-ribitylaminouracil; 5-Amino-6-ribitylamino uracil; 5-Amino-6-ribitylaminouracil; 6-Ribitylamino-5-aminouracil; a-4-RAP; 5-Arpd; 5-a-RU; ARP



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

376 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(27)

WikiPathways(0)

Plant Reactome(222)

INOH(0)

PlantCyc(126)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 1 LAMP1
Endosome membrane 1 LAMP1
Endoplasmic reticulum membrane 1 MR1
Nucleus 4 CD274, KLK3, MR1, PNKD
cytosol 1 LAMP1
nucleoplasm 1 CD274
Cell membrane 3 CD274, LAMP1, MR1
Early endosome membrane 2 CD274, MR1
Golgi apparatus membrane 1 MR1
Golgi membrane 2 C1GALT1, MR1
lysosomal membrane 1 LAMP1
sarcolemma 1 LAMP1
synaptic vesicle 1 LAMP1
Lysosome 1 LAMP1
plasma membrane 4 CD274, KLK3, LAMP1, MR1
Membrane 4 C1GALT1, LAMP1, MR1, PNKD
extracellular exosome 3 CD274, KLK3, LAMP1
Lysosome membrane 1 LAMP1
endoplasmic reticulum 1 MR1
extracellular space 2 KLK3, MR1
perinuclear region of cytoplasm 1 LAMP1
mitochondrion 2 MR1, PNKD
protein-containing complex 1 KLK3
Single-pass type I membrane protein 3 CD274, LAMP1, MR1
extracellular region 1 KLK3
Single-pass membrane protein 1 MR1
external side of plasma membrane 3 CD274, LAMP1, MR1
multivesicular body 1 LAMP1
actin cytoskeleton 1 CD274
Single-pass type II membrane protein 1 C1GALT1
secretory granule 1 KLK3
Late endosome 1 LAMP1
Late endosome membrane 2 LAMP1, MR1
autophagosome membrane 1 LAMP1
Recycling endosome membrane 1 CD274
Melanosome 1 LAMP1
azurophil granule membrane 1 LAMP1
ficolin-1-rich granule membrane 1 LAMP1
[Isoform 1]: Cell membrane 2 CD274, MR1
[Isoform 4]: Secreted 2 CD274, MR1
presynaptic cytosol 2 MR1, PNKD
[Isoform 3]: Cell membrane 1 MR1
MHC class I protein complex 1 MR1
Autolysosome 1 LAMP1
Cytolytic granule membrane 1 LAMP1
phagolysosome membrane 1 LAMP1
[Isoform 2]: Endomembrane system 1 CD274


文献列表