D-4'-Phosphopantothenate (BioDeep_00000005223)

 

Secondary id: BioDeep_00001869270

human metabolite Endogenous


代谢物信息卡片


N-[(2R)-2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanine

化学式: C9H18NO8P (299.077)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 9.22%

分子结构信息

SMILES: CC(C)(COP(=O)(O)O)C(C(=O)NCCC(=O)O)O
InChI: InChI=1S/C9H18NO8P/c1-9(2,5-18-19(15,16)17)7(13)8(14)10-4-3-6(11)12/h7,13H,3-5H2,1-2H3,(H,10,14)(H,11,12)(H2,15,16,17)/t7-/m0/s1

描述信息

D-4-Phosphopantothenate is a product of the enzyme pantothenate kinase [EC 2.7.1.33] and is involved in the pantothenate and CoA biosynthesis pathway (KEGG). D-4-Phosphopantothenate is an intermediate in coenzyme A (CoA) biosynthesis pathway. Coenzyme A is a cofactor of ubiquitous occurrence in plants, bacteria, and animals. It is needed in a large number of enzymatic reactions central to intermediary metabolism, including the oxidation of fatty acids, carbohydrates, and amino acids.

同义名列表

30 个代谢物同义名

N-[(2R)-2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanine; (R)-N-(2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl)-beta-alanine; N-[(2R)-2-Hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine; N-[(2R)-2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-β-alanine; (R)-N-(2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl)-b-alanine; (R)-N-(2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl)-β-alanine; N-[(2R)-2-Hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-β-alanine; N-[(2R)-2-Hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-b-alanine; Phosphopantothenic acid, calcium salt, (R)-isomer; Phosphopantothenic acid, calcium salt (2:1); D-Pantothenic acid 4’-phosphate; D-Pantothenic acid 4-phosphate; (R)-4’-phosphonatopantothenate; (R)-4-Phosphonatopantothenate; 4’-phospho-D-pantothenic acid; (R)-4-Phosphopantothenic acid; 4-Phospho-D-pantothenic acid; D-4’-phosphopantothenic acid; D-4-Phosphopantothenic acid; (R)-4’-phosphopantothenate; 4’-phosphopantothenic acid; 4-Phosphopantothenic acid; (R)-4-Phosphopantothenate; D-4’-phosphopantothenate; D-4-Phosphopantothenate; Phosphopantothenic acid; 4’-phosphopantothenate; 4-Phosphopantothenate; Phosphopantothenate; 4-P-Pantothenate



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

267 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(1)

WikiPathways(0)

Plant Reactome(240)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(11)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKR1C4, EGFR, FGF2, LGALS3, PANK1, PANK3, PANK4, PPCS, STAT3, TYMS
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, HSD11B1
Nucleus 12 EGFR, FGF2, HPSE, LGALS3, NR2E1, PANK1, PANK2, PANK3, PANK4, PPCS, STAT3, TYMS
cytosol 10 AKR1C4, LGALS3, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, STAT3, TYMS
nucleoplasm 4 HPSE, LGALS3, NR2E1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 1 EGFR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, LGALS3
glutamatergic synapse 1 EGFR
Golgi membrane 1 EGFR
lysosomal membrane 1 HPSE
mitochondrial inner membrane 2 LGALS3, TYMS
Cytoplasm, cytosol 1 AKR1C4
Lysosome 1 HPSE
endosome 1 EGFR
plasma membrane 3 EGFR, LGALS3, STAT3
Membrane 5 EGFR, HPSE, HSD11B1, LGALS3, PANK2
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 4 AKR1C4, ALDH2, LGALS3, MMP9
extracellular space 7 CRP, EGFR, FGF2, HPSE, IL2, LGALS3, MMP9
lysosomal lumen 1 HPSE
perinuclear region of cytoplasm 1 EGFR
mitochondrion 4 ABAT, ALDH2, PANK2, TYMS
protein-containing complex 1 EGFR
intracellular membrane-bounded organelle 2 HPSE, HSD11B1
Single-pass type I membrane protein 1 EGFR
Secreted 5 CRP, FGF2, HPSE, IL2, LGALS3
extracellular region 6 CRP, FGF2, HPSE, IL2, LGALS3, MMP9
Mitochondrion matrix 2 ALDH2, TYMS
mitochondrial matrix 3 ABAT, ALDH2, TYMS
transcription regulator complex 1 STAT3
nuclear membrane 1 EGFR
Secreted, extracellular space, extracellular matrix 1 MMP9
nucleolus 1 PANK1
recycling endosome 1 PANK1
Single-pass type II membrane protein 1 HSD11B1
Mitochondrion inner membrane 1 TYMS
Membrane raft 2 EGFR, HPSE
focal adhesion 1 EGFR
extracellular matrix 1 HPSE
intracellular vesicle 1 EGFR
Mitochondrion intermembrane space 1 PANK2
mitochondrial intermembrane space 1 PANK2
collagen-containing extracellular matrix 2 LGALS3, MMP9
receptor complex 1 EGFR
chromatin 2 NR2E1, STAT3
cell periphery 1 PANK1
[Isoform 1]: Mitochondrion 1 PANK2
Nucleus, nucleolus 1 PANK1
spliceosomal complex 1 LGALS3
[Isoform 2]: Cytoplasm, cytosol 1 PANK1
basal plasma membrane 1 EGFR
[Isoform 3]: Cytoplasm 1 PANK2
[Isoform 4]: Cytoplasm 1 PANK2
clathrin-coated vesicle 1 PANK1
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MMP9
secretory granule membrane 1 LGALS3
specific granule lumen 1 HPSE
tertiary granule lumen 1 MMP9
Cytoplasmic vesicle, clathrin-coated vesicle 1 PANK1
immunological synapse 1 LGALS3
[Isoform 2]: Cytoplasm 1 PANK2
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 PANK1
ficolin-1-rich granule membrane 1 LGALS3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
4-aminobutyrate transaminase complex 1 ABAT
phosphopantothenoylcysteine decarboxylase complex 1 PPCDC


文献列表

  • Giulio Auciello, Annalise Di Marco, Odalys Gonzalez Paz, Savina Malancona, Steven Harper, Maria Beconi, Ilaria Rossetti, Alina Ciammaichella, Paola Fezzardi, Andrea Vecchi, Elena Bracacel, Daniel Cicero, Edith Monteagudo, Daniel Elbaum. Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration. Journal of medicinal chemistry. 2020 12; 63(24):15785-15801. doi: 10.1021/acs.jmedchem.0c01531. [PMID: 33320012]
  • E Naruta, V Buko. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2001 Oct; 53(5):393-8. doi: 10.1078/0940-2993-00205. [PMID: 11817109]
  • V S Slyshenkov, M Rakowska, A G Moiseenok, L Wojtczak. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation. Free radical biology & medicine. 1995 Dec; 19(6):767-72. doi: 10.1016/0891-5849(95)00084-b. [PMID: 8582649]
  • L I Sushko, V M Sheĭbak, G Z Abakumov, A K Moĭseenok. [Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes]. Voprosy meditsinskoi khimii. 1986 Jul; 32(4):20-4. doi: . [PMID: 3765494]