L-Glutamic acid 5-phosphate (BioDeep_00000005163)

 

Secondary id: BioDeep_00001869287

human metabolite Endogenous


代谢物信息卡片


(2S)-2-Amino-5-oxo-5-(phosphonooxy)pentanoic acid

化学式: C5H10NO7P (227.0195)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 3.61%

分子结构信息

SMILES: C(CC(=O)OP(=O)(O)O)C(C(=O)O)N
InChI: InChI=1S/C5H10NO7P/c6-3(5(8)9)1-2-4(7)13-14(10,11)12/h3H,1-2,6H2,(H,8,9)(H2,10,11,12)/t3-/m0/s1

描述信息

L-Glutamic acid 5-phosphate is an intermediate in the urea cycle and the metabolism of amino groups. It is a substrate of aldehyde dehydrogenase 18 family, member A1 [EC:2.7.2.11 1.2.1.41] (KEGG)In citrulline biosynthesis, it is a substrate of the enzyme glutamate-5-semialdehyde dehydrogenase [EC 1.2.1.41] and in proline synthesis it is a substrate of the enzyme Glutamate 5-kinase [EC 2.7.2.11] (BioCyc).
L-Glutamic acid 5-phosphate is an intermediate in the urea cycle and metabolism of amino groups, a substrate of aldehyde dehydrogenase 18 family, member A1 [EC:2.7.2.11 1.2.1.41] (KEGG)

同义名列表

17 个代谢物同义名

(2S)-2-Amino-5-oxo-5-(phosphonooxy)pentanoic acid; (2S)-2-Amino-5-oxo-5-(phosphonooxy)pentanoate; 5-oxo-5-(Phosphonooxy)-L-norvaline; L-Glutamic acid 5-phosphoric acid; L-Glutam-5-yl phosphoric acid; L-gamma-Glutamyl-5-phosphate; L-Glutamyl 5-phosphoric acid; L-Glutamic acid 5-phosphate; L-gamma-glutamyl phosphate; gamma-Glutamyl phosphate; L-Glutamate 5-phosphate; L-Glutamate-5-phosphate; L-Glutam-5-yl phosphate; L-Glutamyl 5-phosphate; γ-Glutamyl phosphate; L-gamma-Glutamyl-5-P; L-Glutamyl-5-P



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

400 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(395)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

  • Proline Metabolism: Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
  • Proline Metabolism: Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
  • Proline Metabolism: Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, GLUL, OAT
Nucleus 2 ALB, GLUL
cytosol 4 ALB, GCLM, GLUL, GSS
centrosome 1 ALB
nucleoplasm 2 ATP2B1, OAT
Cell membrane 2 ATP2B1, GLUL
Lipid-anchor 1 GLUL
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 ALB
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 GLUL
plasma membrane 2 ATP2B1, GLUL
synaptic vesicle membrane 1 ATP2B1
Membrane 1 ATP2B1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ALB, ATP2B1, GLUL, GSS, LYZ
endoplasmic reticulum 2 ALB, GLUL
extracellular space 2 ALB, LYZ
mitochondrion 3 GLUL, OAT, PYCR1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 ATP2B1
Secreted 1 ALB
extracellular region 2 ALB, LYZ
Mitochondrion matrix 1 OAT
mitochondrial matrix 2 OAT, PYCR1
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
Microsome 1 GLUL
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
immunological synapse 1 ATP2B1
glial cell projection 1 GLUL
photoreceptor ribbon synapse 1 ATP2B1
glutamate-cysteine ligase complex 1 GCLM
ciliary transition fiber 1 ALB


文献列表

  • Hanan Stein, Arik Honig, Gad Miller, Oran Erster, Haviva Eilenberg, Laszlo N Csonka, László Szabados, Csaba Koncz, Aviah Zilberstein. Elevation of free proline and proline-rich protein levels by simultaneous manipulations of proline biosynthesis and degradation in plants. Plant science : an international journal of experimental plant biology. 2011 Aug; 181(2):140-50. doi: 10.1016/j.plantsci.2011.04.013. [PMID: 21683879]
  • Jun Hiratake, Makoto Inoue, Kanzo Sakata. gamma-Glutamyltranspeptidase and gamma-glutamyl peptide ligases: fluorophosphonate and phosphonodifluoromethyl ketone analogs as probes of tetrahedral transition state and gamma-glutamyl-phosphate intermediate. Methods in enzymology. 2002; 354(?):272-95. doi: 10.1016/s0076-6879(02)54023-4. [PMID: 12418234]