2-Keto-glutaramic acid (BioDeep_00000004523)
Secondary id: BioDeep_00001869274
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
5-Amino-2,5-dioxopentanoic acid
化学式: C5H7NO4 (145.0375)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 19.77%
分子结构信息
SMILES: C(CC(=O)N)C(=O)C(=O)O
InChI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)
描述信息
deaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure [HMDB]
deaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure.
同义名列表
16 个代谢物同义名
5-Amino-2,5-dioxopentanoic acid; 4-carbamoyl-2-oxobutanoic acid; alpha-Ketoglutaramic acid; 2-Keto-glutaramic acid; a-Ketoglutaramic acid; α-Ketoglutaramic acid; 2-Ketoglutaramic acid; alpha-Ketoglutaramate; 2-Oxoglutaramic acid; 4-oxoglutaramic acid; 2-keto-Glutaramate; 2-Ketoglutaramate; a-Ketoglutaramate; α-Ketoglutaramate; 2-Oxoglutaramate; 2-Oxoglutaramate
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:30882
- KEGG: C00940
- PubChem: 48
- HMDB: HMDB0001552
- Metlin: METLIN6318
- MetaCyc: 2-KETO-GLUTARAMATE
- foodb: FDB022686
- chemspider: 47
- CAS: 18465-19-5
- PMhub: MS000017031
- ChEBI: CHEBI:16769
- PubChem: 4192
- 3DMET: B00205
- NIKKAJI: J39.559E
- RefMet: 2-Keto-glutaramic acid
- KNApSAcK: 16769
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
65 个相关的代谢反应过程信息。
Reactome(65)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
H2O + L-Asn ⟶ L-Asp + ammonia - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Amino acid synthesis and interconversion (transamination):
H2O + L-Asn ⟶ L-Asp + ammonia - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 9646 - Ailuropoda melanoleuca: 10.1371/JOURNAL.PONE.0143417
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
- 29760 - Vitis vinifera: 10.1016/J.DIB.2020.106469
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yevgeniya I Shurubor, Arthur J L Cooper, Elena P Isakova, Yulia I Deryabina, M Flint Beal, Boris F Krasnikov. HPLC determination of α-ketoglutaramate [5-amino-2,5-dioxopentanoate] in biological samples.
Analytical biochemistry.
2016 Feb; 494(?):52-4. doi:
10.1016/j.ab.2015.11.003. [PMID: 26576832] - Kenneth W Ellens, Lynn G L Richardson, Océane Frelin, Joseph Collins, Cintia Leite Ribeiro, Yih-Feng Hsieh, Robert T Mullen, Andrew D Hanson. Evidence that glutamine transaminase and omega-amidase potentially act in tandem to close the methionine salvage cycle in bacteria and plants.
Phytochemistry.
2015 May; 113(?):160-9. doi:
10.1016/j.phytochem.2014.04.012. [PMID: 24837359] - Arthur J L Cooper, Tomiko Kuhara. α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle.
Metabolic brain disease.
2014 Dec; 29(4):991-1006. doi:
10.1007/s11011-013-9444-9. [PMID: 24234505] - Lenka Halámková, Shay Mailloux, Jan Halámek, Arthur J L Cooper, Evgeny Katz. Enzymatic analysis of α-ketoglutaramate--a biomarker for hyperammonemia.
Talanta.
2012 Oct; 100(?):7-11. doi:
10.1016/j.talanta.2012.08.022. [PMID: 23141304] - Tomiko Kuhara, Morimasa Ohse, Yoshito Inoue, Arthur J L Cooper. A GC/MS-based metabolomic approach for diagnosing citrin deficiency.
Analytical and bioanalytical chemistry.
2011 Jun; 400(7):1881-94. doi:
10.1007/s00216-011-4766-0. [PMID: 21365350] - Tomiko Kuhara, Yoshito Inoue, Morimasa Ohse, Boris F Krasnikov, Arthur J L Cooper. Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders.
Analytical and bioanalytical chemistry.
2011 Jun; 400(7):1843-51. doi:
10.1007/s00216-011-4688-x. [PMID: 21298421] - Arthur J L Cooper. The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
Neurochemistry international.
2004 Jun; 44(8):557-77. doi:
10.1016/j.neuint.2003.12.002. [PMID: 15016471] - Monica Mosca, Cristina Croci, Marina Mostardini, Jerome Breton, Jan Malyszko, Nilla Avanzi, Salvatore Toma, Luca Benatti, Silvia Gatti. Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs.
Biochimica et biophysica acta.
2003 Jul; 1628(1):1-10. doi:
10.1016/s0167-4781(03)00071-x. [PMID: 12850267] - I Nissim, S Wehrli, B States, I Nissim, M Yudkoff. Analysis and physiological implications of renal 2-oxoglutaramate metabolism.
The Biochemical journal.
1991 Jul; 277 ( Pt 1)(?):33-8. doi:
10.1042/bj2770033. [PMID: 1854345] - S Marklund. Determination of plasma or serum haemoglobin by peroxidase activity employing 2,2'-azino-di-(3-ethyl-benzthiazolinsulphonate-6) as chromogen.
Scandinavian journal of clinical and laboratory investigation.
1978 Oct; 38(6):543-7. doi:
10.1080/00365517809108817. [PMID: 30165] - O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse.
Immunology.
1978 Jan; 34(1):167-73. doi:
NULL. [PMID: 23994] - R D Holbert, J E Pearson, F M Gonzalez. Effect of sodium acetate infusion on renal function in the dog.
Archives internationales de pharmacodynamie et de therapie.
1976 Feb; 219(2):211-22. doi:
NULL. [PMID: 5975] - J Ditzel. Oxygen transport impairment in diabetes.
Diabetes.
1976; 25(2 SUPPL):832-8. doi:
. [PMID: 9322]
