Uncarine (BioDeep_00000000422)

   

PANOMIX_OTCML-2023


代谢物信息卡片


SPIRO(3H-INDOLE-3,6(4AH)-(1H)PYRANO(3,4-F)INDOLIZINE)-4-CARBOXYLIC ACID, 1,2,5,5A,7,8,10,10A-OCTAHYDRO-1-METHYL-2-OXO-, METHYL ESTER, (1S,3S,4AS,5AS,10AS)-

化学式: C21H24N2O4 (368.1736)
中文名称: 异翅果定碱, 钩藤碱 E, 钩藤碱E
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 90.28%

分子结构信息

SMILES: CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O
InChI: InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14-,18-,21-/m0/s1

描述信息

Uncarine E is a member of indolizines.
Isopteropodine is a natural product found in Uncaria lanosa, Uncaria tomentosa, and other organisms with data available.
See also: Cats Claw (part of).
Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC. Isopteropodine acts as positive modulators of muscarinic M1 and 5-HT2 receptors[1].
Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC. Isopteropodine acts as positive modulators of muscarinic M1 and 5-HT2 receptors[1].
Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC. Isopteropodine acts as positive modulators of muscarinic M1 and 5-HT2 receptors[1].

同义名列表

22 个代谢物同义名

SPIRO(3H-INDOLE-3,6(4AH)-(1H)PYRANO(3,4-F)INDOLIZINE)-4-CARBOXYLIC ACID, 1,2,5,5A,7,8,10,10A-OCTAHYDRO-1-METHYL-2-OXO-, METHYL ESTER, (1S,3S,4AS,5AS,10AS)-; (1S,3S,4aS,5aS,10aS)-1,2,5,5a,7,8,10,10a-octahydro-1-methyl-2-oxospiro(3H-indole-3,6(4aH)-(1H)pyrano(3,4-f)indolizine)-4-carboxylic acid methyl ester; Methyl (1S,3S,4aS,5aS,10aS)-1-methyl-2-oxo-4a,5,5a,7,8,10a-hexahydro-1H,10H-spiro[indoline-3,6-pyrano[3,4-f]indolizine]-4-carboxylate; methyl (1S,4aS,5aS,6S,10aS)-1-methyl-2-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3-1H-indole]-4-carboxylate; (1S,3S,4aS,5aS,10aS)-methyl 1-methyl-2-oxo-1,4a,5,5a,7,8,10,10a-octahydrospiro[indoline-3,6-pyrano[3,4-f]indolizine]-4-carboxylate; FORMOSANAN-16-CARBOXYLIC ACID, 19-METHYL-2-OXO-, METHYL ESTER, (7.ALPHA.,19.ALPHA.,20.ALPHA.)-; Formosanan-16-carboxylic acid, 19-methyl-2-oxo-, methyl ester, (7alpha,19alpha,20alpha)-; Isopteropodine, United States Pharmacopeia (USP) Reference Standard; ISOPTEROPODINE (UNCARINE A) (CONSTITUENT OF CATS CLAW) [DSC]; ISOPTEROPODINE (UNCARINE A) (CONSTITUENT OF CATS CLAW); ISOPTEROPODINE (USP-RS); ISOPTEROPODINE [USP-RS]; allo-Isopteropodine; 7-Isopteropodine; UNII-J9IZ1U593L; Isopteropodine; Isopteropodin; J9IZ1U593L; uncarine E; UNCARINEE; Uncarine; Uncarine E



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 BCL2, CAT, CDKN2A, MARS1
Peripheral membrane protein 1 PTPMT1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 4 BCL2, CDKN2A, NR1I2, PTPMT1
cytosol 4 BCL2, CAT, CDKN2A, MARS1
nuclear body 1 NR1I2
nucleoplasm 2 CDKN2A, NR1I2
Cell membrane 1 GRID1
Multi-pass membrane protein 1 GRID1
glutamatergic synapse 1 GRID1
mitochondrial inner membrane 1 PTPMT1
Cytoplasm, cytosol 1 MARS1
plasma membrane 1 GRID1
Membrane 3 BCL2, CAT, MARS1
extracellular exosome 3 CAT, GRID1, MARS1
endoplasmic reticulum 1 BCL2
mitochondrion 4 BCL2, CAT, CDKN2A, PTPMT1
protein-containing complex 3 BCL2, CAT, CDKN2A
intracellular membrane-bounded organelle 1 CAT
extracellular region 1 CAT
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 CAT, CDKN2A
transcription regulator complex 1 NR1I2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
nucleolus 2 CDKN2A, MARS1
postsynaptic membrane 1 GRID1
Mitochondrion inner membrane 1 PTPMT1
Matrix side 1 PTPMT1
pore complex 1 BCL2
focal adhesion 1 CAT
GABA-ergic synapse 1 GRID1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Postsynaptic cell membrane 1 GRID1
chromatin 1 NR1I2
Nucleus, nucleolus 2 CDKN2A, MARS1
Nucleus, nucleoplasm 1 CDKN2A
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 NR1I2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
postsynaptic density membrane 1 GRID1
aminoacyl-tRNA synthetase multienzyme complex 1 MARS1
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
senescence-associated heterochromatin focus 1 CDKN2A
[Isoform smARF]: Mitochondrion 1 CDKN2A


文献列表

  • María Celeste Bigliani, María Celeste Rosso, Paula M Zunino, Gustavo Baiardi, Andrés Alberto Ponce. Anxiogenic-like effects of Uncaria tomentosa (Willd.) DC. aqueous extract in an elevated plus maze test in mice: a preliminary study. Natural product research. 2013; 27(18):1682-5. doi: 10.1080/14786419.2012.761617. [PMID: 23327494]
  • Tai-Hyun Kang, Kinzo Matsumoto, Michihisa Tohda, Yukihisa Murakami, Hiromitsu Takayama, Mariko Kitajima, Norio Aimi, Hiroshi Watanabe. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte. European journal of pharmacology. 2002 May; 444(1-2):39-45. doi: 10.1016/s0014-2999(02)01608-4. [PMID: 12191580]