Oripavine (BioDeep_00000004178)

 

Secondary id: BioDeep_00000418830

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,14,16-pentaen-10-ol

化学式: C18H19NO3 (297.1365)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 49.58%

分子结构信息

SMILES: CN1CCC23C4C(=CC=C2C1CC5=C3C(=C(C=C5)O)O4)OC
InChI: InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3

描述信息

Alkaloid from opium poppy (Papaver somniferum). Oripavine is found in many foods, some of which are redcurrant, teff, muscadine grape, and date.
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
Oripavine is an alkaloid from opium poppy (Papaver somniferum

同义名列表

4 个代谢物同义名

14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,14,16-pentaen-10-ol; 6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol; SCHEMBL10031251; Oripavine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CYP2D6, FTO, PIK3C2A, POMC
Endoplasmic reticulum membrane 2 CYP2D6, UGT2B7
Nucleus 3 FTO, PIK3C2A, TOP1
cytosol 2 FTO, PIK3C2A
dendrite 3 OPRM1, PDYN, PNOC
trans-Golgi network 1 PIK3C2A
nucleoplasm 3 FTO, PIK3C2A, TOP1
Cell membrane 5 OPRD1, OPRL1, OPRM1, OR2H2, PIK3C2A
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 4 OPRD1, OPRL1, OPRM1, OR2H2
Synapse 3 OPRM1, PDYN, PNOC
Golgi apparatus 1 OPRM1
neuronal cell body 2 PDYN, PNOC
presynaptic membrane 1 OPRD1
endosome 1 OPRM1
plasma membrane 9 F2, FTO, OPRD1, OPRL1, OPRM1, OR2H2, PDYN, PIK3C2A, PNOC
synaptic vesicle membrane 1 OPRD1
Membrane 5 CYP2D6, OPRD1, OPRM1, PIK3C2A, UGT2B7
axon 1 OPRM1
extracellular exosome 2 F2, PIK3C2A
endoplasmic reticulum 2 CYP2D6, OPRM1
extracellular space 2 F2, POMC
mitochondrion 1 CYP2D6
intracellular membrane-bounded organelle 3 CYP2D6, FTO, PIK3C2A
Microsome membrane 1 CYP2D6
Secreted 4 F2, PDYN, PNOC, POMC
extracellular region 4 F2, PDYN, PNOC, POMC
Single-pass membrane protein 2 CYP2D6, UGT2B7
hippocampal mossy fiber to CA3 synapse 1 PDYN
perikaryon 2 OPRM1, TOP1
cytoplasmic vesicle 1 OPRL1
nucleolus 1 TOP1
P-body 1 TOP1
vesicle 1 PIK3C2A
collagen-containing extracellular matrix 1 F2
secretory granule 1 POMC
nuclear speck 1 FTO
neuron projection 3 OPRD1, OPRL1, OPRM1
Chromosome 1 TOP1
Golgi apparatus, trans-Golgi network 1 PIK3C2A
Nucleus, nucleolus 1 TOP1
blood microparticle 1 F2
fibrillar center 1 TOP1
Nucleus, nucleoplasm 1 TOP1
Cell projection, dendrite 1 OPRM1
Nucleus speckle 1 FTO
clathrin-coated vesicle 1 PIK3C2A
synaptic membrane 1 PNOC
secretory granule lumen 1 POMC
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
male germ cell nucleus 1 TOP1
axon terminus 3 OPRD1, PDYN, PNOC
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 OPRD1, PDYN
protein-DNA complex 1 TOP1
dendrite membrane 1 OPRD1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1


文献列表

  • Veniero Gambaro, Paola Minghetti, Sebastiano Arnoldi, Maria Laura Colombo, Lucia Dellʼacqua, Antonella Casiraghi, Katia Guerrini, Fiorenza Farè, Gabriella Roda. Analysis of fluid extracts obtained from Papaver rhoeas petals contaminated with Papaver bracteatum petals. Planta medica. 2012 Aug; 78(12):1395-8. doi: 10.1055/s-0032-1314981. [PMID: 22763738]
  • Yan Zhang, Zhiwei Wang, D Phillip Cox, Olivier Civelli. Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system. Neurochemical research. 2012 Feb; 37(2):410-6. doi: 10.1007/s11064-011-0627-7. [PMID: 22002663]
  • Jillian M Hagel, Peter J Facchini. Biochemistry and occurrence of o-demethylation in plant metabolism. Frontiers in physiology. 2010; 1(?):14. doi: 10.3389/fphys.2010.00014. [PMID: 21423357]
  • Raymond G Reid, David G Durham, Susanne P Boyle, Ann S Low, Jinda Wangboonskul. Differentiation of opium and poppy straw using capillary electrophoresis and pattern recognition techniques. Analytica chimica acta. 2007 Dec; 605(1):20-7. doi: 10.1016/j.aca.2007.10.023. [PMID: 18022406]
  • Jacqui L Adcock, Paul S Francis, Kent M Agg, Graham D Marshall, Neil W Barnett. A hybrid FIA/HPLC system incorporating monolithic column chromatography. Analytica chimica acta. 2007 Sep; 600(1-2):136-41. doi: 10.1016/j.aca.2007.03.048. [PMID: 17903475]
  • Kayo Yoshimatsu, Fumiyuki Kiuchi, Koichiro Shimomura, Yukiko Makino. A rapid and reliable solid-phase extraction method for high-performance liquid chromatographic analysis of opium alkaloids from papaver plants. Chemical & pharmaceutical bulletin. 2005 Nov; 53(11):1446-50. doi: 10.1248/cpb.53.1446. [PMID: 16272729]
  • Robert S Allen, Anthony G Millgate, Julie A Chitty, Jennifer Thisleton, James A C Miller, Anthony J Fist, Wayne L Gerlach, Philip J Larkin. RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy. Nature biotechnology. 2004 Dec; 22(12):1559-66. doi: 10.1038/nbt1033. [PMID: 15543134]
  • Anthony G Millgate, Barry J Pogson, Iain W Wilson, Toni M Kutchan, Meinhart H Zenk, Wayne L Gerlach, Anthony J Fist, Philip J Larkin. Analgesia: morphine-pathway block in top1 poppies. Nature. 2004 Sep; 431(7007):413-4. doi: 10.1038/431413a. [PMID: 15386001]
  • H Kodaira, S Spector. Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes. Proceedings of the National Academy of Sciences of the United States of America. 1988 Feb; 85(4):1267-71. doi: 10.1073/pnas.85.4.1267. [PMID: 3422490]