Icarin (BioDeep_00000405861)

   


代谢物信息卡片


Icarin

化学式: C33H40O15 (676.2367)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O
InChI: InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3

描述信息

同义名列表

1 个代谢物同义名

Icarin



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, BCL2, CA2, CASP12, CENPJ, MAPK14, RUNX2, SMAD1, SMAD5, TNFSF11
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 2 BCL2, SPP1
Nucleus 7 AKT1, BCL2, JUN, MAPK14, RUNX2, SMAD1, SMAD5
cytosol 9 ACP5, AKT1, BCL2, CA2, CENPJ, MAPK14, RUNX2, SMAD1, SMAD5
centrosome 1 CENPJ
nucleoplasm 6 AKT1, JUN, MAPK14, RUNX2, SMAD1, SMAD5
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 4 AKT1, CA2, SPP1, TNFSF11
Cytoplasmic side 1 GORASP1
lamellipodium 1 AKT1
Multi-pass membrane protein 1 SPP1
Golgi apparatus membrane 1 GORASP1
Synapse 1 CRH
cell cortex 1 AKT1
cell surface 2 BMP2, TNFRSF10B
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 GORASP1, SPP1
Golgi membrane 2 GORASP1, INS
postsynapse 1 AKT1
Lysosome 1 ACP5
plasma membrane 6 AKT1, BMP2, CA2, SPP1, TNFRSF10B, TNFSF11
Membrane 6 ACP5, AKT1, BCL2, SMAD1, TNFRSF10B, TNFSF11
axon 1 CCK
extracellular exosome 3 BMP3, CA2, SPP1
endoplasmic reticulum 2 BCL2, CASP12
extracellular space 7 BMP2, BMP3, CCK, CRH, INS, SPP1, TNFSF11
perinuclear region of cytoplasm 1 SPP1
mitochondrion 3 BCL2, MAPK14, SMAD5
protein-containing complex 4 AKT1, BCL2, SMAD1, SMAD5
intracellular membrane-bounded organelle 1 BMP2
Secreted 7 BMP2, BMP3, CCK, CRH, INS, SPP1, TNFSF11
extracellular region 8 BMP2, BMP3, CCK, CRH, INS, MAPK14, SPP1, TNFSF11
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 4 JUN, RUNX2, SMAD1, SMAD5
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CENPJ
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
microtubule cytoskeleton 1 AKT1
apical part of cell 1 CA2
cell-cell junction 1 AKT1
Single-pass type II membrane protein 1 TNFSF11
vesicle 1 AKT1
pore complex 1 BCL2
microtubule 1 CENPJ
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
nuclear inner membrane 1 SMAD1
ciliary basal body 2 AKT1, CENPJ
chromatin 4 JUN, RUNX2, SMAD1, SMAD5
cell projection 1 SPP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CENPJ
centriole 1 CENPJ
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
endosome lumen 1 INS
euchromatin 1 JUN
myelin sheath 2 BCL2, CA2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, SPP1
procentriole replication complex 1 CENPJ
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
heteromeric SMAD protein complex 2 SMAD1, SMAD5
SMAD protein complex 2 SMAD1, SMAD5
transcription factor AP-1 complex 1 JUN
BAD-BCL-2 complex 1 BCL2
BMP receptor complex 1 BMP2
NLRP1 inflammasome complex 1 CASP12
homomeric SMAD protein complex 1 SMAD1
gamma-tubulin small complex 1 CENPJ


文献列表

  • Peng Yu, Zhen Qian, Hongmei Yang, Tianyang Xu, Yulin Dai, Laihui Song, Jinling Liang, Yuying Shi, Zhiguo Zhang, Lijing Li. Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress. European journal of pharmacology. 2022 Dec; 937(?):175378. doi: 10.1016/j.ejphar.2022.175378. [PMID: 36372277]
  • Zhiqiang Qian, Ling Zhu, Yeli Li, Yiqi Li, Yuting Wu, Shu Fu, Danli Yang. Icarrin prevents cardiomyocyte apoptosis in spontaneously hypertensive rats by inhibiting endoplasmic reticulum stress pathways. The Journal of pharmacy and pharmacology. 2021 Jul; 73(8):1023-1032. doi: 10.1093/jpp/rgaa016. [PMID: 34018553]
  • Qisheng Feng, Lin Tong, Huiwen Guo, Chang Ma, Feng Qin, Zhili Xiong. Tailor-made deep eutectic solvents extraction combined with UPLC-MS/MS determination of icarrin and icarisid II in rat plasma and its comparative pharmacokinetic application. Journal of pharmaceutical and biomedical analysis. 2021 May; 199(?):114054. doi: 10.1016/j.jpba.2021.114054. [PMID: 33831735]
  • Lei Ye, Yaping Yu, Yanping Zhao. Icariin-induced miR-875-5p attenuates epithelial-mesenchymal transition by targeting hedgehog signaling in liver fibrosis. Journal of gastroenterology and hepatology. 2020 Mar; 35(3):482-491. doi: 10.1111/jgh.14875. [PMID: 31617598]
  • Si Sun, Le Liu, Xiaojun Tian, Yanghongyun Guo, Yingkang Cao, Yunqing Mei, Changhua Wang. Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells. Planta medica. 2019 Apr; 85(6):473-482. doi: 10.1055/a-0837-0975. [PMID: 30703815]
  • Mi Huang, Jing Feng, Zai-Xuan Zhong, Shun-Ping He, Yu-Qin Shu, Jiang-Yan He, Ying Wang. [Activity Study of Icarlin and Epimedin C Monomer under the Same Molarity in Osteoporosis Ze- brafish Model]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2016 08; 36(8):986-990. doi: . [PMID: 30640996]
  • Yan-Qiu Liu, Xiao-Fei Han, Tiegang Liu, Meng-Chun Cheng, Hong-Bin Xiao. A cell-based model of bone remodeling for identifying activity of icarrin in the treatment of osteoporosis. Biotechnology letters. 2015 Jan; 37(1):219-26. doi: 10.1007/s10529-014-1661-8. [PMID: 25257584]