Etomidate (BioDeep_00000405817)
Main id: BioDeep_00000001469
代谢物信息卡片
Etomidate
化学式: C14H16N2O2 (244.1211716)
中文名称: 依托咪酯
谱图信息:
最多检出来源 Homo sapiens(blood) 7.69%
分子结构信息
SMILES: CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
InChI: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:4910
- KEGG: C07522
- KEGGdrug: D00548
- PubChem: 667484
- DrugBank: DB00292
- ChEMBL: CHEMBL681
- MeSH: Etomidate
- CAS: 33125-97-2
- MoNA: MoNA038757
- MoNA: MoNA037445
- MoNA: MoNA036651
- MoNA: MoNA036648
- MoNA: MoNA036646
- MoNA: MoNA032931
- MoNA: MoNA032930
- MoNA: MoNA032929
- MoNA: FiehnHILIC001926
- MoNA: FiehnHILIC000343
- PubChem: 9725
- PDB-CCD: V8D
- NIKKAJI: J17.549H
- RefMet: Etomidate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Siming Ding, Kan Li, Xing Han, Wenting Lin, Yingjun Qin, Renjuan Cao, Yuan Ren. Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice.
Toxicology.
2024 May; 504(?):153802. doi:
10.1016/j.tox.2024.153802. [PMID: 38604439] - Hao Gao, Qian Zhao, Jian-Gang Song, Guo-Xia Hu, Wei-Feng Yu, Ying-Fu Jiao, Jin-Chao Song. Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation.
BMC pharmacology & toxicology.
2023 09; 24(1):46. doi:
10.1186/s40360-023-00675-w. [PMID: 37740245] - Mostafa Mohammed Elhamamsy, Ahmed Mohammed Aldemerdash, Fathi Badie Zahran, Gehan Fawzy Mahmoud Ezz, Sara Abou AlSaud, Maged Labib Boules, Mahdy Ahmed Abdelhady, Mohamed Ahmed Hamed. Effects of adding low-dose ketamine to etomidate on serum cortisol levels in critically ill cardiac patients: a randomized clinical trial.
BMC anesthesiology.
2022 04; 22(1):114. doi:
10.1186/s12871-022-01654-0. [PMID: 35448950] - Jin-Chao Song, Xiao-Yan Meng, Hua Yang, Hao Gao, Mei-Hua Cai, Ma-Zhong Zhang, Wei-Feng Yu. Obstructive Jaundice does not Change the Population Pharmacokinetics of Etomidate in Patients who Underwent Bile Duct Surgery.
Current drug delivery.
2022; 19(5):635-641. doi:
10.2174/1567201818666210617101630. [PMID: 34139982] - Dandan Geng, Yan Li, Chunyan Wang, Bo Ren, Heping Wang, Chensi Wu, Yirong Zhang, Linlin Zhao, Ligang Zhao. Optimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion.
Drug delivery.
2021 Dec; 28(1):873-883. doi:
10.1080/10717544.2021.1917729. [PMID: 33960250] - J D Gao, H Song, P Fu, Y X Guo, H Y Zhang, M Qiu. Effects of etomidate on cell apoptosis during myocardial ischemia-reperfusion.
Journal of biological regulators and homeostatic agents.
2021 Jul; 35(Special Issue on Internal Medicine n.1):. doi:
10.23812/21-si1-10. [PMID: 34350750] - YiNan Zhang, YuJun Zhang, ChaoYi Deng, DeYing Gong, Yi Kang, Jin Liu, WenSheng Zhang. Non-clinical single- and repeated-dose toxicity studies of ET-26 hydrochloride in rats.
Journal of applied toxicology : JAT.
2020 08; 40(8):1099-1112. doi:
10.1002/jat.3970. [PMID: 32170788] - Jian-Bo Ma, Hong-Wei Wu, Yu-Feng Liao, Qiu-Hong Rui, Yan Zhu, Yun Zhang. Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples.
Talanta.
2020 Apr; 210(?):120652. doi:
10.1016/j.talanta.2019.120652. [PMID: 31987200] - Stephanie Cj Keating, Adrianna M Sage, Tamas D Ambrisko, Amy Somrak, Meredith Q Carroll, Patricia M Oba, Bianca Martins, Kelly S Swanson. The effect of midazolam or lidocaine administration prior to etomidate induction of anesthesia on heart rate, arterial pressure, intraocular pressure and serum cortisol concentration in healthy dogs.
Veterinary anaesthesia and analgesia.
2020 Mar; 47(2):160-167. doi:
10.1016/j.vaa.2019.09.004. [PMID: 31813669] - Yu-Kyung Jung, Soo Young You, Seon Yeong Kim, Jin Young Kim, Ki-Jung Paeng. Simultaneous Determination of Etomidate and Its Major Metabolite, Etomidate Acid, in Urine Using Dilute and Shoot Liquid Chromatography-Tandem Mass Spectrometry.
Molecules (Basel, Switzerland).
2019 Dec; 24(24):. doi:
10.3390/molecules24244459. [PMID: 31817432] - Megan McGrath, Alissa Hofmann, Douglas E Raines. Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats.
BMC pharmacology & toxicology.
2019 08; 20(1):48. doi:
10.1186/s40360-019-0328-4. [PMID: 31383012] - Beatrijs I Valk, Megan McGrath, Dario Lehoux, Brad Zerler, John J A Marota, Douglas E Raines. Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid.
Anesthesiology.
2019 08; 131(2):287-304. doi:
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Nuclear medicine and biology.
2019 Jan; 68-69(?):14-21. doi:
10.1016/j.nucmedbio.2018.11.002. [PMID: 30578137] - Yu Jun Zhang, ChaoYi Deng, Jun Yang, DeYing Gong, Yi Kang, Jin Liu, WenSheng Zhang. Preclinical Pharmacokinetics Study of a Novel Intravenous Anesthetic ET-26 Hydrochloride.
Current drug metabolism.
2019; 20(13):1073-1081. doi:
10.2174/1389200221666191223105504. [PMID: 31870260] - Yiwei Liao, Xiang Liu, Youssef Jounaidi, Stuart A Forman, Hua-Jun Feng. Etomidate Effects on Desensitization and Deactivation of α4β3δ GABAA Receptors Inducibly Expressed in HEK293 TetR Cells.
The Journal of pharmacology and experimental therapeutics.
2019 01; 368(1):100-105. doi:
10.1124/jpet.118.252403. [PMID: 30389723] - Rachel J Chance, Gary A Cameron, Mark Fordyce, Patricia Noguera, Tiehui Wang, Catherine Collins, Christopher J Secombes, Bertrand Collet. Effects of repeated anaesthesia on gill and general health of Atlantic salmon, Salmo salar.
Journal of fish biology.
2018 Dec; 93(6):1069-1081. doi:
10.1111/jfb.13803. [PMID: 30242832] - Briony D Smith, Krystal J Vail, Gwendolyn L Carroll, Maggie C Taylor, Nicholas D Jeffery, Tracy H Vemulapalli, James J Elliott. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus laevis).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 03; 57(2):202-209. doi:
NULL. [PMID: 29555009] - Xu Chen, Wensheng Zhang, Sandy Rios, Miriam B Morkos, Xiaoli Ye, Gen Li, Xuehua Jiang, Zhijun Wang, Ling Wang. An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats.
Journal of pharmaceutical and biomedical analysis.
2018 Feb; 149(?):381-386. doi:
10.1016/j.jpba.2017.11.017. [PMID: 29149702] - Adekunle T Bademosi, James Steeves, Shanker Karunanithi, Oressia H Zalucki, Rachel S Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A Meunier, Bruno van Swinderen. Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic.
Cell reports.
2018 01; 22(2):427-440. doi:
10.1016/j.celrep.2017.12.054. [PMID: 29320738] - Bin Wang, Junli Jiang, Jun Yang, Jun Chen, Zhaoqiong Zhu, Jin Liu, Wensheng Zhang. Pharmacologic studies on ET-26 hydrochloride in a rat model of lipopolysaccharide-induced sepsis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109(?):441-445. doi:
10.1016/j.ejps.2017.09.005. [PMID: 28882766] - Bin Wang, Jun Yang, Jun Chen, Yi Kang, Ling-Hui Yang, Jin Liu, Wen-Sheng Zhang. An Etomidate Analogue With Less Adrenocortical Suppression, Stable Hemodynamics, and Improved Behavioral Recovery in Rats.
Anesthesia and analgesia.
2017 08; 125(2):442-450. doi:
10.1213/ane.0000000000002063. [PMID: 28514325] - Emmanuel Besnier, Thomas Clavier, Marie-Christine Tonon, Jean Selim, Antoine Lefevre-Scelles, Fabrice Morin, Fabienne Tamion, Bertrand Dureuil, Hélène Castel, Vincent Compere. Ketamine and Etomidate Down-regulate the Hypothalamic-Pituitary-Adrenal Axis in an Endotoxemic Mouse Model.
Anesthesiology.
2017 08; 127(2):347-354. doi:
10.1097/aln.0000000000001704. [PMID: 28542000] - Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N Seubert, Timothy E Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E Martynyuk. Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology.
2017 Jul; 81(?):96-104. doi:
10.1016/j.psyneuen.2017.04.001. [PMID: 28433802] - Te Wang, Changdong Liu, Pihong Wei, Lili Lv, Zaiqi Yang. The inhibiting effect of intravenous anesthesia on adrenal gland functions under the sepsis condition.
International journal of immunopathology and pharmacology.
2017 Jun; 30(2):188-193. doi:
10.1177/0394632017705049. [PMID: 28406323] - Jun Yang, Yi Kang, Bin Wang, Linghui Yang, Jin Liu, Wensheng Zhang. Metabolite-inactive etomidate analogues alleviating suppression on adrenal function in Beagle dogs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Mar; 99(?):343-349. doi:
10.1016/j.ejps.2016.12.041. [PMID: 28057551] - Ryu Komatsu, Natalya Makarova, Jing You, Daniel I Sessler, David G Anthony, Yusuke Kasuya, Edward G Soltesz, Alparslan Turan. Etomidate and the Risk of Complications After Cardiac Surgery: A Retrospective Cohort Analysis.
Journal of cardiothoracic and vascular anesthesia.
2016 Dec; 30(6):1516-1522. doi:
10.1053/j.jvca.2016.04.022. [PMID: 27554237] - Abed Abubaih, Charles Weissman. Anesthesia for Patients with Concomitant Sepsis and Cardiac Dysfunction.
Anesthesiology clinics.
2016 Dec; 34(4):761-774. doi:
10.1016/j.anclin.2016.06.010. [PMID: 27816133] - Fengliu Deng, Mingwen Ouyang, Xiaofei Wang, Xueqing Yao, Yeming Chen, Tao Tao, Xuegang Sun, Lijun Xu, Jing Tang, Liang Zhao. Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.
Oncotarget.
2016 Nov; 7(47):77087-77095. doi:
10.18632/oncotarget.12800. [PMID: 27780923] - Yang Shen, Mei-Hua Cai, Wei Ji, Jie Bai, Yue Huang, Ying Sun, Lin Lin, Jing Niu, Ma-Zhong Zhang. Unrepaired Tetralogy of Fallot-related Pathophysiologic Changes Reduce Systemic Clearance of Etomidate in Children.
Anesthesia and analgesia.
2016 09; 123(3):722-30. doi:
10.1213/ane.0000000000001477. [PMID: 27537760] - Wei Liu, Aijie Liu, Guoqiang Liu, Dewei Wang, Kui Chen, Hongying Wang. Biophysical study on the interaction of etomidate and the carrier protein in vitro.
Pharmaceutical development and technology.
2016 Aug; 21(5):528-34. doi:
10.3109/10837450.2015.1022790. [PMID: 25757642] - Y Nyman, A Fredriksson, P-A Lönnqvist, H Viberg. Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour.
Acta anaesthesiologica Scandinavica.
2016 May; 60(5):588-96. doi:
10.1111/aas.12685. [PMID: 26763687] - Changqing Xu, Christoph N Seubert, Nikolaus Gravenstein, Anatoly E Martynyuk. Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.
Neuroscience letters.
2016 Apr; 618(?):1-5. doi:
10.1016/j.neulet.2016.02.045. [PMID: 26923669] - Krystallenia I Alexandraki, Ashley B Grossman. Therapeutic Strategies for the Treatment of Severe Cushing's Syndrome.
Drugs.
2016 Mar; 76(4):447-58. doi:
10.1007/s40265-016-0539-6. [PMID: 26833215] - Bangyong Qin, Hongzhuan Hu, Baofeng Cao, Zhaoqiong Zhu. Effects of continuous infusion of etomidate at various dose rates on adrenal function in dogs.
BMC anesthesiology.
2016 Jan; 16(?):2. doi:
10.1186/s12871-015-0171-0. [PMID: 26743223] - Han Chow Chua, Emilie T H Christensen, Kirsten Hoestgaard-Jensen, Leonny Y Hartiadi, Iqbal Ramzan, Anders A Jensen, Nathan L Absalom, Mary Chebib. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.
PloS one.
2016; 11(6):e0157700. doi:
10.1371/journal.pone.0157700. [PMID: 27332705] - Marcin Możański, Dariusz Tomaszewski, Zbigniew Rybicki, Jolanta Bejm, Mariusz Bałkota. Etomidate, but not thiopental, decreases serum cortisol concentration in morbidly obese patients. A randomized controlled trial.
Anaesthesiology intensive therapy.
2016; 48(1):7-12. doi:
10.5603/ait.2016.0002. [PMID: 26966106] - K Liu, Y Jounaidi, S A Forman, H-J Feng. Etomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.
Neuroscience.
2015 Aug; 300(?):307-13. doi:
10.1016/j.neuroscience.2015.05.051. [PMID: 26028470] - Manee Raksakietisak, Chutimart Ngamlamiad, Thitiganya Duangrat, Suvit Soontarinka, Kasana Raksamani. The Changes in Cortisol Levels during Cardiac Surgery: A Randomized Double-Blinded Study between Two Induction Agents Etomidate and Thiopentone.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2015 Aug; 98(8):775-81. doi:
NULL. [PMID: 26437535] - Peter Santer, Ervin Pejo, Yan Feng, Wei Chao, Douglas E Raines. Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis.
Anesthesiology.
2015 Aug; 123(2):368-76. doi:
10.1097/aln.0000000000000721. [PMID: 26035348] - Hongbin Gu, Mazhong Zhang, Meihua Cai, Jinfen Liu. Comparison of Adrenal Suppression between Etomidate and Dexmedetomidine in Children with Congenital Heart Disease.
Medical science monitor : international medical journal of experimental and clinical research.
2015 May; 21(?):1569-76. doi:
10.12659/msm.893410. [PMID: 26022508] - Ram Prasad Kaushal, Ajay Vatal, Radhika Pathak. Effect of etomidate and propofol induction on hemodynamic and endocrine response in patients undergoing coronary artery bypass grafting/mitral valve and aortic valve replacement surgery on cardiopulmonary bypass.
Annals of cardiac anaesthesia.
2015 Apr; 18(2):172-8. doi:
10.4103/0971-9784.154470. [PMID: 25849685] - Felice Su, Mohammed H El-Komy, Gregory B Hammer, Adam Frymoyer, Carol A Cohane, David R Drover. Population pharmacokinetics of etomidate in neonates and infants with congenital heart disease.
Biopharmaceutics & drug disposition.
2015 Mar; 36(2):104-14. doi:
10.1002/bdd.1924. [PMID: 25377074] - Hua-Cheng Liu, Danyan Zhu, Chan Wang, Hongguo Guan, Senlin Li, Cong Hu, Zhichuan Chen, Yuanyuan Hu, Han Lin, Qing-Quan Lian, Ren-Shan Ge. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells.
PloS one.
2015; 10(11):e0139311. doi:
10.1371/journal.pone.0139311. [PMID: 26555702] - Yu Zhang, Ruomeng Li, Jie Zhu, Zhaohui Wang, Shen Lv, Jun-Yu Xiong. Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency.
The Journal of surgical research.
2015 Jan; 193(1):399-406. doi:
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Journal of clinical anesthesia.
2014 Dec; 26(8):628-33. doi:
10.1016/j.jclinane.2014.05.014. [PMID: 25439407] - Jason A Campagna, Kevin Pojasek, David Grayzel, John Randle, Douglas E Raines. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.
Anesthesiology.
2014 Dec; 121(6):1203-16. doi:
10.1097/aln.0000000000000416. [PMID: 25170571] - Qingzhong Hu, Lina Yin, Rolf W Hartmann. Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
Journal of medicinal chemistry.
2014 Jun; 57(12):5011-22. doi:
10.1021/jm401430e. [PMID: 24422519] - Yonathan Freund, Patricia Jabre, Jerome Mourad, Frederic Lapostolle, Paul-Georges Reuter, Maguy Woimant, Nicolas Javaud, Frederic Adnet. Relative adrenal insufficiency in critically ill patient after rapid sequence intubation: KETASED ancillary study.
Journal of critical care.
2014 Jun; 29(3):386-9. doi:
10.1016/j.jcrc.2013.12.018. [PMID: 24508204] - H-J Feng, Y Jounaidi, M Haburcak, X Yang, S A Forman. Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.
British journal of pharmacology.
2014 Feb; 171(3):789-98. doi:
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The Journal of surgical research.
2013 Aug; 183(2):783-91. doi:
10.1016/j.jss.2013.02.017. [PMID: 23498343] - Huashan Xu, Shengxi Chen, Wanjun Luo, Haihe Jiang. [Role of stress in myocardial protection of ischemic preconditioning].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2013 Aug; 38(8):804-8. doi:
10.3969/j.issn.1672-7347.2013.08.008. [PMID: 23981998] - Ping Li, Megan M Eaton, Joe Henry Steinbach, Gustav Akk. The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.
Anesthesiology.
2013 Jun; 118(6):1417-25. doi:
10.1097/aln.0b013e318289bcd3. [PMID: 23407108] - Si-Si Zhang, Cheng Zhou, Jin Liu, Yi Kang, Pu Zhang, Wen-Sheng Zhang. [30\% intralipid shortens the duration of anesthesia induced by etomidate in rats].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2013 May; 44(3):402-4, 423. doi:
NULL. [PMID: 23898522] - Rooma Desai, Keith W Miller, Douglas E Raines. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.
Anesthesia and analgesia.
2013 Mar; 116(3):573-9. doi:
10.1213/ane.0b013e31827d204d. [PMID: 23400978] - Liang Zou, Hao Yuan, Hai-yan Wang, Zhi-yu Geng, Lei Xu, Li Sun. [Role of target controlled infusion of remifentanil for the prevention of etomidate induced myoclonus during general anesthesia].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2013 Feb; 35(1):112-5. doi:
NULL. [PMID: 23599979] - Rile Ge, Ervin Pejo, Joseph F Cotten, Douglas E Raines. Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.
Critical care (London, England).
2013 Jan; 17(1):R20. doi:
10.1186/cc12494. [PMID: 23363638] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2012 Jul; 28(7):1055-62. doi:
10.1007/s00381-012-1782-0. [PMID: 22562195] - David W Pierce, Ervin Pejo, Douglas E Raines, Stuart A Forman. Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.
Anesthesia and analgesia.
2012 Jul; 115(1):70-2. doi:
10.1213/ane.0b013e318254273e. [PMID: 22543065] - Lin Lin, Jian-Wei Zhang, Yue Huang, Jie Bai, Mei-Hua Cai, Ma-Zhong Zhang. Population pharmacokinetics of intravenous bolus etomidate in children over 6 months of age.
Paediatric anaesthesia.
2012 Apr; 22(4):318-26. doi:
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Fish physiology and biochemistry.
2012 Apr; 38(2):401-11. doi:
10.1007/s10695-011-9516-x. [PMID: 21638007] - Logan J Voss, Magdalena Brock, Cecilia Carlsson, Alistair Steyn-Ross, Moira Steyn-Ross, James W Sleigh. Investigating paradoxical hysteresis effects in the mouse neocortical slice model.
European journal of pharmacology.
2012 Jan; 675(1-3):26-31. doi:
10.1016/j.ejphar.2011.11.045. [PMID: 22166374] - Ervin Pejo, Yan Feng, Wei Chao, Joseph F Cotten, Ri Le Ge, Douglas E Raines. Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.
Critical care medicine.
2012 Jan; 40(1):187-92. doi:
10.1097/ccm.0b013e31822d7924. [PMID: 21926608] - Jean-Francois Payen, Clément Dupuis, Thibaut Trouve-Buisson, Marc Vinclair, Christophe Broux, Pierre Bouzat, Céline Genty, Denis Monneret, Patrice Faure, Olivier Chabre, Jean-Luc Bosson. Corticosteroid after etomidate in critically ill patients: a randomized controlled trial.
Critical care medicine.
2012 Jan; 40(1):29-35. doi:
10.1097/ccm.0b013e31822d7938. [PMID: 21926601] - Ning Wang, Xiao Hai Wang, Jun Lu, Jian You Zhang. The effect of repeated etomidate anesthesia on adrenocortical function during a course of electroconvulsive therapy.
The journal of ECT.
2011 Dec; 27(4):281-5. doi:
10.1097/yct.0b013e3182182be0. [PMID: 22080238] - Derek J Roberts, Richard I Hall, Andreas H Kramer, Helen Lee Robertson, Clare N Gallagher, David A Zygun. Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials.
Critical care medicine.
2011 Dec; 39(12):2743-51. doi:
10.1097/ccm.0b013e318228236f. [PMID: 22094498] - J C Song, Y M Sun, M Z Zhang, L Q Yang, T Z Tao, W F Yu. The etomidate requirement is decreased in patients with obstructive jaundice.
Anesthesia and analgesia.
2011 Nov; 113(5):1028-32. doi:
10.1213/ane.0b013e31822dac4a. [PMID: 21865492] - Joseph F Cotten, Ri Le Ge, Natalie Banacos, Ervin Pejo, S Shaukat Husain, James H Williams, Douglas E Raines. Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.
Anesthesiology.
2011 Oct; 115(4):764-73. doi:
10.1097/aln.0b013e31821950de. [PMID: 21572317] - Y Nyman, K von Hofsten, C Ritzmo, S Eksborg, P A Lönnqvist. Effect of a small priming dose on myoclonic movements after intravenous anaesthesia induction with Etomidate-Lipuro in children.
British journal of anaesthesia.
2011 Aug; 107(2):225-8. doi:
10.1093/bja/aer129. [PMID: 21632605] - Kotaro Kaneda, Susumu Yamashita, Sukyung Woo, Tae-Hyung Han. Population pharmacokinetics and pharmacodynamics of brief etomidate infusion in healthy volunteers.
Journal of clinical pharmacology.
2011 Apr; 51(4):482-91. doi:
10.1177/0091270010369242. [PMID: 20498288] - Filip Gabalec, Alzbeta Zavrelová, Eduard Havel, Jaroslav Cerman, Jakub Radocha, Ioannis Svilias, Jan Cáp. Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome--a description of two cases.
Acta medica (Hradec Kralove).
2011; 54(3):127-30. doi:
10.14712/18059694.2016.35. [PMID: 22250484] - Jinhwa Chang, Sujin Kim, Joohyun Jung, Heechun Lee, Dongwoo Chang, Youngwon Lee, Inhyung Lee, Junghee Yoon, Mincheol Choi. Evaluation of the effects of thiopental, propofol, and etomidate on glomerular filtration rate measured by the use of dynamic computed tomography in dogs.
American journal of veterinary research.
2011 Jan; 72(1):146-51. doi:
10.2460/ajvr.72.1.146. [PMID: 21194347] - Helen L Lutgers, Joris Vergragt, Phi-Vu Dong, Jakob de Vries, Robin P F Dullaart, Gerrit van den Berg, Jack J M Ligtenberg. Severe hypercortisolism: a medical emergency requiring urgent intervention.
Critical care medicine.
2010 Jul; 38(7):1598-601. doi:
10.1097/ccm.0b013e3181e47b7a. [PMID: 20495451] - Yong-qiu Xie, He-na Jiao, Qu-lian Guo, Chan Cheng. [Effects of etomidate infusion on serum cortisol in patients undergoing radical resection of lung cancer].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 May; 30(5):1047-9. doi:
NULL. [PMID: 20501391] - Kenneth A Myers, Gregory A Kline. Addison disease presenting with acute neurologic deterioration: a rare presentation yields new lessons from old observations in primary adrenal failure.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2010 May; 16(3):433-6. doi:
10.4158/ep09282.cr. [PMID: 20061283] - José L Iribarren, Juan J Jiménez, Domingo Hernández, Lisset Lorenzo, Maitane Brouard, Antonio Milena, María L Mora, Rafael Martínez. Relative adrenal insufficiency and hemodynamic status in cardiopulmonary bypass surgery patients. A prospective cohort study.
Journal of cardiothoracic surgery.
2010 Apr; 5(?):26. doi:
10.1186/1749-8090-5-26. [PMID: 20403156] - Zafer Dogan, Mehmet Fatih Yuzbasioglu, Ergul Belge Kurutas, Huseyin Yildiz, Ismail Coskuner, Nimet Senoglu, Hafize Oksuz, Ertan Bülbüloglu. Thiopental improves renal ischemia-reperfusion injury.
Renal failure.
2010 Jan; 32(3):391-5. doi:
10.3109/08860221003611752. [PMID: 20370458] - Ashley B Saunders, Andrew S Hanzlicek, Elizabeth A Martinez, Mark J Stickney, Jörg M Steiner, Jan S Suchodolski, Geoffery T Fosgate. Assessment of cardiac troponin I and C-reactive protein concentrations associated with anesthetic protocols using sevoflurane or a combination of fentanyl, midazolam, and sevoflurane in dogs.
Veterinary anaesthesia and analgesia.
2009 Sep; 36(5):449-56. doi:
10.1111/j.1467-2995.2009.00483.x. [PMID: 19709049] - L Seravalli, F Pralong, J-P Revelly, Y A Que, M Chollet, R Chioléro. [Adrenal function after induction of cardiac surgery patients with an etomidate bolus: a retrospective study].
Annales francaises d'anesthesie et de reanimation.
2009 Sep; 28(9):743-7. doi:
10.1016/j.annfar.2009.07.074. [PMID: 19683891] - Nicole Mettauer, Joe Brierley. A novel use of etomidate for intentional adrenal suppression to control severe hypercortisolemia in childhood.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2009 May; 10(3):e37-40. doi:
10.1097/pcc.0b013e318198b096. [PMID: 19433940] - Pratap Meera, Richard W Olsen, Thomas S Otis, Martin Wallner. Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells.
Neuropharmacology.
2009 Jan; 56(1):155-60. doi:
10.1016/j.neuropharm.2008.08.011. [PMID: 18778723] - Ali Dabbagh, Navid Sa'adat, Zahra Heidari. Etomidate infusion in the critical care setting for suppressing the acute phase of Cushing's syndrome.
Anesthesia and analgesia.
2009 Jan; 108(1):238-9. doi:
10.1213/ane.0b013e318187ed37. [PMID: 19095856] - I Giménez, F I Montero, M J Sernández, J L Aguilar. [General anesthesia in a patient with POEMS syndrome].
Revista espanola de anestesiologia y reanimacion.
2008 Dec; 55(10):645-6. doi:
10.1016/s0034-9356(08)70679-0. [PMID: 19177869] - Mark P Yeager, Patricia A Pioli, Kathleen Wardwell, Michael L Beach, Peter Martel, Hong K Lee, Athos J Rassias, Paul M Guyre. In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytes.
Anesthesia and analgesia.
2008 Nov; 107(5):1726-34. doi:
10.1213/ane.0b013e3181875fb0. [PMID: 18931239] - J-F Payen, M Vinclair, C Broux, P Faure, O Chabre. [Should etomidate still be used?].
Annales francaises d'anesthesie et de reanimation.
2008 Nov; 27(11):915-9. doi:
10.1016/j.annfar.2008.09.016. [PMID: 18980826] - Haci Ahmed Alici, Deniz Ekinci, Sükrü Beydemir. Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo.
Clinical biochemistry.
2008 Nov; 41(16-17):1384-90. doi:
10.1016/j.clinbiochem.2008.06.017. [PMID: 18640108] - James Kraus, Daniel Oreadi, Kalpakam Shastri, Morton Rosenberg. Perioperative management of a patient with short chain acyl-CoA dehydrogenase deficiency: a case report.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2008 Oct; 66(10):2164-5. doi:
10.1016/j.joms.2008.04.007. [PMID: 18848120] - Amy N Hildreth, Vicente A Mejia, Robert A Maxwell, Philip W Smith, Benjamin W Dart, Donald E Barker. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study.
The Journal of trauma.
2008 Sep; 65(3):573-9. doi:
10.1097/ta.0b013e31818255e8. [PMID: 18784570] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Marc Vinclair, Christophe Broux, Patrice Faure, Julien Brun, Céline Genty, Claude Jacquot, Olivier Chabre, Jean-François Payen. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients.
Intensive care medicine.
2008 Apr; 34(4):714-9. doi:
10.1007/s00134-007-0970-y. [PMID: 18092151] - C Rempf, K Helmke, A Gottschalk, F Farokhzad, M A Burmeister. Intraoperative anisocoria in a child during renal transplantation.
Acta anaesthesiologica Scandinavica.
2008 Feb; 52(2):307-9. doi:
10.1111/j.1399-6576.2007.01505.x. [PMID: 18005382] - Charles L Sprung, Djillali Annane, Didier Keh, Rui Moreno, Mervyn Singer, Klaus Freivogel, Yoram G Weiss, Julie Benbenishty, Armin Kalenka, Helmuth Forst, Pierre-Francois Laterre, Konrad Reinhart, Brian H Cuthbertson, Didier Payen, Josef Briegel. Hydrocortisone therapy for patients with septic shock.
The New England journal of medicine.
2008 Jan; 358(2):111-24. doi:
10.1056/nejmoa071366. [PMID: 18184957] - Huijun Zhong, Dirk Rüsch, Stuart A Forman. Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.
Anesthesiology.
2008 Jan; 108(1):103-12. doi:
10.1097/01.anes.0000296074.33999.52. [PMID: 18156888] - Florence C Riché, Carole M Boutron, Patrice Valleur, Christine Berton, Marie-Josèphe Laisné, Jean-Marie Launay, Philippe Chappuis, Jacqueline Peynet, Eric Vicaut, Didier Payen, Bernard P Cholley. Adrenal response in patients with septic shock of abdominal origin: relationship to survival.
Intensive care medicine.
2007 Oct; 33(10):1761-6. doi:
10.1007/s00134-007-0770-4. [PMID: 17618417] - James E Richardson, Paul S Garcia, Kate K O'Toole, Jason M C Derry, Shannon V Bell, Andrew Jenkins. A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol.
Anesthesiology.
2007 Sep; 107(3):412-8. doi:
10.1097/01.anes.0000278875.36639.2c. [PMID: 17721243] - Michelle P McIntosh, Hideyuki Narita, Yoshiyuki Kameyama, Roger A Rajewski, Hiroshi Goto. Evaluation of mean arterial blood pressure, heart rate, and sympathetic nerve activity in rabbits after administration of two formulations of etomidate.
Veterinary anaesthesia and analgesia.
2007 May; 34(3):149-56. doi:
10.1111/j.1467-2995.2006.00312.x. [PMID: 17444927] - Damian P Bright, Sara D Adham, Lucienne C J M Lemaire, Rodrigo Benavides, Marco Gruss, Graham W Taylor, Edward H Smith, Nicholas P Franks. Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel.
The Journal of biological chemistry.
2007 Apr; 282(16):12038-47. doi:
10.1074/jbc.m700479200. [PMID: 17311911] - S Bendel, E Ruokonen, P Pölönen, A Uusaro. Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate.
Acta anaesthesiologica Scandinavica.
2007 Mar; 51(3):284-9. doi:
10.1111/j.1399-6576.2006.01206.x. [PMID: 17390417] - Tami N Johnson, Todd W Canada. Etomidate use for Cushing's syndrome caused by an ectopic adrenocorticotropic hormone-producing tumor.
The Annals of pharmacotherapy.
2007 Feb; 41(2):350-3. doi:
10.1345/aph.1h365. [PMID: 17213295]