Aminocaproic acid (BioDeep_00000405481)

Main id: BioDeep_00000001271

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


6-Aminocaproic acid

化学式: C6H13NO2 (131.0946)
中文名称: 6-氨基己酸, 氨基己酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCC(=O)O)CCN
InChI: InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

描述信息

B - Blood and blood forming organs > B02 - Antihemorrhagics > B02A - Antifibrinolytics > B02AA - Amino acids
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

同义名列表

7 个代谢物同义名

6-Aminocaproic acid; Aminocaproic acid; EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid; 6-Aminohexanoate; Aminocaproic acid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ELANE, PLAT, SERPINB2, TP53
Nucleus 1 TP53
cytosol 2 ELANE, TP53
phagocytic vesicle 1 ELANE
centrosome 1 TP53
nucleoplasm 1 TP53
Cell membrane 1 ITGAM
cell surface 7 ELANE, EPO, ITGAM, PLAT, PLAU, PLG, SERPINF2
glutamatergic synapse 2 PLAT, PLG
Golgi membrane 1 INS
lysosomal membrane 1 EGF
plasma membrane 11 EGF, F2, F7, F9, ITGAM, KNG1, PLAU, PLG, REN, SERPINB2, SERPINC1
Membrane 4 EGF, ITGAM, REN, TP53
extracellular exosome 13 EGF, ELANE, EPO, F2, F9, ITGAM, KNG1, PLAT, PLAU, PLG, SERPINC1, SERPINF2, VWF
endoplasmic reticulum 2 TP53, VWF
extracellular space 19 EGF, ELANE, EPO, F2, F7, F9, IL6, INS, ITGAM, KNG1, LPA, PLAT, PLAU, PLG, REN, SERPINB2, SERPINC1, SERPINF2, VWF
Schaffer collateral - CA1 synapse 2 PLAT, PLG
mitochondrion 1 TP53
protein-containing complex 1 TP53
Single-pass type I membrane protein 1 ITGAM
Secreted 11 EPO, F2, F7, F9, IL6, INS, PLAT, PLAU, PLG, REN, VWF
extracellular region 18 EGF, ELANE, EPO, F2, F7, F9, IL6, INS, KNG1, LPA, PLAT, PLAU, PLG, REN, SERPINB2, SERPINC1, SERPINF2, VWF
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 3 ITGAM, PLAU, PLG
Secreted, extracellular space, extracellular matrix 1 VWF
nucleolus 1 TP53
apical part of cell 2 PLAT, REN
vesicle 1 F7
Membrane raft 1 ITGAM
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 PLAU
extracellular matrix 1 VWF
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 9 ELANE, F2, F7, F9, KNG1, PLG, SERPINC1, SERPINF2, VWF
secretory granule 2 ELANE, PLAT
chromatin 1 TP53
Secreted, extracellular space 2 KNG1, SERPINC1
blood microparticle 5 F2, KNG1, PLG, SERPINC1, SERPINF2
site of double-strand break 1 TP53
endosome lumen 1 INS
Cornified envelope 1 SERPINB2
specific granule membrane 2 ITGAM, PLAU
tertiary granule membrane 2 ITGAM, PLAU
cell body 1 EPO
germ cell nucleus 1 TP53
replication fork 1 TP53
platelet alpha granule 1 VWF
plasma membrane raft 1 ITGAM
secretory granule lumen 2 EPO, INS
Golgi lumen 4 F2, F7, F9, INS
endoplasmic reticulum lumen 7 F2, F7, F9, IL6, INS, KNG1, SERPINC1
nuclear matrix 1 TP53
transcription repressor complex 2 ELANE, TP53
platelet alpha granule lumen 5 EGF, KNG1, PLG, SERPINF2, VWF
specific granule lumen 1 ELANE
transport vesicle 1 INS
azurophil granule lumen 1 ELANE
serine-type endopeptidase complex 1 PLAU
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGF
[Isoform 1]: Nucleus 1 TP53
serine protease inhibitor complex 2 PLAT, PLAU
Cytoplasmic vesicle, phagosome 1 ELANE
integrin complex 1 ITGAM
protein complex involved in cell-matrix adhesion 1 PLAU
fibrinogen complex 1 SERPINF2
Weibel-Palade body 1 VWF
integrin alphaM-beta2 complex 1 ITGAM
interleukin-6 receptor complex 1 IL6
plasma lipoprotein particle 1 LPA
serine-type peptidase complex 1 F7


文献列表

  • Fasika A Woreta, Kristina B Lindsley, Almutez Gharaibeh, Sueko M Ng, Roberta W Scherer, Morton F Goldberg. Medical interventions for traumatic hyphema. The Cochrane database of systematic reviews. 2023 03; 3(?):CD005431. doi: 10.1002/14651858.cd005431.pub5. [PMID: 36912744]
  • Dong-Wan Kang, Bong Geun Cha, Jee Hoon Lee, Wookjin Yang, Seul Ki Ki, Ju Hee Han, Ha Yoon Cho, Eunchae Park, Sohyun Jeon, Seung-Hoon Lee. Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy. Nanomedicine : nanotechnology, biology, and medicine. 2022 09; 45(?):102586. doi: 10.1016/j.nano.2022.102586. [PMID: 35868519]
  • Taylor E Wallen, Kathleen E Singer, Matthew R Baucom, Lisa G England, Rebecca M Schuster, Timothy A Pritts, Michael D Goodman. Effects of antifibrinolytics on systemic and cerebral inflammation after traumatic brain injury. The journal of trauma and acute care surgery. 2022 07; 93(1):30-37. doi: 10.1097/ta.0000000000003607. [PMID: 35319541]
  • Xiao-Long Fan. Comment on article by Zhong et al.: Local administration of epsilon-aminocaproic acid reduces post-operative blood loss from surgery for closed, Sanders III-IV calcaneal fractures. International orthopaedics. 2022 06; 46(6):1427-1428. doi: 10.1007/s00264-022-05355-8. [PMID: 35262758]
  • Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M Verhamme, Owen J T McCarty, Ruby H P Law, David Gailani. Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains. Blood advances. 2022 05; 6(10):3142-3154. doi: 10.1182/bloodadvances.2021005976. [PMID: 35086137]
  • Philip C Spinella, Julie C Leonard, Barbara A Gaines, James F Luther, Stephen R Wisniewski, Cassandra D Josephson, Christine M Leeper. Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study. Critical care medicine. 2022 04; 50(4):e382-e392. doi: 10.1097/ccm.0000000000005383. [PMID: 34661553]
  • Ebtehal F Anwer, Deena A M Nour El-Deen, Sayed M Derayea, Mahmoud A Omar. Benzofurazan -based fluorophore for the spectrofluorimetric determination of 6-Aminocaproic acid: Application to spiked human plasma and urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Mar; 268(?):120723. doi: 10.1016/j.saa.2021.120723. [PMID: 34915229]
  • Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nature communications. 2021 12; 12(1):7293. doi: 10.1038/s41467-021-27488-x. [PMID: 34911940]
  • Ebtehal F Anwer, Deena A M Nour El-Deen, Mahmoud A Omar. An innovational validated spectrofluorimetric technique for determination of 6-Aminocaproic acid in pure form and its tablet: Application to spiked human plasma and urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Nov; 261(?):119984. doi: 10.1016/j.saa.2021.119984. [PMID: 34087772]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Madison Coleman, Joel Davis, Kevin O Maher, Shriprasad R Deshpande. Clinical and Hematological Outcomes of Aminocaproic Acid Use During Pediatric Cardiac ECMO. The journal of extra-corporeal technology. 2021 Mar; 53(1):40-45. doi: 10.1182/ject-2000032. [PMID: 33814604]
  • Erik R Strauss, Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S Gammie, Bradley Taylor, Michael A Mazzeffi, Jogarao V S Gobburu, Kenichi A Tanaka. A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass. Journal of cardiothoracic and vascular anesthesia. 2021 Feb; 35(2):406-417. doi: 10.1053/j.jvca.2020.07.048. [PMID: 32811752]
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  • Jian Jing, Zhenhuan Du, Songyang Ji, Keqiang Han. Urinary proteome analysis of acute hypercoagulable state in rat model induced by ε-aminocaproic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Feb; 110(?):275-284. doi: 10.1016/j.biopha.2018.11.148. [PMID: 30513505]
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  • Vance G Nielsen, Paul M Ford. The ratio of concentrations of aminocaproic acid and tranexamic acid that prevent plasmin activation of platelets does not provide equivalent inhibition of plasmatic fibrinolysis. Journal of thrombosis and thrombolysis. 2018 Oct; 46(3):365-370. doi: 10.1007/s11239-018-1705-3. [PMID: 29926296]
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  • Clifford Kent Boese, Leslie Centeno, Ryan W Walters. Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty. The Journal of bone and joint surgery. American volume. 2017 Oct; 99(19):1621-1628. doi: 10.2106/jbjs.16.00738. [PMID: 28976426]
  • Huiyoung Kwon, In Ho Jung, Ji Hyun Yi, Jae Hoon Kim, Jung Hoon Park, Seungheon Lee, Ji Wook Jung, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim. The Seed of Zizyphus jujuba var. spinosa Attenuates Alzheimer's Disease-Associated Hippocampal Synaptic Deficits through BDNF/TrkB Signaling. Biological & pharmaceutical bulletin. 2017; 40(12):2096-2104. doi: 10.1248/bpb.b17-00378. [PMID: 29199234]
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  • Jamie C Brown, Benjamin M Brainard, Daniel J Fletcher, Ben Nie, Robert D Arnold, Chad W Schmiedt. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. American journal of veterinary research. 2016 Nov; 77(11):1258-1265. doi: 10.2460/ajvr.77.11.1258. [PMID: 27805439]
  • Seung H Yoo, Emilee Venn, Lauren A Sullivan, Christine S Olver. Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2016 Sep; 26(5):737-42. doi: 10.1111/vec.12467. [PMID: 26990227]
  • Ramona Nicolau-Raducu, Timothy C Ku, Donald R Ganier, Brian M Evans, Joseph Koveleskie, William J Daly, Brian Fish, Ari J Cohen, Trevor W Reichman, Humberto E Bohorquez, David S Bruce, Ian C Carmody, George E Loss, Marina Gitman, Thomas Marshall, Bobby D Nossaman. Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality After Liver Transplantation. Journal of cardiothoracic and vascular anesthesia. 2016 Aug; 30(4):917-23. doi: 10.1053/j.jvca.2015.12.003. [PMID: 27020101]
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  • Michael P Eaton, George M Alfieris, Dawn M Sweeney, Ronald E Angona, Jill M Cholette, Charles Venuto, Brian Anderson. Pharmacokinetics of ε-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass. Anesthesiology. 2015 May; 122(5):1002-9. doi: 10.1097/aln.0000000000000616. [PMID: 25723765]
  • P A Stricker, M R Gastonguay, D Singh, J E Fiadjoe, E M Sussman, E Y Pruitt, T K Goebel, A F Zuppa. Population pharmacokinetics of ϵ-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery. British journal of anaesthesia. 2015 Apr; 114(4):689-99. doi: 10.1093/bja/aeu459. [PMID: 25586726]
  • M Stalnaker, P Esquivel. Managing menorrhagia in a familial case of factor V deficiency. Journal of pediatric and adolescent gynecology. 2015 Feb; 28(1):e9-e12. doi: 10.1016/j.jpag.2014.03.007. [PMID: 25256869]
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  • Daniel J Fletcher, Kelly J Blackstock, Kira Epstein, Benjamin M Brainard. Evaluation of tranexamic acid and ε-aminocaproic acid concentrations required to inhibit fibrinolysis in plasma of dogs and humans. American journal of veterinary research. 2014 Aug; 75(8):731-8. doi: 10.2460/ajvr.75.8.731. [PMID: 25061704]
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  • D J Fletcher, B M Brainard, K Epstein, R Radcliffe, T Divers. Therapeutic plasma concentrations of epsilon aminocaproic acid and tranexamic acid in horses. Journal of veterinary internal medicine. 2013 Nov; 27(6):1589-95. doi: 10.1111/jvim.12202. [PMID: 24118238]
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