Homoarginine (BioDeep_00000405327)
Main id: BioDeep_00000003130
PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
Homo-L-arginine
化学式: C7H16N4O2 (188.12731960000002)
中文名称: 高精氨酸, L-高精氨酸
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-07-15.
Cite this Page
Homoarginine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/homoarginine (retrieved
2024-11-22) (BioDeep RN: BioDeep_00000405327). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CCN=C(N)N)CC(C(=O)O)N
InChI: InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)
描述信息
An L-lysine derivative that is the L-enantiomer of homoarginine.
Homoarginine is a guanidino compounds of guanidinoethanesulfonic acid. It is an organ-specific uncompetitive inhibitor of human liver and bone alkaline phosphohydrolase. (PMID 5063678). L-Homoarginine is found in grass pea.
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.
同义名列表
6 个代谢物同义名
L-Homoarginine; Homoarginine; Homo-L-arginine; H-HoArg-OH; Homoarginine; L-Homoarginine
数据库引用编号
33 个数据库交叉引用编号
- ChEBI: CHEBI:27747
- KEGG: C01924
- PubChem: 9085
- DrugBank: DB03974
- ChEMBL: CHEMBL589752
- MeSH: Homoarginine
- foodb: FDB001490
- CAS: 13094-78-5
- CAS: 156-86-5
- MoNA: MoNA038767
- MoNA: MoNA037463
- MoNA: MoNA036671
- MoNA: MoNA036670
- MoNA: MoNA036669
- MoNA: MoNA032965
- MoNA: MoNA032961
- MoNA: MoNA032960
- MoNA: FiehnHILIC002748
- MoNA: FiehnHILIC001986
- MoNA: FiehnHILIC001247
- MoNA: FiehnHILIC000415
- MoNA: HMDB0000670_ms_ms_921
- MoNA: HMDB0000670_ms_ms_923
- MoNA: HMDB0000670_ms_ms_922
- MetaboLights: MTBLC27747
- KNApSAcK: C00001364
- PDB-CCD: HRG
- NIKKAJI: J24H
- RefMet: Homoarginine
- medchemexpress: HY-W008385
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-983
- PubChem: 5030
- KNApSAcK: 27747
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 3856 - Lathyrus cicera: 10.1002/JSFA.6792
- 3860 - Lathyrus sativus: 10.1002/JSFA.6792
- 3862 - Lathyrus tingitanus: 10.1016/S0031-9422(00)81117-6
- 5691 - Trypanosoma brucei:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dietmar Funck, Malte Sinn, Giuseppe Forlani, Jörg S Hartig. Guanidine production by plant homoarginine-6-hydroxylases.
eLife.
2024 Apr; 12(?):. doi:
10.7554/elife.91458. [PMID: 38619227] - Christine J Kleist, Chi-Un Choe, Dorothee Atzler, Mirjam Schönhoff, Rainer Böger, Edzard Schwedhelm, Sebastian G Wicha. Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction.
Amino acids.
2022 Jun; 54(6):889-896. doi:
10.1007/s00726-022-03169-x. [PMID: 35618975] - Svetlana Baskal, Laurianne Dimina, Stefanos A Tsikas, Laurent Mosoni, Didier Remond, François Mariotti, Dimitrios Tsikas. Lysine and homoarginine are closely interrelated metabolites in the rat.
Amino acids.
2022 Jun; 54(6):967-976. doi:
10.1007/s00726-022-03158-0. [PMID: 35352207] - Salvatore Sotgia, Fiammetta Berlinguer, Christian Porcu, Valeria Pasciu, Giovanni Molle, Maria Dattena, Marilia Gallus, Stefania Bassu, Arduino A Mangoni, Ciriaco Carru, Angelo Zinellu. Plasma homoarginine concentrations in ewe's pregnancy and association with the number of fetuses.
Research in veterinary science.
2022 May; 144(?):175-180. doi:
10.1016/j.rvsc.2021.11.012. [PMID: 34823870] - Tien F Lee, Andrew D Bersten, Leonie K Heilbronn, Angelo Zinellu, Ciriaco Carru, Salvatore Sotgia, Arduino A Mangoni, Morton G Burt. ADMA and homoarginine independently predict mortality in critically ill patients.
Nitric oxide : biology and chemistry.
2022 05; 122-123(?):47-53. doi:
10.1016/j.niox.2022.03.002. [PMID: 35367633] - Dimitrios Tsikas, Björn Redfors. Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy.
International journal of molecular sciences.
2022 Apr; 23(9):. doi:
10.3390/ijms23094734. [PMID: 35563125] - Beatrice Hanusch, Kathrin Sinningen, Folke Brinkmann, Stefanie Dillenhöfer, Mirjam Frank, Karl-Heinz Jöckel, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Christian Langrock, Thomas Reinehr, Patricia Maasjosthusmann, Bibiana Beckmann, Eckard Hamelmann, Dimitrios Tsikas, Thomas Lücke. Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23042136. [PMID: 35216250] - Benedetta Porro, Sonia Eligini, Edoardo Conte, Nicola Cosentino, Nicolò Capra, Viviana Cavalca, Cristina Banfi. An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031136. [PMID: 35163055] - Vitali Koch, Christophe Weber, Johannes H Riffel, Kristina Buchner, Sebastian J Buss, Selina Hein, Derliz Mereles, Marco Hagenmueller, Christian Erbel, Winfried März, Christian Booz, Moritz H Albrecht, Thomas J Vogl, Norbert Frey, Stefan E Hardt, Marco Ochs. Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure.
Journal of cardiovascular pharmacology and therapeutics.
2022 Jan; 27(?):10742484211054620. doi:
10.1177/10742484211054620. [PMID: 34994208] - A A Zhloba, T F Subbotina. Homoarginine test for evaluation of metabolic renal dysfunction.
Klinicheskaia laboratornaia diagnostika.
2021 Dec; 66(12):709-717. doi:
10.51620/0869-2084-2021-66-12-709-717. [PMID: 35020282] - Maserame Cleopatra Mokhaneli, Shani Botha-Le Roux, Carla Maria Theresia Fourie, Rainer Böger, Edzard Schwedhelm, Catharina Martha Cornelia Mels. L-homoarginine is associated with decreased cardiovascular- and all-cause mortality.
European journal of clinical investigation.
2021 May; 51(5):e13472. doi:
10.1111/eci.13472. [PMID: 33320332] - Michael D Wetzel, Kristen Stanley, Soumya Maity, Muniswamy Madesh, Jean C Bopassa, Alaa S Awad. Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase-3.
Physiological reports.
2021 03; 9(5):e14766. doi:
10.14814/phy2.14766. [PMID: 33713581] - Usman A Tahir, Daniel H Katz, Tianyi Zhao, Debby Ngo, Daniel E Cruz, Jeremy M Robbins, Zsu-Zsu Chen, Bennet Peterson, Mark D Benson, Xu Shi, Lucas Dailey, Charlotte Andersson, Ramachandran S Vasan, Yan Gao, Changyu Shen, Adolfo Correa, Michael E Hall, Thomas J Wang, Clary B Clish, James G Wilson, Robert E Gerszten. Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study.
Circulation. Heart failure.
2021 01; 14(1):e007275. doi:
10.1161/circheartfailure.120.007275. [PMID: 33464957] - Ashleigh Craig, Catharina M C Mels, Aletta E Schutte, Alexander Bollenbach, Dimitrios Tsikas, Edzard Schwedhelm, Ruan Kruger. Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2021 Jan; 44(1):71-79. doi:
10.1038/s41440-020-0514-1. [PMID: 32681162] - Gian Luca Erre, Arduino Aleksander Mangoni, Giuseppe Passiu, Stefania Bassu, Floriana Castagna, Ciriaco Carru, Matteo Piga, Angelo Zinellu, Salvatore Sotgia. Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.
Microvascular research.
2020 09; 131(?):104038. doi:
10.1016/j.mvr.2020.104038. [PMID: 32622695] - A A Zhloba, T F Subbotina. [The evaluation of homoarginine and folic acid in patients with arterial hypertension.].
Klinicheskaia laboratornaia diagnostika.
2020 Jul; 65(8):474-481. doi:
10.18821/0869-2084-2020-65-8-474-481. [PMID: 32762188] - Emir Taghikhani, Renke Maas, R Verena Taudte, Arne Gessner, Martin F Fromm, Jörg König. Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells.
Amino acids.
2020 Jul; 52(6-7):975-985. doi:
10.1007/s00726-020-02867-8. [PMID: 32642843] - Maserame C Mokhaneli, Carla M T Fourie, Shani Botha-Le Roux, Rainer H Böger, Edzard Schwedhelm, Catharina M C Mels. Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort.
Amino acids.
2020 Jul; 52(6-7):965-973. doi:
10.1007/s00726-020-02866-9. [PMID: 32613307] - Renke Maas, Maren Mieth, Stephanie I Titze, Silvia Hübner, Martin F Fromm, Jan T Kielstein, Matthias Schmid, Anna Köttgen, Florian Kronenberg, Vera Krane, Birgit Hausknecht, Kai-Uwe Eckardt, Markus P Schneider. Drugs linked to plasma homoarginine in chronic kidney disease patients-a cross-sectional analysis of the German Chronic Kidney Disease cohort.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 07; 35(7):1187-1195. doi:
10.1093/ndt/gfy342. [PMID: 30476224] - Erik Hanff, Alexander Bollenbach, Bibiana Beckmann, Gorig Brunner, Dimitrios Tsikas. GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine.
Amino acids.
2020 Feb; 52(2):225-234. doi:
10.1007/s00726-019-02786-3. [PMID: 31541302] - Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Bibiana Beckmann, Björn Redfors. Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat.
Amino acids.
2020 Feb; 52(2):235-245. doi:
10.1007/s00726-019-02808-0. [PMID: 31776762] - Ali Sasani, Sönke Hornig, Ricarda Grzybowski, Kathrin Cordts, Erik Hanff, Dimitris Tsikas, Rainer Böger, Christian Gerloff, Dirk Isbrandt, Axel Neu, Edzard Schwedhelm, Chi-Un Choe. Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure.
Amino acids.
2020 Jan; 52(1):73-85. doi:
10.1007/s00726-019-02812-4. [PMID: 31853708] - Erik Hanff, Mohammad Yusof Said, Arslan Arinc Kayacelebi, Adrian Post, Isidor Minovic, Else van den Berg, Martin H de Borst, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas. High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients.
Amino acids.
2019 Nov; 51(10-12):1485-1499. doi:
10.1007/s00726-019-02783-6. [PMID: 31535220] - Arne Gessner, Maren Mieth, Daniel Auge, Anja Chafai, Fabian Müller, Martin F Fromm, Renke Maas. Establishment of reference values for the lysine acetylation marker Nɛ-acetyllysine in small volume human plasma samples by a multi-target LC-MS/MS method.
Amino acids.
2019 Sep; 51(9):1259-1271. doi:
10.1007/s00726-019-02765-8. [PMID: 31388851] - Michael D Wetzel, Ting Gao, Manjeri Venkatachalam, Sidney M Morris, Alaa S Awad. l-Homoarginine supplementation prevents diabetic kidney damage.
Physiological reports.
2019 09; 7(18):e14235. doi:
10.14814/phy2.14235. [PMID: 31552707] - Alexander Bollenbach, Kathrin Cordts, Erik Hanff, Dorothee Atzler, Chi-Un Choe, Edzard Schwedhelm, Dimitrios Tsikas. Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.
Analytical biochemistry.
2019 07; 577(?):59-66. doi:
10.1016/j.ab.2019.04.019. [PMID: 31028716] - Ewa Wieczorek-Surdacka, Erik Hanff, Bernadeta Chyrchel, Marek Kuźniewski, Andrzej Surdacki, Dimitrios Tsikas. Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease.
Amino acids.
2019 Jun; 51(6):977-982. doi:
10.1007/s00726-019-02738-x. [PMID: 31049693] - Alexander Bollenbach, Erik Hanff, Gorig Brunner, Dimitrios Tsikas. Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection.
Amino acids.
2019 Jun; 51(6):961-971. doi:
10.1007/s00726-019-02737-y. [PMID: 31028565] - Tjark F Schwemer, Navina Deutscher, Nadine Diermann, Rainer Böger, Edzard Schwedhelm, Stefan Blankenberg, Felix W Friedrich. Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial.
Scientific reports.
2019 04; 9(1):5708. doi:
10.1038/s41598-019-42239-1. [PMID: 30952941] - Seidu Adams, Dongsheng Che, Guixin Qin, Mohammed Hamdy Farouk, Jiang Hailong, Han Rui. Novel Biosynthesis, Metabolism and Physiological Functions of L-Homoarginine.
Current protein & peptide science.
2019; 20(2):184-193. doi:
10.2174/1389203719666181026170049. [PMID: 30370846] - Emir Taghikhani, Renke Maas, Martin F Fromm, Jörg König. The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.
PloS one.
2019; 14(3):e0213747. doi:
10.1371/journal.pone.0213747. [PMID: 30865704] - Alexander Bollenbach, Erik Hanff, Dimitrios Tsikas. Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Analytical biochemistry.
2018 12; 563(?):67-70. doi:
10.1016/j.ab.2018.10.012. [PMID: 30312621] - Erik Hanff, Patricia Hafner, Alexander Bollenbach, Ulrike Bonati, Arslan Arinc Kayacelebi, Dirk Fischer, Dimitrios Tsikas. Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications.
Amino acids.
2018 Oct; 50(10):1391-1406. doi:
10.1007/s00726-018-2614-7. [PMID: 30003335] - Jens Martens-Lobenhoffer, Insa E Emrich, Adam M Zawada, Danilo Fliser, Stefan Wagenpfeil, Gunnar H Heine, Stefanie M Bode-Böger. L-Homoarginine and its AGXT2-metabolite GOCA in chronic kidney disease as markers for clinical status and prognosis.
Amino acids.
2018 Oct; 50(10):1347-1356. doi:
10.1007/s00726-018-2610-y. [PMID: 29982953] - Christoph Niekamp, Dorothee Atzler, Francisco M Ojeda, Christoph R Sinning, Karl J Lackner, Rainer H Böger, Thomas Munzel, Manfred E Beutel, Irene Schmidtmann, Norbert Pfeiffer, Anja Leuschner, Stefan Blankenberg, Philipp S Wild, Tanja Zeller, Edzard Schwedhelm, Renate B Schnabel. Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community-The Gutenberg Health Study.
Biomolecules.
2018 08; 8(3):. doi:
10.3390/biom8030086. [PMID: 30200232] - Thea Helm, Kristin Varsi, Christina Herland Fløtre, Agnethe Lund, Gard Frodahl Tveitevåg Svingen, Per Magne Ueland, Anne-Lise Bjørke-Monsen. Plasma Homoarginine Concentrations According to Use of Hormonal Contraception.
Scientific reports.
2018 08; 8(1):12217. doi:
10.1038/s41598-018-30708-y. [PMID: 30111829] - Angelo Zinellu, Panagiotis Paliogiannis, Ciriaco Carru, Arduino A Mangoni. Homoarginine and all-cause mortality: A systematic review and meta-analysis.
European journal of clinical investigation.
2018 Aug; 48(8):e12960. doi:
10.1111/eci.12960. [PMID: 29806958] - Martin Bahls, Dorothee Atzler, Marcello R P Markus, Nele Friedrich, Rainer H Böger, Henry Völzke, Stephan B Felix, Edzard Schwedhelm, Marcus Dörr. Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population.
Biomolecules.
2018 07; 8(3):. doi:
10.3390/biom8030063. [PMID: 30061520] - Mirjam Schönhoff, Gabriele Weineck, Julia Hoppe, Sönke Hornig, Kathrin Cordts, Dorothee Atzler, Christian Gerloff, Rainer Böger, Axel Neu, Edzard Schwedhelm, Chi-Un Choe. Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2018 Apr; 50(?):237-241. doi:
10.1016/j.jocn.2018.01.035. [PMID: 29396070] - Kiterie M E Faller, Dorothee Atzler, Debra J McAndrew, Sevasti Zervou, Hannah J Whittington, Jillian N Simon, Dunja Aksentijevic, Michiel Ten Hove, Chi-Un Choe, Dirk Isbrandt, Barbara Casadei, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate. Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Cardiovascular research.
2018 Mar; 114(3):417-430. doi:
10.1093/cvr/cvx242. [PMID: 29236952] - S Tommasi, D J Elliot, M Da Boit, S R Gray, B C Lewis, A A Mangoni. Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
Scientific reports.
2018 02; 8(1):3697. doi:
10.1038/s41598-018-22099-x. [PMID: 29487337] - A A Zhloba, T F Subbotina, N S Molchan. [The value of detection of homoarginin level in patients with ischemic heart disease under operations of myocardium re-vascularization.].
Klinicheskaia laboratornaia diagnostika.
2018 ; 63(5):281-286. doi:
10.18821/0869-2084-2018-63-5-281-286. [PMID: 30689321] - Duygu Naile Günes, Arslan Arinc Kayacelebi, Erik Hanff, Joel Lundgren, Björn Redfors, Dimitrios Tsikas. Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
Amino acids.
2017 Dec; 49(12):2033-2044. doi:
10.1007/s00726-017-2465-7. [PMID: 28710553] - Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen, Pirkko-Liisa Kellokumpu-Lehtinen. Adjuvant Breast Cancer Treatments Induce Changes in Homoarginine Level - A Prospective Observational Study.
Anticancer research.
2017 12; 37(12):6815-6824. doi:
10.21873/anticanres.12142. [PMID: 29187460] - Elli Mann, Robert Kluesener, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Christoph Melzer, Thomas B Dschietzig. Homoarginine Associates with Zonulin and Tryptophan - Findings in a High-Risk Cohort of Patients Carrying an AICD.
Clinical laboratory.
2017 Nov; 63(11):1911-1918. doi:
10.7754/clin.lab.2017.170725. [PMID: 29226642] - Anjana Radhakutty, Brenda L Mangelsdorf, Sophie M Drake, Andrew Rowland, Malcolm D Smith, Arduino A Mangoni, Campbell H Thompson, Morton G Burt. Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics.
Atherosclerosis.
2017 Nov; 266(?):190-195. doi:
10.1016/j.atherosclerosis.2017.10.004. [PMID: 29035782] - Martin Sebastian Winkler, Stefan Kluge, Maximilian Holzmann, Eileen Moritz, Linda Robbe, Antonia Bauer, Corinne Zahrte, Marion Priefler, Edzard Schwedhelm, Rainer H Böger, Alwin E Goetz, Axel Nierhaus, Christian Zoellner. Markers of nitric oxide are associated with sepsis severity: an observational study.
Critical care (London, England).
2017 Jul; 21(1):189. doi:
10.1186/s13054-017-1782-2. [PMID: 28709458] - Anja Chafai, Martin F Fromm, Jörg König, Renke Maas. The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
Scientific reports.
2017 07; 7(1):4767. doi:
10.1038/s41598-017-04965-2. [PMID: 28684763] - Arslan Arinc Kayacelebi, Isidor Minović, Erik Hanff, Anne-Roos S Frenay, Martin H de Borst, Martin Feelisch, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas. Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.
Amino acids.
2017 07; 49(7):1193-1202. doi:
10.1007/s00726-017-2420-7. [PMID: 28429125] - Arash Haghikia, Georgi Radoslavov Yanchev, Arslan Arinc Kayacelebi, Erik Hanff, Nils Bledau, Christian Widera, Kristina Sonnenschein, Aiden Haghikia, Karin Weissenborn, Johann Bauersachs, Udo Bavendiek, Dimitrios Tsikas. The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.
Amino acids.
2017 06; 49(6):1111-1121. doi:
10.1007/s00726-017-2409-2. [PMID: 28285332] - Anna Buck, Arslan Arinc Kayacelebi, Kristine Chobanyan-Jürgens, Sabine Illsinger, Bettina Bohnhorst, Bibiana Beckmann, Erik Hanff, Anibh M Das, Dimitrios Tsikas, Thomas Lücke. Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth.
Amino acids.
2017 04; 49(4):783-794. doi:
10.1007/s00726-017-2382-9. [PMID: 28161799] - Patrik Persson, Angelica Fasching, Tom Teerlink, Peter Hansell, Fredrik Palm. Cellular transport of l-arginine determines renal medullary blood flow in control rats, but not in diabetic rats despite enhanced cellular uptake capacity.
American journal of physiology. Renal physiology.
2017 Feb; 312(2):F278-F283. doi:
10.1152/ajprenal.00335.2016. [PMID: 27927650] - Tanja Raedle-Hurst, Marieke Mueller, Andreas Meinitzer, Winfried Maerz, Thomas Dschietzig. Homoarginine-A prognostic indicator in adolescents and adults with complex congenital heart disease?.
PloS one.
2017; 12(9):e0184333. doi:
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PloS one.
2017; 12(1):e0168775. doi:
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British journal of clinical pharmacology.
2016 12; 82(6):1477-1485. doi:
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Scientific reports.
2016 10; 6(?):35277. doi:
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Clinical chemistry and laboratory medicine.
2016 Jul; 54(7):1231-7. doi:
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Cardiovascular research.
2016 06; 110(3):408-18. doi:
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Journal of the American Heart Association.
2016 Apr; 5(4):e002565. doi:
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Amino acids.
2016 Apr; 48(4):993-1001. doi:
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Amino acids.
2016 Mar; 48(3):721-732. doi:
10.1007/s00726-015-2120-0. [PMID: 26573540] - Yongqing Hou, Sichao Jia, Gayan Nawaratna, Shengdi Hu, Sudath Dahanayaka, Fuller W Bazer, Guoyao Wu. Analysis of L-homoarginine in biological samples by HPLC involving precolumn derivatization with o-phthalaldehyde and N-acetyl-L-cysteine.
Amino acids.
2015 Sep; 47(9):2005-14. doi:
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Amino acids.
2015 Sep; 47(9):1931-9. doi:
10.1007/s00726-015-1973-6. [PMID: 25894889] - Arslan Arinc Kayacelebi, Ann-Kathrin Knöfel, Bibiana Beckmann, Erik Hanff, Gregor Warnecke, Dimitrios Tsikas. Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS.
Amino acids.
2015 Sep; 47(9):2023-34. doi:
10.1007/s00726-015-1984-3. [PMID: 25957527] - Stefan Pilz, Andreas Meinitzer, Martin Gaksch, Martin Grübler, Nicolas Verheyen, Christiane Drechsler, Bríain Ó Hartaigh, Florian Lang, Ioana Alesutan, Jakob Voelkl, Winfried März, Andreas Tomaschitz. Homoarginine in the renal and cardiovascular systems.
Amino acids.
2015 Sep; 47(9):1703-13. doi:
10.1007/s00726-015-1993-2. [PMID: 25929587] - Anne-Roos S Frenay, Arslan Arinc Kayacelebi, Bibiana Beckmann, Sabita S Soedamah-Muhtu, Martin H de Borst, Else van den Berg, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas. High urinary homoarginine excretion is associated with low rates of all-cause mortality and graft failure in renal transplant recipients.
Amino acids.
2015 Sep; 47(9):1827-36. doi:
10.1007/s00726-015-2038-6. [PMID: 26142633] - Christina Carmann, Eggert Lilienthal, Katharina Weigt-Usinger, Anjona Schmidt-Choudhury, Irina Hörster, Arslan Arinc Kayacelebi, Bibiana Beckmann, Kristine Chobanyan-Jürgens, Dimitrios Tsikas, Thomas Lücke. The L-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus.
Amino acids.
2015 Sep; 47(9):1865-74. doi:
10.1007/s00726-015-2027-9. [PMID: 26123986] - Arslan Arinc Kayacelebi, Janina Willers, Vu Vi Pham, Andreas Hahn, Jessica Y Schneider, Sabine Rothmann, Jürgen C Frölich, Dimitrios Tsikas. Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Amino acids.
2015 Sep; 47(9):1885-91. doi:
10.1007/s00726-015-1915-3. [PMID: 25618752] - Marcus May, Arslan Arinc Kayacelebi, Sandor Batkai, Jens Jordan, Dimitrios Tsikas, Stefan Engeli. Plasma and tissue homoarginine concentrations in healthy and obese humans.
Amino acids.
2015 Sep; 47(9):1847-52. doi:
10.1007/s00726-015-1922-4. [PMID: 25655383] - Malte Stockebrand, Sönke Hornig, Axel Neu, Dorothee Atzler, Kathrin Cordts, Rainer H Böger, Dirk Isbrandt, Edzard Schwedhelm, Chi-Un Choe. Homoarginine supplementation improves blood glucose in diet-induced obese mice.
Amino acids.
2015 Sep; 47(9):1921-9. doi:
10.1007/s00726-015-2022-1. [PMID: 26077714] - Dimitrios Tsikas, Guoyao Wu. Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology.
Amino acids.
2015 Sep; 47(9):1697-702. doi:
10.1007/s00726-015-2055-5. [PMID: 26210755] - Kathrin Cordts, Dorothee Atzler, Vazhma Qaderi, Karsten Sydow, Rainer H Böger, Chi-Un Choe, Edzard Schwedhelm. Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application.
Amino acids.
2015 Sep; 47(9):2015-22. doi:
10.1007/s00726-015-2037-7. [PMID: 26159673] - Irina Hörster, Katharina Weigt-Usinger, Christina Carmann, Kristine Chobanyan-Jürgens, Cornelia Köhler, Ulrike Schara, Arslan Arinc Kayacelebi, Bibiana Beckmann, Dimitrios Tsikas, Thomas Lücke. The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids.
Amino acids.
2015 Sep; 47(9):1853-63. doi:
10.1007/s00726-015-2018-x. [PMID: 26066683] - Arslan Arinc Kayacelebi, Jennifer Langen, Katharina Weigt-Usinger, Kristine Chobanyan-Jürgens, François Mariotti, Jessica Y Schneider, Sabine Rothmann, Jürgen C Frölich, Dorothee Atzler, Chi-Un Choe, Edzard Schwedhelm, Jean François Huneau, Thomas Lücke, Dimitrios Tsikas. Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
Amino acids.
2015 Sep; 47(9):1893-908. doi:
10.1007/s00726-015-2012-3. [PMID: 26031828] - Jennifer Langen, Arslan Arinc Kayacelebi, Bibiana Beckmann, Katharina Weigt-Usinger, Christina Carmann, Irina Hörster, Eggert Lilienthal, Annette Richter-Unruh, Dimitrios Tsikas, Thomas Lücke. Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
Amino acids.
2015 Sep; 47(9):1875-83. doi:
10.1007/s00726-015-2028-8. [PMID: 26123987] - Aiden Haghikia, Arslan Arinc Kayacelebi, Bibiana Beckmann, Erik Hanff, Ralf Gold, Arash Haghikia, Dimitrios Tsikas. Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Amino acids.
2015 Sep; 47(9):1837-45. doi:
10.1007/s00726-015-2015-0. [PMID: 26055922] - Stefan Pilz, Csilla Putz-Bankuti, Andreas Meinitzer, Winfried März, Katharina Kienreich, Tatjana Stojakovic, Thomas R Pieber, Rudolf E Stauber. Association of homoarginine and methylarginines with liver dysfunction and mortality in chronic liver disease.
Amino acids.
2015 Sep; 47(9):1817-26. doi:
10.1007/s00726-015-2000-7. [PMID: 25952253] - Christiane Drechsler, Hege Pihlstrøm, Andreas Meinitzer, Stefan Pilz, Andreas Tomaschitz, Sadollah Abedini, Bengt Fellstrom, Alan G Jardine, Christoph Wanner, Winfried März, Hallvard Holdaas. Homoarginine and Clinical Outcomes in Renal Transplant Recipients: Results From the Assessment of Lescol in Renal Transplantation Study.
Transplantation.
2015 Jul; 99(7):1470-6. doi:
10.1097/tp.0000000000000568. [PMID: 25675199] - Gunhild Garmo Hov, Knut Ivar Aasarød, Erling Sagen, Arne Åsberg. Arginine, dimethylated arginine and homoarginine in relation to cardiovascular risk in patients with moderate chronic kidney disease.
Clinical biochemistry.
2015 Jul; 48(10-11):646-51. doi:
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The American journal of the medical sciences.
2015 Apr; 349(4):306-11. doi:
10.1097/maj.0000000000000419. [PMID: 25647833] - Lena Vogl, Johannes Pohlhammer, Andreas Meinitzer, Barbara Rantner, Marietta Stadler, Slobodan Peric, Angelika Hammerer-Lercher, Peter Klein-Weigel, Gustav Fraedrich, Florian Kronenberg, Barbara Kollerits. Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study.
Atherosclerosis.
2015 Apr; 239(2):607-14. doi:
10.1016/j.atherosclerosis.2015.02.019. [PMID: 25746168] - Dorothee Atzler, Edzard Schwedhelm, Matthias Nauck, Till Ittermann, Rainer H Böger, Nele Friedrich. Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
Clinical chemistry and laboratory medicine.
2014 Dec; 52(12):1835-42. doi:
10.1515/cclm-2014-0314. [PMID: 24945429] - Stefan Pilz, Frank Edelmann, Andreas Meinitzer, Götz Gelbrich, Ufuk Döner, Hans-Dirk Düngen, Andreas Tomaschitz, Katharina Kienreich, Martin Gaksch, André Duvinage, Raoul Stahrenberg, Jan Kunde, Albrecht Schmidt, Winfried März, Rolf Wachter, Burkert Pieske. Associations of methylarginines and homoarginine with diastolic dysfunction and cardiovascular risk factors in patients with preserved left ventricular ejection fraction.
Journal of cardiac failure.
2014 Dec; 20(12):923-30. doi:
10.1016/j.cardfail.2014.09.004. [PMID: 25230239] - Dorothee Atzler, M Odette Gore, Colby R Ayers, Chi-un Choe, Rainer H Böger, James A de Lemos, Darren K McGuire, Edzard Schwedhelm. Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study.
Arteriosclerosis, thrombosis, and vascular biology.
2014 Nov; 34(11):2501-7. doi:
10.1161/atvbaha.114.304398. [PMID: 25189571] - Arslan Arinc Kayacelebi, Vu Vi Pham, Janina Willers, Andreas Hahn, Dirk O Stichtenoth, Jens Jordan, Dimitrios Tsikas. Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?.
International journal of cardiology.
2014 Oct; 176(3):1129-31. doi:
10.1016/j.ijcard.2014.07.296. [PMID: 25175517] - Arslan Arinc Kayacelebi, Bibiana Beckmann, Frank-Mathias Gutzki, Jens Jordan, Dimitrios Tsikas. GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples.
Amino acids.
2014 Sep; 46(9):2205-17. doi:
10.1007/s00726-014-1774-3. [PMID: 24923265] - Akihiro Shimomura, Isao Matsui, Takayuki Hamano, Takuya Ishimoto, Yumiko Katou, Kenji Takehana, Kazunori Inoue, Yasuo Kusunoki, Daisuke Mori, Chikako Nakano, Yoshitsugu Obi, Naohiko Fujii, Yoshitsugu Takabatake, Takayoshi Nakano, Yoshiharu Tsubakihara, Yoshitaka Isaka, Hiromi Rakugi. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats.
Journal of the American Society of Nephrology : JASN.
2014 Sep; 25(9):1954-65. doi:
10.1681/asn.2013090967. [PMID: 24652795] - Andreas Tomaschitz, Andreas Meinitzer, Stefan Pilz, Jutta Rus-Machan, Bernd Genser, Christiane Drechsler, Tanja Grammer, Vera Krane, Eberhard Ritz, Marcus E Kleber, Burkert Pieske, Elisabeth Kraigher-Krainer, Astrid Fahrleitner-Pammer, Christoph Wanner, Bernhard O Boehm, Winfried März. Homoarginine, kidney function and cardiovascular mortality risk.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2014 Mar; 29(3):663-71. doi:
10.1093/ndt/gft512. [PMID: 24398889] - Stefan Pilz, Tom Teerlink, Peter G Scheffer, Andreas Meinitzer, Femke Rutters, Andreas Tomaschitz, Christiane Drechsler, Katharina Kienreich, Giel Nijpels, Coen D A Stehouwer, Winfried März, Jacqueline M Dekker. Homoarginine and mortality in an older population: the Hoorn study.
European journal of clinical investigation.
2014 Feb; 44(2):200-8. doi:
10.1111/eci.12208. [PMID: 24251815] - A Nur Onar, Behice Yavuz Erdoğan, Ilknur Ayan, Zeki Acar. Homoarginine, β-ODAP, and asparagine contents of grass pea landraces cultivated in Turkey.
Food chemistry.
2014 Jan; 143(?):277-81. doi:
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Circulation journal : official journal of the Japanese Circulation Society.
2014; 78(5):1254-8. doi:
10.1253/circj.cj-13-1334. [PMID: 24583919] - Aleksandra Jaźwińska-Kozuba, Jens Martens-Lobenhoffer, Olga Kruszelnicka, Jarosław Rycaj, Bernadeta Chyrchel, Andrzej Surdacki, Stefanie M Bode-Böger. Opposite associations of plasma homoarginine and ornithine with arginine in healthy children and adolescents.
International journal of molecular sciences.
2013 Nov; 14(11):21819-32. doi:
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Metabolism: clinical and experimental.
2013 Oct; 62(10):1455-61. doi:
10.1016/j.metabol.2013.05.017. [PMID: 23890667] - Marcus E Kleber, Ilkka Seppälä, Stefan Pilz, Michael M Hoffmann, Andreas Tomaschitz, Niku Oksala, Emma Raitoharju, Leo-Pekka Lyytikäinen, Kari-Matti Mäkelä, Reijo Laaksonen, Mika Kähönen, Olli T Raitakari, Jie Huang, Katharina Kienreich, Astrid Fahrleitner-Pammer, Christiane Drechsler, Vera Krane, Bernhard O Boehm, Wolfgang Koenig, Christoph Wanner, Terho Lehtimäki, Winfried März, Andreas Meinitzer. Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.
Circulation. Cardiovascular genetics.
2013 Oct; 6(5):505-13. doi:
10.1161/circgenetics.113.000108. [PMID: 24047826] - Chi-un Choe, Dorothee Atzler, Philipp S Wild, Angela M Carter, Rainer H Böger, Francisco Ojeda, Olga Simova, Malte Stockebrand, Karl Lackner, Christine Nabuurs, Bart Marescau, Thomas Streichert, Christian Müller, Nicole Lüneburg, Peter P De Deyn, Ralf A Benndorf, Stephan Baldus, Christian Gerloff, Stefan Blankenberg, Arend Heerschap, Peter J Grant, Tim Magnus, Tanja Zeller, Dirk Isbrandt, Edzard Schwedhelm. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.
Circulation.
2013 Sep; 128(13):1451-61. doi:
10.1161/circulationaha.112.000580. [PMID: 24004504] - Leonard P van der Zwan, Mariska Davids, Peter G Scheffer, Jacqueline M Dekker, Coen D A Stehouwer, Tom Teerlink. L-Homoarginine and L-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study.
Journal of hypertension.
2013 Jun; 31(6):1114-23. doi:
10.1097/hjh.0b013e32836037fb. [PMID: 23552121] - Nicole Berthold, Patricia Czihal, Stefanie Fritsche, Ute Sauer, Guido Schiffer, Daniel Knappe, Gottfried Alber, Ralf Hoffmann. Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by gram-negative pathogens.
Antimicrobial agents and chemotherapy.
2013 Jan; 57(1):402-9. doi:
10.1128/aac.01923-12. [PMID: 23114765] - Pietro Ravani, Renke Maas, Fabio Malberti, Paola Pecchini, Maren Mieth, Robert Quinn, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali. Homoarginine and mortality in pre-dialysis chronic kidney disease (CKD) patients.
PloS one.
2013; 8(9):e72694. doi:
10.1371/journal.pone.0072694. [PMID: 24023762] - Christiane Drechsler, Barbara Kollerits, Andreas Meinitzer, Winfried März, Eberhard Ritz, Paul König, Ulrich Neyer, Stefan Pilz, Christoph Wanner, Florian Kronenberg. Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study.
PloS one.
2013; 8(5):e63560. doi:
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