3-ketoadipate (BioDeep_00000405263)

Main id: BioDeep_00000004495

 


代谢物信息卡片


3-Oxoadipic acid

化学式: C6H8O5 (160.0372)
中文名称: 3-氧代己二酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)C(=O)CC(=O)O
InChI: InChI=1S/C6H8O5/c7-4(3-6(10)11)1-2-5(8)9/h1-3H2,(H,8,9)(H,10,11)

描述信息

An oxo dicarboxylic acid consisting of adipic acid having a single oxo group at the 3-position.

同义名列表

3 个代谢物同义名

3-Oxoadipic acid; 3-ketoadipate; 3-Oxoadipate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CDKN3, FH, FLNA, PFDN5, TNIP3
Peripheral membrane protein 2 CYP1B1, MBP
Endoplasmic reticulum membrane 2 ACER3, CYP1B1
Nucleus 5 CDKN3, FH, FLNA, MBP, PFDN5
cytosol 7 ADSL, CDKN3, FH, FLNA, MBP, PFDN5, TNIP3
trans-Golgi network 1 FLNA
Cell membrane 1 PTGER4
Cytoplasmic side 1 MBP
Cell projection, growth cone 1 FLNA
Multi-pass membrane protein 2 ACER3, PTGER4
Golgi apparatus membrane 1 ACER3
Synapse 1 MBP
cell surface 1 MBP
dendritic shaft 1 FLNA
glutamatergic synapse 1 FLNA
Golgi membrane 1 ACER3
neuronal cell body 1 MBP
postsynapse 1 FLNA
plasma membrane 3 FLNA, MBP, PTGER4
Membrane 4 ACER3, CYP1B1, FLNA, PTGER4
brush border 1 FLNA
extracellular exosome 3 FH, FLNA, MBP
perinuclear region of cytoplasm 2 CDKN3, FLNA
mitochondrion 2 CYP1B1, FH
protein-containing complex 2 ADSL, MBP
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
extracellular region 2 FLNA, MBP
mitochondrial matrix 1 FH
actin cytoskeleton 1 FLNA
perikaryon 1 FLNA
Z disc 1 FLNA
nucleolus 1 FLNA
cell-cell junction 1 FLNA
Cytoplasm, perinuclear region 1 CDKN3
Cytoplasm, cytoskeleton 1 FLNA
focal adhesion 1 FLNA
collagen-containing extracellular matrix 1 MBP
axonal growth cone 1 FLNA
cell periphery 1 MBP
Chromosome 1 FH
Cell projection, podosome 1 FLNA
podosome 1 FLNA
[Isoform 3]: Nucleus 1 MBP
Cytoplasm, cell cortex 1 FLNA
actin filament 1 FLNA
site of double-strand break 1 FH
myelin sheath 1 MBP
intermediate filament cytoskeleton 1 PFDN5
ficolin-1-rich granule lumen 1 MBP
transport vesicle 1 MBP
prefoldin complex 1 PFDN5
apical dendrite 1 FLNA
intracellular non-membrane-bounded organelle 1 FLNA
cyclin-dependent protein kinase holoenzyme complex 1 CDKN3
actin filament bundle 1 FLNA
compact myelin 1 MBP
internode region of axon 1 MBP
cortical cytoskeleton 1 FLNA
glycoprotein Ib-IX-V complex 1 FLNA
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
Myb complex 1 FLNA
[Bone marrow proteoglycan]: Secreted 1 MBP
Myelin membrane 1 MBP


文献列表

  • Michael Sgro, Nicholas Chow, Farnaz Olyaie, Mark Arentshorst, Nicholas Geoffrion, Arthur F J Ram, Justin Powlowski, Adrian Tsang. Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger. The Journal of biological chemistry. 2023 Jul; ?(?):105003. doi: 10.1016/j.jbc.2023.105003. [PMID: 37399977]
  • Simone Marcelletti, Marco Scortichini. Some strains that have converged to infect Prunus spp. trees are members of distinct Pseudomonas syringae genomospecies and ecotypes as revealed by in silico genomic comparison. Archives of microbiology. 2019 Jan; 201(1):67-80. doi: 10.1007/s00203-018-1573-4. [PMID: 30229267]
  • Reuben W Nowell, Bridget E Laue, Paul M Sharp, Sarah Green. Comparative genomics reveals genes significantly associated with woody hosts in the plant pathogen Pseudomonas syringae. Molecular plant pathology. 2016 12; 17(9):1409-1424. doi: 10.1111/mpp.12423. [PMID: 27145446]
  • Tiago M Martins, Diego O Hartmann, Sébastien Planchon, Isabel Martins, Jenny Renaut, Cristina Silva Pereira. The old 3-oxoadipate pathway revisited: new insights in the catabolism of aromatics in the saprophytic fungus Aspergillus nidulans. Fungal genetics and biology : FG & B. 2015 Jan; 74(?):32-44. doi: 10.1016/j.fgb.2014.11.002. [PMID: 25479309]
  • Caroline B Michielse, Linda Reijnen, Chantal Olivain, Claude Alabouvette, Martijn Rep. Degradation of aromatic compounds through the β-ketoadipate pathway is required for pathogenicity of the tomato wilt pathogen Fusarium oxysporum f. sp. lycopersici. Molecular plant pathology. 2012 Dec; 13(9):1089-100. doi: 10.1111/j.1364-3703.2012.00818.x. [PMID: 22827542]
  • Samer Shalaby, Benjamin A Horwitz, Olga Larkov. Structure-activity relationships delineate how the maize pathogen Cochliobolus heterostrophus uses aromatic compounds as signals and metabolites. Molecular plant-microbe interactions : MPMI. 2012 Jul; 25(7):931-40. doi: 10.1094/mpmi-01-12-0015-r. [PMID: 22452657]
  • Darren M Soanes, Apratim Chakrabarti, Konrad H Paszkiewicz, Angus L Dawe, Nicholas J Talbot. Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae. PLoS pathogens. 2012 Feb; 8(2):e1002514. doi: 10.1371/journal.ppat.1002514. [PMID: 22346750]
  • Jinyun Li, Nian Wang. Genome-wide mutagenesis of Xanthomonas axonopodis pv. citri reveals novel genetic determinants and regulation mechanisms of biofilm formation. PloS one. 2011; 6(7):e21804. doi: 10.1371/journal.pone.0021804. [PMID: 21750733]
  • Benoît Remenant, Bénédicte Coupat-Goutaland, Alice Guidot, Gilles Cellier, Emmanuel Wicker, Caitilyn Allen, Mark Fegan, Olivier Pruvost, Mounira Elbaz, Alexandra Calteau, Gregory Salvignol, Damien Mornico, Sophie Mangenot, Valérie Barbe, Claudine Médigue, Philippe Prior. Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence. BMC genomics. 2010 Jun; 11(?):379. doi: 10.1186/1471-2164-11-379. [PMID: 20550686]
  • Matthew de la Peña Mattozzi, Jay D Keasling. Rationally engineered biotransformation of p-nitrophenol. Biotechnology progress. 2010 May; 26(3):616-21. doi: 10.1002/btpr.382. [PMID: 20196144]
  • Hamid Sobhanian, Roya Razavizadeh, Yohei Nanjo, Ali Akbar Ehsanpour, Ferdous Rastgar Jazii, Nasrin Motamed, Setsuko Komatsu. Proteome analysis of soybean leaves, hypocotyls and roots under salt stress. Proteome science. 2010 Mar; 8(?):19. doi: 10.1186/1477-5956-8-19. [PMID: 20350314]
  • Danhua Li, Yongliang Yan, Shuzhen Ping, Ming Chen, Wei Zhang, Liang Li, Wenna Lin, Lizhao Geng, Wei Liu, Wei Lu, Min Lin. Genome-wide investigation and functional characterization of the beta-ketoadipate pathway in the nitrogen-fixing and root-associated bacterium Pseudomonas stutzeri A1501. BMC microbiology. 2010 Feb; 10(?):36. doi: 10.1186/1471-2180-10-36. [PMID: 20137101]
  • Alice R Wattam, Kelly P Williams, Eric E Snyder, Nalvo F Almeida, Maulik Shukla, A W Dickerman, O R Crasta, R Kenyon, J Lu, J M Shallom, H Yoo, T A Ficht, R M Tsolis, C Munk, R Tapia, C S Han, J C Detter, D Bruce, T S Brettin, Bruno W Sobral, Stephen M Boyle, João C Setubal. Analysis of ten Brucella genomes reveals evidence for horizontal gene transfer despite a preferred intracellular lifestyle. Journal of bacteriology. 2009 Jun; 191(11):3569-79. doi: 10.1128/jb.01767-08. [PMID: 19346311]
  • Caroline B Michielse, Ringo van Wijk, Linda Reijnen, Ben J C Cornelissen, Martijn Rep. Insight into the molecular requirements for pathogenicity of Fusarium oxysporum f. sp. lycopersici through large-scale insertional mutagenesis. Genome biology. 2009; 10(1):R4. doi: 10.1186/gb-2009-10-1-r4. [PMID: 19134172]
  • Bastian Omokoko, Uwe K Jäntges, Martin Zimmermann, Monika Reiss, Winfried Hartmeier. Isolation of the phe-operon from G. stearothermophilus comprising the phenol degradative meta-pathway genes and a novel transcriptional regulator. BMC microbiology. 2008 Nov; 8(?):197. doi: 10.1186/1471-2180-8-197. [PMID: 19014555]
  • Derrick E Fouts, Heather L Tyler, Robert T DeBoy, Sean Daugherty, Qinghu Ren, Jonathan H Badger, Anthony S Durkin, Heather Huot, Susmita Shrivastava, Sagar Kothari, Robert J Dodson, Yasmin Mohamoud, Hoda Khouri, Luiz F W Roesch, Karen A Krogfelt, Carsten Struve, Eric W Triplett, Barbara A Methé. Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice. PLoS genetics. 2008 Jul; 4(7):e1000141. doi: 10.1371/journal.pgen.1000141. [PMID: 18654632]
  • Mary Beth Leigh, Vivian H Pellizari, Ondrej Uhlík, Robin Sutka, Jorge Rodrigues, Nathaniel E Ostrom, Jizhong Zhou, James M Tiedje. Biphenyl-utilizing bacteria and their functional genes in a pine root zone contaminated with polychlorinated biphenyls (PCBs). The ISME journal. 2007 Jun; 1(2):134-48. doi: 10.1038/ismej.2007.26. [PMID: 18043623]
  • Anja Brencic, Anatol Eberhard, Stephen C Winans. Signal quenching, detoxification and mineralization of vir gene-inducing phenolics by the VirH2 protein of Agrobacterium tumefaciens. Molecular microbiology. 2004 Feb; 51(4):1103-15. doi: 10.1046/j.1365-2958.2003.03887.x. [PMID: 14763983]
  • Iris Bertani, Milan Kojic, Vittorio Venturi. Regulation of the p-hydroxybenzoic acid hydroxylase gene (pobA) in plant-growth-promoting Pseudomonas putida WCS358. Microbiology (Reading, England). 2001 Jun; 147(Pt 6):1611-1620. doi: 10.1099/00221287-147-6-1611. [PMID: 11390692]
  • R Blasco, R M Wittich, M Mallavarapu, K N Timmis, D H Pieper. From xenobiotic to antibiotic, formation of protoanemonin from 4-chlorocatechol by enzymes of the 3-oxoadipate pathway. The Journal of biological chemistry. 1995 Dec; 270(49):29229-35. doi: 10.1074/jbc.270.49.29229. [PMID: 7493952]
  • P D SHAW, L P HAGER. Biological chlorination. III. beta-Ketoadipate chlorinase: a soluble enzyme system. The Journal of biological chemistry. 1959 Oct; 234(?):2565-9. doi: . [PMID: 14445652]
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