carvedilol (BioDeep_00000398977)

Main id: BioDeep_00000001929

 

natural product


代谢物信息卡片


carvedilol

化学式: C24H26N2O4 (406.18924760000004)
中文名称: 卡维地洛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12=CC=CC(=C1C3=C(N2)C=CC=C3)OCC(CNCCOC4=CC=CC=C4OC)O
InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AG - Alpha and beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D020011 - Protective Agents > D000975 - Antioxidants
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

同义名列表

2 个代谢物同义名

carvedilol; BM 14190



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jaroslaw Szponar, Agnieszka Gorska, Marta Ostrowska-Lesko, Agnieszka Korga-Plewko, Michal Tchorz, Erwin Ciechanski, Anna Dabrowska, Ewa Poleszak, Franciszek Burdan, Jaroslaw Dudka, Marek Murias, Slawomir Mandziuk. Assessment of the Impact of Carvedilol Administered Together with Dexrazoxan and Doxorubicin on Liver Structure and Function, Iron Metabolism, and Myocardial Redox System in Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042219. [PMID: 38396896]
  • Mila Kovačević, Alenka Zvonar Pobirk, Ilija German Ilić. The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Feb; 193(?):106582. doi: 10.1016/j.ejps.2023.106582. [PMID: 37709174]
  • Bingqiong Wang, Jialing Zhou, Xiaoning Wu, Yameng Sun, Lei Li, Ping Li, Minghui Li, Wei Jiang, Mingyi Xu, Bo Feng, Xiaoyuan Xu, Jilin Cheng, Wen Xie, Tao Han, Xiaozhong Wang, Hai Li, Hongxin Piao, Xinyu Zhao, Shuyan Chen, Tongtong Meng, Qiushuang Guan, Fandong Meng, Yuanyuan Kong, Xiaojuan Ou, Jidong Jia, Hong You. Carvedilol plus NUCs for compensated HBV-cirrhosis patients under virological suppression: a randomised, open-label trial. The American journal of gastroenterology. 2023 Nov; ?(?):. doi: 10.14309/ajg.0000000000002569. [PMID: 37929952]
  • Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis. Drugs in R&D. 2023 Aug; ?(?):. doi: 10.1007/s40268-023-00435-5. [PMID: 37556093]
  • Qi Song, Song Li. Identification of Plant Co-regulatory Modules Using CoReg. Methods in molecular biology (Clifton, N.J.). 2023; 2594(?):217-223. doi: 10.1007/978-1-0716-2815-7_16. [PMID: 36264499]
  • Marcella Pavan, Priscila Yamamoto, Rodrigo Moreira da Silva, Wilson Salgado Junior, José Dos Santos, Rafael Kemp, Ajith Sankarankutty, Natália de Moraes, Cristiane de Gaitani. Chemometric optimization of salting-out assisted liquid-liquid extraction (SALLE) combined with LC-MS/MS for the analysis of carvedilol enantiomers in human plasma: Application to clinical pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Aug; 1205(?):123338. doi: 10.1016/j.jchromb.2022.123338. [PMID: 35724550]
  • Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury. Drug and chemical toxicology. 2022 Jul; 45(4):1558-1564. doi: 10.1080/01480545.2020.1846551. [PMID: 33198524]
  • Mehmet Tolga Kafadar, Mehmet Ali Gök. Effects of Carvedilol on liver ischemia-reperfusion injury in rats. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2022 Jul; 28(7):885-893. doi: 10.14744/tjtes.2021.57824. [PMID: 35775675]
  • S Balasurya, Mohammad K Okla, Ibrahim A Alaraidh, Walid Soufan, Abdullah A Al-Ghamdi, Syed R Ahamad, Mostafa A Abdel-Maksoud, Hamada AbdElgawad, Lija L Raju, Ajith M Thomas, S Sudheer Khan. Photodegradation of 5-flurouracil, carvedilol, para-chlorophenol and methimazole with 3D MnWO4 nanoflower modified Ag2WO4 nanorods: A non-genotoxic nanomaterial for water treatment. Chemosphere. 2022 Jun; 297(?):134130. doi: 10.1016/j.chemosphere.2022.134130. [PMID: 35257704]
  • Xian-Tao Li. Beneficial effects of carvedilol modulating potassium channels on the control of glucose. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113057. doi: 10.1016/j.biopha.2022.113057. [PMID: 35658228]
  • Rasha M S M Mohamed, Enssaf Ahmad Ahmad, Bothina H F Omran, Amr T Sakr, Islam A A E-H Ibrahim, Mona F Mahmoud, Mostafa E El-Naggar. Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway. Life sciences. 2022 Mar; 293(?):120304. doi: 10.1016/j.lfs.2022.120304. [PMID: 35016879]
  • Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):413-423. doi: 10.1161/hypertensionaha.121.18026. [PMID: 34879704]
  • Md Abdullah Shamim, Steven Yeung, Ayaz Shahid, Mengbing Chen, Jeffrey Wang, Preshita Desai, Cyrus Parsa, Robert Orlando, Frank L Meyskens, Kristen M Kelly, Bradley T Andresen, Ying Huang. Topical carvedilol delivery prevents UV-induced skin cancer with negligible systemic absorption. International journal of pharmaceutics. 2022 Jan; 611(?):121302. doi: 10.1016/j.ijpharm.2021.121302. [PMID: 34793935]
  • Michael Rode, Kolja Nenoff, Kerstin Wirkner, Katrin Horn, Andrej Teren, Ralf Regenthal, Markus Loeffler, Joachim Thiery, Achim Aigner, Janne Pott, Holger Kirsten, Markus Scholz. Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers. PloS one. 2022; 17(4):e0266897. doi: 10.1371/journal.pone.0266897. [PMID: 35446883]
  • Hoda M S Ahmed, Samar G Mohamed, Wael S Ibrahim, Asmaa M Rezk, Amr A A Mahmoud, Mona F Mahmoud, Islam A A E-H Ibrahim. Acute and chronic metabolic effects of carvedilol in high-fructose, high-fat diet-fed mice: implication of β-arrestin2 pathway. Canadian journal of physiology and pharmacology. 2022 Jan; 100(1):68-77. doi: 10.1139/cjpp-2021-0299. [PMID: 34570983]
  • Wen Zhang, Guiming Deng, Jia Hu, Ran Yan, Junliu Hu, Jianmin Fan. Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension. Computational and mathematical methods in medicine. 2022; 2022(?):7889024. doi: 10.1155/2022/7889024. [PMID: 35936366]
  • Rasha M S M Mohamed, Shimaa M Elshazly, Ola E Nafea, Dalia M Abd El Motteleb. Comparative cardioprotective effects of carvedilol versus atenolol in a rat model of cardiorenal syndrome type 4. Naunyn-Schmiedeberg's archives of pharmacology. 2021 10; 394(10):2117-2128. doi: 10.1007/s00210-021-02130-1. [PMID: 34398250]
  • Sarah A Baraka, Mai F Tolba, Doaa A Elsherbini, Reem N El-Naga, Azza S Awad, Ebtehal El-Demerdash. Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signalling. Clinical and experimental pharmacology & physiology. 2021 10; 48(10):1358-1370. doi: 10.1111/1440-1681.13535. [PMID: 34081810]
  • Hope Onohuean, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Safaa Qusti, Eida M Alshammari, Gaber El-Saber Batiha. Covid-19 and development of heart failure: mystery and truth. Naunyn-Schmiedeberg's archives of pharmacology. 2021 10; 394(10):2013-2021. doi: 10.1007/s00210-021-02147-6. [PMID: 34480616]
  • Georgios N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis, Haralampos Milionis. Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites. Journal of clinical gastroenterology. 2021 09; 55(8):721-729. doi: 10.1097/mcg.0000000000001431. [PMID: 32991355]
  • Qingtong Wang, Ying Wang, Toni M West, Yongming Liu, Gopireddy R Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K Xiang. Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovascular research. 2021 08; 117(10):2237-2251. doi: 10.1093/cvr/cvaa266. [PMID: 32956449]
  • Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175137. [PMID: 34500571]
  • Sanaa A Ahmed, Walaa I Mohammed. Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111594. doi: 10.1016/j.biopha.2021.111594. [PMID: 33878623]
  • Nahed Mohamed Sallam, Rania Abdel Basset Sanad, Mahgoub Mohamed Ahmed, E L Sayed Khafagy, Mamdouh Ghorab, Shadeed Gad. Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models. Drug delivery and translational research. 2021 06; 11(3):1009-1036. doi: 10.1007/s13346-020-00814-4. [PMID: 32607938]
  • Syed Mohammed Basheeruddin Asdaq, Obulesu Challa, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, Abdulrahman Hadi Almutiri, Majed Sadun Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113203. [PMID: 34071846]
  • Julian C Dunkley, Camila I Irion, Keyvan Yousefi, Serene A Shehadeh, Guerline Lambert, Krista John-Williams, Keith A Webster, Jeffrey J Goldberger, Lina A Shehadeh. Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in Col4a3-/- Alport mice. American journal of physiology. Heart and circulatory physiology. 2021 05; 320(5):H1862-H1872. doi: 10.1152/ajpheart.00535.2020. [PMID: 33769915]
  • Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):704-712. doi: 10.1053/j.ajkd.2020.07.023. [PMID: 33010357]
  • Abhilash Chandra, Namrata Rao, Divya Srivastava, Prabhaker Mishra. Better peridialytic blood pressure control using carvedilol in end stage renal disease patients on twice weekly maintenance hemodialysis. International urology and nephrology. 2021 May; 53(5):1007-1014. doi: 10.1007/s11255-020-02716-3. [PMID: 33387227]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Peter McGranaghan, Anshul Saxena, Hans-Dirk Düngen, Muni Rubens, Sandeep Appunni, Joseph Salami, Emir Veledar, Philipp Lacour, Florian Blaschke, Danilo Obradovic, Goran Loncar, Elvis Tahirovic, Frank Edelmann, Burkert Pieske, Tobias Daniel Trippel. Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure. Scientific reports. 2021 04; 11(1):8164. doi: 10.1038/s41598-021-87776-w. [PMID: 33854188]
  • Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. Urology journal. 2021 Apr; 18(3):337-342. doi: 10.22037/uj.v18i.5678. [PMID: 33840085]
  • Ji Eun Choi, Jung Suk Kim, Min-Jong Choi, Kyungho Baek, Mi Ran Woo, Jong Oh Kim, Han-Gon Choi, Sung Giu Jin. Effects of different physicochemical characteristics and supersaturation principle of solidified SNEDDS and surface-modified microspheres on the bioavailability of carvedilol. International journal of pharmaceutics. 2021 Mar; 597(?):120377. doi: 10.1016/j.ijpharm.2021.120377. [PMID: 33581270]
  • Tanja Gangnus, Bjoern B Burckhardt. Low-volume LC-MS/MS method for the pharmacokinetic investigation of carvedilol, enalapril and their metabolites in whole blood and plasma: Application to a paediatric clinical trial. Drug testing and analysis. 2021 Mar; 13(3):694-708. doi: 10.1002/dta.2949. [PMID: 33126289]
  • Najla Locatelli Santos Esteves, Lígia Marquez Andrade, Anna Paula Krawczyk-Santos, Bruno Dos Santos Souza, Ricardo Neves Marreto, Stephânia Fleury Taveira. Development of carvedilol-loaded lipid nanoparticles with compatible lipids and enhanced skin permeation in different skin models. Journal of microencapsulation. 2021 Mar; 38(2):124-133. doi: 10.1080/02652048.2020.1857862. [PMID: 33305646]
  • Asmaa M Rezk, Islam A A E-H Ibrahim, Mona F Mahmoud, Amr A A Mahmoud. Quercetin and lithium chloride potentiate the protective effects of carvedilol against renal ischemia-reperfusion injury in high-fructose, high-fat diet-fed Swiss albino mice independent of renal lipid signaling. Chemico-biological interactions. 2021 Jan; 333(?):109307. doi: 10.1016/j.cbi.2020.109307. [PMID: 33159969]
  • Maha Sabry, Seham Mostafa, Laila Rashed, Marwa Abdelgwad, Samaa Kamar, Suzanne Estaphan. Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats. PloS one. 2021; 16(2):e0244650. doi: 10.1371/journal.pone.0244650. [PMID: 33571214]
  • Hala Salah Abdel-Kawy. Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats. Drug and chemical toxicology. 2021 Jan; 44(1):101-111. doi: 10.1080/01480545.2019.1576718. [PMID: 30810389]
  • Yuan-Hsi Tseng, Chia-Yen Liu, Chuan-Pin Lee, Meng-Hung Lin, Yao-Hsu Yang. Effect of carvedilol on arteriovenous graft primary patency. Vascular. 2020 Dec; 28(6):765-774. doi: 10.1177/1708538120923886. [PMID: 32408854]
  • Yihua Zhang, Manman Li, Liuyan Li, Gui Qian, Yu Wang, Zijuan Chen, Jing Liu, Chao Fang, Feng Huang, Daqiao Guo, Quanming Zou, Yiwei Chu, Dapeng Yan. β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion. Nature communications. 2020 11; 11(1):6000. doi: 10.1038/s41467-020-19849-9. [PMID: 33243993]
  • Reetu Sharma. Network-based approach highlighting interplay among anti-hypertensives: target coding-genes: diseases. Scientific reports. 2020 11; 10(1):20152. doi: 10.1038/s41598-020-76605-1. [PMID: 33214616]
  • Natesan Vasanthakumar. Beta-Adrenergic Blockers as a Potential Treatment for COVID-19 Patients. BioEssays : news and reviews in molecular, cellular and developmental biology. 2020 11; 42(11):e2000094. doi: 10.1002/bies.202000094. [PMID: 32815593]
  • Osama M Ahmed, Hossam Ebaid, El-Shaymaa El-Nahass, Mahmoud Ragab, Ibrahim M Alhazza. Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak. Biomolecules. 2020 09; 10(9):. doi: 10.3390/biom10091317. [PMID: 32937925]
  • Qi Zhang, Kunkun Guo, Xin Wang, Baolin Huang, Zimin Lin, Zheng Cai. Optimization of lipid materials in the formulation of S-carvedilol self-microemulsifying drug-delivery systems. Drug development and industrial pharmacy. 2020 Sep; 46(9):1507-1516. doi: 10.1080/03639045.2020.1810265. [PMID: 32806972]
  • Charbel Skayem, Nakhle Ayoub. Carvedilol and COVID-19: A Potential Role in Reducing Infectivity and Infection Severity of SARS-CoV-2. The American journal of the medical sciences. 2020 09; 360(3):300. doi: 10.1016/j.amjms.2020.05.030. [PMID: 32631576]
  • I Ahmed, M A Elkablawy, D S El-Agamy, A A Bazarbay, N Ahmed. Carvedilol safeguards against aspirin-induced gastric damage in rats. Human & experimental toxicology. 2020 Sep; 39(9):1257-1267. doi: 10.1177/0960327120918306. [PMID: 32295429]
  • Zhouke Tan, Guibao Ke, Junlin Huang, Die Yang, Mingjing Pi, Li Li, Xiaolin Liu, Shaohua Tao, Lvlin Chen, Guobiao Liang, Shuangxin Liu. Effects of Carvedilol on Cardiovascular Events and Mortality in Hemodialysis Patients, A Systematic Review and Meta-Analysis. Iranian journal of kidney diseases. 2020 07; 14(4):256-266. doi: NULL. [PMID: 32655020]
  • Madhumita Premkumar, Devaraja Rangegowda, Tanmay Vyas, Jelen S Khumuckham, Saggere M Shasthry, Sherin S Thomas, Ritu Goyal, Guresh Kumar, Shiv K Sarin. Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis. Journal of clinical gastroenterology. 2020 07; 54(6):561-568. doi: 10.1097/mcg.0000000000001219. [PMID: 31305281]
  • Marko Krstić, Luka Manić, Nikola Martić, Dragana Vasiljević, Svetlana Đogo Mračević, Saša Vukmirović, Aleksandar Rašković. Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Jul; 150(?):105343. doi: 10.1016/j.ejps.2020.105343. [PMID: 32376386]
  • Wael S Ibrahim, Islam A A E-H Ibrahim, Mona F Mahmoud, Amr A A Mahmoud. Carvedilol Diminishes Cardiac Remodeling Induced by High-Fructose/High-Fat Diet in Mice via Enhancing Cardiac β-Arrestin2 Signaling. Journal of cardiovascular pharmacology and therapeutics. 2020 07; 25(4):354-363. doi: 10.1177/1074248420905683. [PMID: 32052660]
  • Linlin Fang, Yanyan Zhao, Chao Wang, Changyuan Wang, Xu Han, Pengjun Chen, Lizhu Zhao, Jingping Wang, Shuang Li, Zhen Jiang. Preparation of a thiols β-cyclodextrin/gold nanoparticles-coated open tubular column for capillary electrochromatography enantioseparations. Journal of separation science. 2020 Jun; 43(11):2209-2216. doi: 10.1002/jssc.201901323. [PMID: 32160391]
  • Y Hori, E Fujimoto, Y Nishikawa, T Nakamura. Left ventricular outflow tract pressure gradient changes after carvedilol-disopyramide cotherapy in a cat with hypertrophic obstructive cardiomyopathy. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2020 Jun; 29(?):40-46. doi: 10.1016/j.jvc.2020.04.002. [PMID: 32464577]
  • Shaurya Srivastava, Tyler Kemnic, Kyle R Hildebrandt. BRASH syndrome. BMJ case reports. 2020 Feb; 13(2):. doi: 10.1136/bcr-2019-233825. [PMID: 32094236]
  • Rodrigo Carrasco, María Cristina Ramirez, Kjersti Nes, Andrés Schuster, Rubén Aguayo, Marcelo Morales, Cristobal Ramos, Daniel Hasson, Camilo G Sotomayor, Pablo Henriquez, Ignacio Cortés, Marcia Erazo, Claudio Salas, Juan G Gormaz. Prevention of doxorubicin-induced Cardiotoxicity by pharmacological non-hypoxic myocardial preconditioning based on Docosahexaenoic Acid (DHA) and carvedilol direct antioxidant effects: study protocol for a pilot, randomized, double-blind, controlled trial (CarDHA trial). Trials. 2020 Feb; 21(1):137. doi: 10.1186/s13063-019-3963-6. [PMID: 32019575]
  • Estela Hanauer Schaab, Vera Lucia Lanchote, Glauco Henrique Balthazar Nardotto, Maria Paula Marques Pereira, Márcio Dantas, Carlos Eduardo Paiva, Eduardo Barbosa Coelho. Effect of Lercanidipine on the Pharmacokinetics-Pharmacodynamics of Carvedilol Enantiomers in Patients With Chronic Kidney Disease. Journal of clinical pharmacology. 2020 01; 60(1):75-85. doi: 10.1002/jcph.1485. [PMID: 31353479]
  • Brito R Selvaraj, Seshaiah K Sridhar, Bhaskar R Kesavan, Sucharitha Palagati. Application of Statistical Tooling Techniques for Designing of Carvedilol Nanolipid Transferosomes and its Dermatopharmacokinetic and Pharmacodynamic Studies. Pharmaceutical nanotechnology. 2020; 8(6):452-470. doi: 10.2174/2211738508666200928164820. [PMID: 32988361]
  • Mohamed S El Shahawy, Zakarya M Shady, Abdullah Gaafar. The Efficacy of Argon Plasma Coagulation versus Carvedilol for Treatment of Portal Hypertensive Gastropathy. Digestion. 2020; 101(6):651-658. doi: 10.1159/000502814. [PMID: 31563912]
  • Vamshi M Krishna, Vijaya B Kumar, Narendar Dudhipala. In-situ Intestinal Absorption and Pharmacokinetic Investigations of Carvedilol Loaded Supersaturated Self-emulsifying Drug System. Pharmaceutical nanotechnology. 2020; 8(3):207-224. doi: 10.2174/2211738508666200517121637. [PMID: 32416685]
  • Xiaopeng Tian, Huimin Zhao, Zengcai Guo. Effects of Carvedilol on the Expression of TLR4 and its Downstream Signaling Pathway in the Liver Tissues of Rats with Cholestatic Liver Fibrosis. Current molecular medicine. 2020; 20(9):708-716. doi: 10.2174/1566524020666200220130705. [PMID: 32077825]
  • Samar G Mohammed, Islam A A E-H Ibrahim, Mona F Mahmoud, Amr A A Mahmoud. Carvedilol protects against hepatic ischemia/reperfusion injury in high-fructose/high-fat diet-fed mice: Role of G protein-coupled receptor kinase 2 and 5. Toxicology and applied pharmacology. 2019 11; 382(?):114750. doi: 10.1016/j.taap.2019.114750. [PMID: 31518596]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Manoj Kumar, Sumit Kainth, Ashok Choudhury, Rakhi Maiwall, Lalita G Mitra, Vandana Saluja, Prashant Mohan Agarwal, Saggere Muralikrishna Shasthry, Ankur Jindal, Ankit Bhardwaj, Guresh Kumar, Shiv K Sarin. Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial. Hepatology international. 2019 Nov; 13(6):800-813. doi: 10.1007/s12072-019-09986-9. [PMID: 31541422]
  • Sy-Jou Chen, Pi-Fen Tsui, Yi-Ping Chuang, Dapi Meng-Lin Chiang, Liv Weichien Chen, Shu-Ting Liu, Feng-Yen Lin, Shih-Ming Huang, Shih-Hua Lin, Wan-Lin Wu, Min-Chien Tsai, Chin-Sheng Lin. Carvedilol Ameliorates Experimental Atherosclerosis by Regulating Cholesterol Efflux and Exosome Functions. International journal of molecular sciences. 2019 Oct; 20(20):. doi: 10.3390/ijms20205202. [PMID: 31635197]
  • Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121793. doi: 10.1016/j.jchromb.2019.121793. [PMID: 31629310]
  • Tarek M Ibrahim, Marwa H Abdallah, Nagia A El-Megrab, Hanan M El-Nahas. Transdermal ethosomal gel nanocarriers; a promising strategy for enhancement of anti-hypertensive effect of carvedilol. Journal of liposome research. 2019 Sep; 29(3):215-228. doi: 10.1080/08982104.2018.1529793. [PMID: 30272506]
  • Dahlia Banerji, Raza M Alvi, Maryam Afshar, Noor Tariq, Adam Rokicki, Connor P Mulligan, Lili Zhang, Malek O Hassan, Magid Awadalla, John D Groarke, Tomas G Neilan. Carvedilol Among Patients With Heart Failure With a Cocaine-Use Disorder. JACC. Heart failure. 2019 09; 7(9):771-778. doi: 10.1016/j.jchf.2019.06.010. [PMID: 31466673]
  • Maurizio Sessa, Annamaria Mascolo, Daniel Bech Rasmussen, Kristian Kragholm, Magnus Thorsten Jensen, Liberata Sportiello, Concetta Rafaniello, Giuseppe Michele Tari, Claudia Pagliaro, Morten Andersen, Francesco Rossi, Annalisa Capuano. Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study. Scientific reports. 2019 08; 9(1):11465. doi: 10.1038/s41598-019-47967-y. [PMID: 31391573]
  • Frederik N Ågesen, Peter E Weeke, Peer Tfelt-Hansen, Jacob Tfelt-Hansen. Pharmacokinetic variability of beta-adrenergic blocking agents used in cardiology. Pharmacology research & perspectives. 2019 08; 7(4):e00496. doi: 10.1002/prp2.496. [PMID: 31338197]
  • Vanessa Duarte Ortiz, Patrick Türck, Rayane Teixeira, Bruna Gazzi Lima-Seolin, Denise Lacerda, Schauana Freitas Fraga, Alexandre Hickmann, Tânia Regina Gatelli Fernandes, Adriane Belló-Klein, Alexandre Luz de Castro, Alex Sander da Rosa Araujo. Carvedilol and thyroid hormones co-administration mitigates oxidative stress and improves cardiac function after acute myocardial infarction. European journal of pharmacology. 2019 Jul; 854(?):159-166. doi: 10.1016/j.ejphar.2019.04.024. [PMID: 30991047]
  • Linda C Alskär, Albin Parrow, Janneke Keemink, Pernilla Johansson, Bertil Abrahamsson, Christel A S Bergström. Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?. Journal of controlled release : official journal of the Controlled Release Society. 2019 06; 304(?):90-100. doi: 10.1016/j.jconrel.2019.04.038. [PMID: 31047962]
  • Hiroyuki Tsutsui, Shin-Ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa. Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction　- The CIBIS-J Trial. Circulation journal : official journal of the Japanese Circulation Society. 2019 05; 83(6):1269-1277. doi: 10.1253/circj.cj-18-1199. [PMID: 30956267]
  • Tao Li, Guoliang Yuan, Chengbin Ma, Peng Jin, Changgao Zhou, Wei Li. Clinical efficacy of carvedilol treatment for dilated cardiomyopathy: A meta-analysis of randomized controlled trials. Medicine. 2019 May; 98(18):e15403. doi: 10.1097/md.0000000000015403. [PMID: 31045794]
  • Hassan Heidari, Behnaz Limouei-Khosrowshahi. Magnetic solid phase extraction with carbon-coated Fe3O4 nanoparticles coupled to HPLC-UV for the simultaneous determination of losartan, carvedilol, and amlodipine besylate in plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 May; 1114-1115(?):24-30. doi: 10.1016/j.jchromb.2019.03.025. [PMID: 30927739]
  • Bibek Laha, Rimpa Goswami, Sabyasachi Maiti, Kalyan Kumar Sen. Smart karaya-locust bean gum hydrogel particles for the treatment of hypertension: Optimization by factorial design and pre-clinical evaluation. Carbohydrate polymers. 2019 Apr; 210(?):274-288. doi: 10.1016/j.carbpol.2019.01.069. [PMID: 30732764]
  • Ghada Farouk Soliman, Laila Ahmed Rashed, Heba Morsi, Walaa Ibrahim, Hanan Abdallah, Nermeen Bastawy, Omnia Mohamed Abdel Maksoud. Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats. Life sciences. 2019 Apr; 222(?):175-182. doi: 10.1016/j.lfs.2019.02.057. [PMID: 30826497]
  • Yan Yan Yeap, Jaclyn Lock, Sean Lerkvikarn, Tanner Semin, Nicholas Nguyen, Rebecca L Carrier. Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs. Journal of controlled release : official journal of the Controlled Release Society. 2019 02; 296(?):107-113. doi: 10.1016/j.jconrel.2018.11.023. [PMID: 30527813]
  • Ahmed H Eid, Amany M Gad, Ebtehal Mohammad Fikry, Hany H Arab. Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways. Toxicology and applied pharmacology. 2019 02; 364(?):83-96. doi: 10.1016/j.taap.2018.12.014. [PMID: 30578887]
  • Youn Joung Cho, Karam Nam, Tae Kyong Kim, Seong Woo Choi, Sung Joon Kim, Derek J Hausenloy, Yunseok Jeon. Sevoflurane, Propofol and Carvedilol Block Myocardial Protection by Limb Remote Ischemic Preconditioning. International journal of molecular sciences. 2019 Jan; 20(2):. doi: 10.3390/ijms20020269. [PMID: 30641885]
  • Linh V Nguyen, Quang V Ta, Thao B Dang, Phu H Nguyen, Thach Nguyen, Thi Van Huyen Pham, Trang Ht Nguyen, Stephen Baker, Trung Le Tran, Dong Joo Yang, Ki Woo Kim, Khanh V Doan. Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice. PloS one. 2019; 14(11):e0224674. doi: 10.1371/journal.pone.0224674. [PMID: 31682617]
  • Masahiro Iwaki, Toshiro Niwa, Hiroyuki Tanaka, Atsushi Kawase, Hiroshi Komura. Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2019; 22(1):72-84. doi: 10.18433/jpps30237. [PMID: 30678750]
  • Ying Wu, Zhen Li, Ai-Yuan Xiu, Dong-Xiao Meng, Si-Ning Wang, Chun-Qing Zhang. Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice. Drug design, development and therapy. 2019; 13(?):2667-2676. doi: 10.2147/dddt.s210797. [PMID: 31534314]
  • Qiu-Lan Zhang, Jing-Jie Yang, Hong-Sheng Zhang. Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):71-83. doi: 10.1016/j.biopha.2018.07.037. [PMID: 30396094]
  • Aline Luciano Horta, Vivian Paulino Figueiredo, Ana Luisa Junqueira Leite, Guilherme de Paula Costa, Ana Paula de Jesus Menezes, Camila de Oliveira Ramos, Tamiles Caroline Fernandes Pedrosa, Frank Silva Bezerra, Paula Melo de Abreu Vieira, André Talvani. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz. 2018 Oct; 113(11):e180271. doi: 10.1590/0074-02760180271. [PMID: 30365644]
  • Samaneh Ghassemi, Azadeh Haeri, Soraya Shahhosseini, Simin Dadashzadeh. Labrasol-Enriched Nanoliposomal Formulation: Novel Approach to Improve Oral Absorption of Water-Insoluble Drug, Carvedilol. AAPS PharmSciTech. 2018 Oct; 19(7):2961-2970. doi: 10.1208/s12249-018-1118-9. [PMID: 30030724]
  • Ying Cao, Shujun Chen, Yemei Liang, Ting Wu, Jianxin Pang, Shuwen Liu, Pingzheng Zhou. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels by β-blocker carvedilol. British journal of pharmacology. 2018 10; 175(20):3963-3975. doi: 10.1111/bph.14469. [PMID: 30098004]
  • Sara A El-Wakeel, Rania M Rahmo, Hanan S El-Abhar. Anti-fibrotic impact of Carvedilol in a CCl-4 model of liver fibrosis via serum microRNA-200a/SMAD7 enhancement to bridle TGF-β1/EMT track. Scientific reports. 2018 09; 8(1):14327. doi: 10.1038/s41598-018-32309-1. [PMID: 30254303]
  • Dong Guo, Hong Yang, Qing Li, Hyo Jung Bae, Obinna Obianom, Sujuan Zeng, Tong Su, James E Polli, Yan Shu. Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. Pharmaceutical research. 2018 Sep; 35(11):204. doi: 10.1007/s11095-018-2486-2. [PMID: 30191328]
  • Magdalene M Assimon, M Alan Brookhart, Jason P Fine, Gerardo Heiss, J Bradley Layton, Jennifer E Flythe. A Comparative Study of Carvedilol Versus Metoprolol Initiation and 1-Year Mortality Among Individuals Receiving Maintenance Hemodialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 09; 72(3):337-348. doi: 10.1053/j.ajkd.2018.02.350. [PMID: 29653770]
  • Chandan Vangala, Wolfgang C Winkelmayer. Heterogeneity in Outcomes Among β-Blockers Elucidated by Intradialytic Data. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 09; 72(3):318-321. doi: 10.1053/j.ajkd.2018.03.032. [PMID: 30144835]
  • Enikő Borbás, Petra Tőzsér, Konstantin Tsinman, Oksana Tsinman, Krisztina Takács-Novák, Gergely Völgyi, Bálint Sinkó, Zsombor K Nagy. Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes. Molecular pharmaceutics. 2018 08; 15(8):3308-3317. doi: 10.1021/acs.molpharmaceut.8b00343. [PMID: 29957955]
  • Bruna Eibel, Melissa Kristochek, Thiago R Peres, Lucinara D Dias, Daniela R Dartora, Karina R Casali, Renato A K Kalil, Alexandre M Lehnen, Maria Claudia Irigoyen, Melissa M Markoski. β-blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats. Cardiovascular therapeutics. 2018 Aug; 36(4):e12434. doi: 10.1111/1755-5922.12434. [PMID: 29752864]
  • Manuel Ibarra, Cristian Valiante, Patricia Sopeña, Alejandra Schiavo, Marianela Lorier, Marta Vázquez, Pietro Fagiolino. Integration of in vitro biorelevant dissolution and in silico PBPK model of carvedilol to predict bioequivalence of oral drug products. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jun; 118(?):176-182. doi: 10.1016/j.ejps.2018.03.032. [PMID: 29605455]
  • Luis Antonio D Silva, Susana L Almeida, Ellen C P Alonso, Priscila B R Rocha, Felipe T Martins, Luís A P Freitas, Stephania F Taveira, Marcilio S S Cunha-Filho, Ricardo N Marreto. Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion. International journal of pharmaceutics. 2018 Apr; 541(1-2):1-10. doi: 10.1016/j.ijpharm.2018.02.020. [PMID: 29458210]
  • Alvin Tieu, Thomas J Velenosi, Andrew S Kucey, Matthew A Weir, Bradley L Urquhart. β-Blocker Dialyzability in Maintenance Hemodialysis Patients: A Randomized Clinical Trial. Clinical journal of the American Society of Nephrology : CJASN. 2018 04; 13(4):604-611. doi: 10.2215/cjn.07470717. [PMID: 29519953]
  • Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen. Relationship between heart failure, concurrent chronic obstructive pulmonary disease and beta-blocker use: a Danish nationwide cohort study. European journal of heart failure. 2018 03; 20(3):548-556. doi: 10.1002/ejhf.1045. [PMID: 29159953]
  • Yuji Nagatomo, Tsutomu Yoshikawa, Hiroshi Okamoto, Akira Kitabatake, Masatsugu Hori. Anemia Is Associated With Blunted Response to β-Blocker Therapy Using Carvedilol　- Insights From Japanese Chronic Heart Failure (J-CHF) Study. Circulation journal : official journal of the Japanese Circulation Society. 2018 02; 82(3):691-698. doi: 10.1253/circj.cj-17-0442. [PMID: 28883225]
  • Abidemi J Akindele, Gabriel O Oludadepo, Kennedy I Amagon, Dhirendra Singh, Daniel D Osiagwu. Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Pharmacology research & perspectives. 2018 02; 6(1):. doi: 10.1002/prp2.381. [PMID: 29417758]
  • Min-Soo Kim, In-Hwan Baek. Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jan; 111(?):13-19. doi: 10.1016/j.ejps.2017.09.029. [PMID: 28942006]
  • Khalid Mohamed El-Say, Khaled Mohamed Hosny. Optimization of carvedilol solid lipid nanoparticles: An approach to control the release and enhance the oral bioavailability on rabbits. PloS one. 2018; 13(8):e0203405. doi: 10.1371/journal.pone.0203405. [PMID: 30161251]
  • R Yi, G Xiangyu, S Min. The expression of transforming growth factor-β1 in myocardial tissue and concentration of serum B-type natriuretic peptide in myocardial remodeling of Sprague-Dawley rats treated with carvedilol. European review for medical and pharmacological sciences. 2017 Nov; 21(21):4975-4982. doi: NULL. [PMID: 29164560]