Megestrol acetate (BioDeep_00000398869)
Main id: BioDeep_00000002028
natural product
代谢物信息卡片
Megestrol acetate
化学式: C24H32O4 (384.23)
中文名称: 醋酸孕甾酮, [（8R，9S，10S，13R，14R，17R）-17-乙酰基-6,10,13-三甲基-3-氧代-2,8,9,11,12,14,15,16-八氢-1H-环戊[a]菲-17-基]乙酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C=C2[C@](C1)([C@]3([C@@](C=C2C)([C@]4([C@](CC3)([C@@](CC4)(C(C)=O)OC(=O)C)C)[H])[H])[H])C)=O
InChI: InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D019167 - Appetite Stimulants
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:6723
- KEGG: C08151
- KEGGdrug: D91560
- KEGGdrug: D00952
- PubChem: 11683
- DrugBank: DB00351
- ChEMBL: CHEMBL1201139
- MeSH: Megestrol Acetate
- CAS: 51154-23-5
- CAS: 595-33-5
- MoNA: FiehnHILIC002078
- MoNA: FiehnHILIC000506
- MoNA: CCMSLIB00000078095
- PubChem: 10351
- LipidMAPS: LMST02030118
- 3DMET: B02145
- NIKKAJI: J6.777F
- RefMet: Megestrol acetate
- KNApSAcK: 6723
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jun Kuang, Suwen Sun, Hui Xu, Rong Ni, Fengmei Ke. Curative effects of hysteroscopic resection combined with progesterone on early-stage endometrial cancer and its prognosis.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 Jul; 26(4):1320-1326. doi:
. [PMID: 34564987] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zhigui Zheng, Jianguo Chen, Dongyuan He, Yuankai Xu, Lili Chen, Ting Zhang. The effects of megestrol acetate on nutrition, inflammation and quality of life in elderly haemodialysis patients.
International urology and nephrology.
2019 Sep; 51(9):1631-1638. doi:
10.1007/s11255-019-02245-8. [PMID: 31359357] - Hossieny Ibrahim, Mohamed Ibrahim, Yassien Temerk. A novel megestrol acetate electrochemical sensor based on conducting functionalized acetylene black-CeO2NPs nanohybrids decorated glassy carbon microspheres.
Talanta.
2019 Aug; 200(?):324-332. doi:
10.1016/j.talanta.2019.03.029. [PMID: 31036192] - Jianghuan Hua, Jian Han, Yongyong Guo, Bingsheng Zhou. Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol acetate.
Ecotoxicology and environmental safety.
2018 Nov; 163(?):289-297. doi:
10.1016/j.ecoenv.2018.07.049. [PMID: 30056343] - Bizhan Kouchaki, Ghasem Janbabai, Abbas Alipour, Shahram Ala, Samaneh Borhani, Ebrahim Salehifar. Randomized double-blind clinical trial of combined treatment with megestrol acetate plus celecoxib versus megestrol acetate alone in cachexia-anorexia syndrome induced by GI cancers.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2018 Jul; 26(7):2479-2489. doi:
10.1007/s00520-018-4047-y. [PMID: 29442239] - Sung Woo Kim, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi. A successful live birth with in vitro fertilization and thawed embryo transfer after conservative treatment of recurrent endometrial cancer.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Jan; 34(1):15-19. doi:
10.1080/09513590.2017.1342239. [PMID: 28650773] - Dorian S Houser, Cory D Champagne, Eric D Jensen, Cynthia R Smith, Lara S Cotte, Jenny M Meegan, Rebecca K Booth, Samuel K Wasser. Effects of oral megestrol acetate administration on the hypothalamic-pituitary-adrenal axis of male bottlenose dolphins (Tursiops truncatus).
Journal of the American Veterinary Medical Association.
2017 Jul; 251(2):217-223. doi:
10.2460/javma.251.2.217. [PMID: 28671496] - Jinju Guk, Hankil Son, Dong Woo Chae, Kyungsoo Park. Quantitative Assessment of Food Effect on the Pharmacokinetics of Nano-Crystallized Megestrol Acetate.
Basic & clinical pharmacology & toxicology.
2017 Mar; 120(3):270-277. doi:
10.1111/bcpt.12677. [PMID: 27639080] - Jianghuan Hua, Jian Han, Xianfeng Wang, Yongyong Guo, Bingsheng Zhou. The binary mixtures of megestrol acetate and 17α-ethynylestradiol adversely affect zebrafish reproduction.
Environmental pollution (Barking, Essex : 1987).
2016 Jun; 213(?):776-784. doi:
10.1016/j.envpol.2016.03.031. [PMID: 27038209] - Lori D Wazny, Stewart Nadurak, Cali Orsulak, Lori Giles-Smith, Navdeep Tangri. The Efficacy and Safety of Megestrol Acetate in Protein-Energy Wasting due to Chronic Kidney Disease: A Systematic Review.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2016 05; 26(3):168-76. doi:
10.1053/j.jrn.2015.11.002. [PMID: 26776251] - Christine Skouberdis Smith, John V Logomarsino. Using megestrol acetate to ameliorate protein-energy wasting in chronic kidney disease.
Journal of renal care.
2016 Mar; 42(1):53-9. doi:
10.1111/jorc.12138. [PMID: 26537025] - Malwina Lachowicz, Michał Kołodziejczyk, Marek Lukosek, Jacek Kosno, Paulina Olszewska, Paweł Szyma Nski. New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate.
Molecules (Basel, Switzerland).
2016 Feb; 21(2):. doi:
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Diabetes research and clinical practice.
2015 Dec; 110(3):285-90. doi:
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Biomedical chromatography : BMC.
2015 Oct; 29(10):1548-52. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):24-31. doi:
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Clinical therapeutics.
2015 Feb; 37(2):439-47. doi:
10.1016/j.clinthera.2014.09.022. [PMID: 25450470] - Jie-hua Shi, Ying-yao Zhu, Jing Wang, Jun Chen. A combined spectroscopic and molecular docking approach to characterize binding interaction of megestrol acetate with bovine serum albumin.
Luminescence : the journal of biological and chemical luminescence.
2015 Feb; 30(1):44-52. doi:
10.1002/bio.2688. [PMID: 24852109] - Kyungho Jang, Seonghae Yoon, Sung-Eun Kim, Joo-Youn Cho, Seo Hyun Yoon, Kyoung Soo Lim, Kyung-Sang Yu, In-Jin Jang, Howard Lee. Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state.
Drug design, development and therapy.
2014; 8(?):851-8. doi:
10.2147/dddt.s62176. [PMID: 25028536] - Chunping Qiu, Samina Dongol, Qing-Tao Lv, Ximei Gao, Jie Jiang. Sterol regulatory element-binding protein-1/fatty acid synthase involvement in proliferation inhibition and apoptosis promotion induced by progesterone in endometrial cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2013 Nov; 23(9):1629-34. doi:
10.1097/igc.0000000000000004. [PMID: 24105476] - P Fox, M Hudson, C Brown, S Lord, V Gebski, P De Souza, C K Lee. Markers of systemic inflammation predict survival in patients with advanced renal cell cancer.
British journal of cancer.
2013 Jul; 109(1):147-53. doi:
10.1038/bjc.2013.300. [PMID: 23778526] - Mia Fahlén, Lars Löfgren, Eva von Schoultz, Sabine Naessén, Kjell Carlström, Gunnar Söderqvist. Megestrol acetate may stimulate the production of insulin-like growth factor 1 in breast tissues of women with breast cancer.
Hormone molecular biology and clinical investigation.
2013 Jun; 13(3):51-4. doi:
10.1515/hmbci-2013-0004. [PMID: 25436713] - Ji-Hyung Seo, Ji-Sun Park, Min-Ho Jo, Mi-Sun Park, Ju-Hee Ryu, Young-Wuk Cho, Wang-Sup Shim, Gyu-Jeong Noh, Kyung-Tae Lee. Rapid and sensitive LC-MS/MS method for determination of megestrol acetate in human plasma: application to a human pharmacokinetic study.
Biomedical chromatography : BMC.
2013 Apr; 27(4):409-15. doi:
10.1002/bmc.2807. [PMID: 22961730] - Ozkan Kanat, Erdem Cubukcu, Nilufer Avci, Ferah Budak, Ilker Ercan, Mustafa Canhoroz, Fatih Olmez. Comparison of three different treatment modalities in the management of cancer cachexia.
Tumori.
2013 Mar; 99(2):229-33. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Justyna E Gołębiewska, Monika Lichodziejewska-Niemierko, Ewa Aleksandrowicz-Wrona, Mikołaj Majkowicz, Wiesława Lysiak-Szydłowska, Bolesław Rutkowski. Influence of megestrol acetate on nutrition, inflammation and quality of life in dialysis patients.
International urology and nephrology.
2012 Aug; 44(4):1211-22. doi:
10.1007/s11255-011-0025-8. [PMID: 21805328] - T S F Toydemir, M R Kılıçarslan, V Olgaç. Effects of the GnRH analogue deslorelin implants on reproduction in female domestic cats.
Theriogenology.
2012 Feb; 77(3):662-74. doi:
10.1016/j.theriogenology.2011.07.046. [PMID: 22015158] - Maciej Domański, Kazimierz Ciechanowski. Sarcopenia: a major challenge in elderly patients with end-stage renal disease.
Journal of aging research.
2012; 2012(?):754739. doi:
10.1155/2012/754739. [PMID: 22536505] - Baoying Liu, Lai Wei, Catherine Meyerle, Jingsheng Tuo, H Nida Sen, Zhiyu Li, Sagarika Chakrabarty, Elvira Agron, Chi-Chao Chan, Michael L Klein, Emily Chew, Frederick Ferris, Robert B Nussenblatt. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration.
Journal of translational medicine.
2011 Jul; 9(?):1-12. doi:
10.1186/1479-5876-9-111. [PMID: 21762495] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Justyna E Gołębiewska, Monika Lichodziejewska-Niemierko, Ewa Aleksandrowicz-Wrona, Mikołaj Majkowicz, Wiesława Łysiak-Szydłowska, Bolesław Rutkowski. Megestrol acetate use in hypoalbuminemic dialysis patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2011 Mar; 21(2):200-2. doi:
10.1053/j.jrn.2010.08.006. [PMID: 21239187] - Lebris S Quinn, Barbara G Anderson. Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies.
Journal of obesity.
2011; 2011(?):456347. doi:
10.1155/2011/456347. [PMID: 21603270] - Nagi B Kumar, Aslam Kazi, Tiffany Smith, Theresa Crocker, Daohai Yu, Richard R Reich, Kiran Reddy, Sally Hastings, Martine Exterman, Lodovico Balducci, Kyle Dalton, Gerold Bepler. Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment.
Current treatment options in oncology.
2010 Dec; 11(3-4):107-17. doi:
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2010 Nov; 20(6):408-13. doi:
10.1053/j.jrn.2010.01.010. [PMID: 20430646] - Norleena P Gullett, Gautam Hebbar, Thomas R Ziegler. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting.
The American journal of clinical nutrition.
2010 Apr; 91(4):1143S-1147S. doi:
10.3945/ajcn.2010.28608e. [PMID: 20164318] - M N Vo, M Evans, K Leitzel, S M Ali, M Wilson, L Demers, D B Evans, A Lipton. Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy.
Breast cancer research and treatment.
2010 Feb; 119(3):767-71. doi:
10.1007/s10549-008-0261-5. [PMID: 19115106] - Wai W Cheung, Robert H Mak. Ghrelin in chronic kidney disease.
International journal of peptides.
2010; 2010(?):. doi:
10.1155/2010/567343. [PMID: 20721357] - Shing-Shing Yeh, Mozhdeh Marandi, Henry C Thode, Daniel M Levine, Thomas Parker, Troy Dixon, Michael W Schuster. Report of a pilot, double-blind, placebo-controlled study of megestrol acetate in elderly dialysis patients with cachexia.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2010 Jan; 20(1):52-62. doi:
10.1053/j.jrn.2009.08.005. [PMID: 19819724] - M Fernández Lucas, J L Teruel, V Burguera, H Sosa, M Rivera, J R Rodríguez Palomares, R Marcén, C Quereda. [Treatment of uraemic anorexia with megestrol acetate].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2010; 30(6):646-52. doi:
10.3265/nefrologia.pre2010.aug.10546. [PMID: 21113214] - George Kaklamanos, Georgios Theodoridis, Themistoklis Dabalis. Gel permeation chromatography clean-up for the determination of gestagens in kidney fat by liquid chromatography-tandem mass spectrometry and validation according to 2002/657/EC.
Journal of chromatography. A.
2009 Nov; 1216(46):8067-71. doi:
10.1016/j.chroma.2009.04.050. [PMID: 19423118] - Quanlin Wang, Aizhi Zhang, Liren Chen. [Study on simultaneous determination method for banded synthesis hormones residues in egg products].
Wei sheng yan jiu = Journal of hygiene research.
2009 Nov; 38(6):740-6. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2009 May; 26(5):672-82. doi:
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2009 Mar; 19(2):167-71. doi:
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European journal of medical research.
2009; 14(?):59-64. doi:
10.1186/2047-783x-14-2-59. [PMID: 19258214] - Justyna Gołebiewska, Monika Lichodziejewska-Niemierko, Ewa Aleksandrowicz, Mikołaj Majkowicz, Wiesława Lysiak-Szydłowska, Bolesław Rutkowski. Influence of megestrol acetate on nutrition and inflammation in dialysis patients - preliminary results.
Acta biochimica Polonica.
2009; 56(4):733-7. doi:
10.18388/abp.2009_2510. [PMID: 19997653] - Maurizio Bossola, Luigi Tazza, Giovanna Luciani. Mechanisms and treatment of anorexia in end-stage renal disease patients on hemodialysis.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2009 Jan; 19(1):2-9. doi:
10.1053/j.jrn.2008.10.003. [PMID: 19121762] - Yi Liu, Zhongwu Jia, Lei Dong, Rui Wang, Genquan Qiu. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients.
Evidence-based complementary and alternative medicine : eCAM.
2008 Sep; 5(3):337-44. doi:
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Core evidence.
2008 Jul; 2(4):251-8. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2008 May; 26(14):2285-91. doi:
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Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2008 Apr; 10(4):235-7. doi:
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2008 Jan; 18(1):107-13. doi:
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PloS one.
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Cancer.
2007 May; 109(10):1933-9. doi:
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Theriogenology.
2006 Oct; 66(6-7):1513-7. doi:
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BMC women's health.
2006 Sep; 6(?):14. doi:
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Kidney international.
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The American journal of geriatric pharmacotherapy.
2005 Sep; 3(3):160-7. doi:
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British journal of cancer.
2005 Aug; 93 Suppl 1(?):S23-7. doi:
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2005 Jul; 15(3):345-55. doi:
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Journal of the American Geriatrics Society.
2005 Jun; 53(6):970-5. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 May; 819(2):245-51. doi:
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Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
2005 Feb; 20(1):93-7. doi:
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Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2005 Jan; 14(1):1-5. doi:
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Mayo Clinic proceedings.
2004 Dec; 79(12):1557-61. doi:
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Gynecologic oncology.
2004 Dec; 95(3):769-71. doi:
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Clinical chemistry.
2004 Dec; 50(12):2345-52. doi:
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Journal of the American Geriatrics Society.
2004 Oct; 52(10):1708-12. doi:
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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2004 Sep; 12(9):640-4. doi:
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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2004 Jul; 12(7):503-10. doi:
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BMC cancer.
2004 Jun; 4(?):29. doi:
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British journal of cancer.
2004 Mar; 90(5):955-61. doi:
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Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.
2004; 20(?):209-12. doi:
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Drugs.
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The oncologist.
2004; 9(2):126-36. doi:
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Clinical prostate cancer.
2003 Dec; 2(3):147-52. doi:
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Clinical journal of oncology nursing.
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Cancer.
2003 Jul; 98(2):397-405. doi:
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The journals of gerontology. Series A, Biological sciences and medical sciences.
2003 Jul; 58(7):644-7. doi:
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Anticancer research.
2003 Jul; 23(4):3485-91. doi:
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The journals of gerontology. Series A, Biological sciences and medical sciences.
2003 Feb; 58(2):165-70. doi:
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British journal of cancer.
2002 Dec; 87(12):1370-8. doi:
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Cancer.
2002 Nov; 95(9):2006-16. doi:
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British journal of cancer.
2002 Oct; 87(9):950-5. doi:
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Cancer chemotherapy and pharmacology.
2002 Sep; 50(3):179-85. doi:
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Expert opinion on pharmacotherapy.
2002 Sep; 3(9):1329-39. doi:
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Urology.
2002 Sep; 60(3 Suppl 1):87-92; discussion 93. doi:
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Clinical chemistry.
2002 Aug; 48(8):1314-20. doi:
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European journal of cancer (Oxford, England : 1990).
2002 Jul; 38(11):1490-4. doi:
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The Analyst.
2002 Jun; 127(6):748-54. doi:
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Clinical and diagnostic laboratory immunology.
2002 May; 9(3):583-7. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2002 Apr; 85(4):424-32. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2002 Mar; 20(6):1467-72. doi:
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CA: a cancer journal for clinicians.
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2002 Mar; 8(3):665-9. doi:
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