alprazolam (BioDeep_00000397506)
Main id: BioDeep_00000001423
代谢物信息卡片
alprazolam
化学式: C17H13ClN4 (308.0829)
中文名称: 阿普唑仑
谱图信息:
最多检出来源 Homo sapiens(urine) 55.32%
分子结构信息
SMILES: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4
InChI: InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
CONFIDENCE standard compound; INTERNAL_ID 1570
同义名列表
2 个代谢物同义名
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:2611
- KEGG: C06817
- KEGGdrug: D00225
- PubChem: 2118
- DrugBank: DB00404
- ChEMBL: CHEMBL661
- MeSH: Alprazolam
- CAS: 1246182-61-5
- CAS: 28981-97-7
- CAS: 51339-48-1
- MoNA: WA000905
- MoNA: WA000904
- MoNA: WA000903
- MoNA: WA000902
- MoNA: WA000901
- MoNA: FiehnHILIC001754
- MoNA: FiehnHILIC000177
- MoNA: AU157006
- PubChem: 9035
- PDB-CCD: 08H
- NIKKAJI: J9.279G
- RefMet: Alprazolam
- KNApSAcK: 2611
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiang Chen, Xinru Chen, Yuqing Zhu, Xiali Yu. A relatively rare traditional Chinese medicine pattern of primary Sjögren syndrome: A case report.
Medicine.
2024 Apr; 103(15):e37744. doi:
10.1097/md.0000000000037744. [PMID: 38608118] - Natália Ferreira Silva, Fernanda Naves Araújo do Prado Mascarenhas, Daniele Lisboa Ribeiro, Renata Graciele Zanon. Alterations in the dentate gyrus of the offspring of rats treated with alprazolam during gestation.
Journal of chemical neuroanatomy.
2023 Feb; ?(?):102253. doi:
10.1016/j.jchemneu.2023.102253. [PMID: 36841439] - Huma Rao, Saeed Ahmad, Asadullah Madni, Iqra Rao, Mohammed Ghazwani, Umme Hani, Muhammad Umair, Imtiaz Ahmad, Nadia Rai, Maqsood Ahmed, Kashif Ur Rehman Khan. Compritol-Based Alprazolam Solid Lipid Nanoparticles for Sustained Release of Alprazolam: Preparation by Hot Melt Encapsulation.
Molecules (Basel, Switzerland).
2022 Dec; 27(24):. doi:
10.3390/molecules27248894. [PMID: 36558027] - Somayeh Golbaz, Mirzaman Zamanzadeh, Kamyar Yaghmaeian, Ramin Nabizadeh, Nushin Rastkari, Hadi Esfahani. Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-23667-5. [PMID: 36374381] - QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao, Ke Lan. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2022 06; 50(6):741-749. doi:
10.1124/dmd.122.000864. [PMID: 35351776] - Brittany P Chapman, Jeffrey T Lai, Alex J Krotulski, Melissa F Fogarty, Matthew K Griswold, Barry K Logan, Kavita M Babu. A Case of Unintentional Opioid (U-47700) Overdose in a Young Adult After Counterfeit Xanax Use.
Pediatric emergency care.
2021 Sep; 37(9):e579-e580. doi:
10.1097/pec.0000000000001775. [PMID: 30789871] - Rajanandh Muhasaparur Ganesan, Dinesh Kumar Settu, Yogeshkumar Murkunde, Chamundeeswari Duraipandian. Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety.
Journal of ethnopharmacology.
2021 Jan; 265(?):113337. doi:
10.1016/j.jep.2020.113337. [PMID: 32890709] - Jayantee Kalita, Nikhil Dongre, Usha K Misra. Myasthenic crisis due to anxiety and insomnia during COVID -19 pandemic.
Sleep medicine.
2020 11; 75(?):532-533. doi:
10.1016/j.sleep.2020.08.008. [PMID: 32839085] - Szabolcs Sofalvi, Eric S Lavins, Claire K Kaspar, Haley M Michel, Christie L Mitchell-Mata, Marilyn A Huestis, Luigino G Apollonio. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction.
Journal of analytical toxicology.
2020 Oct; 44(7):708-717. doi:
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International journal of legal medicine.
2020 Sep; 134(5):1727-1731. doi:
10.1007/s00414-020-02352-7. [PMID: 32607751] - M S Zastrozhin, V Yu Skryabin, V V Smirnov, A E Petukhov, E P Pankratenko, A K Zastrozhina, E A Grishina, K A Ryzhikova, I V Bure, P A Golovinskii, S G Koporov, E A Bryun, D A Sychev. Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder.
Gene.
2020 May; 739(?):144513. doi:
10.1016/j.gene.2020.144513. [PMID: 32112986] - Meenu Dutt, Ravinder Naik Dharavath, Tanzeer Kaur, Navpreet Kaur, Kanwaljit Chopra, Shweta Sharma. Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate.
Indian journal of pharmacology.
2020 May; 52(3):216-221. doi:
10.4103/ijp.ijp_758_19. [PMID: 32874006] - Luying Chen, Richard B van Breemen. Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):112983. doi:
10.1016/j.jpba.2019.112983. [PMID: 31744669] - Péter Szabó, Mátyás Mayer, Zoltán Horváth-Szalai, Krisztina Tóth, Sándor Márton, Gábor Menyhei, László Sínay, Tihamér Molnár. Awake Sedation With Propofol Attenuates Intraoperative Stress of Carotid Endarterectomy in Regional Anesthesia.
Annals of vascular surgery.
2020 Feb; 63(?):311-318. doi:
10.1016/j.avsg.2019.06.047. [PMID: 31563659] - Saeeda Nadir Ali, Shumaila Akram, Amtul Qayoom, Nida Naz, Anjum Ayub. Liquid chromatographic method for simultaneous determination of alprazolam with NSAIDs in bulk drug, pharmaceutical formulation and human serum.
Pakistan journal of pharmaceutical sciences.
2020 Jan; 33(1):121-127. doi:
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PloS one.
2020; 15(9):e0238954. doi:
10.1371/journal.pone.0238954. [PMID: 32941505] - Jana Hořínková, Petr Kozlík, Tomáš Křížek, Danica Michaličková, Martin Šíma, Ondřej Slanař. Post-mortem Redistribution of Alprazolam in Rats.
Prague medical report.
2020; 121(4):244-253. doi:
10.14712/23362936.2020.21. [PMID: 33270012] - Rowan Saloner, David J Grelotti, Griffin Tyree, Erin E Sundermann, Qing Ma, Scott Letendre, Robert K Heaton, Mariana Cherner. Benzodiazepine Use Is Associated With an Increased Risk of Neurocognitive Impairment in People Living With HIV.
Journal of acquired immune deficiency syndromes (1999).
2019 12; 82(5):475-482. doi:
10.1097/qai.0000000000002183. [PMID: 31714426] - Kazuhiro Yamamoto, Sachiyo Fukushima, Yui Mishima, Mari Hashimoto, Kei Yamakawa, Kazumichi Fujioka, Kazumoto Iijima, Ikuko Yano. Pharmacokinetic assessment of alprazolam-induced neonatal abstinence syndrome using physiologically based pharmacokinetic model.
Drug metabolism and pharmacokinetics.
2019 Dec; 34(6):400-402. doi:
10.1016/j.dmpk.2019.09.002. [PMID: 31699653] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zeynab Tavakoli, Majid Soleimani, Mir Mohammad Alavi Nikje. Characterization and performance evaluation of functional monomer effect on molecular imprinted polyurethane foam.
Journal of chromatography. A.
2019 Sep; 1602(?):30-40. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Aug; 1124(?):308-312. doi:
10.1016/j.jchromb.2019.06.025. [PMID: 31265992] - Zeynab Tavakoli, Majid Soleimani, Mir Mohammad Alavi Nikje. Evaluation of an Experimentally Designed Molecular Imprinted Polyurethane Foam Performance for Extraction of Alprazolam.
Journal of chromatographic science.
2019 Aug; 57(7):662-670. doi:
10.1093/chromsci/bmz032. [PMID: 31004434] - Jeffry Adiwidjaja, Alan V Boddy, Andrew J McLachlan. Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort.
Clinical pharmacokinetics.
2019 07; 58(7):911-926. doi:
10.1007/s40262-019-00736-6. [PMID: 30675694] - Ayako Furugen, Ayako Nishimura, Masaki Kobayashi, Takeshi Umazume, Katsuya Narumi, Ken Iseki. Quantification of eight benzodiazepines in human breastmilk and plasma by liquid-liquid extraction and liquid-chromatography tandem mass spectrometry: Application to evaluation of alprazolam transfer into breastmilk.
Journal of pharmaceutical and biomedical analysis.
2019 May; 168(?):83-93. doi:
10.1016/j.jpba.2019.02.011. [PMID: 30798209] - J M Witkin, R Cerne, P G Davis, K B Freeman, J M do Carmo, J K Rowlett, K R Methuku, A Okun, S D Gleason, X Li, M J Krambis, M Poe, G Li, J M Schkeryantz, R Jahan, L Yang, W Guo, L K Golani, W H Anderson, J T Catlow, T M Jones, F Porreca, J L Smith, K L Knopp, J M Cook. The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.
Pharmacology, biochemistry, and behavior.
2019 05; 180(?):22-31. doi:
10.1016/j.pbb.2019.02.013. [PMID: 30825491] - Wenche Rødseth Brede, Hege-Merete Krabseth, Lisbeth Solem Michelsen, Harald Aarset, John-Petter Jamt, Lars Slørdal. A Wolf in Sheep's Clothing.
Journal of analytical toxicology.
2019 03; 43(2):e7-e8. doi:
10.1093/jat/bky080. [PMID: 30295817] - Vidar Temte, Kari Kjeldstadli, Lina Dorthea Bruun, Morris Birdal, Liliana Bachs, Ritva Karinen, Gerrit Middelkoop, Elisabeth Øiestad, Gudrun Høiseth. An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses.
Journal of analytical toxicology.
2019 Mar; 43(2):104-111. doi:
10.1093/jat/bky062. [PMID: 30517712] - Harunobu Tahara, Miwa Watanabe, Maki Hasegawa. A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys.
Biopharmaceutics & drug disposition.
2019 Feb; 40(2):81-93. doi:
10.1002/bdd.2173. [PMID: 30724384] - Taís Regina Fiorentin, Barry Kerr Logan. Toxicological findings in 1000 cases of suspected drug facilitated sexual assault in the United States.
Journal of forensic and legal medicine.
2019 Feb; 61(?):56-64. doi:
10.1016/j.jflm.2018.11.006. [PMID: 30453150] - Ofelia Romero-Cerecero, Ana Laura Islas-Garduño, Alejandro Zamilpa, Armando Herrera-Arellano, Enrique Jiménez-Ferrer, Jaime Tortoriello. Galphimine-B Standardized Extract versus Alprazolam in Patients with Generalized Anxiety Disorder: A Ten-Week, Double-Blind, Randomized Clinical Trial.
BioMed research international.
2019; 2019(?):1037036. doi:
10.1155/2019/1037036. [PMID: 30834253] - Simonas Masiulis, Rooma Desai, Tomasz Uchański, Itziar Serna Martin, Duncan Laverty, Dimple Karia, Tomas Malinauskas, Jasenko Zivanov, Els Pardon, Abhay Kotecha, Jan Steyaert, Keith W Miller, A Radu Aricescu. GABAA receptor signalling mechanisms revealed by structural pharmacology.
Nature.
2019 01; 565(7740):454-459. doi:
10.1038/s41586-018-0832-5. [PMID: 30602790] - Siddharth Iyengar, Charles Bornmann, Farid Abdelmalak, Tulisa LaRocca. Catatonia due to alprazolam withdrawal.
BMJ case reports.
2018 Dec; 11(1):. doi:
10.1136/bcr-2018-227175. [PMID: 30567266] - Marzieh Karimian Amroabadi, Asghar Taheri-Kafrani, Leily Heidarpoor Saremi, Ali Asghar Rastegari. Spectroscopic studies of the interaction between alprazolam and apo-human serum transferrin as a drug carrier protein.
International journal of biological macromolecules.
2018 Mar; 108(?):263-271. doi:
10.1016/j.ijbiomac.2017.11.179. [PMID: 29199122] - Ailton Spiacci, Heloisa H Vilela-Costa, Ana Beatriz Sant'Ana, Gabriel Gripp Fernandes, Alana Tercino Frias, Glauber S Ferreira da Silva, José Antunes-Rodrigues, Hélio Zangrossi. Panic-like escape response elicited in mice by exposure to CO2, but not hypoxia.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 Feb; 81(?):178-186. doi:
10.1016/j.pnpbp.2017.10.018. [PMID: 29111406] - Jonathan H Sin, Andrew Tom, Alexander Toyoda, Nathalie Roy, Bryan D Hayes. High-dose intravenous lipid emulsion affecting successful initiation of continuous venovenous hemofiltration and extracorporeal membrane oxygenation.
Clinical toxicology (Philadelphia, Pa.).
2018 02; 56(2):149-150. doi:
10.1080/15563650.2017.1341633. [PMID: 28681624] - Jagriti Narang, Nitesh Malhotra, Chaitali Singhal, Ashish Mathur, Anoop Krishna Pn, C S Pundir. Detection of alprazolam with a lab on paper economical device integrated with urchin like Ag@ Pd shell nano-hybrids.
Materials science & engineering. C, Materials for biological applications.
2017 Nov; 80(?):728-735. doi:
10.1016/j.msec.2016.11.128. [PMID: 28866222] - Yan Li, Gaotong Lin, Bingbao Chen, Jing Zhang, Lingtian Wang, Zixia Li, Yungang Cao, Congcong Wen, Xuezhi Yang, Gaozhong Cao, Xianqin Wang, Guoquan Cao. Effect of alprazolam on rat serum metabolic profiles.
Biomedical chromatography : BMC.
2017 Sep; 31(9):. doi:
10.1002/bmc.3956. [PMID: 28187228] - Nasser Goudarzi, Monavar Amirnavaee, Mansour Arab Chamjangali, Sahar Farsimadan. Application of Ultrasound-Assisted Surfactant-Enhanced Emulsification Microextraction Based on Solidification of Floating Organic Droplets and High Performance Liquid Chromatography for Preconcentration and Determination of Alprazolam and Chlordiazepoxide in Human Serum Samples.
Journal of chromatographic science.
2017 Jul; 55(6):669-675. doi:
10.1093/chromsci/bmx017. [PMID: 28334890] - Meltem Güner Can, Özgen Ilgaz Koçyiğit, Uğur Aksu, Ali Özer, Fevzi Toraman. Effect of Alprazolam on Redox Status in Renal Transplantation Donors and Recipients.
Annals of transplantation.
2017 Jun; 22(?):354-360. doi:
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Neurochemical research.
2017 May; 42(5):1333-1344. doi:
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JAMA internal medicine.
2016 10; 176(10):1554-1555. doi:
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Diabetes.
2016 09; 65(9):2754-9. doi:
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Epilepsy & behavior : E&B.
2016 08; 61(?):63-71. doi:
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2016 Mar; 61(2):573-575. doi:
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2015 Dec; 40(13):2969-80. doi:
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Forensic science international.
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Diabetes.
2015 Sep; 64(9):3253-61. doi:
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Therapeutic drug monitoring.
2015 Aug; 37(4):451-60. doi:
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Analytical chemistry.
2015 Jun; 87(12):6212-9. doi:
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2015 Jun; 38(3):301-4. doi:
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2015 Apr; 39(3):225-8. doi:
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Forensic science international.
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Psychopharmacology.
2014 Oct; 231(19):3817-28. doi:
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2014 Sep; 39(18):3519-26. doi:
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The American journal of emergency medicine.
2014 Sep; 32(9):1103-8. doi:
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Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
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2014 Mar; 27(1):33-8. doi:
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Clinical toxicology (Philadelphia, Pa.).
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