Ethylumbelliferone (BioDeep_00000395658)

Main id: BioDeep_00000008464

 

PANOMIX_OTCML-2023


代谢物信息卡片


2H-1-Benzopyran-2-one, 7-ethoxy-

化学式: C11H10O3 (190.063)
中文名称: 7-乙氧基香豆素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=CC2=C(C=C1)C=CC(=O)O2
InChI: InChI=1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3

描述信息

7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It is functionally related to an umbelliferone.
A member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group.
7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs[1].
7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs[1].

同义名列表

15 个代谢物同义名

2H-1-Benzopyran-2-one, 7-ethoxy-; 7-ethoxy-2H-1-benzopyran-2-one; 7-Ethoxy-1-benzopyran-2-one; 7-ethoxy-2H-chromen-2-one; 7-Ethoxycoumarin, 99.5\\%; 7-ethoxychromen-2-one; Coumarin, 7-ethoxy-; Ethylumbelliferone; 7-Ethoxycoumarine; 7-Ethoxycoumarin; UNII-C8K66XCQ6L; C8K66XCQ6L; 1ST164100; 7-O-Ethylumbelliferone; 7-Ethoxycoumarin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AHR, AHRR, ALB, CAT, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HPGDS
Peripheral membrane protein 3 CYP2B6, CYP2E1, FDXR
Endoplasmic reticulum membrane 10 CYP19A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HSP90B1
Nucleus 4 AHR, AHRR, ALB, HSP90B1
cytosol 7 AHR, AHRR, ALB, CAT, GPT, HPGDS, HSP90B1
centrosome 1 ALB
nucleoplasm 3 AHR, AHRR, HPGDS
Multi-pass membrane protein 2 CYP19A1, SLC45A2
Golgi apparatus 1 ALB
Golgi membrane 1 INS
mitochondrial inner membrane 2 CYP2E1, FDXR
smooth endoplasmic reticulum 1 HSP90B1
plasma membrane 3 CYP2C19, CYP2C9, IFNLR1
Membrane 8 CAT, CYP19A1, CYP2A6, CYP2D6, CYP3A4, HSP90B1, IFNLR1, SLC45A2
extracellular exosome 4 ALB, CAT, GPT, HSP90B1
endoplasmic reticulum 4 ALB, CYP19A1, CYP2D6, HSP90B1
extracellular space 2 ALB, INS
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 3 CAT, CYP2D6, FDXR
protein-containing complex 4 AHR, ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 10 CAT, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HPGDS
Microsome membrane 7 CYP19A1, CYP1A2, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Single-pass type I membrane protein 1 IFNLR1
Secreted 2 ALB, INS
extracellular region 4 ALB, CAT, HSP90B1, INS
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 2 CAT, FDXR
anchoring junction 1 ALB
transcription regulator complex 1 AHR
Melanosome membrane 1 SLC45A2
midbody 1 HSP90B1
Mitochondrion inner membrane 2 CYP2E1, FDXR
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
ciliary basal body 1 ALB
chromatin 2 AHR, AHRR
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
aryl hydrocarbon receptor complex 2 AHR, AHRR
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, HSP90B1, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Sarcoplasmic reticulum lumen 1 HSP90B1
cytoplasmic microtubule 1 CYP2A6
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D'Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. Journal of medicinal chemistry. 2022 12; 65(23):15805-15818. doi: 10.1021/acs.jmedchem.2c01457. [PMID: 36395526]
  • Chiara Borsari, Erhan Keles, Denise Rageot, Andrea Treyer, Thomas Bohnacker, Lukas Bissegger, Martina De Pascale, Anna Melone, Rohitha Sriramaratnam, Florent Beaufils, Matthias Hamburger, Paul Hebeisen, Wolfgang Löscher, Doriano Fabbro, Petra Hillmann, Matthias P Wymann. 4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders. Journal of medicinal chemistry. 2020 11; 63(22):13595-13617. doi: 10.1021/acs.jmedchem.0c00620. [PMID: 33166139]
  • Tomohide Uno, Ryosuke Nakano, Kengo Kanamaru, Shinji Takenaka, Yuichi Uno, Hiromasa Imaishi. Metabolism of 7-ethoxycoumarin, flavanone and steroids by cytochrome P450 2C9 variants. Biopharmaceutics & drug disposition. 2017 Nov; 38(8):486-493. doi: 10.1002/bdd.2090. [PMID: 28758225]
  • Peng Jiang, Jianshe Wang, Nan Sheng, Dongbing Wei, Jiayin Dai. Effects of pentachlorophenol on the quail (Coturnix japonica) liver detoxification pathway. Chemosphere. 2017 Jun; 177(?):44-50. doi: 10.1016/j.chemosphere.2017.02.154. [PMID: 28284116]
  • Kristoffer Dalhoff, Michele Gottardi, Andreas Kretschmann, Nina Cedergreen. What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?. Aquatic toxicology (Amsterdam, Netherlands). 2016 Mar; 172(?):95-102. doi: 10.1016/j.aquatox.2015.12.007. [PMID: 26784738]
  • Michele Gottardi, Andreas Kretschmann, Nina Cedergreen. Measuring cytochrome P450 activity in aquatic invertebrates: a critical evaluation of in vitro and in vivo methods. Ecotoxicology (London, England). 2016 Mar; 25(2):419-30. doi: 10.1007/s10646-015-1600-z. [PMID: 26686507]
  • Litao Guo, Wen Xie, Shaoli Wang, Qingjun Wu, Rumei Li, Nina Yang, Xin Yang, Huipeng Pan, Youjun Zhang. Detoxification enzymes of Bemisia tabaci B and Q: biochemical characteristics and gene expression profiles. Pest management science. 2014 Oct; 70(10):1588-94. doi: 10.1002/ps.3751. [PMID: 24488614]
  • C Tamames-Tabar, E Imbuluzqueta, M A Campanero, P Horcajada, M J Blanco-Prieto. A simple and robust high-performance liquid chromatography coupled to a diode-array detector method for the analysis of genistein in mouse tissues. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Sep; 935(?):47-53. doi: 10.1016/j.jchromb.2013.07.020. [PMID: 23939202]
  • Casey L Sayre, Jody K Takemoto, Stephanie E Martinez, Neal M Davies. Chiral analytical method development and application to pre-clinical pharmacokinetics of pinocembrin. Biomedical chromatography : BMC. 2013 Jun; 27(6):681-4. doi: 10.1002/bmc.2853. [PMID: 23212747]
  • Xiaoning Liu, Lei Zhang, Xuetao Zhang, Gao Xiwu. Molecular cloning and recombinant expression of cytochrome P450 CYP6B6 from Helicoverpa armigera in Escherichia coli. Molecular biology reports. 2013 Feb; 40(2):1211-7. doi: 10.1007/s11033-012-2163-1. [PMID: 23096085]
  • Lian Zhou, Randy C Dockens, Peggy Liu-Kreyche, Scott J Grossman, Ramaswamy A Iyer. In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jun; 40(6):1093-103. doi: 10.1124/dmd.111.043596. [PMID: 22381334]
  • Paul M van Midwoud, Arnout Janse, Marjolijn T Merema, Geny M M Groothuis, Elisabeth Verpoorte. Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Analytical chemistry. 2012 May; 84(9):3938-44. doi: 10.1021/ac300771z. [PMID: 22444457]
  • Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS neglected tropical diseases. 2011 Jun; 5(6):e1151. doi: 10.1371/journal.pntd.0001151. [PMID: 21738803]
  • Kasturi Dasgupta, Savita Ganesan, Sindhu Manivasagam, Brian G Ayre. A cytochrome P450 monooxygenase commonly used for negative selection in transgenic plants causes growth anomalies by disrupting brassinosteroid signaling. BMC plant biology. 2011 Apr; 11(?):67. doi: 10.1186/1471-2229-11-67. [PMID: 21496250]
  • Miguel Angel Campanero, Manuel Escolar, Guiomar Perez, Emilio Garcia-Quetglas, Belen Sadaba, Jose Ramon Azanza. Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2010 Mar; 51(4):875-81. doi: 10.1016/j.jpba.2009.09.012. [PMID: 19800189]
  • Kahina Si-Ahmed, Fairouz Tazerouti, Ahmed Y Badjah-Hadj-Ahmed, Zeineb Aturki, Giovanni D'Orazio, Anna Rocco, Salvatore Fanali. Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2010 Jan; 51(1):225-9. doi: 10.1016/j.jpba.2009.08.015. [PMID: 19740618]
  • Hiroshi Hamamoto, Akiko Tonoike, Kazuya Narushima, Ryo Horie, Kazuhisa Sekimizu. Silkworm as a model animal to evaluate drug candidate toxicity and metabolism. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2009 Apr; 149(3):334-9. doi: 10.1016/j.cbpc.2008.08.008. [PMID: 18804554]
  • James P Hardwick, Douglas Osei-Hyiaman, Homer Wiland, Mohamed A Abdelmegeed, Byoung-Joon Song. PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. PPAR research. 2009; 2009(?):952734. doi: 10.1155/2009/952734. [PMID: 20300478]
  • Janja Plazar, Metka Filipic, Geny M M Groothuis. Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicology in vitro : an international journal published in association with BIBRA. 2008 Mar; 22(2):318-27. doi: 10.1016/j.tiv.2007.09.009. [PMID: 17981005]
  • Dayanidhi Behera, Anagha Damre, Alice Varghese, Veeranjaneyulu Addepalli. In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data. Drug metabolism and drug interactions. 2008; 23(3-4):329-50. doi: 10.1515/dmdi.2008.23.3-4.329. [PMID: 19326776]
  • Wataru Kuki, Keisuke Hosotani, Hajime Ohigashi, Akira Murakami. Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin. Nutrition and cancer. 2008; 60(3):368-72. doi: 10.1080/01635580701745327. [PMID: 18444171]
  • Inge A M de Graaf, Ruben de Kanter, Marina H de Jager, Raquel Camacho, Elise Langenkamp, Esther G van de Kerkhof, Geny M M Groothuis. Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):591-9. doi: 10.1124/dmd.105.006726. [PMID: 16415126]
  • Hong-Fang Lu, Wei Seng Lim, Peng-Chi Zhang, Ser Mien Chia, Hanry Yu, Hai-Quan Mao, Kam W Leong. Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture. Tissue engineering. 2005 Nov; 11(11-12):1667-77. doi: 10.1089/ten.2005.11.1667. [PMID: 16411812]
  • Kathryn Roupe, Steven Halls, Neal M Davies. Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics. Journal of pharmaceutical and biomedical analysis. 2005 Jun; 38(1):148-54. doi: 10.1016/j.jpba.2004.12.015. [PMID: 15907633]
  • Feras Imad Kanaze, Melpomeni I Bounartzi, Ioannis Niopas. A validated HPLC determination of the flavone aglycone diosmetin in human plasma. Biomedical chromatography : BMC. 2004 Dec; 18(10):800-4. doi: 10.1002/bmc.391. [PMID: 15386576]
  • Feras Imad Kanaze, Eugene Kokkalou, Manolis Georgarakis, Ioannis Niopas. A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. Journal of pharmaceutical and biomedical analysis. 2004 Sep; 36(1):175-81. doi: 10.1016/j.jpba.2004.05.015. [PMID: 15351063]
  • Feras Imad Kanaze, Eugene Kokkalou, Manolis Georgarakis, Ioannis Niopas. Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Mar; 801(2):363-7. doi: 10.1016/j.jchromb.2003.11.030. [PMID: 14751808]
  • R De Kanter, M Monshouwer, A L Draaisma, M H De Jager, I A M de Graaf, J H Proost, D K F Meijer, G M M Groothuis. Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica; the fate of foreign compounds in biological systems. 2004 Mar; 34(3):229-41. doi: 10.1080/004982502000196758. [PMID: 15204696]
  • Bin Ji, Y Masubuchi, T Horie. The relationship between oxidative metabolism and lipid peroxidation in rat liver microsomes. Research communications in molecular pathology and pharmacology. 2003; 113-114(?):181-92. doi: ". [PMID: 15686117]
  • Yune-Fang Ueng, Ming-Jaw Don, Hsiao-Chi Peng, Shu-Yun Wang, Jong-Jing Wang, Chieh-Fu Chen. Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes. Japanese journal of pharmacology. 2002 Jul; 89(3):267-73. doi: 10.1254/jjp.89.267. [PMID: 12184732]
  • R De Kanter, M H De Jager, A L Draaisma, J U Jurva, P Olinga, D K F Meijer, G M M Groothuis. Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica; the fate of foreign compounds in biological systems. 2002 May; 32(5):349-62. doi: 10.1080/00498250110112006. [PMID: 12065058]
  • Y Minamiyama, S Imaoka, S Takemura, S Okada, M Inoue, Y Funae. Escape from tolerance of organic nitrate by induction of cytochrome P450. Free radical biology & medicine. 2001 Dec; 31(11):1498-508. doi: 10.1016/s0891-5849(01)00733-x. [PMID: 11728822]
  • D Müller-Enoch, R Fintelmann, A Nicolaev, H Gruler. Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2001 Nov; 56(11-12):1082-90. doi: 10.1515/znc-2001-11-1227. [PMID: 11837661]
  • B Laube, S Winkler, B Ladstetter, T Scheller, L R Schwarz. Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora. Archives of toxicology. 2000 Sep; 74(7):379-87. doi: 10.1007/s002040000137. [PMID: 11043493]
  • Y Sakai, K Naruse, I Nagashima, T Muto, M Suzuki. A new bioartificial liver using porcine hepatocyte spheroids in high-cell-density suspension perfusion culture: in vitro performance in synthesized culture medium and in 100\% human plasma. Cell transplantation. 1999 Sep; 8(5):531-41. doi: 10.1177/096368979900800508. [PMID: 10580347]
  • K Inouye, T Mae, S Kondo, H Ohkawa. Inhibitory effects of vitamin A and vitamin K on rat cytochrome P4501A1-dependent monooxygenase activity. Biochemical and biophysical research communications. 1999 Aug; 262(2):565-9. doi: 10.1006/bbrc.1999.1240. [PMID: 10462515]
  • T Lacour, H Ohkawa. Engineering and biochemical characterization of the rat microsomal cytochrome P4501A1 fused to ferredoxin and ferredoxin-NADP(+) reductase from plant chloroplasts. Biochimica et biophysica acta. 1999 Aug; 1433(1-2):87-102. doi: 10.1016/s0167-4838(99)00154-5. [PMID: 10446362]
  • J Liu, J Pan, S Naik, H Santangini, D Trenkler, N Thompson, A Rifai, J R Chowdhury, H O Jauregui. Characterization and evaluation of detoxification functions of a nontumorigenic immortalized porcine hepatocyte cell line (HepLiu). Cell transplantation. 1999 May; 8(3):219-32. doi: 10.1177/096368979900800301. [PMID: 10442735]
  • D J Carlile, A J Stevens, E I Ashforth, D Waghela, J B Houston. In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 1998 Mar; 26(3):216-21. doi: NULL. [PMID: 9492383]
  • W Klinger, H Oelschläger, E Karge, D Rothley. Interaction of chlormezanone with rat liver microsomes and its degradation. European journal of drug metabolism and pharmacokinetics. 1997 Apr; 22(2):165-71. doi: 10.1007/bf03189801. [PMID: 9248786]
  • L B Kong, S Chen, A A Demetriou, J Rozga. Matrix-induced liver cell aggregates (MILCA) for bioartificial liver use. The International journal of artificial organs. 1996 Jan; 19(1):72-8. doi: . [PMID: 8641823]
  • T Terada, H Kaneko, S Terashita, Z Tozuka, Y Tokuma, T Hata. A species comparison of 14C-labeled 7-ethoxycoumarin metabolism in precision-cut liver slices from guinea pig and dog using a phosphor imaging system. Research communications in molecular pathology and pharmacology. 1996 Jan; 91(1):41-56. doi: NULL. [PMID: 8824930]
  • K Monostory, L Vereczkey. Interaction of theophylline and ipriflavone at the cytochrome P450 level. European journal of drug metabolism and pharmacokinetics. 1995 Jan; 20(1):43-7. doi: 10.1007/bf03192287. [PMID: 7588993]
  • D S Raiford, M C Thigpen. Kupffer cell stimulation with Corynebacterium parvum reduces some cytochrome P450-dependent activities and diminishes acetaminophen and carbon tetrachloride-induced liver injury in the rat. Toxicology and applied pharmacology. 1994 Nov; 129(1):36-45. doi: 10.1006/taap.1994.1226. [PMID: 7974494]
  • A Steensma, J A Beamand, D G Walters, R J Price, B G Lake. Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Sep; 24(9):893-907. doi: 10.3109/00498259409043288. [PMID: 7810171]
  • A R Goeptar, E J Groot, H Scheerens, J N Commandeur, N P Vermeulen. Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450. Cancer research. 1994 May; 54(9):2411-8. doi: ". [PMID: 8162589]
  • R Ryan, S W Grimm, K M Kedzie, J R Halpert, R M Philpot. Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney. Archives of biochemistry and biophysics. 1993 Aug; 304(2):454-63. doi: 10.1006/abbi.1993.1375. [PMID: 8346920]
  • F Centeno, C Gutiérrez-Merino. Location of functional centers in the microsomal cytochrome P450 system. Biochemistry. 1992 Sep; 31(36):8473-81. doi: 10.1021/bi00151a013. [PMID: 1390631]
  • J Zaleski, G Y Kwei, R G Thurman, F C Kauffman. Suppression of benzo[a]pyrene metabolism by accumulation of triacylglycerols in rat hepatocytes: effect of high-fat and food-restricted diets. Carcinogenesis. 1991 Nov; 12(11):2073-9. doi: 10.1093/carcin/12.11.2073. [PMID: 1934292]
  • S M Wishnies, A R Parrish, I G Sipes, A J Gandolfi, C W Putnam, C L Krumdieck, K Brendel. Biotransformation activity in vitrified human liver slices. Cryobiology. 1991 Jun; 28(3):216-26. doi: 10.1016/0011-2240(91)90026-k. [PMID: 1864080]
  • H Kraul, J Truckenbrodt, H Sigusch, M Hippius, G Machnik, A Hoffmann. [Comparison of ICG elimination with biotransformation of model substances and histological features of liver biopsy in liver diseases]. Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR. 1991; 51(3-4):123-8. doi: NULL. [PMID: 1811655]
  • D Werck-Reichhart, B Gabriac, H Teutsch, F Durst. Two cytochrome P-450 isoforms catalysing O-de-ethylation of ethoxycoumarin and ethoxyresorufin in higher plants. The Biochemical journal. 1990 Sep; 270(3):729-35. doi: 10.1042/bj2700729. [PMID: 2241905]
  • T Andersson. Sex differences in cytochrome P-450-dependent xenobiotic and steroid metabolism in the mature rainbow trout kidney. The Journal of endocrinology. 1990 Jul; 126(1):9-16. doi: 10.1677/joe.0.1260009. [PMID: 2380656]
  • E F Perdu-Durand, J P Cravedi. Characterization of xenobiotic metabolizing enzymes in sturgeon (Acipenser baeri). Comparative biochemistry and physiology. B, Comparative biochemistry. 1989; 93(4):921-8. doi: 10.1016/0305-0491(89)90067-9. [PMID: 2509131]
  • M Pesonen, T Andersson. Subcellular localization and properties of cytochrome P-450 and UDP glucuronosyltransferase in the rainbow trout kidney. Biochemical pharmacology. 1987 Mar; 36(6):823-9. doi: 10.1016/0006-2952(87)90170-5. [PMID: 3105537]
  • R J Gerson, A Serroni, D Gilfor, J M Ellen, J L Farber. Killing of cultured hepatocytes by the mixed-function oxidation of ethoxycoumarin. Biochemical pharmacology. 1986 Dec; 35(23):4311-9. doi: 10.1016/0006-2952(86)90711-2. [PMID: 3790155]
  • R Gugler, J C Jensen. Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gastroenterology. 1985 Dec; 89(6):1235-41. doi: 10.1016/0016-5085(85)90638-9. [PMID: 3932118]
  • R G Thurman, F C Kauffman. Sublobular compartmentation of pharmacologic events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule. Hepatology (Baltimore, Md.). 1985 Jan; 5(1):144-51. doi: 10.1002/hep.1840050128. [PMID: 3967857]
  • C R Wolf, J B Hook, E A Lock. Differential destruction of cytochrome P-450-dependent monooxygenases in rat and mouse kidney following hexachloro-1:3-butadiene administration. Molecular pharmacology. 1983 Jan; 23(1):206-12. doi: NULL. [PMID: 6865899]
  • A Poole, L F Chasseaud, J W Bridges. Preparation and properties of primary maintenance cultures of adult rabbit hepatocytes. Toxicology. 1982; 24(2):141-57. doi: 10.1016/0300-483x(82)90052-x. [PMID: 7135410]
  • M Ingelman-Sundberg, T Haaparanta, J Rydström. Membrane charge as effector of cytochrome P-450LM2 catalyzed reactions in reconstituted liposomes. Biochemistry. 1981 Jul; 20(14):4100-6. doi: 10.1021/bi00517a024. [PMID: 6974566]
  • J R Fry, N K Perry. The effect of Aroclor 1254 pretreatment on the phase I and phase II metabolism of 7-ethoxycoumarin in isolated viable rat kidney cells. Biochemical pharmacology. 1981 Jun; 30(11):1197-201. doi: 10.1016/0006-2952(81)90297-5. [PMID: 6791649]
  • R B Franklin, M J Vodicnik. Sex steroids and extrahepatic mixed-function oxidase activity. Journal of steroid biochemistry. 1981 Apr; 14(4):367-75. doi: 10.1016/0022-4731(81)90156-4. [PMID: 7230799]