L-Dopaquinone (BioDeep_00000035725)

   

human metabolite


代谢物信息卡片


2-amino-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)propanoic acid

化学式: C9H9NO4 (195.0532)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 11.97%

分子结构信息

SMILES: C1=CC(=O)C(=O)C=C1CC(C(=O)O)N
InChI: InChI=1S/C9H9NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6H,3,10H2,(H,13,14)

描述信息

Implicated in food discolouration (enzymatic browning).
Implicated in food discolouration (enzymatic browning)

同义名列表

9 个代谢物同义名

2-amino-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)propanoic acid; 2-Amino-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)propanoate; 4-(2-Carboxy-2-aminoethyl)-1,2-benzoquinone; Dopaquinone, (S)-isomer; Dopa O-quinone; L-dopaquinone; O-Dopaquinone; Dopaquinone; Dopaquinone



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 MITF, TH, TYR, TYRP1
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 TYRP1
Nucleus 3 MITF, PDE7A, TH
cytosol 5 DCT, GCLM, MITF, PDE7A, TH
dendrite 1 TH
nucleoplasm 1 MITF
Cell projection, axon 1 TH
Early endosome membrane 1 HSD17B6
Golgi membrane 1 INS
lysosomal membrane 1 MITF
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Lysosome 1 TYR
plasma membrane 1 DCT
terminal bouton 1 TH
Membrane 1 DCT
axon 1 TH
Lysosome membrane 1 MITF
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 1 INS
perinuclear region of cytoplasm 3 PDE7A, TH, TYR
mitochondrion 1 TH
protein-containing complex 1 MITF
intracellular membrane-bounded organelle 3 DCT, HSD17B6, TYR
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 3 DCT, TYR, TYRP1
Secreted 1 INS
extracellular region 1 INS
cytoplasmic side of plasma membrane 1 TH
perikaryon 1 TH
cytoplasmic vesicle 1 TH
Melanosome membrane 4 DCT, TH, TYR, TYRP1
Golgi-associated vesicle 1 TYR
Cytoplasm, perinuclear region 1 TH
intracellular vesicle 1 TYRP1
neuron projection 1 TH
chromatin 1 MITF
endosome lumen 1 INS
Melanosome 3 DCT, TYR, TYRP1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 TYRP1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
glutamate-cysteine ligase complex 1 GCLM
[Isoform PDE7A1]: Cytoplasm, cytosol 1 PDE7A
[Isoform PDE7A2]: Cytoplasm 1 PDE7A


文献列表

  • Yehyang Kim, Sohun Lee, Ji Hye Ryu, Kee Dong Yoon, Song Seok Shin. Effect of Aurea Helianthus stem extract on anti-melanogenesis. Bioscience, biotechnology, and biochemistry. 2018 Nov; 82(11):1871-1879. doi: 10.1080/09168451.2018.1506311. [PMID: 30146944]
  • Beata Gasowska, Hubert Wojtasek, Józef Hurek, Marcin Drag, Kornel Nowak, Paweł Kafarski. Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase. European journal of biochemistry. 2002 Aug; 269(16):4098-104. doi: 10.1046/j.1432-1033.2002.03103.x. [PMID: 12180986]
  • K Tsukamoto, M Furue, Y Sato, O Takayama, R Akasu, N Ohtake, K Wakamatsu, S Ito, K Tamaki, S Shimada. Generalized melanosis in metastatic malignant melanoma: the possible role of DOPAquinone metabolites. Dermatology (Basel, Switzerland). 1998; 197(4):338-42. doi: 10.1159/000018028. [PMID: 9873171]
  • G Prota. The role of peroxidase in melanogenesis revisited. Pigment cell research. 1992; Suppl 2(?):25-31. doi: 10.1111/j.1600-0749.1990.tb00344.x. [PMID: 1329073]