Clupanodonic acid (BioDeep_00000003493)

 

Secondary id: BioDeep_00000175124, BioDeep_00000229693

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(7Z,10Z,13Z,16Z,19Z)-Docosa-7,10,13,16,19-pentaenoic acid

化学式: C22H34O2 (330.2559)
中文名称: 二十二碳五烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 40.96%

Reviewed

Last reviewed on 2024-09-24.

Cite this Page

Clupanodonic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/clupanodonic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003493). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CCCCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)(=O)O
InChI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

描述信息

Docosapentaenoic acid (also known as clupanodonic acid) is an essential omega-3 fatty acid (EFA) which is prevalent in fish oils. Docosapentaenoic acid, commonly called DPA, is an intermediary between eicosapentaenoic acid (EPA, 20:5 ω-3) and docosahexaenoic acid (DHA, 22:6 ω-3). Seal oil is a rich source. There are three functions of docosapentaenoic acid. The most important is as part of phospholipids in all animal cellular membranes: a deficiency of docosapentaenoic acid leads to faulty membranes being formed. A second is in the transport and oxidation of cholesterol: clupanodonic acid tends to lower plasma cholesterol. A third function is as a precursor of prostanoids which are only formed from docosapentaenoic acid. Deficiency of this in experimental animals causes lesions mainly attributable to faulty cellular membranes: sudden failure of growth, lesions of skin and kidney and connective tissue, erythrocyte fragility, impaired fertility, uncoupling of oxidation and phosphorylation. In man pure deficiency of docosapentaenoic acid has been studied particularly in persons fed intravenously. A relative deficiency (that is, a low ratio in the body of docosapentaenoic to long-chain saturated fatty acids and isomers of docosapentaenoate) is common on Western diets and plays an important part in the causation of atherosclerosis, coronary thrombosis, multiple sclerosis, the triopathy of diabetes mellitus, hypertension and certain forms of malignant disease. Various factors affect the dietary requirement of docosapentaenoic acid. (PMID: 6469703) [HMDB]. 7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid is found in many foods, some of which are green zucchini, green bell pepper, green bean, and red bell pepper.
Docosapentaenoic acid (22n-3) (also known as clupanodonic acid) is an essential omega-3 fatty acid (EFA) which is prevalent in fish oils. Docosapentaenoic acid, commonly called DPA, is an intermediary between eicosapentaenoic acid (EPA, 20:5 ω-3) and docosahexaenoic acid (DHA, 22:6 ω-3). Seal oil is a rich source of this metabolite. There are three functions of docosapentaenoic acid. Most importantly, it is a component of phospholipids found in all animal cell membranes, and a deficiency of docosapentaenoic acid leads to faulty membranes being formed. Secondly, it is involved in the transport and oxidation of cholesterol, and clupanodonic acid tends to lower plasma cholesterol. A third function is as a precursor of prostanoids which are only formed from docosapentaenoic acid. Deficiency of this in experimental animals causes lesions mainly attributable to faulty cellular membranes. Outcomes include sudden failure of growth, lesions of the skin, kidney, and connective tissue, erythrocyte fragility, impaired fertility, and the uncoupling of oxidation and phosphorylation. In humans, pure deficiency of docosapentaenoic acid has been studied particularly in persons fed intravenously. A relative deficiency (that is, a low ratio in the body of docosapentaenoic to long-chain saturated fatty acids and isomers of docosapentaenoate) is common in Western diets and plays an important part in the causation of atherosclerosis, coronary thrombosis, multiple sclerosis, the triopathy of diabetes mellitus, hypertension, and certain forms of malignant disease. Various factors affect the dietary requirement of docosapentaenoic acid (PMID: 6469703).
Docosapentaenoic acid (22n-3) is a component of phospholipids found in all animal cell membranes.

同义名列表

45 个代谢物同义名

(7Z,10Z,13Z,16Z,19Z)-Docosa-7,10,13,16,19-pentaenoic acid; (7Z,10Z,13Z,16Z,19Z)-Docosa 7,10,13,16,19-pentaenoic acid; (7Z,10Z,13Z,16Z,19Z)-7,10,13,16,19-Docosapentaenoic acid; (7Z,10Z,13Z,16Z,19Z)-Docosa-7,10,13,16,19-pentaenoate; (7Z,10Z,13Z,16Z,19Z)-Docosa 7,10,13,16,19-pentaenoate; 7,10,13,16,19-Docosapentaenoic acid, (all-Z)-isomer; (all-Z)-7, 10, 13, 16, 19-Docosapentaenoic acid; 7Z, 10Z, 13Z, 16Z, 19Z-docosapentaenoic acid; all-cis-7,10,13,16,19-Docosapentaenoic acid; (all Z)-7,10,13,16,19-Docosapentaenoic acid; (all-Z)-7,10,13,16,19-Docosapentaenoic acid; (7Z,10Z,13Z,16Z,19Z)-Docosapentaenoic acid; Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic acid; 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acid; delta7,10,13,16,19-Docosapentaenoic acid; all-cis-7,10,13,16,19-Docosapentaenoate; (all Z)-7,10,13,16,19-Docosapentaenoate; cis-7,10,13,16,19-Docosapentaenoic acid; Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoate; Docosapentaenoic acid, (all Z)-isomer; docosa-7,10,13,16,19-pentaenoic acid; Δ7,10,13,16,19-Docosapentaenoic acid; 7Z,10Z,13Z,16Z,19Z-Docosapentaenoate; 7,10,13,16,19-docosapentaenoic acid; cis-7,10,13,16,19-Docosapentaenoate; Docosapentaenoic acid (22:5(n-3)); Docosapentaenoic acid (C22:5 N3); 7,10,13,16,19-Docosapentaenoate; Docosapentaenoic acid (22n-3); omega3-Docosapentaenoic acid; FA(22:5(7Z,10Z,13Z,16Z,19Z)); Docosapentaenoate (22N-3); ω3-Docosapentaenoic acid; docosapentaenoic acid; C22:5n-3,6,9,12,15; Docosapentaenoate; Clupanodonic acid; Clupanodonate; Osbonds acid; Osbond acid; FA(22:5n3); FA 22:5; DPAn-3; DPA; (7Z,10Z,13Z,16Z,19Z)-Docosapentaenoic acid



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

29 个相关的代谢反应过程信息。

Reactome(22)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, FABP4, FASN, PTGS2, SREBF1
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 7 ELOVL2, ELOVL5, FADS1, FADS2, PTGS2, SCD, SREBF1
Nucleus 4 ALB, FABP4, PPARA, SREBF1
cytosol 6 ALB, FABP4, FASN, IL1B, LEP, SREBF1
dendrite 2 ELOVL2, ELOVL5
centrosome 1 ALB
nucleoplasm 2 PPARA, SREBF1
Cell membrane 1 TNF
Multi-pass membrane protein 7 ELOVL2, ELOVL5, FADS1, FADS2, RHO, SCD, SREBF1
Golgi apparatus membrane 1 SREBF1
cell surface 2 ADIPOQ, TNF
Golgi apparatus 3 ALB, FASN, RHO
Golgi membrane 3 INS, RHO, SREBF1
neuronal cell body 3 ELOVL2, ELOVL5, TNF
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
plasma membrane 4 FADS2, FASN, RHO, TNF
Membrane 7 ELOVL2, ELOVL5, FADS1, FADS2, FASN, RHO, SCD
caveola 1 PTGS2
extracellular exosome 3 ALB, FABP4, FASN
endoplasmic reticulum 7 ADIPOQ, ALB, ELOVL2, ELOVL5, PTGS2, SCD, SREBF1
extracellular space 9 ADIPOQ, ALB, CRP, IL10, IL1B, IL6, INS, LEP, TNF
mitochondrion 1 FADS1
protein-containing complex 3 ALB, PTGS2, SREBF1
intracellular membrane-bounded organelle 1 FADS1
Microsome membrane 1 PTGS2
Secreted 8 ADIPOQ, ALB, CRP, IL10, IL1B, IL6, INS, LEP
extracellular region 9 ADIPOQ, ALB, CRP, IL10, IL1B, IL6, INS, LEP, TNF
anchoring junction 1 ALB
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 1 RHO
external side of plasma membrane 1 TNF
nucleolus 1 SCD
cell-cell junction 1 RHO
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
collagen trimer 1 ADIPOQ
collagen-containing extracellular matrix 1 ADIPOQ
secretory granule 1 IL1B
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 2 PPARA, SREBF1
phagocytic cup 1 TNF
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 RHO
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 RHO
nuclear envelope 1 SREBF1
endosome lumen 1 INS
Lipid droplet 1 FABP4
[Isoform 1]: Endoplasmic reticulum membrane 1 FADS1
Cytoplasmic vesicle membrane 1 SREBF1
Cell projection, dendrite 2 ELOVL2, ELOVL5
Melanosome 1 FASN
Golgi-associated vesicle membrane 1 RHO
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, PTGS2
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 INS
Secreted, extracellular exosome 1 IL1B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ER to Golgi transport vesicle membrane 1 SREBF1
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
[Isoform 2]: Endoplasmic reticulum membrane 1 FADS1
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
photoreceptor disc membrane 1 RHO
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
rod photoreceptor outer segment 1 RHO
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
dendritic tree 2 ELOVL2, ELOVL5
glycogen granule 1 FASN
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Satoshi Hirako, Takahiro Hirabayashi, Junko Shibato, Ai Kimura, Michio Yamashita, Yuzuru Iizuka, Nobuhiro Wada, Naoko Kaibara, Fumiko Takenoya, Seiji Shioda. Docosapentaenoic acid-rich oil lowers plasma glucose and lipids in a mouse model of diabetes and mild obesity. Nutrition research (New York, N.Y.). 2023 Aug; 118(?):128-136. doi: 10.1016/j.nutres.2023.08.004. [PMID: 37660501]
  • Kenta Furutani, Ouyang Chen, Aidan McGinnis, Yuqing Wang, Charles N Serhan, Trond Vidar Hansen, Ru-Rong Ji. Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice. Pain. 2023 06; 164(6):1340-1354. doi: 10.1097/j.pain.0000000000002824. [PMID: 36378290]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Kevin C Maki, Harold E Bays, Christie M Ballantyne, James A Underberg, John J P Kastelein, Judith B Johnson, James J Ferguson. A Head-to-Head Comparison of a Free Fatty Acid Formulation of Omega-3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE-IT Study. Journal of the American Heart Association. 2022 03; 11(6):e024176. doi: 10.1161/jaha.121.024176. [PMID: 35232215]
  • Chang-Yu Wu, Tomoyo Okuda, Akinori Ando, Ayami Hatano, Hiroshi Kikukawa, Jun Ogawa. Isolation and characterization of the ω3-docosapentaenoic acid-producing microorganism Aurantiochytrium sp. T7. Journal of bioscience and bioengineering. 2022 Mar; 133(3):229-234. doi: 10.1016/j.jbiosc.2021.10.011. [PMID: 34893429]
  • Lifang Wang, Hack Sun Choi, Yan Su, Jung-Hyun Ju, Sun-Yeon Heo, Jong-Jae Yi, Back-Rock Oh, Yong-Suk Jang, Jeong-Woo Seo. The docosahexaenoic acid derivatives, diHEP-DPA and TH-DPA, synthesized via recombinant lipoxygenase, ameliorate disturbances in lipid metabolism and liver inflammation in high fat diet-fed mice. Life sciences. 2022 Feb; 291(?):120219. doi: 10.1016/j.lfs.2021.120219. [PMID: 35041834]
  • Srinivas Belide, Pushkar Shrestha, Yoko Kennedy, Antonio Leonforte, Malcolm D Devine, James R Petrie, Surinder P Singh, Xue-Rong Zhou. Engineering docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) in Brassica juncea. Plant biotechnology journal. 2022 01; 20(1):19-21. doi: 10.1111/pbi.13739. [PMID: 34694688]
  • Alicia Leikin-Frenkel, Aya Mohr-Sasson, Matan Anteby, Michal Kandel-Kfir, Ayelet Harari, Roni Rahav, Yehuda Kamari, Aviv Shaish, Dror Harats, Hofit Cohen, Israel Hendler. Blood fatty acid analysis reveals similar n-3 fatty acid composition in non-pregnant and pregnant women and their neonates in an Israeli pilot study. Prostaglandins, leukotrienes, and essential fatty acids. 2021 10; 173(?):102339. doi: 10.1016/j.plefa.2021.102339. [PMID: 34487973]
  • Jeffery L Heileson, Anthony J Anzalone, Aaron F Carbuhn, Andrew T Askow, Jason D Stone, Stephanie M Turner, Lyn M Hillyer, David W L Ma, Joel A Luedke, Andrew R Jagim, Jonathan M Oliver. The effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: a multi-site, non-randomized study. Journal of the International Society of Sports Nutrition. 2021 Sep; 18(1):65. doi: 10.1186/s12970-021-00461-1. [PMID: 34579748]
  • Devaraj Parasannanavar, Indraja Gaddam, Tulja Bukya, Ahamed Ibrahim S, Suryam Reddy K, Santosh Kumar Banjara, Blessy P Priyanka Salvadi, Naveen Kumar B, Sylvia Fernandez Rao, J J Babu Geddam, Hemalatha Rajkumar. Omega-3 polyunsaturated fatty acid intake and plasma fatty acids of school going Indian children - a cross-sectional study. Prostaglandins, leukotrienes, and essential fatty acids. 2021 07; 170(?):102294. doi: 10.1016/j.plefa.2021.102294. [PMID: 34052598]
  • Samaneh Ghasemi Fard, David Cameron-Smith, Andrew J Sinclair. n - 3 Docosapentaenoic acid: the iceberg n - 3 fatty acid. Current opinion in clinical nutrition and metabolic care. 2021 03; 24(2):134-138. doi: 10.1097/mco.0000000000000722. [PMID: 33315722]
  • Michael A Crawford, Walter F Schmidt, C Leigh Broadhurst, Yiqun Wang. Lipids in the origin of intracellular detail and speciation in the Cambrian epoch and the significance of the last double bond of docosahexaenoic acid in cell signaling. Prostaglandins, leukotrienes, and essential fatty acids. 2021 03; 166(?):102230. doi: 10.1016/j.plefa.2020.102230. [PMID: 33588307]
  • Kei Hamazaki, Yutaka J Matsuoka, Taiki Yamaji, Norie Sawada, Masaru Mimura, Shoko Nozaki, Ryo Shikimoto, Shoichiro Tsugane. Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study. Scientific reports. 2021 02; 11(1):4003. doi: 10.1038/s41598-021-83478-5. [PMID: 33597590]
  • Chen Zhang, Miao-Miao Zhou, Tian-Tian Zhang, Pei-Xu Cong, Jie Xu, Chang-Hu Xue, Teruyoshi Yanagita, Zi-Hao Wei, Yu-Ming Wang. Effects of Dietary Supplementation with EPA-enriched Phosphatidylcholine and Phosphatidylethanolamine on Glycerophospholipid Profile in Cerebral Cortex of SAMP8 Mice fed with High-fat Diet. Journal of oleo science. 2021 Feb; 70(2):275-287. doi: 10.5650/jos.ess20212. [PMID: 33456004]
  • Yongliang Fan, Abdelaziz Adam Idriss Arbab, Huimin Zhang, Yi Yang, Xubin Lu, Ziyin Han, Zhangping Yang. MicroRNA-193a-5p Regulates the Synthesis of Polyunsaturated Fatty Acids by Targeting Fatty Acid Desaturase 1 (FADS1) in Bovine Mammary Epithelial Cells. Biomolecules. 2021 01; 11(2):. doi: 10.3390/biom11020157. [PMID: 33504005]
  • Xingjun Meng, Bo Zhu, Yan Liu, Lei Fang, Binbin Yin, Yanni Sun, Mengni Ma, Yuli Huang, Yuning Zhu, Yunlong Zhang. Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling. Journal of diabetes research. 2021; 2021(?):6689414. doi: 10.1155/2021/6689414. [PMID: 34212051]
  • Juan Lei, Yu Zhou, Huakan Zhao, Yu Chen, Guifang Yan, Lei Wu, Yanquan Xu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Dingshan Li, Yongsheng Li. Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production. Theranostics. 2021; 11(9):4251-4261. doi: 10.7150/thno.50182. [PMID: 33754059]
  • Anandita Pal, Adam H Metherel, Lauren Fiabane, Nicole Buddenbaum, Richard P Bazinet, Saame Raza Shaikh. Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?. Nutrients. 2020 Dec; 12(12):. doi: 10.3390/nu12123718. [PMID: 33276463]
  • Siting Li, Zhangli Hu, Xuewei Yang, Yan Li. Effect of Nitrogen Sources on Omega-3 Polyunsaturated Fatty Acid Biosynthesis and Gene Expression in Thraustochytriidae sp. Marine drugs. 2020 Dec; 18(12):. doi: 10.3390/md18120612. [PMID: 33271856]
  • Kerry Flannagan, Sheila Gahagan, Arun Das, Raquel Burrows, Betsy Lozoff, Eduardo Villamor. Serum polyunsaturated fatty acids in infancy are associated with body composition in adolescence. Pediatric obesity. 2020 11; 15(11):e12656. doi: 10.1111/ijpo.12656. [PMID: 32426929]
  • Esteban A Gomez, Romain A Colas, Patricia R Souza, Rebecca Hands, Myles J Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli. Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis. Nature communications. 2020 10; 11(1):5420. doi: 10.1038/s41467-020-19176-z. [PMID: 33110080]
  • Sebastian Dams, Sandra Holasek, Melina Tsiountsioura, Martin Edelsbrunner, Pavel Dietz, Harald Koefeler, Daniela-Eugenia Malliga, Ayse Gürbüz, Nathalie Meier-Allard, Brigitte Poncza, Sonja Lackner, Elke Schwarzenberger, Yvonne Jansenberger, Manfred Lamprecht. Effects of a plant-based fatty acid supplement and a powdered fruit, vegetable and berry juice concentrate on omega-3-indices and serum micronutrient concentrations in healthy subjects. International journal of food sciences and nutrition. 2020 Sep; 71(6):769-780. doi: 10.1080/09637486.2020.1725960. [PMID: 32064970]
  • Melinda S Schaller, Mian Chen, Romain A Colas, Thomas A Sorrentino, Ann A Lazar, S Marlene Grenon, Jesmond Dalli, Michael S Conte. Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease. Journal of the American Heart Association. 2020 08; 9(15):e016113. doi: 10.1161/jaha.120.016113. [PMID: 32696697]
  • So-Ichiro Hirata, Takahiro Nagatake, Kento Sawane, Koji Hosomi, Tetsuya Honda, Sachiko Ono, Noriko Shibuya, Emiko Saito, Jun Adachi, Yuichi Abe, Junko Isoyama, Hidehiko Suzuki, Ayu Matsunaga, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Makoto Arita, Jun Kunisawa. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020 08; 75(8):1939-1955. doi: 10.1111/all.14217. [PMID: 32027039]
  • Xiao-Fei Guo, Wen-Feng Tong, Yue Ruan, Andrew J Sinclair, Duo Li. Different metabolism of EPA, DPA and DHA in humans: A double-blind cross-over study. Prostaglandins, leukotrienes, and essential fatty acids. 2020 07; 158(?):102033. doi: 10.1016/j.plefa.2019.102033. [PMID: 31740197]
  • Maria K Pangopoulos, Jens M N Nolsøe, Simen G Antonsen, Romain A Colas, Jesmond Dalli, Marius Aursnes, Yngve Stenstrøm, Trond Vidar Hansen. Enzymatic studies with 3-oxa n-3 DPA. Bioorganic chemistry. 2020 03; 96(?):103653. doi: 10.1016/j.bioorg.2020.103653. [PMID: 32062066]
  • Ge Liu, Robert A Gibson, Damien Callahan, Xiao-Fei Guo, Duo Li, Andrew J Sinclair. Pure omega 3 polyunsaturated fatty acids (EPA, DPA or DHA) are associated with increased plasma levels of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in a short-term study in women. Food & function. 2020 Mar; 11(3):2058-2066. doi: 10.1039/c9fo02440a. [PMID: 32142084]
  • Xingyu Zhu, Shuangfei Li, Liangxu Liu, Siting Li, Yanqing Luo, Chuhan Lv, Boyu Wang, Christopher H K Cheng, Huapu Chen, Xuewei Yang. Genome Sequencing and Analysis of Thraustochytriidae sp. SZU445 Provides Novel Insights into the Polyunsaturated Fatty Acid Biosynthesis Pathway. Marine drugs. 2020 Feb; 18(2):. doi: 10.3390/md18020118. [PMID: 32085426]
  • Lauren A Roach, Kenneth G Russell, Kelly Lambert, Jane L Holt, Barbara J Meyer. Polyunsaturated fatty acid food frequency questionnaire validation in people with end stage renal disease on dialysis. Nutrition & dietetics: the journal of the Dietitians Association of Australia. 2020 02; 77(1):131-138. doi: 10.1111/1747-0080.12483. [PMID: 30338904]
  • Pablo Perez-Martinez, Niki Katsiki, Dimitri P Mikhailidis. The Role of n-3 Fatty Acids in Cardiovascular Disease: Back to the Future. Angiology. 2020 01; 71(1):10-16. doi: 10.1177/0003319719842005. [PMID: 30966756]
  • Qiu-Lan Ma, Cansheng Zhu, Marco Morselli, Trent Su, Matteo Pelligrini, Zhengqi Lu, Mychica Jones, Paul Denver, Daniel Castro, Xuelin Gu, Frances Relampagos, Kaitlin Caoili, Bruce Teter, Sally A Frautschy, Gregory M Cole. The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models. Frontiers in immunology. 2020; 11(?):558036. doi: 10.3389/fimmu.2020.558036. [PMID: 33178186]
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