DAMGO (BioDeep_00000003437)

   


代谢物信息卡片


(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin

化学式: C26H35N5O6 (513.2587)
中文名称: DAMGO
谱图信息: 最多检出来源 Homo sapiens(not specific) 33.33%

分子结构信息

SMILES: CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
KEIO_ID A226; [MS2] KO008836
KEIO_ID A226; [MS3] KO008837
KEIO_ID A226
DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].

同义名列表

5 个代谢物同义名

(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; Tyr-D-Ala-Gly-MePhe-Gly-ol; DAMGO; SCHEMBL19987691; DAMGO



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CCL5, CNR1, CXCR4, POMC, PRKX
Nucleus 2 FOS, PRKX
cytosol 2 FOS, PRKCQ
dendrite 5 DRD2, HTR1A, OPRM1, PDYN, PNOC
nucleoplasm 2 FOS, PRKX
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 8 CNR1, CXCR4, DRD2, GPRC5A, HTR1A, OPRD1, OPRL1, OPRM1
Cell projection, axon 2 CNR1, OPRM1
Multi-pass membrane protein 8 CNR1, CXCR4, DRD2, GPRC5A, HTR1A, OPRD1, OPRL1, OPRM1
Golgi apparatus membrane 1 DRD2
Synapse 6 DRD2, HTR1A, OPRM1, PDYN, PNOC, TAC1
cell junction 1 CXCR4
cell surface 1 CXCR4
glutamatergic synapse 2 CNR1, DRD2
Golgi apparatus 3 KCNJ6, NPY, OPRM1
Golgi membrane 2 DRD2, INS
growth cone 1 CNR1
neuronal cell body 3 PDYN, PNOC, TAC1
presynaptic membrane 3 CNR1, DRD2, OPRD1
Lysosome 1 CXCR4
Presynapse 1 CNR1
acrosomal vesicle 1 DRD2
endosome 1 OPRM1
plasma membrane 13 CNR1, CXCR4, DRD2, GPRC5A, HTR1A, KCNJ6, KNG1, OPRD1, OPRL1, OPRM1, PDYN, PNOC, PRKCQ
synaptic vesicle membrane 2 DRD2, OPRD1
Membrane 3 CXCR4, OPRD1, OPRM1
axon 4 CNR1, DRD2, OPRM1, TAC1
extracellular exosome 3 CXCR4, GPRC5A, KNG1
endoplasmic reticulum 2 FOS, OPRM1
extracellular space 6 CCL5, INS, KNG1, NPY, POMC, TAC1
protein-containing complex 1 CXCR4
intracellular membrane-bounded organelle 1 GPRC5A
Secreted 6 CCL5, INS, NPY, PDYN, PNOC, POMC
extracellular region 8 CCL5, INS, KNG1, NPY, PDYN, PNOC, POMC, TAC1
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
hippocampal mossy fiber to CA3 synapse 1 PDYN
anchoring junction 1 CXCR4
centriolar satellite 1 PRKCQ
ciliary membrane 1 DRD2
external side of plasma membrane 1 CXCR4
actin cytoskeleton 1 CNR1
dendritic spine 1 DRD2
perikaryon 2 DRD2, OPRM1
cytoplasmic vesicle 2 CXCR4, OPRL1
nucleolus 1 GPRC5A
Early endosome 1 CXCR4
vesicle 1 GPRC5A
postsynaptic membrane 1 DRD2
Membrane raft 1 CNR1
GABA-ergic synapse 3 CNR1, DRD2, NPY
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 POMC
lateral plasma membrane 1 DRD2
Late endosome 1 CXCR4
receptor complex 1 GPRC5A
neuron projection 3 OPRD1, OPRL1, OPRM1
cilium 1 DRD2
chromatin 1 FOS
cell leading edge 1 CXCR4
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 2 HTR1A, OPRM1
synaptic membrane 1 PNOC
voltage-gated potassium channel complex 1 KCNJ6
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
nuclear matrix 1 FOS
platelet alpha granule lumen 1 KNG1
axon terminus 4 DRD2, OPRD1, PDYN, PNOC
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 3 NPY, OPRD1, PDYN
aggresome 1 PRKCQ
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
dendrite membrane 1 OPRD1
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
G protein-coupled receptor complex 1 DRD2
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1


文献列表

  • Marthe M Vandeputte, Nick Verougstraete, Donna Walther, Grant C Glatfelter, Jeroen Malfliet, Michael H Baumann, Alain G Verstraete, Christophe P Stove. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass. Archives of toxicology. 2022 06; 96(6):1865-1880. doi: 10.1007/s00204-022-03294-2. [PMID: 35449307]
  • Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of medicinal chemistry. 2021 09; 64(18):13873-13892. doi: 10.1021/acs.jmedchem.1c01273. [PMID: 34505767]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nelson Jeng-Yeou Chear, Francisco León, Abhisheak Sharma, Siva Rama Raju Kanumuri, Grant Zwolinski, Khalil A Abboud, Darshan Singh, Luis F Restrepo, Avi Patel, Takato Hiranita, Surash Ramanathan, Aidan J Hampson, Lance R McMahon, Christopher R McCurdy. Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. Journal of natural products. 2021 04; 84(4):1034-1043. doi: 10.1021/acs.jnatprod.0c01055. [PMID: 33635670]
  • Qi-Jie Zhang, Jiao-Chen Luan, Ya-Min Wang, Ning-Hong Song, Jia-Dong Xia. [Mu-opioid receptors in the paraventricular nucleus regulate ejaculatory behaviors via the sympathetic nerve system in male rats]. Zhonghua nan ke xue = National journal of andrology. 2020 Nov; 26(10):867-874. doi: NULL. [PMID: 33382216]
  • Caifeng Shao, Pei Chen, Qian Chen, Mingwei Zhao, Wei-Ning Zhang, Kun Yang. Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells. Biochemical and biophysical research communications. 2020 02; 522(4):1059-1062. doi: 10.1016/j.bbrc.2019.12.013. [PMID: 31818459]
  • Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry. 2020 01; 63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. [PMID: 31834797]
  • Maria A Gandini, Ivana A Souza, Dvij Raval, Jin Xu, Ying-Xian Pan, Gerald W Zamponi. Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors. Molecular brain. 2019 11; 12(1):98. doi: 10.1186/s13041-019-0524-6. [PMID: 31775826]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Srgjan Civciristov, Cheng Huang, Bonan Liu, Elsa A Marquez, Arisbel B Gondin, Ralf B Schittenhelm, Andrew M Ellisdon, Meritxell Canals, Michelle L Halls. Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. The Journal of biological chemistry. 2019 11; 294(44):16198-16213. doi: 10.1074/jbc.ra119.008685. [PMID: 31515267]
  • Marissa J Metz, Reagan L Pennock, Diego Krapf, Shane T Hentges. Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking. Scientific reports. 2019 05; 9(1):7297. doi: 10.1038/s41598-019-43657-x. [PMID: 31086197]
  • Wen-Ling Dai, Xin-Tong Liu, Yi-Ni Bao, Bing Yan, Nan Jiang, Bo-Yang Yu, Ji-Hua Liu. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Experimental & molecular medicine. 2018 11; 50(11):1-12. doi: 10.1038/s12276-018-0175-1. [PMID: 30429454]
  • Miriam Stoeber, Damien Jullié, Braden T Lobingier, Toon Laeremans, Jan Steyaert, Peter W Schiller, Aashish Manglik, Mark von Zastrow. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06; 98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. [PMID: 29754753]
  • Shaaban A Mousa, Mohammed Shaqura, Mohammed Al-Madol, Sascha Tafelski, Baled I Khalefa, Mehdi Shakibaei, Michael Schäfer. Accessibility of axonal G protein coupled mu-opioid receptors requires conceptual changes of axonal membrane targeting for pain modulation. Journal of controlled release : official journal of the Controlled Release Society. 2017 Dec; 268(?):352-363. doi: 10.1016/j.jconrel.2017.10.016. [PMID: 29054370]
  • Selena S Schattauer, Benjamin B Land, Kathryn L Reichard, Antony D Abraham, Lauren M Burgeno, Jamie R Kuhar, Paul E M Phillips, Shao En Ong, Charles Chavkin. Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nature communications. 2017 09; 8(1):743. doi: 10.1038/s41467-017-00791-2. [PMID: 28963507]
  • A V Solin, A Yu Lyashev, Yu D Lyashev. Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress. Bulletin of experimental biology and medicine. 2017 Jan; 162(3):313-315. doi: 10.1007/s10517-017-3603-7. [PMID: 28091903]
  • Barbora Melkes, Lucie Hejnova, Jiri Novotny. Biased μ-opioid receptor agonists diversely regulate lateral mobility and functional coupling of the receptor to its cognate G proteins. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Dec; 389(12):1289-1300. doi: 10.1007/s00210-016-1293-8. [PMID: 27600870]
  • Ki Seok Lee, Youping Zhang, Jamila Asgar, Q-Schick Auh, Man-Kyo Chung, Jin Y Ro. Androgen receptor transcriptionally regulates μ-opioid receptor expression in rat trigeminal ganglia. Neuroscience. 2016 09; 331(?):52-61. doi: 10.1016/j.neuroscience.2016.06.023. [PMID: 27320211]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES DSLET AND DAGO ON LIPID PEROXIDATION AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN THE LIVER TISSUE OF RATS IN THE STRESS OF DIFFERENT DURATION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2016 Sep; 102(9):1066-73. doi: ". [PMID: 30193423]
  • Andrew C Kruegel, Madalee M Gassaway, Abhijeet Kapoor, András Váradi, Susruta Majumdar, Marta Filizola, Jonathan A Javitch, Dalibor Sames. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. Journal of the American Chemical Society. 2016 06; 138(21):6754-64. doi: 10.1021/jacs.6b00360. [PMID: 27192616]
  • Michelle L Halls, Holly R Yeatman, Cameron J Nowell, Georgina L Thompson, Arisbel Batista Gondin, Srgjan Civciristov, Nigel W Bunnett, Nevin A Lambert, Daniel P Poole, Meritxell Canals. Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling. Science signaling. 2016 Feb; 9(414):ra16. doi: 10.1126/scisignal.aac9177. [PMID: 26861044]
  • Dominika Labuz, Viola Spahn, Melih Özgür Celik, Halina Machelska. Opioids and TRPV1 in the peripheral control of neuropathic pain--Defining a target site in the injured nerve. Neuropharmacology. 2016 Feb; 101(?):330-40. doi: 10.1016/j.neuropharm.2015.10.003. [PMID: 26453963]
  • Géza Berecki, Leonid Motin, David J Adams. Voltage-Gated R-Type Calcium Channel Inhibition via Human μ-, δ-, and κ-opioid Receptors Is Voltage-Independently Mediated by Gβγ Protein Subunits. Molecular pharmacology. 2016 Jan; 89(1):187-96. doi: 10.1124/mol.115.101154. [PMID: 26490245]
  • Egle M Mambretti, Katrin Kistner, Stefanie Mayer, Dominique Massotte, Brigitte L Kieffer, Carsten Hoffmann, Peter W Reeh, Alexander Brack, Esther Asan, Heike L Rittner. Functional and structural characterization of axonal opioid receptors as targets for analgesia. Molecular pain. 2016; 12(?):. doi: 10.1177/1744806916628734. [PMID: 27030709]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES ON LIPID PEROXIDATION AND ANTIOXIDANT ENZYME ACTIVITY IN RATS AFTER SWIMMING STRESS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2015 Aug; 101(8):929-35. doi: NULL. [PMID: 26591588]
  • Víctor M Campa, Almudena Capilla, María J Varela, Arlet M Acanda de la Rocha, Juan C Fernandez-Troyano, R Belén Barreiro, Juan F Lopez-Gimenez. Endocytosis as a biological response in receptor pharmacology: evaluation by fluorescence microscopy. PloS one. 2015; 10(4):e0122604. doi: 10.1371/journal.pone.0122604. [PMID: 25849355]
  • Kévin Carayon, Lionel Moulédous, Anne Combedazou, Serge Mazères, Evert Haanappel, Laurence Salomé, Catherine Mollereau. Heterologous regulation of Mu-opioid (MOP) receptor mobility in the membrane of SH-SY5Y cells. The Journal of biological chemistry. 2014 Oct; 289(41):28697-706. doi: 10.1074/jbc.m114.588558. [PMID: 25183007]
  • Prabhakar R Polepally, Krzysztof Huben, Eyal Vardy, Vincent Setola, Philip D Mosier, Bryan L Roth, Jordan K Zjawiony. Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. European journal of medicinal chemistry. 2014 Oct; 85(?):818-29. doi: 10.1016/j.ejmech.2014.07.077. [PMID: 25193297]
  • Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Díaz. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. 2014 Jun; 232(6):1793-803. doi: 10.1007/s00221-014-3871-7. [PMID: 24584836]
  • Kellie M Jaremko, Nicholas L Thompson, Beverly A S Reyes, Jay Jin, Brittany Ebersole, Christopher B Jenney, Patricia S Grigson, Robert Levenson, Wade H Berrettini, Elisabeth J Van Bockstaele. Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Progress in neuro-psychopharmacology & biological psychiatry. 2014 Apr; 50(?):53-65. doi: 10.1016/j.pnpbp.2013.12.003. [PMID: 24333843]
  • Anne-Christin Stolt, Helmut Schröder, Hartmud Neurath, Gisela Grecksch, Volker Höllt, Markus R Meyer, Hans H Maurer, Nancy Ziebolz, Ursula Havemann-Reinecke, Axel Becker. Behavioral and neurochemical characterization of kratom (Mitragyna speciosa) extract. Psychopharmacology. 2014 Jan; 231(1):13-25. doi: 10.1007/s00213-013-3201-y. [PMID: 23846544]
  • Javier Llorente, Sarah Withey, Guadalupe Rivero, Margaret Cunningham, Alex Cooke, Kunal Saxena, Jamie McPherson, Sue Oldfield, William L Dewey, Chris P Bailey, Eamonn Kelly, Graeme Henderson. Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons. Molecular pharmacology. 2013 Aug; 84(2):252-60. doi: 10.1124/mol.113.085936. [PMID: 23716621]
  • Prabhakar R Polepally, Kate White, Eyal Vardy, Bryan L Roth, Daneel Ferreira, Jordan K Zjawiony. Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. Bioorganic & medicinal chemistry letters. 2013 May; 23(10):2860-2. doi: 10.1016/j.bmcl.2013.03.111. [PMID: 23587424]
  • Annika Lindqvist, Jaap Rip, Pieter J Gaillard, Sven Björkman, Margareta Hammarlund-Udenaes. Enhanced brain delivery of the opioid peptide DAMGO in glutathione pegylated liposomes: a microdialysis study. Molecular pharmaceutics. 2013 May; 10(5):1533-41. doi: 10.1021/mp300272a. [PMID: 22934681]
  • Philip A Barish, Ying Xu, Jianxin Li, Jiao Sun, Yagna P R Jarajapu, William O Ogle. Design and functional evaluation of an optically active μ-opioid receptor. European journal of pharmacology. 2013 Apr; 705(1-3):42-8. doi: 10.1016/j.ejphar.2013.01.065. [PMID: 23454521]
  • Viola Spahn, Oliver Fischer, Jeannette Endres-Becker, Michael Schäfer, Christoph Stein, Christian Zöllner. Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain. 2013 Apr; 154(4):598-608. doi: 10.1016/j.pain.2012.12.026. [PMID: 23398938]
  • Sonja Andersen, Cecilie Baar, Torill Fladvad, Eivor Alette Laugsand, Frank Skorpen. The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 gene. PloS one. 2013; 8(8):e71024. doi: 10.1371/journal.pone.0071024. [PMID: 23951073]
  • Christian Doll, Florian Pöll, Kenneth Peuker, Anastasia Loktev, Laura Glück, Stefan Schulz. Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. British journal of pharmacology. 2012 Nov; 167(6):1259-70. doi: 10.1111/j.1476-5381.2012.02080.x. [PMID: 22725608]
  • A V Solin, Yu D Lyashev. Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress. Bulletin of experimental biology and medicine. 2012 Oct; 153(6):827-9. doi: 10.1007/s10517-012-1836-z. [PMID: 23113295]
  • Annika Lindqvist, Britt Jansson, Margareta Hammarlund-Udenaes. Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jul; 900(?):11-7. doi: 10.1016/j.jchromb.2012.05.014. [PMID: 22672845]
  • Swetha S Murali, Ian A Napier, Beth K Rycroft, MacDonald J Christie. Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. The Journal of physiology. 2012 Apr; 590(7):1655-67. doi: 10.1113/jphysiol.2012.228429. [PMID: 22371475]
  • Swantje C Duncker, David Philippe, Christine Martin-Paschoud, Mireille Moser, Annick Mercenier, Sophie Nutten. Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors. PloS one. 2012; 7(6):e39841. doi: 10.1371/journal.pone.0039841. [PMID: 22768141]
  • B A S Reyes, K Vakharia, T N Ferraro, R Levenson, W H Berrettini, E J Van Bockstaele. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Experimental neurology. 2012 Jan; 233(1):205-13. doi: 10.1016/j.expneurol.2011.09.037. [PMID: 22001156]
  • Cynthia Wei-Sheng Lee, Jia-Ying Yan, Yao-Chang Chiang, Tsai-Wei Hung, Hung-Li Wang, Lih-Chu Chiou, Ing-Kang Ho. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. Neurochemical research. 2011 Nov; 36(11):2008-21. doi: 10.1007/s11064-011-0525-z. [PMID: 21671107]
  • Esther Krook-Magnuson, Lillian Luu, Sang-Hun Lee, Csaba Varga, Ivan Soltesz. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Oct; 31(42):14861-70. doi: 10.1523/jneurosci.2269-11.2011. [PMID: 22016519]
  • Christian Doll, Jens Konietzko, Florian Pöll, Thomas Koch, Volker Höllt, Stefan Schulz. Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. British journal of pharmacology. 2011 Sep; 164(2):298-307. doi: 10.1111/j.1476-5381.2011.01382.x. [PMID: 21449911]
  • Sylvia Van Dorpe, Antita Adriaens, Simon Vermeire, Ingeborgh Polis, Kathelijne Peremans, Bart De Spiegeleer. Desirability function combining metabolic stability and functionality of peptides. Journal of peptide science : an official publication of the European Peptide Society. 2011 May; 17(5):398-404. doi: 10.1002/psc.1323. [PMID: 21294224]
  • Takashi Yamamoto, Padma Nair, Tally M Largent-Milnes, Neil E Jacobsen, Peg Davis, Shou-Wu Ma, Henry I Yamamura, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of medicinal chemistry. 2011 Apr; 54(7):2029-38. doi: 10.1021/jm101023r. [PMID: 21366266]
  • Erica S Levitt, Lauren C Purington, John R Traynor. Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot. Molecular pharmacology. 2011 Mar; 79(3):461-71. doi: 10.1124/mol.110.064816. [PMID: 21098043]
  • Simona Patierno, Laura Anselmi, Ingrid Jaramillo, David Scott, Rachel Garcia, Catia Sternini. Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology. 2011 Feb; 140(2):618-26. doi: 10.1053/j.gastro.2010.11.005. [PMID: 21070774]
  • Joel S Goldberg. Low Molecular Weight Opioid Peptide Esters Could be Developed as a New Class of Analgesics. Perspectives in medicinal chemistry. 2011; 5(?):19-26. doi: 10.4137/pmc.s6803. [PMID: 21863129]
  • Yu-Jin Won, Fumihito Ono, Stephen R Ikeda. Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. Journal of neurophysiology. 2011 Jan; 105(1):442-53. doi: 10.1152/jn.00625.2010. [PMID: 20962070]
  • Jean-Philippe Fortin, Lei Ci, Jonathan Schroeder, Carmit Goldstein, Maria Claudia Montefusco, Inga Peter, Steven E Reis, Gordon S Huggins, Martin Beinborn, Alan S Kopin. The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. Molecular pharmacology. 2010 Nov; 78(5):837-45. doi: 10.1124/mol.110.064188. [PMID: 20702761]
  • Michael J Wood, Neil H Hyman, Gary M Mawe. The effects of daikenchuto (DKT) on propulsive motility in the colon. The Journal of surgical research. 2010 Nov; 164(1):84-90. doi: 10.1016/j.jss.2009.03.068. [PMID: 19631346]
  • Sonia I Ortiz-Miranda, Govindan Dayanithi, Cristina Velázquez-Marrero, Edward E Custer, Steven N Treistman, José R Lemos. Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals. Journal of cellular physiology. 2010 Oct; 225(1):276-88. doi: 10.1002/jcp.22263. [PMID: 20509142]
  • Ellen E Codd, Jianya Ma, Sui-Po Zhang, Dennis J Stone, Raymond W Colburn, Michael R Brandt, Kristen M Chevalier, Yongxin Zhu, Sean Peng, Chaozhong Cai, Paul D Acton, Christopher M Flores. Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range. Pharmacology, biochemistry, and behavior. 2010 Aug; 96(2):130-5. doi: 10.1016/j.pbb.2010.04.020. [PMID: 20438745]
  • Lenka Bourova, Miroslava Vosahlikova, Dmytro Kagan, Katerina Dlouha, Jiri Novotny, Petr Svoboda. Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits. Medical science monitor : international medical journal of experimental and clinical research. 2010 Aug; 16(8):BR260-70. doi: . [PMID: 20671607]
  • Sylvia Van Dorpe, Antita Adriaens, Ingeborgh Polis, Kathelijne Peremans, Jan Van Bocxlaer, Bart De Spiegeleer. Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides. Peptides. 2010 Jul; 31(7):1390-9. doi: 10.1016/j.peptides.2010.03.029. [PMID: 20347901]
  • Delphine J Debruyne, Marc M Mareel, Marc E Bracke. Opioids affect focal contact-mediated cell-substrate adhesion. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2010 May; 19(3):227-38. doi: 10.1097/cej.0b013e328338770c. [PMID: 20361424]
  • Felix J Kim, Ivanka Kovalyshyn, Maxim Burgman, Claire Neilan, Chih-Cheng Chien, Gavril W Pasternak. Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding. Molecular pharmacology. 2010 Apr; 77(4):695-703. doi: 10.1124/mol.109.057083. [PMID: 20089882]
  • Cecilea C Clayton, Michael R Bruchas, Michael L Lee, Charles Chavkin. Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Molecular pharmacology. 2010 Mar; 77(3):339-47. doi: 10.1124/mol.109.060558. [PMID: 19959593]
  • Sanda Mustapic, Tomislav Radocaj, Antonio Sanchez, Zoran Dogas, Astrid G Stucke, Francis A Hopp, Eckehard A E Stuth, Edward J Zuperku. Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. Journal of neurophysiology. 2010 Jan; 103(1):409-18. doi: 10.1152/jn.00188.2009. [PMID: 19906886]
  • Ana Navarro, Alberto Boveris. Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease. Frontiers in aging neuroscience. 2010; 2(?):. doi: 10.3389/fnagi.2010.00034. [PMID: 20890446]
  • Takashi Yamamoto, Padma Nair, Shou-wu Ma, Peg Davis, Henry I Yamamura, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & medicinal chemistry. 2009 Oct; 17(20):7337-43. doi: 10.1016/j.bmc.2009.08.035. [PMID: 19762245]
  • Takashi Yamamoto, Padma Nair, Neil E Jacobsen, Josef Vagner, Vinod Kulkarni, Peg Davis, Shou-Wu Ma, Edita Navratilova, Henry I Yamamura, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of medicinal chemistry. 2009 Aug; 52(16):5164-75. doi: 10.1021/jm900473p. [PMID: 20560643]
  • Thomas Koch, Anja Seifert, Dai-Fei Wu, Marija Rankovic, Jürgen Kraus, Christine Börner, Lars-Ove Brandenburg, Helmut Schröder, Volker Höllt. mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2. Journal of neurochemistry. 2009 Aug; 110(4):1288-96. doi: 10.1111/j.1471-4159.2009.06217.x. [PMID: 19519662]
  • Qin Wang, Lee-Yuan Liu-Chen, John R Traynor. Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. The Journal of biological chemistry. 2009 Jul; 284(27):18357-67. doi: 10.1074/jbc.m109.015453. [PMID: 19416973]
  • Zdzislaw Salamon, John Fitch, Minying Cai, Suneeta Tumati, Edita Navratilova, Gordon Tollin. Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells. Analytical biochemistry. 2009 Apr; 387(1):95-101. doi: 10.1016/j.ab.2009.01.019. [PMID: 19454250]
  • H Schröder, D F Wu, A Seifert, M Rankovic, S Schulz, V Höllt, T Koch. Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor. Neuropharmacology. 2009 Mar; 56(4):768-78. doi: 10.1016/j.neuropharm.2008.12.010. [PMID: 19162047]
  • T A Roepke, J Qiu, M A Bosch, O K Rønnekleiv, M J Kelly. Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus. Journal of neuroendocrinology. 2009 Mar; 21(4):263-70. doi: 10.1111/j.1365-2826.2009.01846.x. [PMID: 19187465]
  • Michael M Morgan, Michelle D Ashley, Susan L Ingram, MacDonald J Christie. Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats. Neural plasticity. 2009; 2009(?):516328. doi: 10.1155/2009/516328. [PMID: 19266049]
  • E J Cobos, J M Entrena, F R Nieto, C M Cendán, E Del Pozo. Pharmacology and therapeutic potential of sigma(1) receptor ligands. Current neuropharmacology. 2008 Dec; 6(4):344-66. doi: 10.2174/157015908787386113. [PMID: 19587856]
  • Yulin Wang, Elisabeth J Van Bockstaele, Lee-Yuan Liu-Chen. In vivo trafficking of endogenous opioid receptors. Life sciences. 2008 Nov; 83(21-22):693-9. doi: 10.1016/j.lfs.2008.09.023. [PMID: 18930741]
  • Sara M Thomasy, Khursheed R Mama, Scott D Stanley. Comparison of liquid chromatography-mass spectrometry and radioimmunoassay for measurement of fentanyl and determination of pharmacokinetics in equine plasma. Journal of analytical toxicology. 2008 Nov; 32(9):754-9. doi: 10.1093/jat/32.9.754. [PMID: 19021930]
  • Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, Hui-Lin Pan. Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. The Journal of pharmacology and experimental therapeutics. 2008 Nov; 327(2):375-82. doi: 10.1124/jpet.108.141226. [PMID: 18669865]
  • Minoru Hojo, Yuka Sudo, Yuko Ando, Koichiro Minami, Masafumi Takada, Takehiro Matsubara, Masato Kanaide, Kohtaro Taniyama, Koji Sumikawa, Yasuhito Uezono. mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis. Journal of pharmacological sciences. 2008 Nov; 108(3):308-19. doi: 10.1254/jphs.08244fp. [PMID: 19008645]
  • Vladana Vukojević, Yu Ming, Claudio D'Addario, Mats Hansen, Ulo Langel, Rüdiger Schulz, Björn Johansson, Rudolf Rigler, Lars Terenius. Mu-opioid receptor activation in live cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Oct; 22(10):3537-48. doi: 10.1096/fj.08-108894. [PMID: 18587007]
  • Marc L Weber, Mariya Farooqui, Julia Nguyen, Michael Ansonoff, John E Pintar, Robert P Hebbel, Kalpna Gupta. Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors. American journal of physiology. Renal physiology. 2008 Jun; 294(6):F1388-97. doi: 10.1152/ajprenal.00389.2007. [PMID: 18385270]
  • Vladana Vukojević, Yu Ming, Claudio D'Addario, Rudolf Rigler, Björn Johansson, Lars Terenius. Ethanol/naltrexone interactions at the mu-opioid receptor. CLSM/FCS study in live cells. PloS one. 2008; 3(12):e4008. doi: 10.1371/journal.pone.0004008. [PMID: 19104662]
  • María Rodríguez-Muñoz, Elena de la Torre-Madrid, Gema Gaitán, Pilar Sánchez-Blázquez, Javier Garzón. RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. Cellular signalling. 2007 Dec; 19(12):2558-71. doi: 10.1016/j.cellsig.2007.08.003. [PMID: 17825524]
  • Ahmed Hasbi, Tuan Nguyen, Theresa Fan, Regina Cheng, Asim Rashid, Mohammad Alijaniaram, Mark M Rasenick, Brian F O'Dowd, Susan R George. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry. 2007 Nov; 46(45):12997-3009. doi: 10.1021/bi701436w. [PMID: 17941650]
  • Thomas Kroslak, K Steven Laforge, Robert J Gianotti, Ann Ho, David A Nielsen, Mary Jeanne Kreek. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. Journal of neurochemistry. 2007 Oct; 103(1):77-87. doi: 10.1111/j.1471-4159.2007.04738.x. [PMID: 17877633]
  • Raphael Rozenfeld, Lakshmi A Devi. Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007 Aug; 21(10):2455-65. doi: 10.1096/fj.06-7793com. [PMID: 17384143]
  • Supriya Srinivasan, Pamela Santiago, Cecile Lubrano, Christian Vaisse, Bruce R Conklin. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PloS one. 2007 Aug; 2(7):e668. doi: 10.1371/journal.pone.0000668. [PMID: 17668051]
  • Danxin Wang, Xiaochun Sun, Wolfgang Sadee. Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):544-52. doi: 10.1124/jpet.106.118810. [PMID: 17267582]
  • Ying-Jian Liang, Dai-Fei Wu, Li-Quan Yang, Volker Höllt, Thomas Koch. Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling. Molecular pharmacology. 2007 Jan; 71(1):123-31. doi: 10.1124/mol.106.026062. [PMID: 17005904]
  • Mee-Ra Rhyu, Jian Lu, Donna E Webster, Daniel S Fabricant, Norman R Farnsworth, Z Jim Wang. Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor. Journal of agricultural and food chemistry. 2006 Dec; 54(26):9852-7. doi: 10.1021/jf062808u. [PMID: 17177511]
  • Ying Wang, Wei-Yan Xie, Yi He, Min Wang, Yan-Rui Yang, Ying Zhang, Dong-Min Yin, Kelly L Jordan-Sciutto, Ji-Sheng Han, Yun Wang. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. Experimental neurology. 2006 Dec; 202(2):313-23. doi: 10.1016/j.expneurol.2006.06.005. [PMID: 16879821]
  • Mary J Clark, John R Traynor. Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3. Journal of neurochemistry. 2006 Dec; 99(6):1494-504. doi: 10.1111/j.1471-4159.2006.04176.x. [PMID: 17230639]
  • Laelie A Snook, Graeme Milligan, Brigitte L Kieffer, Dominique Massotte. Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions. The Journal of pharmacology and experimental therapeutics. 2006 Aug; 318(2):683-90. doi: 10.1124/jpet.106.101220. [PMID: 16690720]
  • Elizabeth A Johnson, Sue Oldfield, Ellen Braksator, Ana Gonzalez-Cuello, Daniel Couch, Kellie J Hall, Stuart J Mundell, Chris P Bailey, Eamonn Kelly, Graeme Henderson. Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells. Molecular pharmacology. 2006 Aug; 70(2):676-85. doi: 10.1124/mol.106.022376. [PMID: 16682505]
  • D E Webster, J Lu, S-N Chen, N R Farnsworth, Z Jim Wang. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. Journal of ethnopharmacology. 2006 Jun; 106(2):216-21. doi: 10.1016/j.jep.2005.12.025. [PMID: 16439081]
  • Kenjiro Matsumoto, Hiromitsu Takayama, Hayato Ishikawa, Norio Aimi, Dhavadee Ponglux, Kazuo Watanabe, Syunji Horie. Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum. Life sciences. 2006 Apr; 78(19):2265-71. doi: 10.1016/j.lfs.2005.09.030. [PMID: 16266723]
  • Thomas Koch, Dai-Fei Wu, Li-Quan Yang, Lars-Ove Brandenburg, Volker Höllt. Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors. Journal of neurochemistry. 2006 Apr; 97(2):365-72. doi: 10.1111/j.1471-4159.2006.03736.x. [PMID: 16539674]
  • Jörn Lötsch, Carsten Skarke, Johannes Wieting, Bruno Georg Oertel, Helmut Schmidt, Jürgen Brockmöller, Gerd Geisslinger. Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action. Clinical pharmacology and therapeutics. 2006 Jan; 79(1):72-89. doi: 10.1016/j.clpt.2005.09.010. [PMID: 16413243]
  • Gavin Bart, James H Schluger, Lisa Borg, Ann Ho, Jean M Bidlack, Mary Jeanne Kreek. Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 Dec; 30(12):2254-62. doi: 10.1038/sj.npp.1300811. [PMID: 15988468]
  • Lutea A A de Jong, Katharina Krämer, Marieke P H Kroeze, Rainer Bischoff, Donald R A Uges, Jan Piet Franke. Development and validation of a radioreceptor assay for the determination of morphine and its active metabolites in serum. Journal of pharmaceutical and biomedical analysis. 2005 Oct; 39(5):964-71. doi: 10.1016/j.jpba.2005.04.049. [PMID: 15985356]
  • Miaw-Chyi Luo, Dong-Qin Zhang, Shou-Wu Ma, Yuan-Yuan Huang, Sam J Shuster, Frank Porreca, Josephine Lai. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Molecular pain. 2005 Sep; 1(?):29. doi: 10.1186/1744-8069-1-29. [PMID: 16191203]
  • Eddy H T Wu, Yung H Wong. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells. Biochemical and biophysical research communications. 2005 Sep; 334(3):838-44. doi: 10.1016/j.bbrc.2005.06.184. [PMID: 16053916]