2-Oxoadipic acid (BioDeep_00000003399)
Secondary id: BioDeep_00000400102, BioDeep_00000419346
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
2-Oxohexanedionic acid
化学式: C6H8O5 (160.0372)
中文名称: 2-氧代己二酸, 2-Oxoadipic acid单钠盐
谱图信息:
最多检出来源 Homo sapiens(blood) 19.61%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
2-Oxoadipic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/2-oxoadipic_acid (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000003399). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(=O)(CCCC(=O)O)C(=O)O
InChI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)
描述信息
2-Oxoadipic acid is produced from lysine in the cytosol of cells via the saccharopine and the pipecolic acid pathways. Catabolites of hydroxylysine and tryptophan enter these pathways as 2-aminoadipic- -semialdehyde and 2-oxoadipate, respectively. In the matrix of mitochondria, 2-oxoadipate is decarboxylated to glutaryl-CoA by the 2-oxoadipate dehydrogenase complex and then converted to acetyl-CoA. 2-Oxoadipic aciduria is an in-born error of metabolism of lysine, tryptophan, and hydroxylysine, in which abnormal quantities of 2-aminoadipic acid are found in body fluids along with 2-oxoadipic acid. Patients with 2-Oxoadipic acidemias are mentally retarded with hypotonia or seizures. 2-Oxoadipic aciduria can occur in patients with Kearns-Sayre Syndrome, a progressive disorder with onset prior to 20 years of age in which multiple organ systems are affected, including progressive external ophthalmoplegia, retinopathy, and the age of onset, and these are associated classically with abnormalities in cardiac conduction, cerebellar signs, and elevated cerebrospinal fluid protein (PMID: 10655159, 16183823, 11083877). Oxoadipic acid is found to be associated with alpha-aminoadipic aciduria, which is an inborn error of metabolism.
Present in pea seedlings
KEIO_ID K009
Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
同义名列表
24 个代谢物同义名
2-Oxohexanedionic acid; 2-oxo-hexanedioic acid; alpha-Ketoadipic acid; 2-Oxohexanedioic acid; alpha-Oxoadipic acid; 2-oxo-Hexanedioate; α-Ketoadipic acid; alpha-Ketoadipate; 2-Ketoadipic acid; 2-Oxohexanedioate; a-Ketoadipic acid; a-Oxoadipic acid; alpha-Oxoadipate; 2-Oxoadipic acid; α-Oxoadipic acid; 2-Keto-adipate; Oxoadipic acid; 2-Ketoadipate; a-Ketoadipate; a-Oxoadipate; 2-Oxoadipate; Oxoadipate; Oxoadipic acid; 2-Oxoadipate
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:15753
- KEGG: C00322
- PubChem: 71
- HMDB: HMDB0000225
- Metlin: METLIN322
- MetaCyc: 2K-ADIPATE
- KNApSAcK: C00000770
- foodb: FDB003362
- chemspider: 70
- CAS: 3184-35-8
- MoNA: KO001259
- MoNA: KO001257
- MoNA: KO001260
- MoNA: KO001258
- MoNA: KO001256
- PMhub: MS000009608
- LipidMAPS: LMFA01170121
- PDB-CCD: OOG
- 3DMET: B00088
- NIKKAJI: J39.063A
- RefMet: 2-Oxoadipic acid
- medchemexpress: HY-113227
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-499
- PubChem: 3616
- KNApSAcK: 15753
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
417 个相关的代谢反应过程信息。
Reactome(68)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Lysine catabolism:
2OG + H+ + L-Lys + TPNH ⟶ H2O + SACN + TPN - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Lysine catabolism:
2OG + H+ + L-Lys + TPNH ⟶ H2O + SACN + TPN - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
ATP + L-His + b-Ala ⟶ ADP + CARN + Pi - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
Oxygen + PPCA ⟶ H2O2 + P6C - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
CoA + NAD + aKADA ⟶ GL-CoA + NADH + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Lysine catabolism:
2OG + H+ + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
Oxygen + PPCA ⟶ H2O2 + P6C
BioCyc(0)
WikiPathways(2)
- Cerebral organic acidurias, including diseases:
L-2-Aminoadipic acid ⟶ 2-Oxoadipic acid - Metabolic Epileptic Disorders:
P-enolpyruvate ⟶ Pyruvate
Plant Reactome(320)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + SACN ⟶ L-Glu + NADH + allysine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
H2O + L-Asn ⟶ L-Asp + ammonia - Lysine degradation II:
LIPAM + aKADA ⟶ S-glutaryldihydrolipoamide + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + SACN ⟶ L-Glu + NADH + allysine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
2OG + L-Val ⟶ Glu + KIV - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
H2O + L-Asn ⟶ L-Asp + ammonia - Lysine degradation II:
LIPAM + aKADA ⟶ S-glutaryldihydrolipoamide + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
H2O + L-Asn ⟶ L-Asp + ammonia - Lysine degradation II:
LIPAM + aKADA ⟶ S-glutaryldihydrolipoamide + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + SACN ⟶ L-Glu + NADH + allysine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid catabolism:
2OG + L-Val ⟶ Glu + KIV - Lysine degradation II:
H2O + NAD + SACN ⟶ L-Glu + NADH + allysine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
2OG + L-Lys + TPNH ⟶ H2O + SACN + TPN - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate
INOH(2)
- Lysine degradation ( Lysine degradation ):
2-Oxo-glutaric acid + L-Lysine + NADH ⟶ H2O + L-Saccharopine + NAD+ - L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid ( Lysine degradation ):
2-Oxo-glutaric acid + L-2-Amino-adipic acid ⟶ 2-Oxo-adipic acid + L-Glutamic acid
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(25)
- Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Metabolism:
Hydrogen Ion + meso-diaminopimelate ⟶ Carbon dioxide + L-Lysine - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Amino-3-Carboxymuconate Semialdehyde Degradation:
2-Amino-3-carboxymuconic acid semialdehyde + Hydrogen Ion ⟶ 2-Aminomuconic acid semialdehyde + Carbon dioxide - Lysine Metabolism:
Adenosine triphosphate + Aminoadipic acid + holo-[LYS2 peptidyl-carrier-protein] ⟶ Adenosine monophosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + Pyrophosphate
PharmGKB(0)
4 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 13689 - Sphingomonas paucimobilis: 10.1128/JB.187.3.847-853.2005
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuanyuan Hu, John E Cronan. α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism.
Nature communications.
2020 11; 11(1):5598. doi:
10.1038/s41467-020-19251-5. [PMID: 33154364] - Artem V Artiukhov, Aneta Grabarska, Ewelina Gumbarewicz, Vasily A Aleshin, Thilo Kähne, Toshihiro Obata, Alexey V Kazantsev, Nikolay V Lukashev, Andrzej Stepulak, Alisdair R Fernie, Victoria I Bunik. Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues.
Scientific reports.
2020 02; 10(1):1886. doi:
10.1038/s41598-020-58701-4. [PMID: 32024885] - Veronika Boczonadi, Martin S King, Anthony C Smith, Monika Olahova, Boglarka Bansagi, Andreas Roos, Filmon Eyassu, Christoph Borchers, Venkateswaran Ramesh, Hanns Lochmüller, Tuomo Polvikoski, Roger G Whittaker, Angela Pyle, Helen Griffin, Robert W Taylor, Patrick F Chinnery, Alan J Robinson, Edmund R S Kunji, Rita Horvath. Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.
Genetics in medicine : official journal of the American College of Medical Genetics.
2018 10; 20(10):1224-1235. doi:
10.1038/gim.2017.251. [PMID: 29517768] - Janaína Camacho da Silva, Alexandre Umpierrez Amaral, Cristiane Cecatto, Alessandro Wajner, Kálita Dos Santos Godoy, Rafael Teixeira Ribeiro, Aline de Mello Gonçalves, Ângela Zanatta, Mateus Struecker da Rosa, Samanta Oliveira Loureiro, Carmen Regla Vargas, Guilhian Leipnitz, Diogo Onofre Gomes de Souza, Moacir Wajner. α-Ketoadipic Acid and α-Aminoadipic Acid Cause Disturbance of Glutamatergic Neurotransmission and Induction of Oxidative Stress In Vitro in Brain of Adolescent Rats.
Neurotoxicity research.
2017 Aug; 32(2):276-290. doi:
10.1007/s12640-017-9735-8. [PMID: 28429309] - Katsumi Shibata, Chifumi Nakata, Tsutomu Fukuwatari. High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats.
Bioscience, biotechnology, and biochemistry.
2016; 80(2):304-12. doi:
10.1080/09168451.2015.1083395. [PMID: 26745680] - Jacob Hagen, Heleen te Brinke, Ronald J A Wanders, Alida C Knegt, Esmee Oussoren, A Jeannette M Hoogeboom, George J G Ruijter, Daniel Becker, Karl Otfried Schwab, Ingo Franke, Marinus Duran, Hans R Waterham, Jörn Oliver Sass, Sander M Houten. Genetic basis of alpha-aminoadipic and alpha-ketoadipic aciduria.
Journal of inherited metabolic disease.
2015 Sep; 38(5):873-9. doi:
10.1007/s10545-015-9841-9. [PMID: 25860818] - Katsumi Shibata, Kasumi Inomoto, Chifumi Nakata, Tsutomu Fukuwatari. Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats.
Journal of nutritional science and vitaminology.
2013; 59(6):509-15. doi:
10.3177/jnsv.59.509. [PMID: 24477247] - Katharina Danhauser, Sven W Sauer, Tobias B Haack, Thomas Wieland, Christian Staufner, Elisabeth Graf, Johannes Zschocke, Tim M Strom, Thorsten Traub, Jürgen G Okun, Thomas Meitinger, Georg F Hoffmann, Holger Prokisch, Stefan Kölker. DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.
American journal of human genetics.
2012 Dec; 91(6):1082-7. doi:
10.1016/j.ajhg.2012.10.006. [PMID: 23141293] - Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects.
Frontiers in plant science.
2012; 3(?):2. doi:
10.3389/fpls.2012.00002. [PMID: 22639632] - Peng Jiang, Weixing Dai, Shikai Yan, Zhongliang Chen, Ruilin Xu, Jianmi Ding, Li Xiang, Shuping Wang, Runhui Liu, Weidong Zhang. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method.
Journal of ethnopharmacology.
2011 Nov; 138(2):530-6. doi:
10.1016/j.jep.2011.09.049. [PMID: 22001859] - Jia V Li, Jasmina Saric, Yulan Wang, Jennifer Keiser, Jürg Utzinger, Elaine Holmes. Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni.
Parasites & vectors.
2011 Sep; 4(?):179. doi:
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