D-Leucic acid (BioDeep_00000003198)

 

Secondary id: BioDeep_00000027625, BioDeep_00000400460, BioDeep_00000405325, BioDeep_00000605916, BioDeep_00001868597, BioDeep_00001873781

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


delta-2-Hydroxy-4-methylpentanoic acid

化学式: C6H12O3 (132.0786402)
中文名称: DL-白氨酸, DL-闪白酸, 2-羟基-4-甲基戊酸, (R)-2-羟基-4-甲基戊酸
谱图信息: 最多检出来源 Viridiplantae(plant) 0.21%

分子结构信息

SMILES: CC(C)CC(C(=O)O)O
InChI: InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)

描述信息

D-Leucic acid is an alpha-hydroxycarboxylic acid present in patients affected with Short-bowel syndrome (an Inborn errors of metabolism, OMIM 175200) (PMID 9766851), and in Maple Syrup Urine Disease (MSUD, an autosomal recessive inherited metabolic disorder of branched-chain amino acid) (PMID 9766851). [HMDB]
D-Leucic acid is an alpha-hydroxycarboxylic acid present in patients affected with Short-bowel syndrome (an Inborn errors of metabolism, OMIM 175200) (PMID 9766851), and in Maple Syrup Urine Disease (MSUD, an autosomal recessive inherited metabolic disorder of branched-chain amino acid) (PMID 9766851).
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID H091
(R)-Leucic acid is an amino acid metabolite[1].

同义名列表

59 个代谢物同义名

delta-2-Hydroxy-4-methylpentanoic acid; (2R)-2-hydroxy-4-methylpentanoic acid; 2-Hydroxy-4-methyl-delta-valeric acid; (R)-2-Hydroxy-4-methyl-pentanoic acid; (R)-2-Hydroxy-4-methylpentanoic acid; delta-2-Hydroxy-4-methylvaleric acid; 2R-hydroxy-4-methyl-pentanoic acid; D-2-Hydroxy-4-methylpentanoic acid; (R)-2-Hydroxy-4-methylvaleric acid; delta-2-Hydroxy-4-methylpentanoate; delta-alpha-Hydroxyisocaproic acid; 2-Hydroxy-4-methyl-D-valeric acid; 2-Hydroxy-4-methyl-delta-valerate; (R)-2-Hydroxy-4-methyl-pentanoate; (-)-alpha-Hydroxyisocaproic acid; D-2-Hydroxy-4-methylvaleric acid; (R)-2-Hydroxy-4-methylpentanoate; delta-2-Hydroxy-4-methylvalerate; 2-Hydroxy-4-methylpentanoic acid; delta-alpha-Hydroxyisocaproate; (R)-2-Hydroxy-4-methylvalerate; 2-hydroxy-4-methylvaleric acid; delta-2-Hydroxyisocaproic acid; D-2-Hydroxy-4-methylpentanoate; 2-Hydroxy-4-methyl-D-valerate; (R)-2-Hydroxyisocaproic acid; (-)-2-Hydroxyisocaproic acid; 2-Hydroxy-4-methylpentanoate; D-2-Hydroxy-4-methylvalerate; (-)-a-Hydroxyisocaproic acid; alpha-Hydroxyisocaproic acid; (-)-alpha-Hydroxyisocaproate; delta-2-Hydroxyisocaproate; D-2-Hydroxyisocaproic acid; D-a-Hydroxyisocaproic acid; a-Hydroxyisocaproic acid; Α-hydroxyisocaproic acid; (-)-α-hydroxyisocaproate; (-)-a-Hydroxyisocaproate; 2-Hydroxyisocaproic acid; (-)-2-Hydroxyisocaproate; alpha-Hydroxyisocaproate; (R)-2-Hydroxyisocaproate; D-a-Hydroxyisocaproate; D-2-Hydroxyisocaproate; Α-hydroxyisocaproate; a-Hydroxyisocaproate; delta-Leucic acid; (R)-Leucic acid; DL-Leucic Acid; Δ-leucic acid; D-Leucic acid; delta-Leucate; Leucic acid; (R)-Leucate; D-Leucate; Δ-leucate; Leucate; D-α-Hydroxyisocaproic acid



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cristina Piras, Stella Conte, Monica Pibiri, Giacomo Rao, Sandro Muntoni, Vera Piera Leoni, Gabriele Finco, Luigi Atzori. Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity. Scientific reports. 2020 11; 10(1):20418. doi: 10.1038/s41598-020-76876-8. [PMID: 33235303]
  • M Sakko, L Tjäderhane, T Sorsa, P Hietala, R Rautemaa. Antimicrobial 2-hydroxyisocaproic acid and chlorhexidine resist inactivation by dentine. International endodontic journal. 2016 Apr; 49(4):352-60. doi: 10.1111/iej.12465. [PMID: 25944560]
  • M Sakko, C Moore, L Novak-Frazer, V Rautemaa, T Sorsa, P Hietala, A Järvinen, P Bowyer, L Tjäderhane, R Rautemaa. 2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species. Mycoses. 2014 Apr; 57(4):214-21. doi: 10.1111/myc.12145. [PMID: 24125484]
  • Dora Ndagano, Thibaut Lamoureux, Carine Dortu, Sophie Vandermoten, Philippe Thonart. Antifungal activity of 2 lactic acid bacteria of the Weissella genus isolated from food. Journal of food science. 2011 Aug; 76(6):M305-11. doi: 10.1111/j.1750-3841.2011.02257.x. [PMID: 21729073]
  • Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Molecular bioSystems. 2010 May; 6(5):909-21. doi: 10.1039/b914182k. [PMID: 20567778]
  • Michael H T Li, Peter M U Ung, James Zajkowski, Sylvie Garneau-Tsodikova, David H Sherman. Automated genome mining for natural products. BMC bioinformatics. 2009 Jun; 10(?):185. doi: 10.1186/1471-2105-10-185. [PMID: 19531248]
  • Vilson de Castro Vasques, Fabrício Brinco, Moacir Wajner. Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks. Journal of the neurological sciences. 2005 May; 232(1-2):11-21. doi: 10.1016/j.jns.2004.12.015. [PMID: 15850577]
  • Alexandra Muth, Jochen Jung, Steffi Bilke, Annette Scharrer, Armin Mosandl, Adrian C Sewell, Hans Böhles. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 792(2):269-77. doi: 10.1016/s1570-0232(03)00285-x. [PMID: 12860034]
  • K D Webster, M W Anders. Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid. Archives of biochemistry and biophysics. 1989 Sep; 273(2):562-71. doi: 10.1016/0003-9861(89)90516-x. [PMID: 2774567]
  • L J Spaapen, D Ketting, S K Wadman, L Bruinvis, M Duran. Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin. Journal of inherited metabolic disease. 1987; 10(4):383-90. doi: 10.1007/bf01799981. [PMID: 3126358]
  • E Haan, G Brown, A Bankier, D Mitchell, S Hunt, J Blakey, G Barnes. Severe illness caused by the products of bacterial metabolism in a child with a short gut. European journal of pediatrics. 1985 May; 144(1):63-5. doi: 10.1007/bf00491929. [PMID: 4018104]
  • C Jakobs, L Sweetman, W L Nyhan. Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Clinica chimica acta; international journal of clinical chemistry. 1984 Jul; 140(2):157-66. doi: 10.1016/0009-8981(84)90340-1. [PMID: 6467607]
  • T Kuhara, T Shinka, Y Inoue, M Matsumoto, M Yoshino, Y Sakaguchi, I Matsumoto. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Clinica chimica acta; international journal of clinical chemistry. 1983 Sep; 133(2):133-40. doi: 10.1016/0009-8981(83)90398-4. [PMID: 6688766]